Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5529 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Protein phosphatase 2 regulatory subunit B'epsilon |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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PPP2R5E |
SynonymsGene synonyms aliases
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B56E, B56epsilon |
ChromosomeChromosome number
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14 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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14q23.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a co |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000159 |
Component |
Protein phosphatase type 2A complex |
IBA |
21873635 |
GO:0005515 |
Function |
Protein binding |
IPI |
15380617, 17540176, 18201571, 18782753, 19156129, 21699783, 21878643, 23555304, 24705354, 26496610, 27173435, 28330616, 30595372, 32814053 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
TAS |
8703017 |
GO:0005829 |
Component |
Cytosol |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0006470 |
Process |
Protein dephosphorylation |
IBA |
21873635 |
GO:0007165 |
Process |
Signal transduction |
IEA |
|
GO:0019888 |
Function |
Protein phosphatase regulator activity |
TAS |
8703017 |
GO:0031952 |
Process |
Regulation of protein autophosphorylation |
IBA |
21873635 |
GO:0043666 |
Process |
Regulation of phosphoprotein phosphatase activity |
IEA |
|
GO:0072542 |
Function |
Protein phosphatase activator activity |
IBA |
21873635 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q16537 |
Protein name |
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) |
Protein function |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
PDB |
8UWB
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01603 |
B56 |
48 → 453 |
Protein phosphatase 2A regulatory B subunit (B56 family) |
Family |
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Sequence |
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Sequence length |
467 |
Interactions |
View interactions |