PPP2R2A (protein phosphatase 2 regulatory subunit Balpha)

Gene

• Entrez ID: 5520
• Gene name: Protein phosphatase 2 regulatory subunit Balpha
• Gene symbol: PPP2R2A
• Synonyms: B55, B55A, B55ALPHA, PR52A, PR55A, PR55alpha
• Chromosome: 8
• Chromosome location: 8p21.2
• Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heter

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000490	hsa-miR-31-5p	qRT-PCR, Luciferase reporter assay	20237410
MIRT003191	hsa-miR-222-3p	Luciferase reporter assay, Western blot	20103675
MIRT003191	hsa-miR-222-3p	Luciferase reporter assay, Western blot	20103675
MIRT020735	hsa-miR-155-5p	Proteomics	18668040
MIRT023787	hsa-miR-1-3p	Proteomics	18668040
MIRT003191	hsa-miR-222-3p	Reporter assay;Western blot	21656127
MIRT028533	hsa-miR-30a-5p	Proteomics	18668040
MIRT029553	hsa-miR-26b-5p	Microarray	19088304
MIRT052508	hsa-let-7a-5p	CLASH	23622248
MIRT052126	hsa-let-7b-5p	CLASH	23622248
MIRT049716	hsa-miR-92a-3p	CLASH	23622248
MIRT003191	hsa-miR-222-3p	CLASH	23622248
MIRT438060	hsa-miR-136-5p	Luciferase reporter assay, qRT-PCR, Western blot	23959478
MIRT438060	hsa-miR-136-5p	Luciferase reporter assay, qRT-PCR, Western blot	23959478
MIRT438060	hsa-miR-136-5p	Luciferase reporter assay, qRT-PCR, Western blot	23959478
MIRT438060	hsa-miR-136-5p	Luciferase reporter assay, qRT-PCR, Western blot	23959478
MIRT224728	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT224722	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT322414	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT322409	hsa-miR-551b-5p	PAR-CLIP	20371350
MIRT322413	hsa-miR-3910	PAR-CLIP	20371350
MIRT322407	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT322410	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT566298	hsa-miR-4533	PAR-CLIP	20371350
MIRT566297	hsa-miR-3202	PAR-CLIP	20371350
MIRT561721	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT561719	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT561719	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT561718	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT561717	hsa-miR-4801	PAR-CLIP	20371350
MIRT561716	hsa-miR-4719	PAR-CLIP	20371350
MIRT561715	hsa-miR-1185-5p	PAR-CLIP	20371350
MIRT561714	hsa-miR-3679-5p	PAR-CLIP	20371350
MIRT561713	hsa-miR-3605-5p	PAR-CLIP	20371350
MIRT322426	hsa-let-7c-5p	PAR-CLIP	23446348
MIRT052508	hsa-let-7a-5p	PAR-CLIP	23446348
MIRT322427	hsa-let-7d-5p	PAR-CLIP	23446348
MIRT322428	hsa-let-7e-5p	PAR-CLIP	23446348
MIRT052126	hsa-let-7b-5p	PAR-CLIP	23446348
MIRT322431	hsa-let-7g-5p	PAR-CLIP	23446348
MIRT322432	hsa-let-7i-5p	PAR-CLIP	23446348
MIRT322434	hsa-miR-4500	PAR-CLIP	23446348
MIRT322430	hsa-miR-98-5p	PAR-CLIP	23446348
MIRT322429	hsa-let-7f-5p	PAR-CLIP	23446348
