PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha)

Gene

• Entrez ID: 5523
• Gene name: Protein phosphatase 2 regulatory subunit B''alpha
• Gene symbol: PPP2R3A
• Synonyms: PPP2R3, PR130, PR72
• Chromosome: 3
• Chromosome location: 3q22.2-q22.3
• Summary: This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B`/PR61, and B``/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B`` family. The B`` family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B``. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019482	hsa-miR-148b-3p	Microarray	17612493
MIRT621043	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621044	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621045	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT649470	hsa-miR-3117-3p	HITS-CLIP	23824327
MIRT649471	hsa-miR-8083	HITS-CLIP	23824327
MIRT649472	hsa-miR-3169	HITS-CLIP	23824327
MIRT649473	hsa-miR-4759	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0000159	Component	Protein phosphatase type 2A complex	IDA	17055435
GO:0000159	Component	Protein phosphatase type 2A complex	ISS	1849734
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	9847399, 30595372
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	ISS	1849734
GO:0019888	Function	Protein phosphatase regulator activity	IBA	21873635
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0061053	Process	Somite development	ISS	16567647

Other IDs

• MIM: 604944
• HGNC: 9307
• e!Ensembl: ENSG00000073711

Protein

• UniProt ID: Q06190
• Protein name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B)
• Protein function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
• PDB: 4I5J, 4I5K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17958	EF-hand_13	796 → 885	EF-hand domain	Domain
  PF13499	EF-hand_7	900 → 1002	EF-hand domain pair	Domain

• Sequence:

  MAATYRLVVSTVNHYSSVVIDRRFEQAIHYCTGTCHTFTHGIDCIVVHHSVCADLLHIPV
  SQFKDADLNSMFLPHENGLSSAEGDYPQQAFTGIPRVKRGSTFQNTYNLKDIAGEAISFA
  SGKIKEFSFEKLKNSNHAAYRKGRKVKSDSFNRRSVDLDLLCGHYNNDGNAPSFGLLRSS
  SVEEKPLSHRNSLDTNLTSMFLQNFSEEDLVTQILEKHKIDNFSSGTDIKMCLDILLKCS
  EDLKKCTDIIKQCIKKKSGSSISEGSGNDTISSSETVYMNVMTRLASYLKKLPFEFMQSG
  NNEALDLTELISNMPSLQLTPFSPVFGTEQPPKYEDVVQLSASDSGRFQTIELQNDKPNS
  RKMDTVQSIPNNSTNSLYNLEVNDPRTLKAVQVQSQSLTMNPLENVSSDDLMETLYIEEE
  SDGKKALDKGQKTENGPSHELLKVNEHRAEFPEHATHLKKCPTPMQNEIGKIFEKSFVNL
  PKEDCKSKVSKFEEGDQRDFTNSSSQEEIDKLLMDLESFSQKMETSLREPLAKGKNSNFL
  NSHSQLTGQTLVDLEPKSKVSSPIEKVSPSCLTRIIETNGHKIEEEDRALLLRILESIED
  FAQELVECKSSRGSLSQEKEMMQILQETLTTSSQANLSVCRSPVGDKAKDTTSAVLIQQT
  PEVIKIQNKPEKKPGTPLPPPATSPSSPRPLSPVPHVNNVVNAPLSINIPRFYFPEGLPD
  TCSNHEQTLSRIETAFMDIEEQKADIYEMGKIAKVCGCPLYWKAPMFRAAGGEKTGFVTA
  QSFIAMWRKLLNNHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPE
  FHSRYITTVIQRIFYTVNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSYEHF
  YVIYCKFWELDTDHDLYISQADLSRYNDQASSSRIIERIFSGAVTRGKTIQKEGRMSYAD
  FVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHD
  LLCQMLDLVKPAVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPFAVQKDVENDG
  PEPSDWDRFAAEEYETLVAEESAQAQFQEGFEDYETDEPASPSEFGNKSNKILSASLPEK
  CGKLQSVDEE

• Sequence length: 1150