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PPP1CA (protein phosphatase 1 catalytic subunit alpha)

Gene

5499

Protein phosphatase 1 catalytic subunit alpha

PPP1CA

PP-1A, PP1A, PP1alpha, PPP1A

11q13.2

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which de

Show/Hide all(147)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006127	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21935352
MIRT006127	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21935352
MIRT006127	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21935352
MIRT006127	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21935352
MIRT006127	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21935352
MIRT006127	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21935352
MIRT016090	hsa-miR-769-5p	Sequencing	20371350
MIRT024705	hsa-miR-215-5p	Microarray	19074876
MIRT026892	hsa-miR-192-5p	Microarray	19074876
MIRT051034	hsa-miR-17-5p	CLASH	23622248
MIRT037406	hsa-miR-744-5p	CLASH	23622248
MIRT006127	hsa-miR-125b-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	25240408
MIRT006127	hsa-miR-125b-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	25240408
MIRT006127	hsa-miR-125b-5p	Luciferase reporter assay, Western blot, qRT-PCR	25001178
MIRT006127	hsa-miR-125b-5p	Luciferase reporter assay, Western blot, qRT-PCR	25001178
MIRT1254835	hsa-miR-1202	CLIP-seq
MIRT1254836	hsa-miR-125a-5p	CLIP-seq
MIRT1254837	hsa-miR-125b	CLIP-seq
MIRT1254838	hsa-miR-3189-5p	CLIP-seq
MIRT1254839	hsa-miR-3194-5p	CLIP-seq
MIRT1254840	hsa-miR-335	CLIP-seq
MIRT1254841	hsa-miR-3940-5p	CLIP-seq
MIRT1254842	hsa-miR-3972	CLIP-seq
MIRT1254843	hsa-miR-4272	CLIP-seq
MIRT1254844	hsa-miR-4319	CLIP-seq
MIRT1254845	hsa-miR-4507	CLIP-seq
MIRT1254846	hsa-miR-4649-3p	CLIP-seq
MIRT1254847	hsa-miR-4661-3p	CLIP-seq
MIRT1254848	hsa-miR-4758-3p	CLIP-seq
MIRT1254849	hsa-miR-4786-5p	CLIP-seq
MIRT1254850	hsa-miR-544b	CLIP-seq
MIRT1254851	hsa-miR-192	CLIP-seq
MIRT1254852	hsa-miR-215	CLIP-seq
MIRT1254840	hsa-miR-335	CLIP-seq
MIRT1254853	hsa-miR-4267	CLIP-seq
MIRT1254843	hsa-miR-4272	CLIP-seq
MIRT1254849	hsa-miR-4786-5p	CLIP-seq
MIRT2075177	hsa-miR-1275	CLIP-seq
MIRT2075178	hsa-miR-3199	CLIP-seq
MIRT2075179	hsa-miR-3654	CLIP-seq
MIRT2075180	hsa-miR-4292	CLIP-seq
MIRT2075181	hsa-miR-4514	CLIP-seq
MIRT2075182	hsa-miR-4515	CLIP-seq
MIRT2075183	hsa-miR-4525	CLIP-seq
MIRT2075184	hsa-miR-4652-5p	CLIP-seq
MIRT1254847	hsa-miR-4661-3p	CLIP-seq
MIRT2075185	hsa-miR-4665-5p	CLIP-seq
MIRT2075186	hsa-miR-4692	CLIP-seq
MIRT2075187	hsa-miR-4723-5p	CLIP-seq
MIRT2075188	hsa-miR-625	CLIP-seq
MIRT2075189	hsa-miR-637	CLIP-seq
MIRT2075190	hsa-miR-664	CLIP-seq
MIRT2075191	hsa-miR-940	CLIP-seq
MIRT1254836	hsa-miR-125a-5p	CLIP-seq
MIRT1254837	hsa-miR-125b	CLIP-seq
MIRT2075192	hsa-miR-3177-3p	CLIP-seq
MIRT1254844	hsa-miR-4319	CLIP-seq
MIRT1254847	hsa-miR-4661-3p	CLIP-seq
MIRT2075190	hsa-miR-664	CLIP-seq
MIRT2301796	hsa-miR-103a	CLIP-seq
MIRT2301797	hsa-miR-107	CLIP-seq
MIRT2301798	hsa-miR-1178	CLIP-seq
