PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma)

Gene

• Entrez ID: 5527
• Gene name: Protein phosphatase 2 regulatory subunit B'gamma
• Gene symbol: PPP2R5C
• Synonyms: B56G, B56gamma, HJS4, PR61G
• Chromosome: 14
• Chromosome location: 14q32.31
• Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common het

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1595460164	G>A	Likely-pathogenic	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001428	hsa-miR-16-5p	pSILAC	18668040
MIRT028561	hsa-miR-30a-5p	Proteomics	18668040
MIRT001428	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT038933	hsa-miR-31-3p	CLASH	23622248
MIRT053099	hsa-miR-135b-5p	Luciferase reporter assay, qRT-PCR, Western blot	23594704
MIRT053099	hsa-miR-135b-5p	Luciferase reporter assay, qRT-PCR, Western blot	23594704
MIRT277505	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT277506	hsa-miR-107	PAR-CLIP	20371350
MIRT277507	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT277510	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT277508	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT277509	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT277504	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT001428	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT277520	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT555315	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT277511	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT555313	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT555312	hsa-miR-646	PAR-CLIP	20371350
MIRT277516	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT277513	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT555309	hsa-miR-29c-5p	PAR-CLIP	20371350
MIRT277512	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT277515	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT277517	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT277518	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT277514	hsa-miR-3611	PAR-CLIP	20371350
MIRT277519	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT277505	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT277506	hsa-miR-107	PAR-CLIP	21572407
MIRT277507	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT277510	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT277508	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT277509	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT277504	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT001428	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT277520	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT555315	hsa-miR-548ao-3p	PAR-CLIP	21572407
MIRT277511	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT555314	hsa-miR-3664-5p	PAR-CLIP	21572407
MIRT555313	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT555312	hsa-miR-646	PAR-CLIP	21572407
MIRT277516	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT277513	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT277521	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT555311	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT555310	hsa-miR-4680-5p	PAR-CLIP	21572407
MIRT555309	hsa-miR-29c-5p	PAR-CLIP	21572407
