PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)

Gene

• Entrez ID: 5296
• Gene name: Phosphoinositide-3-kinase regulatory subunit 2
• Gene symbol: PIK3R2
• Synonyms: MPPH, MPPH1, P85B, p85, p85-BETA, p85beta
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subun

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs372272045	G>C,T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs587776934	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs587777624	T>C	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs886041591	A>G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs886041602	A>G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1057519801	A>G	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs1131691683	C>G	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs1212577459	G>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1418268495	C>A,T	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant, stop gained
rs1555815238	A>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1568636630	C>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1568637223	C>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003894	hsa-miR-126-3p	Western blot	18663744
MIRT003894	hsa-miR-126-3p	qRT-PCR	18663744
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay	18663744
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay	18663744
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay	18663744
MIRT003894	hsa-miR-126-3p	Review	20029422
MIRT004644	hsa-miR-126-5p	Review	20029422
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, Western blot	18987025
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, Western blot	21249429
MIRT007136	hsa-miR-30c-5p	qRT-PCR	23418453
MIRT003894	hsa-miR-126-3p	Reporter assay;Western blot	21249429
MIRT021712	hsa-miR-133a-3p	Reporter assay	21249429
MIRT048832	hsa-miR-93-5p	CLASH	23622248
MIRT038442	hsa-miR-296-3p	CLASH	23622248
MIRT003894	hsa-miR-126-3p	qRT-PCR, Western blot	24969300
MIRT731593	hsa-miR-30d-5p	LacZ reporter assay	27165190
MIRT731593	hsa-miR-30d-5p	LacZ reporter assay	27165190
MIRT003894	hsa-miR-126-3p	Immunohistochemistry, In situ hybridization, qRT-PCR, Western blot	26381870
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	27191494
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	27191494
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	27191494
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	27191494
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	27191494
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	27191494
MIRT732302	hsa-miR-552-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26485640
MIRT732302	hsa-miR-552-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26485640
