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PLCG2 (phospholipase C gamma 2)

Gene

5336

Phospholipase C gamma 2

PLCG2

APLAID, FCAS3, PLC-IV, PLC-gamma-2

16q23.3

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 an

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs189301790	C>T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs397514562	C>A	Pathogenic	Missense variant, coding sequence variant
rs1057519831	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057519832	A>C,G,T	Likely-pathogenic	Coding sequence variant, missense variant, synonymous variant

Show/Hide all(536)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019144	hsa-miR-335-5p	Microarray	18185580
MIRT654989	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT654988	hsa-miR-4703-3p	HITS-CLIP	23824327
MIRT654987	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT654986	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT654985	hsa-miR-4420	HITS-CLIP	23824327
MIRT654984	hsa-miR-4452	HITS-CLIP	23824327
MIRT654983	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT654981	hsa-miR-3674	HITS-CLIP	23824327
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	24906430
MIRT499427	hsa-miR-5683	HITS-CLIP	24906430
MIRT499425	hsa-miR-504-5p	HITS-CLIP	24906430
MIRT499424	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	24906430
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	24906430
MIRT499421	hsa-miR-575	HITS-CLIP	24906430
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	24906430
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	24906430
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	24906430
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	24906430
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	24906430
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	24906430
MIRT499391	hsa-miR-8053	HITS-CLIP	24906430
MIRT499386	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT499384	hsa-miR-4651	HITS-CLIP	24906430
MIRT499383	hsa-miR-608	HITS-CLIP	24906430
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT499379	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	24906430
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	24906430
MIRT499427	hsa-miR-5683	HITS-CLIP	24906430
MIRT499425	hsa-miR-504-5p	HITS-CLIP	24906430
MIRT499424	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	24906430
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	24906430
MIRT499421	hsa-miR-575	HITS-CLIP	24906430
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	24906430
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	24906430
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	24906430
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	24906430
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	24906430
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	24906430
MIRT499391	hsa-miR-8053	HITS-CLIP	24906430
MIRT499386	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT499384	hsa-miR-4651	HITS-CLIP	24906430
MIRT499383	hsa-miR-608	HITS-CLIP	24906430
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT499379	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	24906430
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	24906430
MIRT499427	hsa-miR-5683	HITS-CLIP	24906430
MIRT499425	hsa-miR-504-5p	HITS-CLIP	24906430
MIRT499424	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	24906430
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	24906430
MIRT499421	hsa-miR-575	HITS-CLIP	24906430
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	24906430
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	24906430
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	24906430
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	24906430
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	24906430
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	24906430
MIRT499391	hsa-miR-8053	HITS-CLIP	24906430
MIRT499386	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT499384	hsa-miR-4651	HITS-CLIP	24906430
MIRT499383	hsa-miR-608	HITS-CLIP	24906430
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT499379	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	24906430
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	24906430
MIRT499427	hsa-miR-5683	HITS-CLIP	24906430
MIRT499425	hsa-miR-504-5p	HITS-CLIP	24906430
MIRT499424	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	24906430
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	24906430
MIRT499421	hsa-miR-575	HITS-CLIP	24906430
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	24906430
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	24906430
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	24906430
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	24906430
