Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5500 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Protein phosphatase 1 catalytic subunit beta |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PPP1CB |
SynonymsGene synonyms aliases
|
HEL-S-80p, MP, NSLH2, PP-1B, PP1B, PP1beta, PP1c, PPP1CD, PPP1beta |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2p23.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs886037952 |
C>G |
Pathogenic |
Coding sequence variant, missense variant |
rs886037953 |
G>T |
Likely-pathogenic |
Coding sequence variant, missense variant |
rs886037954 |
A>C,T |
Pathogenic |
Coding sequence variant, missense variant |
rs886037955 |
G>A |
Likely-pathogenic, pathogenic |
Coding sequence variant, missense variant |
rs1114167429 |
G>C |
Pathogenic |
Missense variant, coding sequence variant |
rs1553310744 |
C>A |
Likely-pathogenic |
Coding sequence variant, missense variant |
rs1553311527 |
C>T |
Likely-pathogenic |
Coding sequence variant, missense variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000086 |
Process |
G2/M transition of mitotic cell cycle |
TAS |
|
GO:0000164 |
Component |
Protein phosphatase type 1 complex |
IEA |
|
GO:0000781 |
Component |
Chromosome, telomeric region |
IDA |
24270157 |
GO:0004722 |
Function |
Protein serine/threonine phosphatase activity |
IBA |
21873635 |
GO:0005515 |
Function |
Protein binding |
IPI |
11067852, 17511879, 18586956, 20424263, 20516061, 20926688, 21516116, 21998301, 23414517, 23555304, 25416956, 25544563, 25785436, 25910212, 26496610, 26871637, 27107012, 27173435, 28296156, 28330616, 28514442, 32296183, 32814053 |
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005730 |
Component |
Nucleolus |
IEA |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
IDA |
|
GO:0005925 |
Component |
Focal adhesion |
HDA |
21423176 |
GO:0005977 |
Process |
Glycogen metabolic process |
IEA |
|
GO:0005979 |
Process |
Regulation of glycogen biosynthetic process |
IEA |
|
GO:0005981 |
Process |
Regulation of glycogen catabolic process |
IEA |
|
GO:0006470 |
Process |
Protein dephosphorylation |
ISS |
|
GO:0016791 |
Function |
Phosphatase activity |
ISS |
|
GO:0017018 |
Function |
Myosin phosphatase activity |
ISS |
|
GO:0019901 |
Function |
Protein kinase binding |
IPI |
20354225 |
GO:0030155 |
Process |
Regulation of cell adhesion |
IDA |
20354225 |
GO:0032922 |
Process |
Circadian regulation of gene expression |
IBA |
21873635 |
GO:0032922 |
Process |
Circadian regulation of gene expression |
ISS |
|
GO:0042587 |
Component |
Glycogen granule |
IEA |
|
GO:0042752 |
Process |
Regulation of circadian rhythm |
IBA |
21873635 |
GO:0042752 |
Process |
Regulation of circadian rhythm |
IMP |
21712997 |
GO:0043153 |
Process |
Entrainment of circadian clock by photoperiod |
ISS |
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0050115 |
Function |
Myosin-light-chain-phosphatase activity |
IDA |
20354225 |
GO:0051301 |
Process |
Cell division |
IEA |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19199708 |
GO:0072357 |
Component |
PTW/PP1 phosphatase complex |
IDA |
20354225, 20516061 |
GO:0106306 |
Function |
Protein serine phosphatase activity |
IEA |
|
GO:0106307 |
Function |
Protein threonine phosphatase activity |
IEA |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P62140 |
Protein name |
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) |
Protein function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regu |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF16891 |
STPPase_N |
8 → 55 |
Serine-threonine protein phosphatase N-terminal domain |
Family |
PF00149 |
Metallophos |
56 → 251 |
Calcineurin-like phosphoesterase |
Domain |
|
Sequence |
|
Sequence length |
327 |
Interactions |
View interactions |