MIRT003894	hsa-miR-126-3p	Immunofluorescence, Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting	33350092
MIRT003894	hsa-miR-126-3p	qRT-PCR	32490599
MIRT004644	hsa-miR-126-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), Immunofluorescence, qRT-PCR	33098220
MIRT003894	hsa-miR-126-3p	qRT-PCR	32425976
MIRT003894	hsa-miR-126-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR, In situ hybridization, Flow cytometry	34107168
MIRT003894	hsa-miR-126-3p	Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR	31502903
MIRT1234639	hsa-miR-1178	CLIP-seq
MIRT1234640	hsa-miR-1197	CLIP-seq
MIRT1234641	hsa-miR-1207-5p	CLIP-seq
MIRT1234642	hsa-miR-1252	CLIP-seq
MIRT1234643	hsa-miR-1258	CLIP-seq
MIRT1234644	hsa-miR-126	CLIP-seq
MIRT1234645	hsa-miR-1275	CLIP-seq
MIRT1234646	hsa-miR-1277	CLIP-seq
MIRT1234647	hsa-miR-1289	CLIP-seq
MIRT1234648	hsa-miR-1321	CLIP-seq
MIRT1234649	hsa-miR-1343	CLIP-seq
MIRT1234650	hsa-miR-15a	CLIP-seq
MIRT1234651	hsa-miR-15b	CLIP-seq
MIRT1234652	hsa-miR-16	CLIP-seq
MIRT1234653	hsa-miR-185	CLIP-seq
MIRT1234654	hsa-miR-195	CLIP-seq
MIRT1234655	hsa-miR-1976	CLIP-seq
MIRT1234656	hsa-miR-2467-3p	CLIP-seq
MIRT1234657	hsa-miR-2682	CLIP-seq
MIRT1234658	hsa-miR-3074-3p	CLIP-seq
MIRT1234659	hsa-miR-30a	CLIP-seq
MIRT1234660	hsa-miR-30b	CLIP-seq
MIRT1234661	hsa-miR-30c	CLIP-seq
MIRT1234662	hsa-miR-30d	CLIP-seq
MIRT1234663	hsa-miR-30e	CLIP-seq
MIRT1234664	hsa-miR-3117-3p	CLIP-seq
MIRT1234665	hsa-miR-3125	CLIP-seq
MIRT1234666	hsa-miR-3140-5p	CLIP-seq
MIRT1234667	hsa-miR-3144-5p	CLIP-seq
MIRT1234668	hsa-miR-3150b-3p	CLIP-seq
MIRT1234669	hsa-miR-3151	CLIP-seq
MIRT1234670	hsa-miR-3154	CLIP-seq
MIRT1234671	hsa-miR-3179	CLIP-seq
MIRT1234672	hsa-miR-3184	CLIP-seq
MIRT1234673	hsa-miR-3187-3p	CLIP-seq
MIRT1234674	hsa-miR-3198	CLIP-seq
MIRT1234675	hsa-miR-335	CLIP-seq
MIRT1234676	hsa-miR-342-5p	CLIP-seq
MIRT1234677	hsa-miR-34a	CLIP-seq
MIRT1234678	hsa-miR-34c-5p	CLIP-seq
MIRT1234679	hsa-miR-3607-3p	CLIP-seq
MIRT1234680	hsa-miR-3616-3p	CLIP-seq
MIRT1234681	hsa-miR-3649	CLIP-seq
MIRT1234682	hsa-miR-365	CLIP-seq
MIRT1234683	hsa-miR-3655	CLIP-seq
MIRT1234684	hsa-miR-3663-5p	CLIP-seq
MIRT1234685	hsa-miR-3665	CLIP-seq
MIRT1234686	hsa-miR-3667-3p	CLIP-seq
MIRT1234687	hsa-miR-3675-5p	CLIP-seq
MIRT1234688	hsa-miR-3677-3p	CLIP-seq
MIRT1234689	hsa-miR-3678-5p	CLIP-seq
MIRT1234690	hsa-miR-3686	CLIP-seq
MIRT1234691	hsa-miR-369-5p	CLIP-seq
MIRT1234692	hsa-miR-3916	CLIP-seq
MIRT1234693	hsa-miR-3917	CLIP-seq
MIRT1234694	hsa-miR-3919	CLIP-seq
MIRT1234695	hsa-miR-3925-5p	CLIP-seq
MIRT1234696	hsa-miR-3926	CLIP-seq
MIRT1234697	hsa-miR-3935	CLIP-seq
MIRT1234698	hsa-miR-3944-5p	CLIP-seq
MIRT1234699	hsa-miR-3960	CLIP-seq
MIRT1234700	hsa-miR-423-5p	CLIP-seq
