Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5564 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Protein kinase AMP-activated non-catalytic subunit beta 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PRKAB1 |
SynonymsGene synonyms aliases
|
AMPK, HAMPKb |
ChromosomeChromosome number
|
12 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q24.23 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme tha |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
TP53 |
Unknown |
12771025 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0004672 |
Function |
Protein kinase activity |
IDA |
17028174 |
GO:0005515 |
Function |
Protein binding |
IPI |
16306228, 17028174, 18403135, 18480843, 18624398, 20562859, 21072212, 21988832, 22363791, 23455922, 25686248, 25852190, 28514442, 28561066, 32296183 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006468 |
Process |
Protein phosphorylation |
IDA |
17028174 |
GO:0006633 |
Process |
Fatty acid biosynthetic process |
IEA |
|
GO:0007050 |
Process |
Cell cycle arrest |
TAS |
|
GO:0007165 |
Process |
Signal transduction |
IBA |
21873635 |
GO:0007165 |
Process |
Signal transduction |
TAS |
9575201 |
GO:0010628 |
Process |
Positive regulation of gene expression |
IDA |
17028174 |
GO:0016236 |
Process |
Macroautophagy |
TAS |
|
GO:0016241 |
Process |
Regulation of macroautophagy |
TAS |
|
GO:0019901 |
Function |
Protein kinase binding |
IBA |
21873635 |
GO:0031588 |
Component |
Nucleotide-activated protein kinase complex |
IBA |
21873635 |
GO:0035878 |
Process |
Nail development |
IEA |
|
GO:0050790 |
Process |
Regulation of catalytic activity |
IEA |
|
GO:0080090 |
Process |
Regulation of primary metabolic process |
IBA |
21873635 |
GO:0120162 |
Process |
Positive regulation of cold-induced thermogenesis |
ISS |
27411013 |
GO:1901796 |
Process |
Regulation of signal transduction by p53 class mediator |
TAS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q9Y478 |
Protein name |
5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) |
Protein function |
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing p |
PDB |
4CFE
,
4CFF
,
4ZHX
,
5EZV
,
5ISO
,
6B1U
,
6C9F
,
6C9G
,
6C9H
,
6C9J
,
7MYJ
,
8BIK
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF16561 |
AMPK1_CBM |
78 → 161 |
Glycogen recognition site of AMP-activated protein kinase |
Family |
PF04739 |
AMPKBI |
199 → 269 |
|
Family |
|
Sequence |
|
Sequence length |
270 |
Interactions |
View interactions |