MIRT1254835	hsa-miR-1202	CLIP-seq
MIRT1254836	hsa-miR-125a-5p	CLIP-seq
MIRT1254837	hsa-miR-125b	CLIP-seq
MIRT2075177	hsa-miR-1275	CLIP-seq
MIRT2301799	hsa-miR-128	CLIP-seq
MIRT2301800	hsa-miR-27a	CLIP-seq
MIRT2301801	hsa-miR-27b	CLIP-seq
MIRT1254838	hsa-miR-3189-5p	CLIP-seq
MIRT1254839	hsa-miR-3194-5p	CLIP-seq
MIRT2075178	hsa-miR-3199	CLIP-seq
MIRT2301802	hsa-miR-338-3p	CLIP-seq
MIRT2301803	hsa-miR-361-3p	CLIP-seq
MIRT2075179	hsa-miR-3654	CLIP-seq
MIRT2301804	hsa-miR-3665	CLIP-seq
MIRT2301805	hsa-miR-3686	CLIP-seq
MIRT2301806	hsa-miR-370	CLIP-seq
MIRT1254841	hsa-miR-3940-5p	CLIP-seq
MIRT1254842	hsa-miR-3972	CLIP-seq
MIRT2075180	hsa-miR-4292	CLIP-seq
MIRT1254844	hsa-miR-4319	CLIP-seq
MIRT1254845	hsa-miR-4507	CLIP-seq
MIRT2075181	hsa-miR-4514	CLIP-seq
MIRT2075182	hsa-miR-4515	CLIP-seq
MIRT2075183	hsa-miR-4525	CLIP-seq
MIRT1254846	hsa-miR-4649-3p	CLIP-seq
MIRT2301807	hsa-miR-4652-3p	CLIP-seq
MIRT2075184	hsa-miR-4652-5p	CLIP-seq
MIRT1254847	hsa-miR-4661-3p	CLIP-seq
MIRT2075185	hsa-miR-4665-5p	CLIP-seq
MIRT2301808	hsa-miR-4667-5p	CLIP-seq
MIRT2075186	hsa-miR-4692	CLIP-seq
MIRT2301809	hsa-miR-4700-5p	CLIP-seq
MIRT2301810	hsa-miR-4704-3p	CLIP-seq
MIRT2075187	hsa-miR-4723-5p	CLIP-seq
MIRT1254848	hsa-miR-4758-3p	CLIP-seq
MIRT2301811	hsa-miR-486-3p	CLIP-seq
MIRT1254850	hsa-miR-544b	CLIP-seq
MIRT2075188	hsa-miR-625	CLIP-seq
MIRT2075189	hsa-miR-637	CLIP-seq
MIRT2075190	hsa-miR-664	CLIP-seq
MIRT2301812	hsa-miR-764	CLIP-seq
MIRT2301813	hsa-miR-767-3p	CLIP-seq
MIRT2301814	hsa-miR-885-3p	CLIP-seq
MIRT2075191	hsa-miR-940	CLIP-seq
MIRT1254835	hsa-miR-1202	CLIP-seq
MIRT1254836	hsa-miR-125a-5p	CLIP-seq
MIRT1254837	hsa-miR-125b	CLIP-seq
MIRT2075177	hsa-miR-1275	CLIP-seq
MIRT1254839	hsa-miR-3194-5p	CLIP-seq
MIRT2075178	hsa-miR-3199	CLIP-seq
MIRT2075179	hsa-miR-3654	CLIP-seq
MIRT1254842	hsa-miR-3972	CLIP-seq
MIRT2075180	hsa-miR-4292	CLIP-seq
MIRT1254844	hsa-miR-4319	CLIP-seq
MIRT2075182	hsa-miR-4515	CLIP-seq
MIRT2075183	hsa-miR-4525	CLIP-seq
MIRT1254846	hsa-miR-4649-3p	CLIP-seq
MIRT2075184	hsa-miR-4652-5p	CLIP-seq
MIRT2075185	hsa-miR-4665-5p	CLIP-seq
MIRT2075187	hsa-miR-4723-5p	CLIP-seq
MIRT1254850	hsa-miR-544b	CLIP-seq
MIRT2075188	hsa-miR-625	CLIP-seq
MIRT2075189	hsa-miR-637	CLIP-seq
MIRT2075190	hsa-miR-664	CLIP-seq
MIRT1254836	hsa-miR-125a-5p	CLIP-seq
MIRT1254837	hsa-miR-125b	CLIP-seq
MIRT1254844	hsa-miR-4319	CLIP-seq
MIRT1254847	hsa-miR-4661-3p	CLIP-seq
MIRT2075177	hsa-miR-1275	CLIP-seq
MIRT2075178	hsa-miR-3199	CLIP-seq
MIRT2075179	hsa-miR-3654	CLIP-seq
MIRT2301804	hsa-miR-3665	CLIP-seq
MIRT2075180	hsa-miR-4292	CLIP-seq
MIRT2075181	hsa-miR-4514	CLIP-seq
MIRT2075182	hsa-miR-4515	CLIP-seq
MIRT2075183	hsa-miR-4525	CLIP-seq
MIRT2075184	hsa-miR-4652-5p	CLIP-seq
MIRT2075185	hsa-miR-4665-5p	CLIP-seq
MIRT2075186	hsa-miR-4692	CLIP-seq
MIRT2075187	hsa-miR-4723-5p	CLIP-seq
MIRT2075188	hsa-miR-625	CLIP-seq
MIRT2075189	hsa-miR-637	CLIP-seq
MIRT2301812	hsa-miR-764	CLIP-seq
MIRT2075191	hsa-miR-940	CLIP-seq
MIRT2075189	hsa-miR-637	CLIP-seq