MIRT1234701	hsa-miR-424	CLIP-seq
MIRT1234702	hsa-miR-4252	CLIP-seq
MIRT1234703	hsa-miR-4257	CLIP-seq
MIRT1234704	hsa-miR-4258	CLIP-seq
MIRT1234705	hsa-miR-4260	CLIP-seq
MIRT1234706	hsa-miR-4266	CLIP-seq
MIRT1234707	hsa-miR-4267	CLIP-seq
MIRT1234708	hsa-miR-4271	CLIP-seq
MIRT1234709	hsa-miR-4294	CLIP-seq
MIRT1234710	hsa-miR-4302	CLIP-seq
MIRT1234711	hsa-miR-4306	CLIP-seq
MIRT1234712	hsa-miR-4307	CLIP-seq
MIRT1234713	hsa-miR-4309	CLIP-seq
MIRT1234714	hsa-miR-4311	CLIP-seq
MIRT1234715	hsa-miR-4419a	CLIP-seq
MIRT1234716	hsa-miR-4428	CLIP-seq
MIRT1234717	hsa-miR-4434	CLIP-seq
MIRT1234718	hsa-miR-4435	CLIP-seq
MIRT1234719	hsa-miR-4436b-3p	CLIP-seq
MIRT1234720	hsa-miR-4443	CLIP-seq
MIRT1234721	hsa-miR-4447	CLIP-seq
MIRT1234722	hsa-miR-4457	CLIP-seq
MIRT1234723	hsa-miR-4472	CLIP-seq
MIRT1234724	hsa-miR-4497	CLIP-seq
MIRT1234725	hsa-miR-449a	CLIP-seq
MIRT1234726	hsa-miR-449b	CLIP-seq
MIRT1234727	hsa-miR-449c	CLIP-seq
MIRT1234728	hsa-miR-4510	CLIP-seq
MIRT1234729	hsa-miR-4514	CLIP-seq
MIRT1234730	hsa-miR-4516	CLIP-seq
MIRT1234731	hsa-miR-4525	CLIP-seq
MIRT1234732	hsa-miR-4527	CLIP-seq
MIRT1234733	hsa-miR-4531	CLIP-seq
MIRT1234734	hsa-miR-4532	CLIP-seq
MIRT1234735	hsa-miR-4533	CLIP-seq
MIRT1234736	hsa-miR-4640-5p	CLIP-seq
MIRT1234737	hsa-miR-4644	CLIP-seq
MIRT1234738	hsa-miR-4646-3p	CLIP-seq
MIRT1234739	hsa-miR-4651	CLIP-seq
MIRT1234740	hsa-miR-4653-3p	CLIP-seq
MIRT1234741	hsa-miR-4664-5p	CLIP-seq
MIRT1234742	hsa-miR-4665-5p	CLIP-seq
MIRT1234743	hsa-miR-4670-3p	CLIP-seq
MIRT1234744	hsa-miR-4683	CLIP-seq
MIRT1234745	hsa-miR-4685-5p	CLIP-seq
MIRT1234746	hsa-miR-4692	CLIP-seq
MIRT1234747	hsa-miR-4695-5p	CLIP-seq
MIRT1234748	hsa-miR-4701-5p	CLIP-seq
MIRT1234749	hsa-miR-4711-5p	CLIP-seq
MIRT1234750	hsa-miR-4723-5p	CLIP-seq
MIRT1234751	hsa-miR-4725-3p	CLIP-seq
MIRT1234752	hsa-miR-4726-5p	CLIP-seq
MIRT1234753	hsa-miR-4728-5p	CLIP-seq
MIRT1234754	hsa-miR-4736	CLIP-seq
MIRT1234755	hsa-miR-4739	CLIP-seq
MIRT1234756	hsa-miR-4746-3p	CLIP-seq
MIRT1234757	hsa-miR-4747-5p	CLIP-seq
MIRT1234758	hsa-miR-4756-5p	CLIP-seq
MIRT1234759	hsa-miR-4763-3p	CLIP-seq
MIRT1234760	hsa-miR-4772-3p	CLIP-seq
MIRT1234761	hsa-miR-4779	CLIP-seq
MIRT1234762	hsa-miR-4784	CLIP-seq
MIRT1234763	hsa-miR-4802-3p	CLIP-seq
MIRT1234764	hsa-miR-486-3p	CLIP-seq
MIRT1234765	hsa-miR-487a	CLIP-seq
MIRT1234766	hsa-miR-491-5p	CLIP-seq
MIRT1234767	hsa-miR-492	CLIP-seq
MIRT1234768	hsa-miR-497	CLIP-seq
MIRT1234769	hsa-miR-513b	CLIP-seq
MIRT1234770	hsa-miR-516b	CLIP-seq
MIRT1234771	hsa-miR-541	CLIP-seq
MIRT1234772	hsa-miR-548aa	CLIP-seq
MIRT1234773	hsa-miR-548s	CLIP-seq
MIRT1234774	hsa-miR-583	CLIP-seq
MIRT1234775	hsa-miR-588	CLIP-seq
MIRT1234776	hsa-miR-589	CLIP-seq
MIRT1234777	hsa-miR-608	CLIP-seq
MIRT1234778	hsa-miR-625	CLIP-seq
