PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon)

Gene

• Entrez ID: 5529
• Gene name: Protein phosphatase 2 regulatory subunit B'epsilon
• Gene symbol: PPP2R5E
• Synonyms: B56E, B56epsilon
• Chromosome: 14
• Chromosome location: 14q23.2
• Summary: The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006743	hsa-miR-19b-3p	Luciferase reporter assay	20190740
MIRT006743	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT006743	hsa-miR-19b-3p	Luciferase reporter assay	27720936
MIRT044037	hsa-miR-365a-3p	CLASH	23622248
MIRT045699	hsa-miR-125a-5p	CLASH	23622248
MIRT051753	hsa-let-7c-5p	CLASH	23622248
MIRT051983	hsa-let-7b-5p	CLASH	23622248
MIRT054034	hsa-miR-23a-3p	GFP reporter assay, qRT-PCR, Western blot	24997345
MIRT439912	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT470339	hsa-miR-4701-3p	PAR-CLIP	23592263
MIRT470340	hsa-miR-6736-5p	PAR-CLIP	23592263
MIRT470341	hsa-miR-1262	PAR-CLIP	23592263
MIRT470342	hsa-miR-4452	PAR-CLIP	23592263
MIRT470343	hsa-miR-1273e	PAR-CLIP	23592263
MIRT470344	hsa-miR-6794-3p	PAR-CLIP	23592263
MIRT470345	hsa-miR-1273f	PAR-CLIP	23592263
MIRT470346	hsa-miR-4708-5p	PAR-CLIP	23592263
MIRT470347	hsa-miR-6088	PAR-CLIP	23592263
MIRT470348	hsa-miR-4770	PAR-CLIP	23592263
MIRT470349	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT470350	hsa-miR-520h	PAR-CLIP	23592263
MIRT470351	hsa-miR-520g-3p	PAR-CLIP	23592263
MIRT470352	hsa-miR-3973	PAR-CLIP	23592263
MIRT470353	hsa-miR-4712-3p	PAR-CLIP	23592263
MIRT470354	hsa-miR-548l	PAR-CLIP	23592263
MIRT470355	hsa-miR-548aw	PAR-CLIP	23592263
MIRT470356	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT470357	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT470358	hsa-miR-582-5p	PAR-CLIP	23592263
MIRT470359	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT470360	hsa-miR-466	PAR-CLIP	23592263
MIRT470361	hsa-miR-4672	PAR-CLIP	23592263
MIRT470362	hsa-miR-3941	PAR-CLIP	23592263
MIRT470363	hsa-miR-3138	PAR-CLIP	23592263
MIRT470364	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT470365	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT470366	hsa-miR-548x-5p	PAR-CLIP	23592263
MIRT470367	hsa-miR-548g-5p	PAR-CLIP	23592263
MIRT470368	hsa-miR-548f-5p	PAR-CLIP	23592263
MIRT470369	hsa-miR-548aj-5p	PAR-CLIP	23592263
MIRT470370	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT470371	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT470372	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT470373	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT470374	hsa-miR-4272	PAR-CLIP	23592263
MIRT470375	hsa-miR-6504-3p	PAR-CLIP	23592263
MIRT470376	hsa-miR-5586-5p	PAR-CLIP	23592263
MIRT470377	hsa-miR-101-5p	PAR-CLIP	23592263
MIRT470378	hsa-miR-1265	PAR-CLIP	23592263
MIRT470379	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT470380	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT470381	hsa-miR-4801	PAR-CLIP	23592263
MIRT470382	hsa-miR-4731-3p	PAR-CLIP	23592263
MIRT470383	hsa-miR-181a-5p	PAR-CLIP	23592263
MIRT470384	hsa-miR-181c-5p	PAR-CLIP	23592263
MIRT470385	hsa-miR-181d-5p	PAR-CLIP	23592263
MIRT470386	hsa-miR-4262	PAR-CLIP	23592263
MIRT470387	hsa-miR-181b-5p	PAR-CLIP	23592263
MIRT470388	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT542101	hsa-miR-1277-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT542102	hsa-miR-5011-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT542103	hsa-miR-190a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT542104	hsa-miR-3163	PAR-CLIP, HITS-CLIP	21572407
MIRT542105	hsa-miR-410-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT542106	hsa-miR-4662a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT622608	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT622609	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT622610	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT622611	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT622612	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT622613	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT622614	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT710558	hsa-miR-510-3p	HITS-CLIP	19536157
MIRT710559	hsa-miR-2355-5p	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0005515	Function	Protein binding	IPI	15380617, 17540176, 18201571, 18782753, 19156129, 21699783, 21878643, 23555304, 24705354, 26496610, 27173435, 28330616, 30595372, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	TAS	8703017
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007165	Process	Signal transduction	IEA
GO:0019888	Function	Protein phosphatase regulator activity	TAS	8703017
GO:0031952	Process	Regulation of protein autophosphorylation	IBA	21873635
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0072542	Function	Protein phosphatase activator activity	IBA	21873635

Other IDs

• MIM: 601647
• HGNC: 9313
• e!Ensembl: ENSG00000154001

Protein

• UniProt ID: Q16537
• Protein name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)
• Protein function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01603	B56	48 → 453	Protein phosphatase 2A regulatory B subunit (B56 family)	Family

• Sequence:

  MSSAPTTPPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIELTPLPLLKDVPSSEQP
  ELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVS
  CNIFRTLPPSDSNEFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQPSIAKKYIDQKF
  VLQLLELFDSEDPRERDYLKTVLHRIYGKFLGLRAFIRKQINNIFLRFVYETEHFNGVAE
  LLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRSLSLFHAQLAYCIVQFLEKDPSLTE
  PVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEPSQFVKIQEPLFKQIAKCVSSPHFQVA
  ERALYYWNNEYIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNST
  MFDELTATYKSDRQREKKKEKEREELWKKLEDLELKRGLRRDGIIPT

• Sequence length: 467