MIRT277512	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT277515	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT277517	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT277518	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT277514	hsa-miR-3611	PAR-CLIP	21572407
MIRT277519	hsa-miR-6833-5p	PAR-CLIP	21572407
MIRT726880	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT726879	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT277505	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT277506	hsa-miR-107	PAR-CLIP	20371350
MIRT277507	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT277510	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT277508	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT277509	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT277504	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT001428	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT277520	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT555315	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT277511	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT555313	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT555312	hsa-miR-646	PAR-CLIP	20371350
MIRT277516	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT277513	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT555309	hsa-miR-29c-5p	PAR-CLIP	20371350
MIRT277512	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT277515	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT277517	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT277518	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT277514	hsa-miR-3611	PAR-CLIP	20371350
MIRT277519	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT277505	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT277506	hsa-miR-107	PAR-CLIP	21572407
MIRT277507	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT277510	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT277508	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT277509	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT277504	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT001428	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT277520	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT555315	hsa-miR-548ao-3p	PAR-CLIP	21572407
MIRT277511	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT555314	hsa-miR-3664-5p	PAR-CLIP	21572407
MIRT555313	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT555312	hsa-miR-646	PAR-CLIP	21572407
MIRT277516	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT277513	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT277521	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT555311	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT555310	hsa-miR-4680-5p	PAR-CLIP	21572407
MIRT555309	hsa-miR-29c-5p	PAR-CLIP	21572407
MIRT277512	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT277515	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT277517	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT277518	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT277514	hsa-miR-3611	PAR-CLIP	21572407
MIRT277519	hsa-miR-6833-5p	PAR-CLIP	21572407
MIRT1257994	hsa-miR-1185	CLIP-seq
MIRT1257995	hsa-miR-139-5p	CLIP-seq
MIRT1257996	hsa-miR-141	CLIP-seq