MIRT1234779	hsa-miR-654-5p	CLIP-seq
MIRT1234780	hsa-miR-759	CLIP-seq
MIRT1234781	hsa-miR-764	CLIP-seq
MIRT1234782	hsa-miR-767-3p	CLIP-seq
MIRT1234783	hsa-miR-885-3p	CLIP-seq
MIRT1234784	hsa-miR-891b	CLIP-seq
MIRT1234785	hsa-miR-922	CLIP-seq
MIRT1234639	hsa-miR-1178	CLIP-seq
MIRT1234640	hsa-miR-1197	CLIP-seq
MIRT1234641	hsa-miR-1207-5p	CLIP-seq
MIRT2069060	hsa-miR-122	CLIP-seq
MIRT2069061	hsa-miR-1254	CLIP-seq
MIRT1234644	hsa-miR-126	CLIP-seq
MIRT1234646	hsa-miR-1277	CLIP-seq
MIRT1234647	hsa-miR-1289	CLIP-seq
MIRT2069062	hsa-miR-1323	CLIP-seq
MIRT2069063	hsa-miR-135a	CLIP-seq
MIRT2069064	hsa-miR-135b	CLIP-seq
MIRT1234653	hsa-miR-185	CLIP-seq
MIRT2069065	hsa-miR-1908	CLIP-seq
MIRT2069066	hsa-miR-1915	CLIP-seq
MIRT1234656	hsa-miR-2467-3p	CLIP-seq
MIRT1234657	hsa-miR-2682	CLIP-seq
MIRT2069067	hsa-miR-302a	CLIP-seq
MIRT2069068	hsa-miR-302b	CLIP-seq
MIRT2069069	hsa-miR-302c	CLIP-seq
MIRT2069070	hsa-miR-302d	CLIP-seq
MIRT2069071	hsa-miR-302e	CLIP-seq
MIRT1234658	hsa-miR-3074-3p	CLIP-seq
MIRT1234659	hsa-miR-30a	CLIP-seq
MIRT1234660	hsa-miR-30b	CLIP-seq
MIRT1234661	hsa-miR-30c	CLIP-seq
MIRT1234662	hsa-miR-30d	CLIP-seq
MIRT1234663	hsa-miR-30e	CLIP-seq
MIRT2069072	hsa-miR-3116	CLIP-seq
MIRT1234665	hsa-miR-3125	CLIP-seq
MIRT1234667	hsa-miR-3144-5p	CLIP-seq
MIRT2069073	hsa-miR-3148	CLIP-seq
MIRT1234668	hsa-miR-3150b-3p	CLIP-seq
MIRT1234669	hsa-miR-3151	CLIP-seq
MIRT1234670	hsa-miR-3154	CLIP-seq
MIRT2069074	hsa-miR-3176	CLIP-seq
MIRT1234671	hsa-miR-3179	CLIP-seq
MIRT2069075	hsa-miR-3180	CLIP-seq
MIRT2069076	hsa-miR-3180-3p	CLIP-seq
MIRT1234673	hsa-miR-3187-3p	CLIP-seq
MIRT2069077	hsa-miR-3196	CLIP-seq
MIRT1234674	hsa-miR-3198	CLIP-seq
MIRT1234675	hsa-miR-335	CLIP-seq
MIRT1234677	hsa-miR-34a	CLIP-seq
MIRT1234678	hsa-miR-34c-5p	CLIP-seq
MIRT1234679	hsa-miR-3607-3p	CLIP-seq
MIRT1234680	hsa-miR-3616-3p	CLIP-seq
MIRT2069078	hsa-miR-3621	CLIP-seq
MIRT1234681	hsa-miR-3649	CLIP-seq
MIRT1234682	hsa-miR-365	CLIP-seq
MIRT1234683	hsa-miR-3655	CLIP-seq
MIRT1234685	hsa-miR-3665	CLIP-seq
MIRT1234688	hsa-miR-3677-3p	CLIP-seq
MIRT1234689	hsa-miR-3678-5p	CLIP-seq
MIRT1234690	hsa-miR-3686	CLIP-seq
MIRT2069079	hsa-miR-371b-5p	CLIP-seq
MIRT2069080	hsa-miR-372	CLIP-seq
MIRT2069081	hsa-miR-373	CLIP-seq
MIRT2069082	hsa-miR-384	CLIP-seq
MIRT1234692	hsa-miR-3916	CLIP-seq
MIRT2069083	hsa-miR-3922-3p	CLIP-seq
MIRT1234695	hsa-miR-3925-5p	CLIP-seq
MIRT1234696	hsa-miR-3926	CLIP-seq
MIRT1234697	hsa-miR-3935	CLIP-seq
MIRT2069084	hsa-miR-3937	CLIP-seq
MIRT1234698	hsa-miR-3944-5p	CLIP-seq
MIRT1234704	hsa-miR-4258	CLIP-seq
MIRT1234705	hsa-miR-4260	CLIP-seq
MIRT2069085	hsa-miR-4265	CLIP-seq
MIRT1234706	hsa-miR-4266	CLIP-seq
MIRT1234707	hsa-miR-4267	CLIP-seq
MIRT1234708	hsa-miR-4271	CLIP-seq
