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PPP1CB (protein phosphatase 1 catalytic subunit beta)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5500
Gene nameGene Name - the full gene name approved by the HGNC.
Protein phosphatase 1 catalytic subunit beta
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PPP1CB
SynonymsGene synonyms aliases
HEL-S-80p, MP, NSLH2, PP-1B, PP1B, PP1beta, PP1c, PPP1CD, PPP1beta
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p23.2
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs886037952 C>G Pathogenic Coding sequence variant, missense variant
rs886037953 G>T Likely-pathogenic Coding sequence variant, missense variant
rs886037954 A>C,T Pathogenic Coding sequence variant, missense variant
rs886037955 G>A Likely-pathogenic, pathogenic Coding sequence variant, missense variant
rs1114167429 G>C Pathogenic Missense variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024868 hsa-miR-215-5p Microarray 19074876
MIRT026142 hsa-miR-192-5p Microarray 19074876
MIRT031341 hsa-miR-18a-5p Sequencing 20371350
MIRT046516 hsa-miR-15b-5p CLASH 23622248
MIRT046264 hsa-miR-23b-3p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS
GO:0000164 Component Protein phosphatase type 1 complex IEA
GO:0000781 Component Chromosome, telomeric region IDA 24270157
GO:0004722 Function Protein serine/threonine phosphatase activity IBA 21873635
GO:0005515 Function Protein binding IPI 11067852, 17511879, 18586956, 20424263, 20516061, 20926688, 21516116, 21998301, 23414517, 23555304, 25416956, 25544563, 25785436, 25910212, 26496610, 26871637, 27107012, 27173435, 28296156, 28330616, 28514442, 32296183, 32814053
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P62140
Protein name Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Protein function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16891 STPPase_N
8 55
Serine-threonine protein phosphatase N-terminal domain
Family
PF00149 Metallophos
56 251
Calcineurin-like phosphoesterase
Domain
Sequence
Sequence length 327
Interactions View interactions

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