PLCE1 (phospholipase C epsilon 1)

Gene

• Entrez ID: 51196
• Gene name: Phospholipase C epsilon 1
• Gene symbol: PLCE1
• Synonyms: NPHS3, PLCE, PPLC
• Chromosome: 10
• Chromosome location: 10q23.33
• Summary: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate va

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121912601	C>T	Pathogenic	Stop gained, coding sequence variant
rs121912602	C>G,T	Pathogenic	Stop gained, missense variant, coding sequence variant
rs121912604	C>T	Pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs121912605	C>T	Pathogenic	Missense variant, coding sequence variant
rs267606954	C>T	Pathogenic	Coding sequence variant, genic upstream transcript variant, stop gained
rs267606955	C>A,G,T	Pathogenic	Coding sequence variant, stop gained, synonymous variant, missense variant
rs752029771	G>T	Likely-pathogenic	Coding sequence variant, missense variant
rs762245091	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs775052849	C>A,T	Pathogenic	Coding sequence variant, synonymous variant, stop gained, genic downstream transcript variant
rs876657369	G>-	Pathogenic	Coding sequence variant, frameshift variant, genic upstream transcript variant
rs876657370	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs895782232	C>T	Pathogenic	Coding sequence variant, stop gained
rs1589413498	G>A	Pathogenic	Coding sequence variant, stop gained
rs1589433172	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1589509476	T>G	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017291	hsa-miR-335-5p	Microarray	18185580
MIRT024850	hsa-miR-215-5p	Microarray	19074876
MIRT026288	hsa-miR-192-5p	Microarray	19074876
MIRT713660	hsa-miR-5000-5p	HITS-CLIP	19536157
MIRT713659	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713658	hsa-miR-4277	HITS-CLIP	19536157
MIRT713657	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT713656	hsa-miR-4493	HITS-CLIP	19536157
MIRT713655	hsa-miR-6126	HITS-CLIP	19536157
MIRT713654	hsa-miR-3611	HITS-CLIP	19536157
MIRT713660	hsa-miR-5000-5p	HITS-CLIP	19536157
MIRT713659	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713658	hsa-miR-4277	HITS-CLIP	19536157
MIRT713657	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT713656	hsa-miR-4493	HITS-CLIP	19536157
MIRT713655	hsa-miR-6126	HITS-CLIP	19536157
MIRT713654	hsa-miR-3611	HITS-CLIP	19536157
MIRT607402	hsa-miR-8485	HITS-CLIP	23313552
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23313552
MIRT607399	hsa-miR-4269	HITS-CLIP	23313552
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23313552
MIRT607402	hsa-miR-8485	HITS-CLIP	23313552
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23313552
MIRT607399	hsa-miR-4269	HITS-CLIP	23313552
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23313552
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT674694	hsa-miR-490-3p	HITS-CLIP	23824327
MIRT674693	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT674692	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT674691	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT674690	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT674689	hsa-miR-940	HITS-CLIP	23824327
MIRT674688	hsa-miR-3929	HITS-CLIP	23824327
MIRT674687	hsa-miR-4419b	HITS-CLIP	23824327
MIRT674686	hsa-miR-4478	HITS-CLIP	23824327
MIRT674685	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT674684	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT674683	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT674682	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT674681	hsa-miR-1827	HITS-CLIP	23824327
MIRT674680	hsa-miR-6134	HITS-CLIP	23824327
MIRT674679	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT674678	hsa-miR-6086	HITS-CLIP	23824327
MIRT674677	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT674676	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT674675	hsa-miR-3689d	HITS-CLIP	23824327
MIRT674674	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT674673	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT674672	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT674671	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT674670	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT674669	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT674668	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT674667	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT674666	hsa-miR-7847-3p	HITS-CLIP	23824327
MIRT674665	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT674664	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT674663	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT674662	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT674661	hsa-miR-3689c	HITS-CLIP	23824327
MIRT674659	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT674660	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT674658	hsa-miR-665	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT645795	hsa-miR-4438	HITS-CLIP	23824327
MIRT645794	hsa-miR-1913	HITS-CLIP	23824327
MIRT645793	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT645792	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT645791	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT645790	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	24906430
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	24906430
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	24906430
MIRT607399	hsa-miR-4269	HITS-CLIP	24906430
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	24906430
MIRT674681	hsa-miR-1827	PAR-CLIP	27292025
MIRT674682	hsa-miR-3192-5p	PAR-CLIP	27292025
MIRT674693	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT674693	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT674685	hsa-miR-3614-5p	PAR-CLIP	27292025
MIRT674685	hsa-miR-3614-5p	PAR-CLIP	27292025
MIRT674675	hsa-miR-3689d	PAR-CLIP	27292025
MIRT674677	hsa-miR-4722-5p	PAR-CLIP	27292025
MIRT674694	hsa-miR-490-3p	PAR-CLIP	27292025
MIRT674694	hsa-miR-490-3p	PAR-CLIP	27292025
MIRT674680	hsa-miR-6134	PAR-CLIP	27292025
MIRT674684	hsa-miR-6500-3p	PAR-CLIP	27292025
MIRT674684	hsa-miR-6500-3p	PAR-CLIP	27292025
MIRT674691	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT674674	hsa-miR-6851-5p	PAR-CLIP	27292025
MIRT674667	hsa-miR-6880-5p	PAR-CLIP	27292025
MIRT674690	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT674666	hsa-miR-7847-3p	PAR-CLIP	27292025
MIRT674692	hsa-miR-7851-3p	PAR-CLIP	27292025
MIRT674692	hsa-miR-7851-3p	PAR-CLIP	27292025
MIRT674689	hsa-miR-940	PAR-CLIP	27292025
MIRT607399	hsa-miR-4269	HITS-CLIP	27418678
MIRT607399	hsa-miR-4269	HITS-CLIP	27418678
MIRT607399	hsa-miR-4269	HITS-CLIP	27418678
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	27418678
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	27418678
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	27418678
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	27418678
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	27418678
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	27418678