MIRT2069086	hsa-miR-4281	CLIP-seq
MIRT1234709	hsa-miR-4294	CLIP-seq
MIRT2069087	hsa-miR-4296	CLIP-seq
MIRT1234710	hsa-miR-4302	CLIP-seq
MIRT1234711	hsa-miR-4306	CLIP-seq
MIRT1234712	hsa-miR-4307	CLIP-seq
MIRT1234713	hsa-miR-4309	CLIP-seq
MIRT2069088	hsa-miR-4322	CLIP-seq
MIRT1234718	hsa-miR-4435	CLIP-seq
MIRT1234719	hsa-miR-4436b-3p	CLIP-seq
MIRT2069089	hsa-miR-4438	CLIP-seq
MIRT1234720	hsa-miR-4443	CLIP-seq
MIRT1234721	hsa-miR-4447	CLIP-seq
MIRT1234723	hsa-miR-4472	CLIP-seq
MIRT2069090	hsa-miR-4482	CLIP-seq
MIRT1234725	hsa-miR-449a	CLIP-seq
MIRT1234726	hsa-miR-449b	CLIP-seq
MIRT1234727	hsa-miR-449c	CLIP-seq
MIRT2069091	hsa-miR-4505	CLIP-seq
MIRT2069092	hsa-miR-450b-5p	CLIP-seq
MIRT1234729	hsa-miR-4514	CLIP-seq
MIRT1234737	hsa-miR-4644	CLIP-seq
MIRT1234738	hsa-miR-4646-3p	CLIP-seq
MIRT2069093	hsa-miR-4659a-5p	CLIP-seq
MIRT2069094	hsa-miR-4659b-5p	CLIP-seq
MIRT2069095	hsa-miR-4679	CLIP-seq
MIRT1234745	hsa-miR-4685-5p	CLIP-seq
MIRT2069096	hsa-miR-4690-3p	CLIP-seq
MIRT1234746	hsa-miR-4692	CLIP-seq
MIRT1234747	hsa-miR-4695-5p	CLIP-seq
MIRT1234748	hsa-miR-4701-5p	CLIP-seq
MIRT1234751	hsa-miR-4725-3p	CLIP-seq
MIRT2069097	hsa-miR-4726-3p	CLIP-seq
MIRT2069098	hsa-miR-4731-5p	CLIP-seq
MIRT1234754	hsa-miR-4736	CLIP-seq
MIRT1234756	hsa-miR-4746-3p	CLIP-seq
MIRT2069099	hsa-miR-4755-3p	CLIP-seq
MIRT2069100	hsa-miR-4757-5p	CLIP-seq
MIRT1234759	hsa-miR-4763-3p	CLIP-seq
MIRT2069101	hsa-miR-4776-3p	CLIP-seq
MIRT1234761	hsa-miR-4779	CLIP-seq
MIRT2069102	hsa-miR-4783-3p	CLIP-seq
MIRT1234762	hsa-miR-4784	CLIP-seq
MIRT1234763	hsa-miR-4802-3p	CLIP-seq
MIRT1234764	hsa-miR-486-3p	CLIP-seq
MIRT1234765	hsa-miR-487a	CLIP-seq
MIRT1234766	hsa-miR-491-5p	CLIP-seq
MIRT1234767	hsa-miR-492	CLIP-seq
MIRT2069103	hsa-miR-507	CLIP-seq
MIRT2069104	hsa-miR-5095	CLIP-seq
MIRT2069105	hsa-miR-512-3p	CLIP-seq
MIRT2069106	hsa-miR-520a-3p	CLIP-seq
MIRT2069107	hsa-miR-520b	CLIP-seq
MIRT2069108	hsa-miR-520c-3p	CLIP-seq
MIRT2069109	hsa-miR-520d-3p	CLIP-seq
MIRT2069110	hsa-miR-520e	CLIP-seq
MIRT1234771	hsa-miR-541	CLIP-seq
MIRT1234772	hsa-miR-548aa	CLIP-seq
MIRT2069111	hsa-miR-548c-3p	CLIP-seq
MIRT2069112	hsa-miR-548o	CLIP-seq
MIRT1234773	hsa-miR-548s	CLIP-seq
MIRT2069113	hsa-miR-550a	CLIP-seq
MIRT2069114	hsa-miR-557	CLIP-seq
MIRT1234774	hsa-miR-583	CLIP-seq
MIRT1234775	hsa-miR-588	CLIP-seq
MIRT1234776	hsa-miR-589	CLIP-seq
MIRT1234779	hsa-miR-654-5p	CLIP-seq
MIRT2069115	hsa-miR-661	CLIP-seq
MIRT2069116	hsa-miR-663	CLIP-seq
MIRT1234781	hsa-miR-764	CLIP-seq
MIRT1234782	hsa-miR-767-3p	CLIP-seq
MIRT1234783	hsa-miR-885-3p	CLIP-seq
MIRT2069117	hsa-miR-944	CLIP-seq
MIRT1234639	hsa-miR-1178	CLIP-seq
MIRT1234640	hsa-miR-1197	CLIP-seq
MIRT1234641	hsa-miR-1207-5p	CLIP-seq
MIRT1234645	hsa-miR-1275	CLIP-seq
MIRT1234646	hsa-miR-1277	CLIP-seq
