PLCD3 (phospholipase C delta 3)

Gene

• Entrez ID: 113026
• Gene name: Phospholipase C delta 3
• Gene symbol: PLCD3
• Synonyms: PLC-delta-3
• Chromosome: 17
• Chromosome location: 17q21.31
• Summary: This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018736	hsa-miR-335-5p	Microarray	18185580
MIRT044610	hsa-miR-320a	CLASH	23622248
MIRT736806	hsa-miR-1273f	PAR-CLIP	26701625
MIRT736889	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT737602	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT737773	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT738951	hsa-miR-2114-3p	PAR-CLIP	26701625
MIRT739779	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT742029	hsa-miR-3664-3p	PAR-CLIP	26701625
MIRT742281	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT742351	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT742421	hsa-miR-3689c	PAR-CLIP	26701625
MIRT743076	hsa-miR-3929	PAR-CLIP	26701625
MIRT744243	hsa-miR-4419b	PAR-CLIP	26701625
MIRT744365	hsa-miR-4433a-3p	PAR-CLIP	26701625
MIRT744833	hsa-miR-4459	PAR-CLIP	26701625
MIRT745082	hsa-miR-4478	PAR-CLIP	26701625
MIRT747196	hsa-miR-4695-5p	PAR-CLIP	26701625
MIRT747371	hsa-miR-4708-5p	PAR-CLIP	26701625
MIRT747869	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT748629	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT748673	hsa-miR-4770	PAR-CLIP	26701625
MIRT749076	hsa-miR-485-5p	PAR-CLIP	26701625
MIRT749736	hsa-miR-510-5p	PAR-CLIP	26701625
MIRT749758	hsa-miR-512-5p	PAR-CLIP	26701625
MIRT751939	hsa-miR-6088	PAR-CLIP	26701625
MIRT753650	hsa-miR-665	PAR-CLIP	26701625
MIRT755522	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT755596	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT755864	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT756327	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT756536	hsa-miR-6807-5p	PAR-CLIP	26701625
MIRT756913	hsa-miR-6823-3p	PAR-CLIP	26701625
MIRT758030	hsa-miR-6871-5p	PAR-CLIP	26701625
MIRT758449	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT758518	hsa-miR-6884-5p	PAR-CLIP	26701625
MIRT758786	hsa-miR-6894-5p	PAR-CLIP	26701625
MIRT758885	hsa-miR-7106-5p	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IBA	21873635
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016042	Process	Lipid catabolic process	IEA
GO:0032154	Component	Cleavage furrow	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0060716	Process	Labyrinthine layer blood vessel development	IEA

Other IDs

• MIM: 608795
• HGNC: 9061
• e!Ensembl: ENSG00000161714

Protein

• UniProt ID: Q8N3E9
• Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)
• Protein function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14788	EF-hand_10	201 → 250	EF hand	Domain
  PF00388	PI-PLC-X	339 → 483	Phosphatidylinositol-specific phospholipase C, X domain	Family
  PF00387	PI-PLC-Y	528 → 642	Phosphatidylinositol-specific phospholipase C, Y domain	Family
  PF00168	C2	660 → 769	C2 domain	Domain

• Sequence:

  MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDE
  DVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREG
  HQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQR
  ERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEG
  AEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYE
  LNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQ
  IGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFT
  LSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVK
  GKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRL
  RTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQ
  EMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRT
  TLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTL
  QFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATL
  FIQIRIQRS

• Sequence length: 789