Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5501 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Protein phosphatase 1 catalytic subunit gamma |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PPP1CC |
SynonymsGene synonyms aliases
|
PP-1G, PP1C, PPP1G |
ChromosomeChromosome number
|
12 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q24.11 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three close |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000164 |
Component |
Protein phosphatase type 1 complex |
IEA |
|
GO:0000777 |
Component |
Condensed chromosome kinetochore |
IEA |
|
GO:0000781 |
Component |
Chromosome, telomeric region |
IDA |
24270157 |
GO:0003723 |
Function |
RNA binding |
HDA |
22681889 |
GO:0004721 |
Function |
Phosphoprotein phosphatase activity |
TAS |
|
GO:0004722 |
Function |
Protein serine/threonine phosphatase activity |
IBA |
21873635 |
GO:0004722 |
Function |
Protein serine/threonine phosphatase activity |
IMP |
10880350, 17936702 |
GO:0005515 |
Function |
Protein binding |
IPI |
10807923, 11739654, 12761178, 15231748, 17274640, 17511879, 17936702, 17965019, 18448430, 20516061, 20926688, 21397856, 21988832, 21998301, 23414517, 23555304, 24366813, 25416956, 25785436, 26307080, 26496610, 27173435, 27505673, 27913189, 28065597, 28330616, 29892012, 31527615, 322 |
GO:0005521 |
Function |
Lamin binding |
IEA |
|
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
IDA |
11739654 |
GO:0005730 |
Component |
Nucleolus |
IDA |
11739654 |
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
11739654 |
GO:0005739 |
Component |
Mitochondrion |
IDA |
17936702 |
GO:0005741 |
Component |
Mitochondrial outer membrane |
IEA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005925 |
Component |
Focal adhesion |
HDA |
21423176 |
GO:0005977 |
Process |
Glycogen metabolic process |
IEA |
|
GO:0006470 |
Process |
Protein dephosphorylation |
IMP |
22801782 |
GO:0006470 |
Process |
Protein dephosphorylation |
ISS |
|
GO:0007049 |
Process |
Cell cycle |
IEA |
|
GO:0008022 |
Function |
Protein C-terminus binding |
IEA |
|
GO:0008157 |
Function |
Protein phosphatase 1 binding |
IEA |
|
GO:0016607 |
Component |
Nuclear speck |
IEA |
|
GO:0016791 |
Function |
Phosphatase activity |
ISS |
|
GO:0019901 |
Function |
Protein kinase binding |
IPI |
10880350 |
GO:0019904 |
Function |
Protein domain specific binding |
IEA |
|
GO:0030182 |
Process |
Neuron differentiation |
IEA |
|
GO:0030496 |
Component |
Midbody |
IEA |
|
GO:0032154 |
Component |
Cleavage furrow |
IEA |
|
GO:0032922 |
Process |
Circadian regulation of gene expression |
ISS |
|
GO:0032991 |
Component |
Protein-containing complex |
IMP |
10880350 |
GO:0042752 |
Process |
Regulation of circadian rhythm |
IMP |
21712997 |
GO:0043153 |
Process |
Entrainment of circadian clock by photoperiod |
ISS |
|
GO:0043197 |
Component |
Dendritic spine |
IEA |
|
GO:0044877 |
Function |
Protein-containing complex binding |
IEA |
|
GO:0046822 |
Process |
Regulation of nucleocytoplasmic transport |
IEA |
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0047485 |
Function |
Protein N-terminus binding |
IDA |
23789093 |
GO:0051301 |
Process |
Cell division |
IEA |
|
GO:0060252 |
Process |
Positive regulation of glial cell proliferation |
IEA |
|
GO:0072357 |
Component |
PTW/PP1 phosphatase complex |
IDA |
20516061 |
GO:0098793 |
Component |
Presynapse |
IEA |
|
GO:0098978 |
Component |
Glutamatergic synapse |
IEA |
|
GO:0106306 |
Function |
Protein serine phosphatase activity |
IEA |
|
GO:0106307 |
Function |
Protein threonine phosphatase activity |
IEA |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
P36873 |
Protein name |
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) |
Protein function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell |
PDB |
1IT6
,
1JK7
,
1U32
,
2BCD
,
2BDX
,
4UT2
,
4UT3
,
5INB
,
5J28
,
7SD0
,
8B5R
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF16891 |
STPPase_N |
9 → 56 |
Serine-threonine protein phosphatase N-terminal domain |
Family |
PF00149 |
Metallophos |
57 → 252 |
Calcineurin-like phosphoesterase |
Domain |
|
Sequence |
|
Sequence length |
323 |
Interactions |
View interactions |