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PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5515
Gene nameGene Name - the full gene name approved by the HGNC.
Protein phosphatase 2 catalytic subunit alpha
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PPP2CA
SynonymsGene synonyms aliases
NEDLBA, PP2Ac, PP2CA, PP2Calpha, RP-C
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
SNPsSNP information provided by dbSNP.
Gene SNPs Transcription factors Other IDs
SNP ID Visualize variation Clinical significance Consequence
rs148071386 G>A Uncertain-significance, likely-pathogenic Coding sequence variant, stop gained, non coding transcript variant
rs764595667 C>G,T Likely-pathogenic Synonymous variant, coding sequence variant, missense variant, non coding transcript variant
rs864622012 AAG>-,AAGAAG Likely-pathogenic, uncertain-significance Coding sequence variant, non coding transcript variant, inframe deletion, inframe insertion
rs915349596 T>C Likely-pathogenic Non coding transcript variant, coding sequence variant, missense variant
rs1561733474 T>C Likely-pathogenic Non coding transcript variant, missense variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT043848 hsa-miR-340-3p CLASH 23622248
MIRT048079 hsa-miR-197-3p CLASH 23622248
MIRT311674 hsa-miR-153-5p PAR-CLIP 23446348
MIRT311674 hsa-miR-153-5p PAR-CLIP 21572407
MIRT311674 hsa-miR-153-5p PAR-CLIP 20371350
Transcription factors
Gene SNPs Transcription factors Other IDs
Transcription factor Regulation Reference
CREB1 Activation 17526027
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
GO ID Ontology Definition Evidence Reference
GO:0000159 Component Protein phosphatase type 2A complex IDA 17055435, 17174897
GO:0000159 Component Protein phosphatase type 2A complex TAS 11007961
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0000188 Process Inactivation of MAPK activity NAS 11007961
GO:0000775 Component Chromosome, centromeric region IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P67775
Protein name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Protein function PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758).
PDB 2IAE , 2IE3 , 2IE4 , 2NPP , 2NYL , 2NYM , 3C5W , 3DW8 , 3FGA , 3K7V , 3K7W , 3P71 , 4I5L , 4I5N , 4IYP , 4LAC , 5W0W , 6NTS , 7CUN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00149 Metallophos
50 → 245
Calcineurin-like phosphoesterase
 Domain
Sequence
Sequence length 309
Interactions View interactions

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