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PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5563
Gene nameGene Name - the full gene name approved by the HGNC.
Protein kinase AMP-activated catalytic subunit alpha 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PRKAA2
SynonymsGene synonyms aliases
AMPK, AMPK2, AMPKa2, PRKAA
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p32.2
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026874 hsa-miR-192-5p Microarray 19074876
MIRT027841 hsa-miR-98-5p Microarray 19088304
MIRT052107 hsa-let-7b-5p CLASH 23622248
MIRT047217 hsa-miR-182-5p CLASH 23622248
MIRT700623 hsa-miR-495-5p HITS-CLIP 23313552
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003682 Function Chromatin binding ISS
GO:0004672 Function Protein kinase activity TAS 7959015
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity ISS
GO:0004679 Function AMP-activated protein kinase activity IDA 18439900
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P54646
Protein name 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)
Protein function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AM
PDB 2H6D , 2LTU , 2YZA , 3AQV , 4CFE , 4CFF , 4ZHX , 5EZV , 5ISO , 6B1U , 6B2E , 6BX6 , 7MYJ , 8BIK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
16 268
Protein kinase domain
Domain
PF16579 AdenylateSensor
401 495
Adenylate sensor of SNF1-like protein kinase
Domain
Sequence
Sequence length 552
Interactions View interactions

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