MIRT1257997	hsa-miR-146a	CLIP-seq
MIRT1257998	hsa-miR-146b-5p	CLIP-seq
MIRT1257999	hsa-miR-183	CLIP-seq
MIRT1258000	hsa-miR-200a	CLIP-seq
MIRT1258001	hsa-miR-216b	CLIP-seq
MIRT1258002	hsa-miR-219-5p	CLIP-seq
MIRT1258003	hsa-miR-3074-3p	CLIP-seq
MIRT1258004	hsa-miR-3124-3p	CLIP-seq
MIRT1258005	hsa-miR-3133	CLIP-seq
MIRT1258006	hsa-miR-3148	CLIP-seq
MIRT1258007	hsa-miR-3160-5p	CLIP-seq
MIRT1258008	hsa-miR-3171	CLIP-seq
MIRT1258009	hsa-miR-337-3p	CLIP-seq
MIRT1258010	hsa-miR-345	CLIP-seq
MIRT1258011	hsa-miR-3605-5p	CLIP-seq
MIRT1258012	hsa-miR-3614-5p	CLIP-seq
MIRT1258013	hsa-miR-3673	CLIP-seq
MIRT1258014	hsa-miR-3679-5p	CLIP-seq
MIRT1258015	hsa-miR-3685	CLIP-seq
MIRT1258016	hsa-miR-384	CLIP-seq
MIRT1258017	hsa-miR-3924	CLIP-seq
MIRT1258018	hsa-miR-3942-3p	CLIP-seq
MIRT1258019	hsa-miR-3978	CLIP-seq
MIRT1258020	hsa-miR-4502	CLIP-seq
MIRT1258021	hsa-miR-4511	CLIP-seq
MIRT1258022	hsa-miR-4699-5p	CLIP-seq
MIRT1258023	hsa-miR-4712-5p	CLIP-seq
MIRT1258024	hsa-miR-4744	CLIP-seq
MIRT1258025	hsa-miR-4753-3p	CLIP-seq
MIRT1258026	hsa-miR-4762-3p	CLIP-seq
MIRT1258027	hsa-miR-4782-3p	CLIP-seq
MIRT1258028	hsa-miR-509-3p	CLIP-seq
MIRT1258029	hsa-miR-548u	CLIP-seq
MIRT1258030	hsa-miR-570	CLIP-seq
MIRT1258031	hsa-miR-579	CLIP-seq
MIRT1258032	hsa-miR-580	CLIP-seq
MIRT1258033	hsa-miR-589	CLIP-seq
MIRT1258034	hsa-miR-616	CLIP-seq
MIRT1258035	hsa-miR-758	CLIP-seq
MIRT1258036	hsa-miR-770-5p	CLIP-seq
MIRT1258037	hsa-miR-890	CLIP-seq
MIRT1258038	hsa-miR-1184	CLIP-seq
MIRT1258039	hsa-miR-1229	CLIP-seq
MIRT1258040	hsa-miR-1538	CLIP-seq
MIRT1258041	hsa-miR-200b	CLIP-seq
MIRT1258042	hsa-miR-200c	CLIP-seq
MIRT1258043	hsa-miR-346	CLIP-seq
MIRT1258044	hsa-miR-34a	CLIP-seq
MIRT1258045	hsa-miR-34c-5p	CLIP-seq
MIRT1258046	hsa-miR-3614-3p	CLIP-seq
MIRT1258047	hsa-miR-371-3p	CLIP-seq
MIRT1258048	hsa-miR-3714	CLIP-seq
MIRT1258049	hsa-miR-4261	CLIP-seq
MIRT1258050	hsa-miR-4276	CLIP-seq
MIRT1258051	hsa-miR-4288	CLIP-seq
MIRT1258052	hsa-miR-429	CLIP-seq
MIRT1258053	hsa-miR-4330	CLIP-seq
MIRT1258054	hsa-miR-4418	CLIP-seq
MIRT1258055	hsa-miR-4420	CLIP-seq
MIRT1258056	hsa-miR-4457	CLIP-seq
MIRT1258057	hsa-miR-4459	CLIP-seq
MIRT1258058	hsa-miR-4477a	CLIP-seq
MIRT1258059	hsa-miR-4493	CLIP-seq
MIRT1258060	hsa-miR-449a	CLIP-seq
MIRT1258061	hsa-miR-449b	CLIP-seq
MIRT1258062	hsa-miR-4519	CLIP-seq
MIRT1258063	hsa-miR-4705	CLIP-seq
MIRT1258064	hsa-miR-4722-5p	CLIP-seq
MIRT1258065	hsa-miR-4745-3p	CLIP-seq
MIRT1258066	hsa-miR-4773	CLIP-seq
MIRT1258067	hsa-miR-509-3-5p	CLIP-seq
MIRT1258068	hsa-miR-509-5p	CLIP-seq
MIRT1258069	hsa-miR-558	CLIP-seq
MIRT1258070	hsa-miR-632	CLIP-seq
MIRT1258071	hsa-miR-885-3p	CLIP-seq
MIRT1258072	hsa-miR-137	CLIP-seq
MIRT1258073	hsa-miR-25	CLIP-seq
MIRT1258074	hsa-miR-32	CLIP-seq
MIRT1258075	hsa-miR-363	CLIP-seq
MIRT1258076	hsa-miR-367	CLIP-seq
MIRT1258077	hsa-miR-548k	CLIP-seq
MIRT1258078	hsa-miR-548n	CLIP-seq
MIRT1258079	hsa-miR-548t	CLIP-seq
MIRT1258080	hsa-miR-561	CLIP-seq
MIRT1258081	hsa-miR-92a	CLIP-seq
MIRT1258082	hsa-miR-92b	CLIP-seq
MIRT1258041	hsa-miR-200b	CLIP-seq
MIRT1258042	hsa-miR-200c	CLIP-seq
MIRT2076023	hsa-miR-224	CLIP-seq
MIRT2076024	hsa-miR-3659	CLIP-seq
MIRT1258052	hsa-miR-429	CLIP-seq
MIRT2076025	hsa-miR-4658	CLIP-seq
MIRT2076026	hsa-miR-4742-3p	CLIP-seq
MIRT2076027	hsa-miR-4761-5p	CLIP-seq