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	24906430
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	24906430
MIRT499391	hsa-miR-8053	HITS-CLIP	24906430
MIRT499386	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT499384	hsa-miR-4651	HITS-CLIP	24906430
MIRT499383	hsa-miR-608	HITS-CLIP	24906430
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT499379	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	24906430
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	20371350
MIRT499427	hsa-miR-5683	PAR-CLIP	20371350
MIRT499425	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT499424	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT499421	hsa-miR-575	PAR-CLIP	20371350
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	20371350
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	20371350
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	20371350
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	20371350
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	20371350
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	20371350
MIRT499391	hsa-miR-8053	PAR-CLIP	20371350
MIRT499386	hsa-miR-342-5p	PAR-CLIP	20371350
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	20371350
MIRT499384	hsa-miR-4651	PAR-CLIP	20371350
MIRT499383	hsa-miR-608	PAR-CLIP	20371350
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	20371350
MIRT499379	hsa-miR-542-3p	PAR-CLIP	20371350
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	20371350
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	20371350
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	20371350
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	20371350
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	22012620
MIRT499427	hsa-miR-5683	PAR-CLIP	22012620
MIRT499425	hsa-miR-504-5p	PAR-CLIP	22012620
MIRT499424	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	22012620
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	22012620
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	22012620
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	22012620
MIRT499391	hsa-miR-8053	PAR-CLIP	22012620
MIRT499386	hsa-miR-342-5p	PAR-CLIP	22012620
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	22012620
MIRT499384	hsa-miR-4651	PAR-CLIP	22012620
MIRT499383	hsa-miR-608	PAR-CLIP	22012620
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	22012620
MIRT499379	hsa-miR-542-3p	PAR-CLIP	22012620
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	22012620
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	22012620
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	22012620
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	22012620
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	23446348
MIRT499427	hsa-miR-5683	PAR-CLIP	23446348
MIRT499425	hsa-miR-504-5p	PAR-CLIP	23446348
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	23446348
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	23446348
MIRT499391	hsa-miR-8053	PAR-CLIP	23446348
MIRT499386	hsa-miR-342-5p	PAR-CLIP	23446348
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	23446348
MIRT499384	hsa-miR-4651	PAR-CLIP	23446348
MIRT499383	hsa-miR-608	PAR-CLIP	23446348
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	23446348
MIRT499379	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	23446348
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	23446348
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	23446348
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	23446348
MIRT499426	hsa-miR-4802-3p	PAR-CLIP	23446348
MIRT499420	hsa-miR-4476	PAR-CLIP	23446348
MIRT499419	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT499417	hsa-miR-4717-3p	PAR-CLIP	23446348
MIRT499413	hsa-miR-6746-5p	PAR-CLIP	23446348
MIRT499412	hsa-miR-3179	PAR-CLIP	23446348
MIRT499411	hsa-miR-3126-5p	PAR-CLIP	23446348
MIRT499410	hsa-miR-6875-5p	PAR-CLIP	23446348
MIRT499409	hsa-let-7a-5p	PAR-CLIP	23446348
MIRT499408	hsa-let-7b-5p	PAR-CLIP	23446348
MIRT499407	hsa-let-7c-5p	PAR-CLIP	23446348
MIRT499406	hsa-let-7d-5p	PAR-CLIP	23446348
MIRT499405	hsa-let-7e-5p	PAR-CLIP	23446348
MIRT499404	hsa-let-7f-5p	PAR-CLIP	23446348
MIRT499403	hsa-let-7g-5p	PAR-CLIP	23446348
MIRT499402	hsa-let-7i-5p	PAR-CLIP	23446348
MIRT499401	hsa-miR-4458	PAR-CLIP	23446348
MIRT499400	hsa-miR-4500	PAR-CLIP	23446348
MIRT499399	hsa-miR-98-5p	PAR-CLIP	23446348
MIRT499398	hsa-miR-202-3p	PAR-CLIP	23446348
MIRT499397	hsa-miR-5589-3p	PAR-CLIP	23446348
MIRT499395	hsa-miR-3202	PAR-CLIP	23446348
MIRT499394	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT499393	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT499390	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT499389	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT499388	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT499387	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT499381	hsa-miR-4710	PAR-CLIP	23446348
