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PIM1 (Pim-1 proto-oncogene, serine/threonine kinase)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5292
Gene nameGene Name - the full gene name approved by the HGNC.
Pim-1 proto-oncogene, serine/threonine kinase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PIM1
SynonymsGene synonyms aliases
PIM
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.2
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004322 hsa-miR-1-3p qRT-PCR, Luciferase reporter assay, Western blot 18818206
MIRT000151 hsa-miR-210-3p Luciferase reporter assay 19782034
MIRT004857 hsa-miR-192-5p Luciferase reporter assay, qRT-PCR 19074876
MIRT004322 hsa-miR-1-3p Luciferase reporter assay, Northern blot, Western blot 21051663
MIRT004322 hsa-miR-1-3p Luciferase reporter assay, Northern blot, Western blot 21051663
Transcription factors
Transcription factor Regulation Reference
ABL1 Activation 15145216
ERG Activation 22140532
STAT1 Unknown 10068671
STAT3 Activation 22273698
STAT3 Unknown 10068671
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 1825810, 18056989
GO:0005515 Function Protein binding IPI 16186805, 16266891, 18056989, 25416956
GO:0005524 Function ATP binding IDA 1825810
GO:0005634 Component Nucleus IDA 21474815
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P11309
Protein name Serine/threonine-protein kinase pim-1 (EC 2.7.11.1)
Protein function Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15528381, PubMed:1825810, PubMed:31548394). Exerts its oncogenic activity thr
PDB 1XQZ , 1XR1 , 1XWS , 1YHS , 1YI3 , 1YI4 , 1YWV , 1YXS , 1YXT , 1YXU , 1YXV , 1YXX , 2BIK , 2BIL , 2BZH , 2BZI , 2BZJ , 2BZK , 2C3I , 2J2I , 2O3P , 2O63 , 2O64 , 2O65 , 2OBJ , 2OI4 , 2XIX , 2XIY , 2XIZ , 2XJ0 , 2XJ1 , 2XJ2 , 3A99 , 3BGP , 3BGQ , 3BGZ , 3BWF , 3C4E , 3CXW , 3CY2 , 3CY3 , 3DCV , 3F2A , 3JPV , 3JXW , 3JY0 , 3JYA , 3MA3 , 3QF9 , 3R00 , 3R01
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
38 290
Protein kinase domain
Domain
Sequence
Sequence length 313
Interactions View interactions

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