MIRT1234648	hsa-miR-1321	CLIP-seq
MIRT2069063	hsa-miR-135a	CLIP-seq
MIRT2069064	hsa-miR-135b	CLIP-seq
MIRT2296084	hsa-miR-146b-3p	CLIP-seq
MIRT1234650	hsa-miR-15a	CLIP-seq
MIRT1234651	hsa-miR-15b	CLIP-seq
MIRT1234652	hsa-miR-16	CLIP-seq
MIRT1234653	hsa-miR-185	CLIP-seq
MIRT2069066	hsa-miR-1915	CLIP-seq
MIRT1234654	hsa-miR-195	CLIP-seq
MIRT1234656	hsa-miR-2467-3p	CLIP-seq
MIRT1234657	hsa-miR-2682	CLIP-seq
MIRT2296085	hsa-miR-3074-5p	CLIP-seq
MIRT1234659	hsa-miR-30a	CLIP-seq
MIRT1234660	hsa-miR-30b	CLIP-seq
MIRT1234661	hsa-miR-30c	CLIP-seq
MIRT1234662	hsa-miR-30d	CLIP-seq
MIRT1234663	hsa-miR-30e	CLIP-seq
MIRT1234666	hsa-miR-3140-5p	CLIP-seq
MIRT1234667	hsa-miR-3144-5p	CLIP-seq
MIRT1234669	hsa-miR-3151	CLIP-seq
MIRT1234670	hsa-miR-3154	CLIP-seq
MIRT2296086	hsa-miR-3173-5p	CLIP-seq
MIRT1234671	hsa-miR-3179	CLIP-seq
MIRT1234672	hsa-miR-3184	CLIP-seq
MIRT1234673	hsa-miR-3187-3p	CLIP-seq
MIRT1234677	hsa-miR-34a	CLIP-seq
MIRT1234678	hsa-miR-34c-5p	CLIP-seq
MIRT1234679	hsa-miR-3607-3p	CLIP-seq
MIRT1234680	hsa-miR-3616-3p	CLIP-seq
MIRT1234681	hsa-miR-3649	CLIP-seq
MIRT1234682	hsa-miR-365	CLIP-seq
MIRT1234685	hsa-miR-3665	CLIP-seq
MIRT1234686	hsa-miR-3667-3p	CLIP-seq
MIRT1234690	hsa-miR-3686	CLIP-seq
MIRT2069082	hsa-miR-384	CLIP-seq
MIRT1234693	hsa-miR-3917	CLIP-seq
MIRT1234696	hsa-miR-3926	CLIP-seq
MIRT1234697	hsa-miR-3935	CLIP-seq
MIRT1234698	hsa-miR-3944-5p	CLIP-seq
MIRT1234699	hsa-miR-3960	CLIP-seq
MIRT2296087	hsa-miR-411	CLIP-seq
MIRT1234700	hsa-miR-423-5p	CLIP-seq
MIRT1234701	hsa-miR-424	CLIP-seq
MIRT1234702	hsa-miR-4252	CLIP-seq
MIRT1234703	hsa-miR-4257	CLIP-seq
MIRT1234704	hsa-miR-4258	CLIP-seq
MIRT1234705	hsa-miR-4260	CLIP-seq
MIRT1234706	hsa-miR-4266	CLIP-seq
MIRT1234707	hsa-miR-4267	CLIP-seq
MIRT2296088	hsa-miR-4300	CLIP-seq
MIRT1234710	hsa-miR-4302	CLIP-seq
MIRT1234711	hsa-miR-4306	CLIP-seq
MIRT1234715	hsa-miR-4419a	CLIP-seq
MIRT1234718	hsa-miR-4435	CLIP-seq
MIRT1234719	hsa-miR-4436b-3p	CLIP-seq
MIRT1234721	hsa-miR-4447	CLIP-seq
MIRT1234722	hsa-miR-4457	CLIP-seq
MIRT1234723	hsa-miR-4472	CLIP-seq
MIRT1234724	hsa-miR-4497	CLIP-seq
MIRT1234725	hsa-miR-449a	CLIP-seq
MIRT1234726	hsa-miR-449b	CLIP-seq
MIRT1234727	hsa-miR-449c	CLIP-seq
MIRT1234728	hsa-miR-4510	CLIP-seq
MIRT1234729	hsa-miR-4514	CLIP-seq
MIRT1234731	hsa-miR-4525	CLIP-seq
MIRT1234734	hsa-miR-4532	CLIP-seq
MIRT1234736	hsa-miR-4640-5p	CLIP-seq
MIRT1234737	hsa-miR-4644	CLIP-seq
MIRT1234742	hsa-miR-4665-5p	CLIP-seq
MIRT1234743	hsa-miR-4670-3p	CLIP-seq
MIRT2069095	hsa-miR-4679	CLIP-seq
MIRT2069096	hsa-miR-4690-3p	CLIP-seq
MIRT1234746	hsa-miR-4692	CLIP-seq
MIRT1234747	hsa-miR-4695-5p	CLIP-seq
MIRT1234748	hsa-miR-4701-5p	CLIP-seq
MIRT1234749	hsa-miR-4711-5p	CLIP-seq
MIRT2296089	hsa-miR-4712-5p	CLIP-seq