MIRT499380	hsa-miR-8065	PAR-CLIP	23446348
MIRT499378	hsa-miR-1294	PAR-CLIP	23446348
MIRT499376	hsa-miR-425-3p	PAR-CLIP	23446348
MIRT499375	hsa-miR-6771-5p	PAR-CLIP	23446348
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	24398324
MIRT499427	hsa-miR-5683	PAR-CLIP	24398324
MIRT499426	hsa-miR-4802-3p	PAR-CLIP	24398324
MIRT499425	hsa-miR-504-5p	PAR-CLIP	24398324
MIRT499424	hsa-miR-383-5p	PAR-CLIP	24398324
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	24398324
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	24398324
MIRT499421	hsa-miR-575	PAR-CLIP	24398324
MIRT499420	hsa-miR-4476	PAR-CLIP	24398324
MIRT499419	hsa-miR-6876-5p	PAR-CLIP	24398324
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	24398324
MIRT499417	hsa-miR-4717-3p	PAR-CLIP	24398324
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	24398324
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	24398324
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	24398324
MIRT499413	hsa-miR-6746-5p	PAR-CLIP	24398324
MIRT499412	hsa-miR-3179	PAR-CLIP	24398324
MIRT499411	hsa-miR-3126-5p	PAR-CLIP	24398324
MIRT499410	hsa-miR-6875-5p	PAR-CLIP	24398324
MIRT499409	hsa-let-7a-5p	PAR-CLIP	24398324
MIRT499408	hsa-let-7b-5p	PAR-CLIP	24398324
MIRT499407	hsa-let-7c-5p	PAR-CLIP	24398324
MIRT499406	hsa-let-7d-5p	PAR-CLIP	24398324
MIRT499405	hsa-let-7e-5p	PAR-CLIP	24398324
MIRT499404	hsa-let-7f-5p	PAR-CLIP	24398324
MIRT499403	hsa-let-7g-5p	PAR-CLIP	24398324
MIRT499402	hsa-let-7i-5p	PAR-CLIP	24398324
MIRT499401	hsa-miR-4458	PAR-CLIP	24398324
MIRT499400	hsa-miR-4500	PAR-CLIP	24398324
MIRT499399	hsa-miR-98-5p	PAR-CLIP	24398324
MIRT499398	hsa-miR-202-3p	PAR-CLIP	24398324
MIRT499397	hsa-miR-5589-3p	PAR-CLIP	24398324
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	24398324
MIRT499395	hsa-miR-3202	PAR-CLIP	24398324
MIRT499394	hsa-miR-1249-5p	PAR-CLIP	24398324
MIRT499393	hsa-miR-6797-5p	PAR-CLIP	24398324
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	24398324
MIRT499391	hsa-miR-8053	PAR-CLIP	24398324
MIRT499390	hsa-miR-149-3p	PAR-CLIP	24398324
MIRT499389	hsa-miR-4728-5p	PAR-CLIP	24398324
MIRT499388	hsa-miR-6785-5p	PAR-CLIP	24398324
MIRT499387	hsa-miR-6883-5p	PAR-CLIP	24398324
MIRT499386	hsa-miR-342-5p	PAR-CLIP	24398324
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	24398324
MIRT499384	hsa-miR-4651	PAR-CLIP	24398324
MIRT499383	hsa-miR-608	PAR-CLIP	24398324
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	24398324
MIRT499381	hsa-miR-4710	PAR-CLIP	24398324
MIRT499380	hsa-miR-8065	PAR-CLIP	24398324
MIRT499379	hsa-miR-542-3p	PAR-CLIP	24398324
MIRT499378	hsa-miR-1294	PAR-CLIP	24398324
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	24398324
MIRT499376	hsa-miR-425-3p	PAR-CLIP	24398324
MIRT499375	hsa-miR-6771-5p	PAR-CLIP	24398324
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	24398324
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	24398324
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	24398324
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	26701625
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	26701625
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	26701625
MIRT499386	hsa-miR-342-5p	PAR-CLIP	26701625
MIRT499386	hsa-miR-342-5p	PAR-CLIP	26701625
MIRT499386	hsa-miR-342-5p	PAR-CLIP	26701625
MIRT499386	hsa-miR-342-5p	PAR-CLIP	26701625
MIRT499424	hsa-miR-383-5p	PAR-CLIP	26701625
MIRT499384	hsa-miR-4651	PAR-CLIP	26701625
MIRT499384	hsa-miR-4651	PAR-CLIP	26701625
MIRT499384	hsa-miR-4651	PAR-CLIP	26701625
MIRT499384	hsa-miR-4651	PAR-CLIP	26701625
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	26701625
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	26701625
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	26701625
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	26701625
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT499425	hsa-miR-504-5p	PAR-CLIP	26701625
MIRT499425	hsa-miR-504-5p	PAR-CLIP	26701625
MIRT499425	hsa-miR-504-5p	PAR-CLIP	26701625
MIRT499425	hsa-miR-504-5p	PAR-CLIP	26701625
MIRT499379	hsa-miR-542-3p	PAR-CLIP	26701625
MIRT499379	hsa-miR-542-3p	PAR-CLIP	26701625
MIRT499379	hsa-miR-542-3p	PAR-CLIP	26701625
MIRT499379	hsa-miR-542-3p	PAR-CLIP	26701625
MIRT499427	hsa-miR-5683	PAR-CLIP	26701625
MIRT499427	hsa-miR-5683	PAR-CLIP	26701625
MIRT499427	hsa-miR-5683	PAR-CLIP	26701625
MIRT499427	hsa-miR-5683	PAR-CLIP	26701625
MIRT499421	hsa-miR-575	PAR-CLIP	26701625
MIRT499383	hsa-miR-608	PAR-CLIP	26701625
MIRT499383	hsa-miR-608	PAR-CLIP	26701625
MIRT499383	hsa-miR-608	PAR-CLIP	26701625
MIRT499383	hsa-miR-608	PAR-CLIP	26701625
