PPP2R5D (protein phosphatase 2 regulatory subunit B'delta)

Gene

• Entrez ID: 5528
• Gene name: Protein phosphatase 2 regulatory subunit B'delta
• Gene symbol: PPP2R5D
• Synonyms: B56D, B56delta, MRD35
• Chromosome: 6
• Chromosome location: 6p21.1
• Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT035781	hsa-miR-1914-5p	CLASH	23622248
MIRT040037	hsa-miR-615-3p	CLASH	23622248
MIRT535057	hsa-miR-3977	PAR-CLIP	22012620
MIRT535057	hsa-miR-3977	PAR-CLIP	20371350
MIRT535058	hsa-miR-4465	PAR-CLIP	22012620
MIRT535058	hsa-miR-4465	PAR-CLIP	20371350
MIRT535059	hsa-miR-26b-5p	PAR-CLIP	22012620
MIRT535059	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT535060	hsa-miR-26a-5p	PAR-CLIP	22012620
MIRT535060	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT535061	hsa-miR-1297	PAR-CLIP	22012620
MIRT535061	hsa-miR-1297	PAR-CLIP	20371350
MIRT535062	hsa-miR-6752-3p	PAR-CLIP	22012620
MIRT535062	hsa-miR-6752-3p	PAR-CLIP	20371350
MIRT535063	hsa-miR-6729-3p	PAR-CLIP	22012620
MIRT535063	hsa-miR-6729-3p	PAR-CLIP	20371350
MIRT535064	hsa-miR-6513-3p	PAR-CLIP	22012620
MIRT535064	hsa-miR-6513-3p	PAR-CLIP	20371350
MIRT535065	hsa-miR-371b-3p	PAR-CLIP	22012620
MIRT535065	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT735899	hsa-miR-1184	PAR-CLIP	26701625
MIRT735989	hsa-miR-1205	PAR-CLIP	26701625
MIRT738006	hsa-miR-17-3p	PAR-CLIP	26701625
MIRT738257	hsa-miR-185-5p	PAR-CLIP	26701625
MIRT738370	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT740480	hsa-miR-3158-5p	PAR-CLIP	26701625
MIRT740679	hsa-miR-3175	PAR-CLIP	26701625
MIRT743913	hsa-miR-4306	PAR-CLIP	26701625
MIRT746385	hsa-miR-4644	PAR-CLIP	26701625
MIRT748758	hsa-miR-4779	PAR-CLIP	26701625
MIRT752329	hsa-miR-6132	PAR-CLIP	26701625
MIRT752534	hsa-miR-619-3p	PAR-CLIP	26701625
MIRT753094	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT753883	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT754027	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT754884	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT757223	hsa-miR-6836-5p	PAR-CLIP	26701625
MIRT757730	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT759894	hsa-miR-7851-3p	PAR-CLIP	26701625
MIRT760231	hsa-miR-8085	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0004721	Function	Phosphoprotein phosphatase activity	IDA	24157919
GO:0005515	Function	Protein binding	IPI	16189514, 17540176, 18782753, 19293187, 22976297, 23555304, 24157919, 25416956, 26496610, 27173435, 28330616, 29892012, 30595372, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IDA	24157919
GO:0007165	Process	Signal transduction	IEA
GO:0007399	Process	Nervous system development	TAS	8703017
GO:0010801	Process	Negative regulation of peptidyl-threonine phosphorylation	IEA
GO:0019888	Function	Protein phosphatase regulator activity	TAS	8703017
GO:0031952	Process	Regulation of protein autophosphorylation	IBA	21873635
GO:0035307	Process	Positive regulation of protein dephosphorylation	IEA
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0072542	Function	Protein phosphatase activator activity	IBA	21873635

Other IDs

• MIM: 601646
• HGNC: 9312
• e!Ensembl: ENSG00000112640

Protein

• UniProt ID: Q14738
• Protein name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta)
• Protein function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01603	B56	103 → 513	Protein phosphatase 2A regulatory B subunit (B56 family)	Family

• Sequence:

  MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPS
  NSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQ
  KLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLF
  RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV
  LALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAEL
  LEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEP
  VIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAE
  RALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKL
  FDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPT
  AEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQE
  AL

• Sequence length: 602