MIRT2296090	hsa-miR-4722-3p	CLIP-seq
MIRT1234750	hsa-miR-4723-5p	CLIP-seq
MIRT2069097	hsa-miR-4726-3p	CLIP-seq
MIRT1234752	hsa-miR-4726-5p	CLIP-seq
MIRT1234753	hsa-miR-4728-5p	CLIP-seq
MIRT2296091	hsa-miR-4732-3p	CLIP-seq
MIRT1234754	hsa-miR-4736	CLIP-seq
MIRT1234755	hsa-miR-4739	CLIP-seq
MIRT1234756	hsa-miR-4746-3p	CLIP-seq
MIRT1234758	hsa-miR-4756-5p	CLIP-seq
MIRT1234759	hsa-miR-4763-3p	CLIP-seq
MIRT1234761	hsa-miR-4779	CLIP-seq
MIRT1234766	hsa-miR-491-5p	CLIP-seq
MIRT1234767	hsa-miR-492	CLIP-seq
MIRT1234768	hsa-miR-497	CLIP-seq
MIRT1234769	hsa-miR-513b	CLIP-seq
MIRT2296092	hsa-miR-539	CLIP-seq
MIRT1234771	hsa-miR-541	CLIP-seq
MIRT1234773	hsa-miR-548s	CLIP-seq
MIRT1234774	hsa-miR-583	CLIP-seq
MIRT1234775	hsa-miR-588	CLIP-seq
MIRT1234778	hsa-miR-625	CLIP-seq
MIRT1234779	hsa-miR-654-5p	CLIP-seq
MIRT1234780	hsa-miR-759	CLIP-seq
MIRT1234781	hsa-miR-764	CLIP-seq
MIRT1234782	hsa-miR-767-3p	CLIP-seq
MIRT2296093	hsa-miR-770-5p	CLIP-seq
MIRT2296094	hsa-miR-874	CLIP-seq
MIRT1234784	hsa-miR-891b	CLIP-seq
MIRT2296095	hsa-miR-920	CLIP-seq
MIRT1234785	hsa-miR-922	CLIP-seq
MIRT2296096	hsa-miR-939	CLIP-seq
MIRT1234639	hsa-miR-1178	CLIP-seq
MIRT1234640	hsa-miR-1197	CLIP-seq
MIRT1234641	hsa-miR-1207-5p	CLIP-seq
MIRT2069060	hsa-miR-122	CLIP-seq
MIRT1234646	hsa-miR-1277	CLIP-seq
MIRT1234653	hsa-miR-185	CLIP-seq
MIRT2069066	hsa-miR-1915	CLIP-seq
MIRT1234659	hsa-miR-30a	CLIP-seq
MIRT1234660	hsa-miR-30b	CLIP-seq
MIRT1234661	hsa-miR-30c	CLIP-seq
MIRT1234662	hsa-miR-30d	CLIP-seq
MIRT1234663	hsa-miR-30e	CLIP-seq
MIRT1234679	hsa-miR-3607-3p	CLIP-seq
MIRT1234680	hsa-miR-3616-3p	CLIP-seq
MIRT1234682	hsa-miR-365	CLIP-seq
MIRT1234685	hsa-miR-3665	CLIP-seq
MIRT1234690	hsa-miR-3686	CLIP-seq
MIRT1234697	hsa-miR-3935	CLIP-seq
MIRT1234698	hsa-miR-3944-5p	CLIP-seq
MIRT1234711	hsa-miR-4306	CLIP-seq
MIRT2069090	hsa-miR-4482	CLIP-seq
MIRT1234737	hsa-miR-4644	CLIP-seq
MIRT2069096	hsa-miR-4690-3p	CLIP-seq
MIRT1234754	hsa-miR-4736	CLIP-seq
MIRT1234759	hsa-miR-4763-3p	CLIP-seq
MIRT1234760	hsa-miR-4772-3p	CLIP-seq
MIRT1234780	hsa-miR-759	CLIP-seq
MIRT1234781	hsa-miR-764	CLIP-seq
MIRT1234782	hsa-miR-767-3p	CLIP-seq
MIRT1234785	hsa-miR-922	CLIP-seq
MIRT1234649	hsa-miR-1343	CLIP-seq
MIRT1234655	hsa-miR-1976	CLIP-seq
MIRT1234675	hsa-miR-335	CLIP-seq
MIRT1234649	hsa-miR-1343	CLIP-seq
MIRT1234655	hsa-miR-1976	CLIP-seq
MIRT1234675	hsa-miR-335	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001678	Process	Cellular glucose homeostasis	ISS
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0005515	Function	Protein binding	IPI	7537096, 16273093, 16963558, 17500595, 19380743, 20936779, 21516116, 21706016, 22402981, 22810585, 23604317, 23853584, 24189400, 24658140, 24728074, 25416956, 25814554, 28169297, 28514442, 29892012, 31515488, 31980649, 32814053