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	26701625
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	26701625
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	26701625
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	26701625
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	26701625
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	26701625
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	26701625
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	26701625
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	26701625
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	26701625
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	26701625
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	26701625
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	26701625
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	26701625
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	26701625
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	26701625
MIRT499391	hsa-miR-8053	PAR-CLIP	26701625
MIRT499391	hsa-miR-8053	PAR-CLIP	26701625
MIRT499391	hsa-miR-8053	PAR-CLIP	26701625
MIRT499391	hsa-miR-8053	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	27292025
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	27292025
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	27292025
MIRT499386	hsa-miR-342-5p	PAR-CLIP	27292025
MIRT499424	hsa-miR-383-5p	PAR-CLIP	27292025
MIRT499384	hsa-miR-4651	PAR-CLIP	27292025
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	27292025
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	27292025
MIRT499425	hsa-miR-504-5p	PAR-CLIP	27292025
MIRT499379	hsa-miR-542-3p	PAR-CLIP	27292025
MIRT499427	hsa-miR-5683	PAR-CLIP	27292025
MIRT499421	hsa-miR-575	PAR-CLIP	27292025
MIRT499383	hsa-miR-608	PAR-CLIP	27292025
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	27292025
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	27292025
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	27292025
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	27292025
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	27292025
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	27292025
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	27292025
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	27292025
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	27292025
MIRT499391	hsa-miR-8053	PAR-CLIP	27292025
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	27418678
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	27418678
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	27418678
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	27418678
MIRT499386	hsa-miR-342-5p	HITS-CLIP	27418678
MIRT499424	hsa-miR-383-5p	HITS-CLIP	27418678
MIRT499384	hsa-miR-4651	HITS-CLIP	27418678
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	27418678
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	27418678
MIRT499425	hsa-miR-504-5p	HITS-CLIP	27418678
MIRT499379	hsa-miR-542-3p	HITS-CLIP	27418678
MIRT499427	hsa-miR-5683	HITS-CLIP	27418678
MIRT499421	hsa-miR-575	HITS-CLIP	27418678
MIRT499383	hsa-miR-608	HITS-CLIP	27418678
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	27418678
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	27418678
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	27418678
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	27418678
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	27418678
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	27418678
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	27418678
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	27418678
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	27418678
MIRT499391	hsa-miR-8053	HITS-CLIP	27418678
MIRT654989	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT654988	hsa-miR-4703-3p	HITS-CLIP	23824327
MIRT654987	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT654986	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT654985	hsa-miR-4420	HITS-CLIP	23824327
MIRT654984	hsa-miR-4452	HITS-CLIP	23824327
MIRT654983	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT654981	hsa-miR-3674	HITS-CLIP	23824327
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	20371350
MIRT499427	hsa-miR-5683	PAR-CLIP	20371350
MIRT499425	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT499424	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT499421	hsa-miR-575	PAR-CLIP	20371350
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	20371350
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	20371350
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	20371350
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	20371350
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	20371350
