GediPNet logo

PRKACA (protein kinase cAMP-activated catalytic subunit alpha)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5566
Gene nameGene Name - the full gene name approved by the HGNC.
Protein kinase cAMP-activated catalytic subunit alpha
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PRKACA
SynonymsGene synonyms aliases
CAFD1, PKACA, PPNAD4
ChromosomeChromosome number
19
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.12
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dime
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs386352352 A>C Pathogenic, likely-pathogenic Missense variant, coding sequence variant
rs724160013 ->CAC Pathogenic Coding sequence variant, inframe insertion
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030635 hsa-miR-22-3p Sequencing 20371350
MIRT044041 hsa-miR-365a-3p CLASH 23622248
MIRT043455 hsa-miR-331-3p CLASH 23622248
MIRT043455 hsa-miR-331-3p CLASH 23622248
MIRT042660 hsa-miR-196b-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS
GO:0000287 Function Magnesium ion binding IEA
GO:0001669 Component Acrosomal vesicle ISS
GO:0001707 Process Mesoderm formation IEA
GO:0001843 Process Neural tube closure IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P17612
Protein name cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Protein function Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:2108549
PDB 2GU8 , 3AGL , 3AGM , 3AMA , 3AMB , 3L9L , 3L9M , 3L9N , 3MVJ , 3NX8 , 3OOG , 3OVV , 3OWP , 3OXT , 3P0M , 3POO , 3VQH , 4AE6 , 4AE9 , 4UJ1 , 4UJ2 , 4UJ9 , 4UJA , 4UJB , 4WB5 , 4WB6 , 4WB7 , 4WB8 , 5BX6 , 5BX7 , 5IZF , 5IZJ , 5J5X , 5N23 , 5UZK , 6BYR , 6BYS , 6C0U , 6FRX , 6NO7 , 6QJ7 , 6WJF , 6WJG , 7Y1G , 8FE2 , 8FE5 , 8FEC , 8X5L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
44 298
Protein kinase domain
Domain
Sequence
Sequence length 351
Interactions View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412