GO:0005634	Component	Nucleus	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0008286	Process	Insulin receptor signaling pathway	IBA	21873635
GO:0010506	Process	Regulation of autophagy	IMP	23604317
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IDA	23604317
GO:0015031	Process	Protein transport	IEA
GO:0019903	Function	Protein phosphatase binding	IPI	23604317
GO:0030971	Function	Receptor tyrosine kinase binding	IPI	10627473
GO:0032869	Process	Cellular response to insulin stimulus	ISS
GO:0034976	Process	Response to endoplasmic reticulum stress	ISS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0042307	Process	Positive regulation of protein import into nucleus	ISS
GO:0043409	Process	Negative regulation of MAPK cascade	IMP	18694566
GO:0043551	Process	Regulation of phosphatidylinositol 3-kinase activity	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046935	Function	1-phosphatidylinositol-3-kinase regulator activity	IBA	21873635
GO:0046982	Function	Protein heterodimerization activity	ISS
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	TAS
GO:0048015	Process	Phosphatidylinositol-mediated signaling	TAS
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0050900	Process	Leukocyte migration	TAS
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051897	Process	Positive regulation of protein kinase B signaling	TAS

Other IDs

• MIM: 603157
• HGNC: 8980
• e!Ensembl: ENSG00000105647

Protein

• UniProt ID: O00459
• Protein name: Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta
• Protein function: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain
• PDB: 2KT1, 2XS6, 3MTT, 3O5Z, 6OX7, 6U28, 7RCH, 7RNU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	125 → 263	RhoGAP domain	Domain
  PF00017	SH2	330 → 405	SH2 domain	Domain
  PF16454	PI3K_P85_iSH2	428 → 596	Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain	Domain
  PF00017	SH2	622 → 696	SH2 domain	Domain

• Sequence:

  MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
  NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
  PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
  LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALG
  PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
  ALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
  IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
  LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
  IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
  KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
  TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
  VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
  PGPPPAAR

• Sequence length: 728