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	20371350
MIRT499391	hsa-miR-8053	PAR-CLIP	20371350
MIRT499386	hsa-miR-342-5p	PAR-CLIP	20371350
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	20371350
MIRT499384	hsa-miR-4651	PAR-CLIP	20371350
MIRT499383	hsa-miR-608	PAR-CLIP	20371350
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	20371350
MIRT499379	hsa-miR-542-3p	PAR-CLIP	20371350
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	20371350
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	20371350
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	20371350
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	20371350
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	22012620
MIRT499427	hsa-miR-5683	PAR-CLIP	22012620
MIRT499425	hsa-miR-504-5p	PAR-CLIP	22012620
MIRT499424	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	22012620
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	22012620
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	22012620
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	22012620
MIRT499391	hsa-miR-8053	PAR-CLIP	22012620
MIRT499386	hsa-miR-342-5p	PAR-CLIP	22012620
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	22012620
MIRT499384	hsa-miR-4651	PAR-CLIP	22012620
MIRT499383	hsa-miR-608	PAR-CLIP	22012620
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	22012620
MIRT499379	hsa-miR-542-3p	PAR-CLIP	22012620
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	22012620
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	22012620
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	22012620
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	22012620
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	23446348
MIRT499427	hsa-miR-5683	PAR-CLIP	23446348
MIRT499425	hsa-miR-504-5p	PAR-CLIP	23446348
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	23446348
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	23446348
MIRT499391	hsa-miR-8053	PAR-CLIP	23446348
MIRT499386	hsa-miR-342-5p	PAR-CLIP	23446348
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	23446348
MIRT499384	hsa-miR-4651	PAR-CLIP	23446348
MIRT499383	hsa-miR-608	PAR-CLIP	23446348
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	23446348
MIRT499379	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	23446348
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	23446348
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	23446348
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	23446348
MIRT499426	hsa-miR-4802-3p	PAR-CLIP	23446348
MIRT499420	hsa-miR-4476	PAR-CLIP	23446348
MIRT499419	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT499417	hsa-miR-4717-3p	PAR-CLIP	23446348
MIRT499413	hsa-miR-6746-5p	PAR-CLIP	23446348
MIRT499412	hsa-miR-3179	PAR-CLIP	23446348
MIRT499411	hsa-miR-3126-5p	PAR-CLIP	23446348
MIRT499410	hsa-miR-6875-5p	PAR-CLIP	23446348
MIRT499409	hsa-let-7a-5p	PAR-CLIP	23446348
MIRT499408	hsa-let-7b-5p	PAR-CLIP	23446348
MIRT499407	hsa-let-7c-5p	PAR-CLIP	23446348
MIRT499406	hsa-let-7d-5p	PAR-CLIP	23446348
MIRT499405	hsa-let-7e-5p	PAR-CLIP	23446348
MIRT499404	hsa-let-7f-5p	PAR-CLIP	23446348
MIRT499403	hsa-let-7g-5p	PAR-CLIP	23446348
MIRT499402	hsa-let-7i-5p	PAR-CLIP	23446348
MIRT499401	hsa-miR-4458	PAR-CLIP	23446348
MIRT499400	hsa-miR-4500	PAR-CLIP	23446348
MIRT499399	hsa-miR-98-5p	PAR-CLIP	23446348
MIRT499398	hsa-miR-202-3p	PAR-CLIP	23446348
MIRT499397	hsa-miR-5589-3p	PAR-CLIP	23446348
MIRT499395	hsa-miR-3202	PAR-CLIP	23446348
MIRT499394	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT499393	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT499390	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT499389	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT499388	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT499387	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT499381	hsa-miR-4710	PAR-CLIP	23446348
MIRT499380	hsa-miR-8065	PAR-CLIP	23446348
MIRT499378	hsa-miR-1294	PAR-CLIP	23446348
MIRT499376	hsa-miR-425-3p	PAR-CLIP	23446348
MIRT499375	hsa-miR-6771-5p	PAR-CLIP	23446348
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	24398324
MIRT499427	hsa-miR-5683	PAR-CLIP	24398324
MIRT499426	hsa-miR-4802-3p	PAR-CLIP	24398324
MIRT499425	hsa-miR-504-5p	PAR-CLIP	24398324
MIRT499424	hsa-miR-383-5p	PAR-CLIP	24398324
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	24398324
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	24398324
MIRT499421	hsa-miR-575	PAR-CLIP	24398324
MIRT499420	hsa-miR-4476	PAR-CLIP	24398324
MIRT499419	hsa-miR-6876-5p	PAR-CLIP	24398324
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	24398324
MIRT499417	hsa-miR-4717-3p	PAR-CLIP	24398324
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	24398324