MIRT322433	hsa-miR-4458	PAR-CLIP	23446348
MIRT506065	hsa-miR-548aa	PAR-CLIP	23446348
MIRT506064	hsa-miR-548ap-3p	PAR-CLIP	23446348
MIRT506063	hsa-miR-548t-3p	PAR-CLIP	23446348
MIRT506062	hsa-miR-154-5p	PAR-CLIP	23446348
MIRT506061	hsa-miR-187-5p	PAR-CLIP	23446348
MIRT439914	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439914	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT003191	hsa-miR-222-3p	Luciferase reporter assay, qRT-PCR, Western blot	26800397
MIRT003191	hsa-miR-222-3p	Luciferase reporter assay, qRT-PCR, Western blot	26800397
MIRT003191	hsa-miR-222-3p	Luciferase reporter assay, qRT-PCR, Western blot	26800397
MIRT003191	hsa-miR-222-3p	Luciferase reporter assay, qRT-PCR, Western blot	26800397
MIRT731778	hsa-miR-556-5p	Luciferase reporter assay, Western blot	26297546
MIRT731778	hsa-miR-556-5p	Luciferase reporter assay, Western blot	26297546
MIRT003191	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT224728	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT224722	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT322414	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT322409	hsa-miR-551b-5p	PAR-CLIP	20371350
MIRT322413	hsa-miR-3910	PAR-CLIP	20371350
MIRT322407	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT322410	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT566298	hsa-miR-4533	PAR-CLIP	20371350
MIRT566297	hsa-miR-3202	PAR-CLIP	20371350
MIRT561721	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT561719	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT561719	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT561718	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT561717	hsa-miR-4801	PAR-CLIP	20371350
MIRT561716	hsa-miR-4719	PAR-CLIP	20371350
MIRT561715	hsa-miR-1185-5p	PAR-CLIP	20371350
MIRT561714	hsa-miR-3679-5p	PAR-CLIP	20371350
MIRT561713	hsa-miR-3605-5p	PAR-CLIP	20371350
MIRT322426	hsa-let-7c-5p	PAR-CLIP	23446348
MIRT052508	hsa-let-7a-5p	PAR-CLIP	23446348
MIRT322427	hsa-let-7d-5p	PAR-CLIP	23446348
MIRT322428	hsa-let-7e-5p	PAR-CLIP	23446348
MIRT052126	hsa-let-7b-5p	PAR-CLIP	23446348
MIRT322431	hsa-let-7g-5p	PAR-CLIP	23446348
MIRT322432	hsa-let-7i-5p	PAR-CLIP	23446348
MIRT322434	hsa-miR-4500	PAR-CLIP	23446348
MIRT322430	hsa-miR-98-5p	PAR-CLIP	23446348
MIRT322429	hsa-let-7f-5p	PAR-CLIP	23446348
MIRT322433	hsa-miR-4458	PAR-CLIP	23446348
MIRT506065	hsa-miR-548aa	PAR-CLIP	23446348
MIRT506064	hsa-miR-548ap-3p	PAR-CLIP	23446348
MIRT506063	hsa-miR-548t-3p	PAR-CLIP	23446348
MIRT506062	hsa-miR-154-5p	PAR-CLIP	23446348
MIRT506061	hsa-miR-187-5p	PAR-CLIP	23446348
MIRT1257501	hsa-miR-1208	CLIP-seq
MIRT1257502	hsa-miR-1299	CLIP-seq
MIRT1257503	hsa-miR-130a	CLIP-seq
MIRT1257504	hsa-miR-130b	CLIP-seq
