PPP2R1B (protein phosphatase 2 scaffold subunit Abeta)

Gene

• Entrez ID: 5519
• Gene name: Protein phosphatase 2 scaffold subunit Abeta
• Gene symbol: PPP2R1B
• Synonyms: PP2A-Abeta, PR65B
• Chromosome: 11
• Chromosome location: 11q23.1
• Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1805076	C>T	Pathogenic	Intron variant, missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022210	hsa-miR-124-3p	Microarray	18668037
MIRT025691	hsa-miR-7-5p	Microarray	19073608
MIRT042516	hsa-miR-423-3p	CLASH	23622248
MIRT051305	hsa-miR-16-5p	CLASH	23622248
MIRT394616	hsa-miR-1-3p	PAR-CLIP	23592263
MIRT394617	hsa-miR-206	PAR-CLIP	23592263
MIRT394618	hsa-miR-613	PAR-CLIP	23592263
MIRT452137	hsa-miR-6505-5p	PAR-CLIP	23592263
MIRT452138	hsa-miR-5579-3p	PAR-CLIP	23592263
MIRT452139	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT452140	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT452141	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT452142	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT452143	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT452144	hsa-miR-5192	PAR-CLIP	23592263
MIRT452145	hsa-miR-4644	PAR-CLIP	23592263
MIRT452146	hsa-miR-4306	PAR-CLIP	23592263
MIRT452147	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT452148	hsa-miR-3134	PAR-CLIP	23592263
MIRT452149	hsa-miR-8082	PAR-CLIP	23592263
MIRT452150	hsa-miR-4534	PAR-CLIP	23592263
MIRT452151	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT452152	hsa-miR-380-3p	PAR-CLIP	23592263
MIRT452153	hsa-miR-411-3p	PAR-CLIP	23592263
MIRT452154	hsa-miR-379-3p	PAR-CLIP	23592263
MIRT452155	hsa-miR-4495	PAR-CLIP	23592263
MIRT452156	hsa-miR-208b-5p	PAR-CLIP	23592263
MIRT452157	hsa-miR-208a-5p	PAR-CLIP	23592263
MIRT606891	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT606891	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT606891	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT606891	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT606891	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT606892	hsa-miR-632	HITS-CLIP	24906430
MIRT606892	hsa-miR-632	HITS-CLIP	23824327
MIRT606892	hsa-miR-632	HITS-CLIP	22927820
MIRT606892	hsa-miR-632	HITS-CLIP	27418678
MIRT606893	hsa-miR-4288	HITS-CLIP	24906430
MIRT606893	hsa-miR-4288	HITS-CLIP	23824327
MIRT606893	hsa-miR-4288	HITS-CLIP	22927820
MIRT606893	hsa-miR-4288	HITS-CLIP	27418678
MIRT606894	hsa-miR-3977	HITS-CLIP	24906430
MIRT606894	hsa-miR-3977	HITS-CLIP	23824327
MIRT606894	hsa-miR-3977	HITS-CLIP	22927820
MIRT606894	hsa-miR-3977	HITS-CLIP	27418678
MIRT606895	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT606895	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT606895	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT606895	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT606895	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT606896	hsa-miR-4711-3p	HITS-CLIP	24906430
MIRT606896	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT606896	hsa-miR-4711-3p	HITS-CLIP	22927820
MIRT606896	hsa-miR-4711-3p	HITS-CLIP	27418678
MIRT606897	hsa-miR-346	HITS-CLIP	24906430
MIRT606897	hsa-miR-346	HITS-CLIP	23824327
MIRT606897	hsa-miR-346	HITS-CLIP	22927820
MIRT606897	hsa-miR-346	HITS-CLIP	27418678
MIRT608583	hsa-miR-5010-3p	HITS-CLIP	24906430
MIRT608583	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608584	hsa-miR-147a	HITS-CLIP	24906430
MIRT608584	hsa-miR-147a	HITS-CLIP	21572407
MIRT608585	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT608585	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608586	hsa-miR-8068	HITS-CLIP	24906430
MIRT608586	hsa-miR-8068	HITS-CLIP	21572407
MIRT608587	hsa-miR-4307	HITS-CLIP	24906430
MIRT608587	hsa-miR-4307	HITS-CLIP	21572407
MIRT622615	hsa-miR-576-5p	HITS-CLIP	23824327
MIRT622616	hsa-miR-4263	HITS-CLIP	23824327
MIRT622617	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT622618	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT622619	hsa-miR-5696	HITS-CLIP	23824327
MIRT622620	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT622621	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT734747	hsa-miR-587	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26247730

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	8392071, 16456541, 17540176, 18715871, 18782753, 19156129, 21172653, 23555304, 26496610, 28330616
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IEA
GO:0008287	Component	Protein serine/threonine phosphatase complex	IBA	21873635
GO:0019888	Function	Protein phosphatase regulator activity	IBA	21873635
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0045121	Component	Membrane raft	IDA	21172653
GO:0060561	Process	Apoptotic process involved in morphogenesis	IMP	21172653
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:2001241	Process	Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP	21172653

Other IDs

• MIM: 603113
• HGNC: 9303
• e!Ensembl: ENSG00000137713

Protein

• UniProt ID: P30154
• Protein name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)
• Protein function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02985	HEAT	178 → 208	HEAT repeat	Repeat
  PF13646	HEAT_2	217 → 319		Family
  PF13646	HEAT_2	378 → 479		Family

• Sequence:

  MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR
  SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA
  VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ
  QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC
  VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ
  NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV
  IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI
  VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK
  LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKM
  AGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLAL
  A

• Sequence length: 601