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	24398324
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	24398324
MIRT499413	hsa-miR-6746-5p	PAR-CLIP	24398324
MIRT499412	hsa-miR-3179	PAR-CLIP	24398324
MIRT499411	hsa-miR-3126-5p	PAR-CLIP	24398324
MIRT499410	hsa-miR-6875-5p	PAR-CLIP	24398324
MIRT499409	hsa-let-7a-5p	PAR-CLIP	24398324
MIRT499408	hsa-let-7b-5p	PAR-CLIP	24398324
MIRT499407	hsa-let-7c-5p	PAR-CLIP	24398324
MIRT499406	hsa-let-7d-5p	PAR-CLIP	24398324
MIRT499405	hsa-let-7e-5p	PAR-CLIP	24398324
MIRT499404	hsa-let-7f-5p	PAR-CLIP	24398324
MIRT499403	hsa-let-7g-5p	PAR-CLIP	24398324
MIRT499402	hsa-let-7i-5p	PAR-CLIP	24398324
MIRT499401	hsa-miR-4458	PAR-CLIP	24398324
MIRT499400	hsa-miR-4500	PAR-CLIP	24398324
MIRT499399	hsa-miR-98-5p	PAR-CLIP	24398324
MIRT499398	hsa-miR-202-3p	PAR-CLIP	24398324
MIRT499397	hsa-miR-5589-3p	PAR-CLIP	24398324
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	24398324
MIRT499395	hsa-miR-3202	PAR-CLIP	24398324
MIRT499394	hsa-miR-1249-5p	PAR-CLIP	24398324
MIRT499393	hsa-miR-6797-5p	PAR-CLIP	24398324
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	24398324
MIRT499391	hsa-miR-8053	PAR-CLIP	24398324
MIRT499390	hsa-miR-149-3p	PAR-CLIP	24398324
MIRT499389	hsa-miR-4728-5p	PAR-CLIP	24398324
MIRT499388	hsa-miR-6785-5p	PAR-CLIP	24398324
MIRT499387	hsa-miR-6883-5p	PAR-CLIP	24398324
MIRT499386	hsa-miR-342-5p	PAR-CLIP	24398324
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	24398324
MIRT499384	hsa-miR-4651	PAR-CLIP	24398324
MIRT499383	hsa-miR-608	PAR-CLIP	24398324
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	24398324
MIRT499381	hsa-miR-4710	PAR-CLIP	24398324
MIRT499380	hsa-miR-8065	PAR-CLIP	24398324
MIRT499379	hsa-miR-542-3p	PAR-CLIP	24398324
MIRT499378	hsa-miR-1294	PAR-CLIP	24398324
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	24398324
MIRT499376	hsa-miR-425-3p	PAR-CLIP	24398324
MIRT499375	hsa-miR-6771-5p	PAR-CLIP	24398324
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	24398324
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	24398324
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	24398324
MIRT2297703	hsa-miR-4643	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0002092	Process	Positive regulation of receptor internalization	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002316	Process	Follicular B cell differentiation	IEA
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IDA	11606584, 12181444
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	TAS
GO:0004629	Function	Phospholipase C activity	TAS
GO:0005515	Function	Protein binding	IPI	15644415, 16273093, 17474147, 24642916, 24658140, 24728074, 25241761, 25814554, 31980649
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	11606584
GO:0005886	Component	Plasma membrane	TAS
GO:0006661	Process	Phosphatidylinositol biosynthetic process	IDA	11606584, 12181444
GO:0009395	Process	Phospholipid catabolic process	IEA
GO:0010634	Process	Positive regulation of epithelial cell migration	IBA	21873635
GO:0016055	Process	Wnt signaling pathway	TAS	18784435
GO:0019722	Process	Calcium-mediated signaling	NAS	11043765
GO:0030168	Process	Platelet activation	TAS
GO:0030183	Process	B cell differentiation	ISS
GO:0032237	Process	Activation of store-operated calcium channel activity	IEA
GO:0032481	Process	Positive regulation of type I interferon production	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032959	Process	Inositol trisphosphate biosynthetic process	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0043069	Process	Negative regulation of programmed cell death	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0050852	Process	T cell receptor signaling pathway	ISS
GO:0050853	Process	B cell receptor signaling pathway	ISS
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IDA	11606584
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0140031	Function	Phosphorylation-dependent protein binding	IEA

MIM	HGNC	e!Ensembl
600220	9066	ENSG00000197943

Protein

UniProt ID

P16885

Protein name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)

Protein function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:

PDB

2K2J , 2W2W , 2W2X , 8JQG , 8JQH , 8JQI , 8T7C

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00388	PI-PLC-X	314 → 457	Phosphatidylinositol-specific phospholipase C, X domain	Family
PF00017	SH2	532 → 617	SH2 domain	Domain
PF00017	SH2	646 → 720	SH2 domain	Domain
PF00018	SH3_1	775 → 821	SH3 domain	Domain
PF00387	PI-PLC-Y	930 → 1042	Phosphatidylinositol-specific phospholipase C, Y domain	Family
PF00168	C2	1061 → 1168	C2 domain	Domain

Sequence

MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN
SKFYS

Sequence length

1265

Interactions

View interactions

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