PRKACA (protein kinase cAMP-activated catalytic subunit alpha)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5566 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Protein kinase cAMP-activated catalytic subunit alpha |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PRKACA |
SynonymsGene synonyms aliases
|
CAFD1, PKACA, PPNAD4 |
ChromosomeChromosome number
|
19 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
19p13.12 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dime |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs386352352 |
A>C |
Pathogenic, likely-pathogenic |
Missense variant, coding sequence variant |
rs724160013 |
->CAC |
Pathogenic |
Coding sequence variant, inframe insertion |
|
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000086 |
Process |
G2/M transition of mitotic cell cycle |
TAS |
|
GO:0000287 |
Function |
Magnesium ion binding |
IEA |
|
GO:0001669 |
Component |
Acrosomal vesicle |
ISS |
|
GO:0001707 |
Process |
Mesoderm formation |
IEA |
|
GO:0001843 |
Process |
Neural tube closure |
IEA |
|
GO:0002027 |
Process |
Regulation of heart rate |
TAS |
23507255 |
GO:0002223 |
Process |
Stimulatory C-type lectin receptor signaling pathway |
TAS |
|
GO:0003091 |
Process |
Renal water homeostasis |
TAS |
|
GO:0004672 |
Function |
Protein kinase activity |
IDA |
12475942 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IDA |
21085490 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IMP |
26537248 |
GO:0004679 |
Function |
AMP-activated protein kinase activity |
IEA |
|
GO:0004691 |
Function |
CAMP-dependent protein kinase activity |
IDA |
11029056 |
GO:0004691 |
Function |
CAMP-dependent protein kinase activity |
ISS |
|
GO:0004691 |
Function |
CAMP-dependent protein kinase activity |
NAS |
2843813 |
GO:0004691 |
Function |
CAMP-dependent protein kinase activity |
TAS |
|
GO:0004712 |
Function |
Protein serine/threonine/tyrosine kinase activity |
IDA |
22797923 |
GO:0005515 |
Function |
Protein binding |
IPI |
11035810, 12475942, 15630084, 15655353, 16387847, 17148597, 17911601, 18836454, 21085490, 23455922, 23602568, 24351927, 24464040, 24605759, 24700472, 24855271, 24860872, 25477193, 26496610, 27107012, 29568061, 31980649, 32296183, 32814053 |
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
IDA |
21085490 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
21085490 |
GO:0005739 |
Component |
Mitochondrion |
IEA |
|
GO:0005813 |
Component |
Centrosome |
IDA |
21399614 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005930 |
Component |
Axoneme |
IDA |
12475942 |
GO:0005952 |
Component |
CAMP-dependent protein kinase complex |
IDA |
12475942 |
GO:0005952 |
Component |
CAMP-dependent protein kinase complex |
NAS |
2843813 |
GO:0006397 |
Process |
MRNA processing |
IDA |
17594903 |
GO:0006468 |
Process |
Protein phosphorylation |
IDA |
12475942 |
GO:0006468 |
Process |
Protein phosphorylation |
NAS |
2843813 |
GO:0007596 |
Process |
Blood coagulation |
TAS |
|
GO:0010389 |
Process |
Regulation of G2/M transition of mitotic cell cycle |
TAS |
|
GO:0010737 |
Process |
Protein kinase A signaling |
IBA |
21873635 |
GO:0010881 |
Process |
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
TAS |
23507255 |
GO:0016020 |
Component |
Membrane |
IDA |
15569306 |
GO:0016241 |
Process |
Regulation of macroautophagy |
TAS |
26046386 |
GO:0016607 |
Component |
Nuclear speck |
IDA |
17594903 |
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
IDA |
10805756, 11029056 |
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
IMP |
26537248 |
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
TAS |
26078884 |
GO:0018107 |
Process |
Peptidyl-threonine phosphorylation |
IEA |
|
GO:0019221 |
Process |
Cytokine-mediated signaling pathway |
