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PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5562
Gene nameGene Name - the full gene name approved by the HGNC.
Protein kinase AMP-activated catalytic subunit alpha 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PRKAA1
SynonymsGene synonyms aliases
AMPK, AMPK alpha 1, AMPKa1
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p13.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5`-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006742 hsa-miR-19b-3p Luciferase reporter assay 20190740
MIRT006742 hsa-miR-19b-3p Luciferase reporter assay 20190740
MIRT019393 hsa-miR-148b-3p Microarray 17612493
MIRT020218 hsa-miR-130b-3p Sequencing 20371350
MIRT021937 hsa-miR-128-3p Microarray 17612493
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000187 Process Activation of MAPK activity NAS 11546797
GO:0001666 Process Response to hypoxia NAS 8557660
GO:0003682 Function Chromatin binding ISS
GO:0004672 Function Protein kinase activity IDA 17028174
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q13131
Protein name 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11
Protein function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reducti
PDB 4RED , 4RER , 4REW , 5EZV , 6C9F , 6C9G , 6C9H , 6C9J , 7JHG , 7JHH , 7JIJ , 7M74
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
27 279
Protein kinase domain
Domain
PF16579 AdenylateSensor
406 503
Adenylate sensor of SNF1-like protein kinase
Domain
Sequence
Sequence length 559
Interactions View interactions

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