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT607402	hsa-miR-8485	HITS-CLIP	27418678
MIRT713660	hsa-miR-5000-5p	HITS-CLIP	19536157
MIRT713659	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713658	hsa-miR-4277	HITS-CLIP	19536157
MIRT713657	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT713656	hsa-miR-4493	HITS-CLIP	19536157
MIRT713655	hsa-miR-6126	HITS-CLIP	19536157
MIRT713654	hsa-miR-3611	HITS-CLIP	19536157
MIRT713660	hsa-miR-5000-5p	HITS-CLIP	19536157
MIRT713659	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT713658	hsa-miR-4277	HITS-CLIP	19536157
MIRT713657	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT713656	hsa-miR-4493	HITS-CLIP	19536157
MIRT713655	hsa-miR-6126	HITS-CLIP	19536157
MIRT713654	hsa-miR-3611	HITS-CLIP	19536157
MIRT607402	hsa-miR-8485	HITS-CLIP	23313552
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23313552
MIRT607399	hsa-miR-4269	HITS-CLIP	23313552
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23313552
MIRT607402	hsa-miR-8485	HITS-CLIP	23313552
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23313552
MIRT607399	hsa-miR-4269	HITS-CLIP	23313552
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23313552
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT674694	hsa-miR-490-3p	HITS-CLIP	23824327
MIRT674693	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT674692	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT674691	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT674690	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT674689	hsa-miR-940	HITS-CLIP	23824327
MIRT674688	hsa-miR-3929	HITS-CLIP	23824327
MIRT674687	hsa-miR-4419b	HITS-CLIP	23824327
MIRT674686	hsa-miR-4478	HITS-CLIP	23824327
MIRT674685	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT674684	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT674683	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT674682	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT674681	hsa-miR-1827	HITS-CLIP	23824327
MIRT674680	hsa-miR-6134	HITS-CLIP	23824327
MIRT674679	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT674678	hsa-miR-6086	HITS-CLIP	23824327
MIRT674677	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT674676	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT674675	hsa-miR-3689d	HITS-CLIP	23824327
MIRT674674	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT674673	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT674672	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT674671	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT674670	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT674669	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT674668	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT674667	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT674666	hsa-miR-7847-3p	HITS-CLIP	23824327
MIRT674665	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT674664	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT674663	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT674662	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT674661	hsa-miR-3689c	HITS-CLIP	23824327
MIRT674659	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT674660	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT674658	hsa-miR-665	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT645795	hsa-miR-4438	HITS-CLIP	23824327
MIRT645794	hsa-miR-1913	HITS-CLIP	23824327
MIRT645793	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT645792	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT645791	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT645790	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT607402	hsa-miR-8485	HITS-CLIP	23824327
MIRT607401	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT614869	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607400	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT607399	hsa-miR-4269	HITS-CLIP	23824327
MIRT607398	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT614868	hsa-miR-4324	HITS-CLIP	23824327
MIRT614867	hsa-miR-544b	HITS-CLIP	23824327
MIRT614866	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT614865	hsa-miR-3975	HITS-CLIP	23824327
MIRT614864	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT614863	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT614862	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT614861	hsa-miR-3188	HITS-CLIP	23824327
MIRT614860	hsa-miR-1200	HITS-CLIP	23824327
MIRT2070562	hsa-miR-135a	CLIP-seq
MIRT2070563	hsa-miR-135b	CLIP-seq
MIRT2070564	hsa-miR-3140-3p	CLIP-seq
MIRT2070565	hsa-miR-4325	CLIP-seq
MIRT2070566	hsa-miR-450b-5p	CLIP-seq
MIRT2070567	hsa-miR-507	CLIP-seq
MIRT2070568	hsa-miR-557	CLIP-seq
MIRT2070569	hsa-miR-604	CLIP-seq
MIRT2070570	hsa-miR-647	CLIP-seq
MIRT2297666	hsa-miR-628-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000187	Process	Activation of MAPK activity	IDA	11022047
GO:0001558	Process	Regulation of cell growth	TAS	11022047
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IBA	21873635
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IDA	11022047, 11022048
GO:0004629	Function	Phospholipase C activity	IDA	11022047
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	11022047
GO:0005515	Function	Protein binding	IPI	11022048, 29058690
GO:0005829	Component	Cytosol	IDA	11022048
GO:0005886	Component	Plasma membrane	IDA	11022048
GO:0005886	Component	Plasma membrane	TAS
GO:0006651	Process	Diacylglycerol biosynthetic process	IMP	29058690
GO:0006651	Process	Diacylglycerol biosynthetic process	TAS	11022047
GO:0006940	Process	Regulation of smooth muscle contraction	TAS	11022047
GO:0007010	Process	Cytoskeleton organization	NAS	11022047
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IMP	29058690
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	NAS	11022048
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	11022047, 11022048
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	TAS	11022047
GO:0007265	Process	Ras protein signal transduction	IDA	11022048
GO:0007507	Process	Heart development	TAS	11022047
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IDA	11022047
GO:0010592	Process	Positive regulation of lamellipodium assembly	IMP	29058690
GO:0016042	Process	Lipid catabolic process	IEA
GO:0019722	Process	Calcium-mediated signaling	NAS	11022048
GO:0019722	Process	Calcium-mediated signaling	TAS	11022047
GO:0019899	Function	Enzyme binding	IPI	11022048
GO:0030027	Component	Lamellipodium	IDA	29058690
GO:0031267	Function	Small GTPase binding	IDA	11022048
GO:0032835	Process	Glomerulus development	IMP	17086182
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0045859	Process	Regulation of protein kinase activity	IDA	11022047
GO:0046578	Process	Regulation of Ras protein signal transduction	IDA	11022047
GO:0046872	Function	Metal ion binding	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0048016	Process	Inositol phosphate-mediated signaling	TAS	11022047

