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PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5515
Gene nameGene Name - the full gene name approved by the HGNC.
Protein phosphatase 2 catalytic subunit alpha
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PPP2CA
SynonymsGene synonyms aliases
HJS3, NEDLBA, PP2Ac, PP2CA, PP2Calpha, RP-C
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which
SNPsSNP information provided by dbSNP.
Gene SNPs Transcription factors Other IDs
SNP ID Visualize variation Clinical significance Consequence
rs148071386 G>A Uncertain-significance, likely-pathogenic Coding sequence variant, stop gained, non coding transcript variant
rs764595667 C>G,T Likely-pathogenic Synonymous variant, coding sequence variant, missense variant, non coding transcript variant
rs864622012 AAG>-,AAGAAG Likely-pathogenic, uncertain-significance Coding sequence variant, non coding transcript variant, inframe deletion, inframe insertion
rs915349596 T>C Likely-pathogenic Non coding transcript variant, coding sequence variant, missense variant
rs1561733474 T>C Likely-pathogenic Non coding transcript variant, missense variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT048079 hsa-miR-197-3p CLASH 23622248
MIRT043848 hsa-miR-340-3p CLASH 23622248
MIRT571790 hsa-miR-125a-5p PAR-CLIP 20371350
MIRT571789 hsa-miR-125b-5p PAR-CLIP 20371350
MIRT571787 hsa-miR-4319 PAR-CLIP 20371350
Transcription factors
Gene SNPs Transcription factors Other IDs
Transcription factor Regulation Reference
CREB1 Activation 17526027
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
GO ID Ontology Definition Evidence Reference
GO:0000159 Component Protein phosphatase type 2A complex IDA 17055435, 17174897
GO:0000159 Component Protein phosphatase type 2A complex TAS 11007961
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0000188 Process Inactivation of MAPK activity NAS 11007961
GO:0000775 Component Chromosome, centromeric region IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P67775
Protein name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Protein function Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, Pub
PDB 2IAE , 2IE3 , 2IE4 , 2NPP , 2NYL , 2NYM , 3C5W , 3DW8 , 3FGA , 3K7V , 3K7W , 3P71 , 4I5L , 4I5N , 4IYP , 4LAC , 4NY3 , 5W0W , 6NTS , 7CUN , 7K36 , 7PKS , 7SOY , 7YCX , 8RBX , 8RBZ , 8RC4 , 8SO0 , 8TTB , 8TWE , 8TWI , 8U1X , 8U89 , 8UWB , 8YJB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00149 Metallophos
50 → 245
Calcineurin-like phosphoesterase
 Domain
Sequence
Sequence length 309
Interactions View interactions

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