TAS |
|
GO:0019901 |
Function |
Protein kinase binding |
IPI |
11035810, 17911601 |
GO:0019904 |
Function |
Protein domain specific binding |
IEA |
|
GO:0030145 |
Function |
Manganese ion binding |
IEA |
|
GO:0031594 |
Component |
Neuromuscular junction |
IEA |
|
GO:0031625 |
Function |
Ubiquitin protein ligase binding |
IDA |
21423175 |
GO:0034199 |
Process |
Activation of protein kinase A activity |
TAS |
|
GO:0034237 |
Function |
Protein kinase A regulatory subunit binding |
IBA |
21873635 |
GO:0034237 |
Function |
Protein kinase A regulatory subunit binding |
IPI |
17911601 |
GO:0034380 |
Process |
High-density lipoprotein particle assembly |
TAS |
|
GO:0034605 |
Process |
Cellular response to heat |
IDA |
21085490 |
GO:0034704 |
Component |
Calcium channel complex |
TAS |
23507255 |
GO:0035584 |
Process |
Calcium-mediated signaling using intracellular calcium source |
TAS |
23507255 |
GO:0036126 |
Component |
Sperm flagellum |
IEA |
|
GO:0043197 |
Component |
Dendritic spine |
IEA |
|
GO:0043393 |
Process |
Regulation of protein binding |
TAS |
23507255 |
GO:0044853 |
Component |
Plasma membrane raft |
IDA |
17911601 |
GO:0045667 |
Process |
Regulation of osteoblast differentiation |
IDA |
19949837 |
GO:0046777 |
Process |
Protein autophosphorylation |
IEA |
|
GO:0046827 |
Process |
Positive regulation of protein export from nucleus |
IEA |
|
GO:0048240 |
Process |
Sperm capacitation |
ISS |
|
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IDA |
21085490 |
GO:0050804 |
Process |
Modulation of chemical synaptic transmission |
IEA |
|
GO:0051480 |
Process |
Regulation of cytosolic calcium ion concentration |
TAS |
23507255 |
GO:0055117 |
Process |
Regulation of cardiac muscle contraction |
TAS |
23507255 |
GO:0060314 |
Process |
Regulation of ryanodine-sensitive calcium-release channel activity |
TAS |
23507255 |
GO:0061136 |
Process |
Regulation of proteasomal protein catabolic process |
IDA |
17565987 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
23533145 |
GO:0070613 |
Process |
Regulation of protein processing |
IEA |
|
GO:0071158 |
Process |
Positive regulation of cell cycle arrest |
ISS |
|
GO:0071333 |
Process |
Cellular response to glucose stimulus |
IDA |
19949837 |
GO:0071374 |
Process |
Cellular response to parathyroid hormone stimulus |
IEA |
|
GO:0071377 |
Process |
Cellular response to glucagon stimulus |
TAS |
|
GO:0071872 |
Process |
Cellular response to epinephrine stimulus |
TAS |
23507255 |
GO:0086064 |
Process |
Cell communication by electrical coupling involved in cardiac conduction |
TAS |
23507255 |
GO:0097546 |
Component |
Ciliary base |
TAS |
|
GO:0097711 |
Process |
Ciliary basal body-plasma membrane docking |
TAS |
|
GO:1901621 |
Process |
Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
IEA |
|
GO:1903779 |
Process |
Regulation of cardiac conduction |
TAS |
|
GO:2000810 |
Process |
Regulation of bicellular tight junction assembly |
IDA |
15905176 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P17612 |
Protein name |
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) |
Protein function |
Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:2108549 |
PDB |
2GU8
,
3AGL
,
3AGM
,
3AMA
,
3AMB
,
3L9L
,
3L9M
,
3L9N
,
3MVJ
,
3NX8
,
3OOG
,
3OVV
,
3OWP
,
3OXT
,
3P0M
,
3POO
,
3VQH
,
4AE6
,
4AE9
,
4UJ1
,
4UJ2
,
4UJ9
,
4UJA
,
4UJB
,
4WB5
,
4WB6
,
4WB7
,
4WB8
,
5BX6
,
5BX7
,
5IZF
,
5IZJ
,
5J5X
,
5N23
,
5UZK
,
6BYR
,
6BYS
,
6C0U
,
6FRX
,
6NO7
,
6QJ7
,
6WJF
,
6WJG
,
7Y1G
,
8FE2
,
8FE5
,
8FEC
,
8X5L
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
44 → 298 |
Protein kinase domain |
Domain |
|
Sequence |
|
Sequence length |
351 |
Interactions |
View interactions |
|
|
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