PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A)

Gene

• Entrez ID: 5502
• Gene name: Protein phosphatase 1 regulatory inhibitor subunit 1A
• Gene symbol: PPP1R1A
• Synonyms: I1, IPP1
• Chromosome: 12
• Chromosome location: 12q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018310	hsa-miR-335-5p	Microarray	18185580
MIRT038385	hsa-miR-296-3p	CLASH	23622248
MIRT519154	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT519154	hsa-miR-1277-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT519155	hsa-miR-6509-5p	PAR-CLIP	23446348
MIRT519155	hsa-miR-6509-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT519156	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519156	hsa-miR-190a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT519157	hsa-miR-331-5p	PAR-CLIP	23446348
MIRT519157	hsa-miR-331-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT519158	hsa-miR-4469	PAR-CLIP	23446348
MIRT519158	hsa-miR-4469	HITS-CLIP	21572407
MIRT519159	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519159	hsa-miR-5011-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT519160	hsa-miR-4678	PAR-CLIP	23446348
MIRT519160	hsa-miR-4678	PAR-CLIP, HITS-CLIP	21572407
MIRT552103	hsa-miR-3924	PAR-CLIP	21572407
MIRT552104	hsa-miR-4486	PAR-CLIP	21572407
MIRT552105	hsa-miR-378g	PAR-CLIP	21572407
MIRT552106	hsa-miR-6860	PAR-CLIP	21572407
MIRT552107	hsa-miR-612	PAR-CLIP	21572407
MIRT552108	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT552109	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT552110	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT552111	hsa-miR-1298-3p	PAR-CLIP	21572407
MIRT552112	hsa-miR-3126-3p	PAR-CLIP	21572407

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004865	Function	Protein serine/threonine phosphatase inhibitor activity	TAS	8611507
GO:0005515	Function	Protein binding	IPI	11564868
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005977	Process	Glycogen metabolic process	IEA
GO:0032515	Process	Negative regulation of phosphoprotein phosphatase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IBA	21873635

Other IDs

• MIM: 613246
• HGNC: 9286
• e!Ensembl: ENSG00000135447

Protein

• UniProt ID: Q13522
• Protein name: Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1)
• Protein function: Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05395	DARPP-32	3 → 166	Protein phosphatase inhibitor 1/DARPP-32	Family

• Sequence:

  MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHL
  KSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTETQESRPPGIPD
  TEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV

• Sequence length: 171