MIRT1257505	hsa-miR-198	CLIP-seq
MIRT1257506	hsa-miR-301a	CLIP-seq
MIRT1257507	hsa-miR-301b	CLIP-seq
MIRT1257508	hsa-miR-3148	CLIP-seq
MIRT1257509	hsa-miR-3156-5p	CLIP-seq
MIRT1257510	hsa-miR-3591-5p	CLIP-seq
MIRT1257511	hsa-miR-3666	CLIP-seq
MIRT1257512	hsa-miR-4295	CLIP-seq
MIRT1257513	hsa-miR-4420	CLIP-seq
MIRT1257514	hsa-miR-4473	CLIP-seq
MIRT1257515	hsa-miR-4493	CLIP-seq
MIRT1257516	hsa-miR-454	CLIP-seq
MIRT1257517	hsa-miR-4671-3p	CLIP-seq
MIRT1257518	hsa-miR-4704-3p	CLIP-seq
MIRT1257519	hsa-miR-548a-3p	CLIP-seq
MIRT1257520	hsa-miR-548e	CLIP-seq
MIRT1257521	hsa-miR-548f	CLIP-seq
MIRT1257522	hsa-miR-548g	CLIP-seq
MIRT1257523	hsa-miR-548l	CLIP-seq
MIRT1257524	hsa-miR-548n	CLIP-seq
MIRT1257525	hsa-miR-548t	CLIP-seq
MIRT1257526	hsa-miR-597	CLIP-seq
MIRT1257527	hsa-miR-598	CLIP-seq
MIRT1257528	hsa-miR-668	CLIP-seq
MIRT1257529	hsa-miR-875-3p	CLIP-seq
MIRT1257530	hsa-miR-892a	CLIP-seq
MIRT1257501	hsa-miR-1208	CLIP-seq
MIRT1257531	hsa-miR-143	CLIP-seq
MIRT1257532	hsa-miR-151-5p	CLIP-seq
MIRT1257533	hsa-miR-151b	CLIP-seq
MIRT1257534	hsa-miR-2053	CLIP-seq
MIRT1257535	hsa-miR-221	CLIP-seq
MIRT1257536	hsa-miR-222	CLIP-seq
MIRT1257537	hsa-miR-31	CLIP-seq
MIRT1257538	hsa-miR-3133	CLIP-seq
MIRT1257539	hsa-miR-3136-5p	CLIP-seq
MIRT1257540	hsa-miR-3185	CLIP-seq
MIRT1257541	hsa-miR-3614-5p	CLIP-seq
MIRT1257542	hsa-miR-3671	CLIP-seq
MIRT1257543	hsa-miR-4285	CLIP-seq
MIRT1257513	hsa-miR-4420	CLIP-seq
MIRT1257544	hsa-miR-4423-3p	CLIP-seq
MIRT1257545	hsa-miR-4426	CLIP-seq
MIRT1257546	hsa-miR-4439	CLIP-seq
MIRT1257547	hsa-miR-4452	CLIP-seq
MIRT1257548	hsa-miR-4462	CLIP-seq
MIRT1257515	hsa-miR-4493	CLIP-seq
MIRT1257549	hsa-miR-4495	CLIP-seq
MIRT1257550	hsa-miR-4503	CLIP-seq
MIRT1257551	hsa-miR-4513	CLIP-seq
MIRT1257552	hsa-miR-4528	CLIP-seq
MIRT1257553	hsa-miR-4647	CLIP-seq
MIRT1257554	hsa-miR-4662b	CLIP-seq
MIRT1257555	hsa-miR-4696	CLIP-seq
MIRT1257556	hsa-miR-4709-3p	CLIP-seq
MIRT1257557	hsa-miR-4718	CLIP-seq
MIRT1257558	hsa-miR-4765	CLIP-seq
MIRT1257525	hsa-miR-548t	CLIP-seq
MIRT1257559	hsa-miR-554	CLIP-seq
MIRT1257526	hsa-miR-597	CLIP-seq
MIRT1257527	hsa-miR-598	CLIP-seq
MIRT1257560	hsa-miR-605	CLIP-seq
MIRT1257561	hsa-miR-607	CLIP-seq
MIRT1257528	hsa-miR-668	CLIP-seq
MIRT1257562	hsa-miR-885-5p	CLIP-seq
MIRT1257563	hsa-miR-887	CLIP-seq
MIRT1257530	hsa-miR-892a	CLIP-seq
MIRT1257564	hsa-miR-939	CLIP-seq
MIRT2075883	hsa-miR-1207-5p	CLIP-seq
MIRT1257501	hsa-miR-1208	CLIP-seq
MIRT1257532	hsa-miR-151-5p	CLIP-seq
MIRT1257533	hsa-miR-151b	CLIP-seq
MIRT2075884	hsa-miR-1909	CLIP-seq
MIRT1257535	hsa-miR-221	CLIP-seq
MIRT1257536	hsa-miR-222	CLIP-seq
MIRT1257537	hsa-miR-31	CLIP-seq
MIRT2075885	hsa-miR-3117-5p	CLIP-seq
MIRT1257539	hsa-miR-3136-5p	CLIP-seq
MIRT2075886	hsa-miR-34c-3p	CLIP-seq
