POPDC2 (popeye domain containing 2)

Gene

• Entrez ID: 64091
• Gene name: Popeye domain containing 2
• Gene symbol: POPDC2
• Synonyms: POP2
• Chromosome: 3
• Chromosome location: 3q13.33
• Summary: This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017710	hsa-miR-335-5p	Microarray	18185580
MIRT631992	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT631993	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT631994	hsa-miR-5095	HITS-CLIP	23824327
MIRT631995	hsa-miR-5787	HITS-CLIP	23824327
MIRT631996	hsa-miR-4505	HITS-CLIP	23824327
MIRT631997	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631998	hsa-miR-4284	HITS-CLIP	23824327
MIRT631999	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT632000	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT632001	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632002	hsa-miR-5689	HITS-CLIP	23824327
MIRT632003	hsa-miR-6860	HITS-CLIP	23824327
MIRT632004	hsa-miR-612	HITS-CLIP	23824327
MIRT632005	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT632006	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT632007	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT632008	hsa-miR-5693	HITS-CLIP	23824327
MIRT632009	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT632010	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT632011	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT632012	hsa-miR-4438	HITS-CLIP	23824327
MIRT633903	hsa-miR-7977	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002027	Process	Regulation of heart rate	ISS
GO:0003674	Function	Molecular_function	ND
GO:0007507	Process	Heart development	IBA	21873635
GO:0007519	Process	Skeletal muscle tissue development	IBA	21873635
GO:0008150	Process	Biological_process	ND
GO:0016021	Component	Integral component of membrane	NAS	10882522
GO:0030552	Function	CAMP binding	IBA	21873635
GO:0042383	Component	Sarcolemma	IBA	21873635
GO:0042383	Component	Sarcolemma	IDA	26642364
GO:0042391	Process	Regulation of membrane potential	IBA	21873635
GO:0051146	Process	Striated muscle cell differentiation	IBA	21873635

Other IDs

• MIM: 605823
• HGNC: 17648
• e!Ensembl: ENSG00000121577

Protein

• UniProt ID: Q9HBU9
• Protein name: Popeye domain-containing protein 2 (Popeye protein 2)
• Protein function: Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04831	Popeye	25 → 251	Popeye protein conserved region	Family

• Sequence:

  MSANSSRVGQLLLQGSACIRWKQDVEGAVYHLANCLLLLGFMGGSGVYGCFYLFGFLSAG
  YLCCVLWGWFSACGLDIVLWSFLLAVVCLLQLAHLVYRLREDTLPEEFDLLYKTLCLPLQ
  VPLQTYKEIVHCCEEQVLTLATEQTYAVEGETPINRLSLLLSGRVRVSQDGQFLHYIFPY
  QFMDSPEWESLQPSEEGVFQVTLTAETSCSYISWPRKSLHLLLTKERYISCLFSALLGYD
  ISEKLYTLNDKLFAKFGLRFDIRLPSLYHVLGPTAADAGPESEKGDEEVCEPAVSPPQAT
  PTSLQQTPPCSTPPATTNFPAPPTRARLSRPDSGILASRIPLQSYSQVISRGQAPLAPTH
  TPEL

• Sequence length: 364