Show/Hide all(54)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000164	Component	Protein phosphatase type 1 complex	IEA
GO:0000781	Component	Chromosome, telomeric region	IDA	24270157
GO:0004721	Function	Phosphoprotein phosphatase activity	ISS
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA	21873635
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS	10640627, 16262633
GO:0005515	Function	Protein binding	IPI	10807923, 11739654, 12434308, 15231748, 16263087, 16732323, 17274640, 17318175, 17511879, 17965019, 18068675, 18842582, 19389623, 20186153, 20305656, 20424263, 20467437, 20516061, 20826336, 20926688, 21094159, 21382349, 21518769, 21666598, 21998301, 22321011, 22365833, 22940584, 233
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	11739654
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	11739654
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005912	Component	Adherens junction	IDA	25468996
GO:0005977	Process	Glycogen metabolic process	IEA
GO:0005979	Process	Regulation of glycogen biosynthetic process	IEA
GO:0005981	Process	Regulation of glycogen catabolic process	IEA
GO:0006470	Process	Protein dephosphorylation	IMP	22311981, 22801782
GO:0006470	Process	Protein dephosphorylation	ISS
GO:0007049	Process	Cell cycle	IEA
GO:0008157	Function	Protein phosphatase 1 binding	IEA
GO:0010288	Process	Response to lead ion	ISS
GO:0016032	Process	Viral process	IEA
GO:0016311	Process	Dephosphorylation	IDA	22311981
GO:0016791	Function	Phosphatase activity	ISS
GO:0030324	Process	Lung development	IEA
GO:0032091	Process	Negative regulation of protein binding	ISS
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0035970	Process	Peptidyl-threonine dephosphorylation	TAS	16262633
GO:0036496	Process	Regulation of translational initiation by eIF2 alpha dephosphorylation	ISS
GO:0042587	Component	Glycogen granule	IEA
GO:0042752	Process	Regulation of circadian rhythm	IMP	21712997
GO:0043021	Function	Ribonucleoprotein complex binding	IEA
GO:0043153	Process	Entrainment of circadian clock by photoperiod	ISS
GO:0043197	Component	Dendritic spine	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048754	Process	Branching morphogenesis of an epithelial tube	IEA
GO:0051301	Process	Cell division	IEA
GO:0060828	Process	Regulation of canonical Wnt signaling pathway	IC	17318175
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070262	Process	Peptidyl-serine dephosphorylation	TAS	16262633
GO:0072357	Component	PTW/PP1 phosphatase complex	IDA	20516061
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	IDA	25468996
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0106306	Function	Protein serine phosphatase activity	IEA
GO:0106307	Function	Protein threonine phosphatase activity	IEA
GO:1904886	Process	Beta-catenin destruction complex disassembly	ISS
GO:2001241	Process	Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA

MIM	HGNC	e!Ensembl
176875	9281	ENSG00000172531

Protein

UniProt ID

P62136

Protein name

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)

Protein function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509,

PDB

3E7A , 3E7B , 3EGG , 3EGH , 3HVQ , 3N5U , 3V4Y , 4G9J , 4MOV , 4MOY , 4MP0 , 4XPN , 5IOH , 6ALZ , 6CZO , 6DCX , 6DNO , 6G0I , 6G0J , 6GHM , 6OBN , 6OBP , 6OBQ , 6OBR , 6OBS , 6OBU , 6ZEE , 6ZEF , 6ZEG , 6ZEH , 6ZEI , 6ZEJ , 6ZK6 , 7QFB , 7QM2 , 7T0Y , 7TVF , 7TXH , 7UPI , 8DWK , 8DWL , 8SW5 , 8SW6 , 8U5G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16891	STPPase_N	9 → 56	Serine-threonine protein phosphatase N-terminal domain	Family
PF00149	Metallophos	57 → 252	Calcineurin-like phosphoesterase	Domain

Sequence

MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK

Sequence length

330

Interactions

View interactions

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