MIRT2075887	hsa-miR-3688-5p	CLIP-seq
MIRT2075888	hsa-miR-4272	CLIP-seq
MIRT2075889	hsa-miR-4282	CLIP-seq
MIRT1257543	hsa-miR-4285	CLIP-seq
MIRT1257544	hsa-miR-4423-3p	CLIP-seq
MIRT1257545	hsa-miR-4426	CLIP-seq
MIRT1257546	hsa-miR-4439	CLIP-seq
MIRT1257548	hsa-miR-4462	CLIP-seq
MIRT2075890	hsa-miR-4474-3p	CLIP-seq
MIRT2075891	hsa-miR-450b-5p	CLIP-seq
MIRT1257551	hsa-miR-4513	CLIP-seq
MIRT2075892	hsa-miR-452	CLIP-seq
MIRT1257553	hsa-miR-4647	CLIP-seq
MIRT1257554	hsa-miR-4662b	CLIP-seq
MIRT2075893	hsa-miR-4676-3p	CLIP-seq
MIRT1257555	hsa-miR-4696	CLIP-seq
MIRT1257518	hsa-miR-4704-3p	CLIP-seq
MIRT2075894	hsa-miR-4733-5p	CLIP-seq
MIRT2075895	hsa-miR-4736	CLIP-seq
MIRT2075896	hsa-miR-4763-3p	CLIP-seq
MIRT1257558	hsa-miR-4765	CLIP-seq
MIRT2075897	hsa-miR-4795-5p	CLIP-seq
MIRT2075898	hsa-miR-548c-3p	CLIP-seq
MIRT1257528	hsa-miR-668	CLIP-seq
MIRT2302512	hsa-miR-150	CLIP-seq
MIRT1257532	hsa-miR-151-5p	CLIP-seq
MIRT1257533	hsa-miR-151b	CLIP-seq
MIRT2302513	hsa-miR-3613-3p	CLIP-seq
MIRT1257543	hsa-miR-4285	CLIP-seq
MIRT1257548	hsa-miR-4462	CLIP-seq
MIRT2302514	hsa-miR-4496	CLIP-seq
MIRT2302515	hsa-miR-4713-5p	CLIP-seq
MIRT1257558	hsa-miR-4765	CLIP-seq
MIRT2302516	hsa-miR-532-3p	CLIP-seq
MIRT1257501	hsa-miR-1208	CLIP-seq
MIRT1257513	hsa-miR-4420	CLIP-seq
MIRT1257551	hsa-miR-4513	CLIP-seq
MIRT1257532	hsa-miR-151-5p	CLIP-seq
MIRT1257533	hsa-miR-151b	CLIP-seq
MIRT1257543	hsa-miR-4285	CLIP-seq
MIRT1257548	hsa-miR-4462	CLIP-seq
MIRT1257558	hsa-miR-4765	CLIP-seq
MIRT1257505	hsa-miR-198	CLIP-seq
MIRT1257518	hsa-miR-4704-3p	CLIP-seq
MIRT2075883	hsa-miR-1207-5p	CLIP-seq
MIRT2599168	hsa-miR-1298	CLIP-seq
MIRT1257531	hsa-miR-143	CLIP-seq
MIRT2599169	hsa-miR-147	CLIP-seq
MIRT1257532	hsa-miR-151-5p	CLIP-seq
MIRT1257533	hsa-miR-151b	CLIP-seq
MIRT2075884	hsa-miR-1909	CLIP-seq
MIRT2599170	hsa-miR-2113	CLIP-seq
MIRT2599171	hsa-miR-218	CLIP-seq
MIRT2075885	hsa-miR-3117-5p	CLIP-seq
MIRT2599172	hsa-miR-3144-3p	CLIP-seq
MIRT2599173	hsa-miR-3156-3p	CLIP-seq
MIRT2599174	hsa-miR-3160-5p	CLIP-seq
MIRT1257540	hsa-miR-3185	CLIP-seq
MIRT2599175	hsa-miR-345	CLIP-seq
MIRT2075887	hsa-miR-3688-5p	CLIP-seq
MIRT1257543	hsa-miR-4285	CLIP-seq
MIRT2599176	hsa-miR-4301	CLIP-seq
MIRT1257548	hsa-miR-4462	CLIP-seq
MIRT2075890	hsa-miR-4474-3p	CLIP-seq
MIRT2075891	hsa-miR-450b-5p	CLIP-seq
MIRT2599177	hsa-miR-4640-3p	CLIP-seq
MIRT2075894	hsa-miR-4733-5p	CLIP-seq
MIRT2075895	hsa-miR-4736	CLIP-seq
MIRT2075896	hsa-miR-4763-3p	CLIP-seq
MIRT1257558	hsa-miR-4765	CLIP-seq
MIRT2599178	hsa-miR-599	CLIP-seq
MIRT2599179	hsa-miR-636	CLIP-seq
MIRT1257562	hsa-miR-885-5p	CLIP-seq
MIRT2599180	hsa-miR-889	CLIP-seq
MIRT2599168	hsa-miR-1298	CLIP-seq
MIRT1257531	hsa-miR-143	CLIP-seq
MIRT2599169	hsa-miR-147	CLIP-seq
