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PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5564
Gene nameGene Name - the full gene name approved by the HGNC.
Protein kinase AMP-activated non-catalytic subunit beta 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PRKAB1
SynonymsGene synonyms aliases
AMPK, HAMPKb
ChromosomeChromosome number
12
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.23
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme tha
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004527 hsa-miR-122-5p Luciferase reporter assay 16459310
MIRT053237 hsa-miR-148b-3p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 23171948
MIRT719926 hsa-miR-483-3p HITS-CLIP 19536157
MIRT719927 hsa-miR-4733-3p HITS-CLIP 19536157
MIRT719926 hsa-miR-483-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
TP53 Unknown 12771025
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004672 Function Protein kinase activity IDA 17028174
GO:0005515 Function Protein binding IPI 16306228, 17028174, 18403135, 18480843, 18624398, 20562859, 21072212, 21988832, 22363791, 23455922, 25686248, 25852190, 28514442, 28561066, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9Y478
Protein name 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)
Protein function Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing p
PDB 4CFE , 4CFF , 4ZHX , 5EZV , 5ISO , 6B1U , 6C9F , 6C9G , 6C9H , 6C9J , 7MYJ , 8BIK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16561 AMPK1_CBM
78 161
Glycogen recognition site of AMP-activated protein kinase
Family
PF04739 AMPKBI
199 269
Family
Sequence
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFE
VFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKP
I
Sequence length 270
Interactions View interactions

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