MIRT2076028	hsa-miR-574-5p	CLIP-seq
MIRT2076029	hsa-miR-624	CLIP-seq
MIRT1258038	hsa-miR-1184	CLIP-seq
MIRT2302620	hsa-miR-1202	CLIP-seq
MIRT2302621	hsa-miR-1289	CLIP-seq
MIRT2302622	hsa-miR-140-3p	CLIP-seq
MIRT2302623	hsa-miR-1911	CLIP-seq
MIRT2302624	hsa-miR-2277-3p	CLIP-seq
MIRT2302625	hsa-miR-3131	CLIP-seq
MIRT2302626	hsa-miR-320e	CLIP-seq
MIRT1258046	hsa-miR-3614-3p	CLIP-seq
MIRT2302627	hsa-miR-3662	CLIP-seq
MIRT2302628	hsa-miR-3690	CLIP-seq
MIRT2302629	hsa-miR-3972	CLIP-seq
MIRT2302630	hsa-miR-4254	CLIP-seq
MIRT1258053	hsa-miR-4330	CLIP-seq
MIRT1258054	hsa-miR-4418	CLIP-seq
MIRT2302631	hsa-miR-4433	CLIP-seq
MIRT1258062	hsa-miR-4519	CLIP-seq
MIRT2302632	hsa-miR-4694-3p	CLIP-seq
MIRT2302633	hsa-miR-4698	CLIP-seq
MIRT1258024	hsa-miR-4744	CLIP-seq
MIRT1258066	hsa-miR-4773	CLIP-seq
MIRT2302634	hsa-miR-485-3p	CLIP-seq
MIRT2302635	hsa-miR-486-3p	CLIP-seq
MIRT2302636	hsa-miR-499a-5p	CLIP-seq
MIRT1258067	hsa-miR-509-3-5p	CLIP-seq
MIRT1258068	hsa-miR-509-5p	CLIP-seq
MIRT2302637	hsa-miR-542-3p	CLIP-seq
MIRT1258029	hsa-miR-548u	CLIP-seq
MIRT2302638	hsa-miR-611	CLIP-seq
MIRT2302621	hsa-miR-1289	CLIP-seq
MIRT1258041	hsa-miR-200b	CLIP-seq
MIRT1258042	hsa-miR-200c	CLIP-seq
MIRT2599263	hsa-miR-2276	CLIP-seq
MIRT2599264	hsa-miR-3140-3p	CLIP-seq
MIRT2599265	hsa-miR-3145-3p	CLIP-seq
MIRT2599266	hsa-miR-3145-5p	CLIP-seq
MIRT2599267	hsa-miR-3183	CLIP-seq
MIRT2599268	hsa-miR-329	CLIP-seq
MIRT2599269	hsa-miR-342-3p	CLIP-seq
MIRT2599270	hsa-miR-3616-3p	CLIP-seq
MIRT2599271	hsa-miR-362-3p	CLIP-seq
MIRT2599272	hsa-miR-3926	CLIP-seq
MIRT2599273	hsa-miR-3941	CLIP-seq
MIRT2599274	hsa-miR-4266	CLIP-seq
MIRT1258052	hsa-miR-429	CLIP-seq
MIRT2599275	hsa-miR-4311	CLIP-seq
MIRT2302631	hsa-miR-4433	CLIP-seq
MIRT2599276	hsa-miR-4446-5p	CLIP-seq
MIRT1258058	hsa-miR-4477a	CLIP-seq
MIRT2599277	hsa-miR-4637	CLIP-seq
MIRT2599278	hsa-miR-4652-3p	CLIP-seq
MIRT2599279	hsa-miR-466	CLIP-seq
MIRT2599280	hsa-miR-4672	CLIP-seq
MIRT2599281	hsa-miR-4695-5p	CLIP-seq
MIRT2599282	hsa-miR-4704-3p	CLIP-seq
MIRT2599283	hsa-miR-4719	CLIP-seq
MIRT2599284	hsa-miR-4723-3p	CLIP-seq
MIRT2599285	hsa-miR-4724-5p	CLIP-seq
MIRT2599286	hsa-miR-4740-3p	CLIP-seq
MIRT2599287	hsa-miR-4772-3p	CLIP-seq
MIRT2599288	hsa-miR-4775	CLIP-seq
MIRT2599289	hsa-miR-4779	CLIP-seq
MIRT2599290	hsa-miR-4789-3p	CLIP-seq
MIRT2599291	hsa-miR-548a-3p	CLIP-seq
MIRT2599292	hsa-miR-548c-3p	CLIP-seq
MIRT2599293	hsa-miR-548e	CLIP-seq
MIRT2599294	hsa-miR-548f	CLIP-seq
MIRT1258032	hsa-miR-580	CLIP-seq
MIRT2599295	hsa-miR-590-3p	CLIP-seq
MIRT2599296	hsa-miR-603	CLIP-seq
MIRT2599297	hsa-miR-651	CLIP-seq
MIRT2599298	hsa-miR-924	CLIP-seq
MIRT2302621	hsa-miR-1289	CLIP-seq
MIRT1258041	hsa-miR-200b	CLIP-seq
MIRT1258042	hsa-miR-200c	CLIP-seq
MIRT2599263	hsa-miR-2276	CLIP-seq
MIRT2599264	hsa-miR-3140-3p	CLIP-seq
MIRT2599265	hsa-miR-3145-3p	CLIP-seq
MIRT2599266	hsa-miR-3145-5p	CLIP-seq
MIRT2599267	hsa-miR-3183	CLIP-seq
MIRT2599268	hsa-miR-329	CLIP-seq
MIRT2599269	hsa-miR-342-3p	CLIP-seq
MIRT2599270	hsa-miR-3616-3p	CLIP-seq
MIRT2599271	hsa-miR-362-3p	CLIP-seq
MIRT2688471	hsa-miR-3647-3p	CLIP-seq
MIRT2688472	hsa-miR-3921	CLIP-seq
MIRT2599272	hsa-miR-3926	CLIP-seq
MIRT2599273	hsa-miR-3941	CLIP-seq
MIRT2599274	hsa-miR-4266	CLIP-seq
MIRT1258052	hsa-miR-429	CLIP-seq