MIRT1257532	hsa-miR-151-5p	CLIP-seq
MIRT1257533	hsa-miR-151b	CLIP-seq
MIRT2599170	hsa-miR-2113	CLIP-seq
MIRT2599171	hsa-miR-218	CLIP-seq
MIRT1257537	hsa-miR-31	CLIP-seq
MIRT2599173	hsa-miR-3156-3p	CLIP-seq
MIRT2599174	hsa-miR-3160-5p	CLIP-seq
MIRT1257543	hsa-miR-4285	CLIP-seq
MIRT2599176	hsa-miR-4301	CLIP-seq
MIRT1257544	hsa-miR-4423-3p	CLIP-seq
MIRT1257545	hsa-miR-4426	CLIP-seq
MIRT1257548	hsa-miR-4462	CLIP-seq
MIRT2075891	hsa-miR-450b-5p	CLIP-seq
MIRT2599177	hsa-miR-4640-3p	CLIP-seq
MIRT1257553	hsa-miR-4647	CLIP-seq
MIRT1257554	hsa-miR-4662b	CLIP-seq
MIRT1257558	hsa-miR-4765	CLIP-seq
MIRT1257559	hsa-miR-554	CLIP-seq
MIRT2599178	hsa-miR-599	CLIP-seq
MIRT2599179	hsa-miR-636	CLIP-seq
MIRT1257562	hsa-miR-885-5p	CLIP-seq
MIRT2599180	hsa-miR-889	CLIP-seq
MIRT1257564	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0000159	Component	Protein phosphatase type 2A complex	IDA	1849734, 17245430
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0005515	Function	Protein binding	IPI	9847399, 15761952, 17245430, 17529992, 17540176, 17632056, 18782753, 19156129, 19293187, 19915589, 20711181, 25816751, 26496610, 26894577, 27173435, 27588481, 28330616, 28609714, 30595372, 30611118, 31046837, 32814053, 33108758
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006470	Process	Protein dephosphorylation	IDA	1849734
GO:0006470	Process	Protein dephosphorylation	IMP	33108758
GO:0007084	Process	Mitotic nuclear envelope reassembly	TAS
GO:0019888	Function	Protein phosphatase regulator activity	IBA	21873635
GO:0019888	Function	Protein phosphatase regulator activity	IDA	1849734
GO:0019888	Function	Protein phosphatase regulator activity	TAS	1849734
GO:0043278	Process	Response to morphine	IEA
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0048156	Function	Tau protein binding	IEA
GO:0051721	Function	Protein phosphatase 2A binding	IEA
GO:0070262	Process	Peptidyl-serine dephosphorylation	IBA	21873635
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 604941
• HGNC: 9304
• e!Ensembl: ENSG00000221914

Protein

• UniProt ID: P63151
• Protein name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)
• Protein function: Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephos
• PDB: 3DW8, 8SO0, 8TTB, 8TWE
• Sequence:

  MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQE
  NKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIK
  LWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHI
  NSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCN
  TFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYM
  MTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTG
  SYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKIL
  HTAWHPKENIIAVATTNNLYIFQDKVN

• Sequence length: 447