Other IDs

• MIM: 608414
• HGNC: 17175
• e!Ensembl: ENSG00000138193

Protein

• UniProt ID: Q9P212
• Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)
• Protein function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates smal
• PDB: 2BYE, 2BYF, 2C5L
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00617	RasGEF	534 → 762	RasGEF domain	Family
  PF09279	EF-hand_like	1323 → 1381	Phosphoinositide-specific phospholipase C, efhand-like	Domain
  PF00388	PI-PLC-X	1394 → 1541	Phosphatidylinositol-specific phospholipase C, X domain	Family
  PF00387	PI-PLC-Y	1740 → 1844	Phosphatidylinositol-specific phospholipase C, Y domain	Family
  PF00168	C2	1870 → 1971	C2 domain	Domain
  PF00788	RA	2135 → 2238	Ras association (RalGDS/AF-6) domain	Domain

• Sequence:

  MTSEEMTASVLIPVTQRKVVSAQSAADESSEKVSDINISKAHTVRRSGETSHTISQLNKL
  KEEPSGSNLPKILSIAREKIVSDENSNEKCWEKIMPDSAKNLNINCNNILRNHQHGLPQR
  QFYEMYNSVAEEDLCLETGIPSPLERKVFPGIQLELDRPSMGISPLGNQSVIIETGRAHP
  DSRRAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKKNYVAYTCKLMEL
  AKNCDNKNEQLQCDHCDTLNDKYFCFEGSCEKVDMVYSGDSFCRKDFTDSQAAKTFLSHF
  EDFPDNCDDVEEDAFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLTA
  WSYIDQKRNGPLLPCGRVMEPPSTVEIRQDGSQRLSEAQWYPIYNAVRREETENTVGSLL
  HFLTKLPASETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGAR
  SGLLSTFGGSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILM
  EQEQTIYRRVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMR
  FNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMW
  QFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGA
  SGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRS
  LETDEEDSPSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAFD
  HGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTAS
  PASSKAKLGVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQN
  KLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQ
  QWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLG
  ISTTKKKKKILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANP
  PNPLPSRRAHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGM
  KGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTI
  DENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLG
  IFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENF
  ASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDC
  WDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEI
  FKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLA
  SMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYN
  EEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGL
  STLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLN
  PTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPN
  PLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLE
  RDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMW
  NEQFLFHVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISS
  LFINSRRMEENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQ
  LLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPE
  EGYMGRIVLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVST
  AQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQ
  AQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSES
  IQTKEEKPVGGLSSSDTMDYRQ

• Sequence length: 2302