MIRT2599275	hsa-miR-4311	CLIP-seq
MIRT2302631	hsa-miR-4433	CLIP-seq
MIRT2599276	hsa-miR-4446-5p	CLIP-seq
MIRT1258058	hsa-miR-4477a	CLIP-seq
MIRT2599277	hsa-miR-4637	CLIP-seq
MIRT2599278	hsa-miR-4652-3p	CLIP-seq
MIRT2688473	hsa-miR-4653-5p	CLIP-seq
MIRT2599279	hsa-miR-466	CLIP-seq
MIRT2599280	hsa-miR-4672	CLIP-seq
MIRT2599281	hsa-miR-4695-5p	CLIP-seq
MIRT2599282	hsa-miR-4704-3p	CLIP-seq
MIRT2599283	hsa-miR-4719	CLIP-seq
MIRT2599284	hsa-miR-4723-3p	CLIP-seq
MIRT2599286	hsa-miR-4740-3p	CLIP-seq
MIRT2688474	hsa-miR-4766-5p	CLIP-seq
MIRT2688475	hsa-miR-4768-5p	CLIP-seq
MIRT2599287	hsa-miR-4772-3p	CLIP-seq
MIRT2599288	hsa-miR-4775	CLIP-seq
MIRT2599289	hsa-miR-4779	CLIP-seq
MIRT2599290	hsa-miR-4789-3p	CLIP-seq
MIRT2599291	hsa-miR-548a-3p	CLIP-seq
MIRT2599292	hsa-miR-548c-3p	CLIP-seq
MIRT2599293	hsa-miR-548e	CLIP-seq
MIRT2599294	hsa-miR-548f	CLIP-seq
MIRT1258030	hsa-miR-570	CLIP-seq
MIRT2599295	hsa-miR-590-3p	CLIP-seq
MIRT2599296	hsa-miR-603	CLIP-seq
MIRT2599297	hsa-miR-651	CLIP-seq
MIRT2599298	hsa-miR-924	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0000159	Component	Protein phosphatase type 2A complex	IDA	17174897
GO:0000159	Component	Protein phosphatase type 2A complex	NAS	8703017
GO:0000775	Component	Chromosome, centromeric region	IDA	16580887
GO:0005515	Function	Protein binding	IPI	1328865, 7592815, 16239230, 16456541, 16580887, 17245430, 17540176, 18782753, 19156129, 19915589, 21460856, 25241761, 27173435, 28174209, 28330616, 30595372
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	8703017
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007165	Process	Signal transduction	NAS	8703017
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	17245430
GO:0014066	Process	Regulation of phosphatidylinositol 3-kinase signaling	TAS
GO:0019888	Function	Protein phosphatase regulator activity	NAS	8703017
GO:0031952	Process	Regulation of protein autophosphorylation	IBA	21873635
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	16717086
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0051898	Process	Negative regulation of protein kinase B signaling	TAS
GO:0072542	Function	Protein phosphatase activator activity	IBA	21873635

Other IDs

• MIM: 601645
• HGNC: 9311
• e!Ensembl: ENSG00000078304

Protein

• UniProt ID: Q13362
• Protein name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)
• Protein function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphor
• PDB: 2IAE, 2JAK, 2NPP, 2NYL, 2NYM, 3FGA, 5JJA, 5K6S, 5SW9, 5SWF, 6OYL, 6TOQ, 6VOY, 6VRO, 7OUF, 7OUG, 7OUH, 7PEL, 7SOY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01603	B56	27 → 437	Protein phosphatase 2A regulatory B subunit (B56 family)	Family

• Sequence:

  MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL
  SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP
  EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD
  FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK
  EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK
  EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS
  DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK
  LKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAH
  QAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR

• Sequence length: 524