PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)

Gene

• Entrez ID: 5295
• Gene name: Phosphoinositide-3-kinase regulatory subunit 1
• Gene symbol: PIK3R1
• Synonyms: AGM7, GRB1, IMD36, p85, p85-ALPHA
• Chromosome: 5
• Chromosome location: 5q13.1
• Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs149905863	A>C,G	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs397509384	G>A	Pathogenic	Genic upstream transcript variant, coding sequence variant, stop gained
rs397514046	ATT>-	Pathogenic, uncertain-significance	Coding sequence variant, inframe deletion
rs397514047	G>A	Pathogenic	Coding sequence variant, missense variant
rs397515453	C>T	Pathogenic	Coding sequence variant, missense variant
rs398122384	->T	Pathogenic	Frameshift variant, coding sequence variant
rs398122385	->C	Pathogenic	Frameshift variant, coding sequence variant
rs515726149	G>A	Pathogenic	Coding sequence variant, missense variant
rs515726150	AA>-	Pathogenic	Frameshift variant, coding sequence variant
rs515726151	T>G	Pathogenic	Coding sequence variant, stop gained
rs587777709	G>A,C,T	Pathogenic, likely-pathogenic	Splice donor variant
rs587784325	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs773686816	C>A,G,T	Likely-pathogenic	Coding sequence variant, synonymous variant, missense variant
rs780724594	T>C	Likely-pathogenic	Splice donor variant
rs797045063	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1057519757	G>A,C	Likely-pathogenic	Missense variant, coding sequence variant
rs1057519838	C>T	Likely-pathogenic, pathogenic	Stop gained, coding sequence variant
rs1057519839	G>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1057519840	GACAAACGTATGAACAGC>-	Likely-pathogenic	Inframe deletion, coding sequence variant
rs1057519841	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs1057519842	CGA>-	Likely-pathogenic	Inframe deletion, coding sequence variant
rs1057520690	C>T	Pathogenic	5 prime UTR variant, coding sequence variant, stop gained
rs1131692242	AGA>-	Likely-pathogenic	Inframe deletion, coding sequence variant
rs1131692243	GGT>-	Likely-pathogenic	Splice acceptor variant, coding sequence variant
rs1403833564	A>G	Likely-pathogenic	Splice acceptor variant
rs1554051033	G>C	Pathogenic	Splice acceptor variant
rs1554051067	TG>-	Pathogenic	Intron variant, splice donor variant
rs1554051075	T>A,G	Pathogenic	Splice donor variant
rs1554051161	G>T	Likely-pathogenic	Coding sequence variant, stop gained
rs1554051268	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1561299903	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1580260232	T>-	Pathogenic	Frameshift variant, upstream transcript variant, coding sequence variant, genic upstream transcript variant
rs1580262965	CCAGG>-	Pathogenic	Splice donor variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004103	hsa-miR-29a-3p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	20943204
MIRT006724	hsa-miR-376a-3p	Luciferase reporter assay, qRT-PCR, Western blot	22684007
MIRT027237	hsa-miR-29b-3p	Western blot	24147037
MIRT027237	hsa-miR-29b-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot, ChIP-PCR	25356754
MIRT030860	hsa-miR-21-5p	Microarray	18591254
MIRT030860	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	26676464
MIRT052505	hsa-let-7a-5p	CLASH	23622248
MIRT053013	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Western blot	22609116
MIRT054427	hsa-miR-503-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	24550137
MIRT054427	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT054427	hsa-miR-503-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT054427	hsa-miR-503-5p	HITS-CLIP	23824327
MIRT054427	hsa-miR-503-5p	HITS-CLIP	23313552
MIRT314051	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT314051	hsa-miR-15a-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314051	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT314051	hsa-miR-15a-5p	HITS-CLIP	23313552
MIRT314052	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT314052	hsa-miR-16-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314052	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT314052	hsa-miR-16-5p	HITS-CLIP	23313552
MIRT314053	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT314053	hsa-miR-15b-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314053	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT314053	hsa-miR-15b-5p	HITS-CLIP	23313552
MIRT314054	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT314054	hsa-miR-195-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314054	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT314054	hsa-miR-195-5p	HITS-CLIP	23313552
MIRT314055	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT314055	hsa-miR-424-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314055	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT314055	hsa-miR-424-5p	HITS-CLIP	23313552
MIRT314056	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT314056	hsa-miR-497-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314056	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT314056	hsa-miR-497-5p	HITS-CLIP	23313552
MIRT314057	hsa-miR-646	PAR-CLIP	23446348
MIRT314057	hsa-miR-646	PAR-CLIP, HITS-CLIP	21572407
MIRT314057	hsa-miR-646	HITS-CLIP	23824327
MIRT314057	hsa-miR-646	HITS-CLIP	23313552
MIRT314059	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT314059	hsa-miR-6838-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314059	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT314059	hsa-miR-6838-5p	HITS-CLIP	23313552
MIRT314070	hsa-miR-448	PAR-CLIP	23446348
MIRT314070	hsa-miR-448	PAR-CLIP, HITS-CLIP	21572407
MIRT314097	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT314097	hsa-miR-103a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT314097	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT314097	hsa-miR-103a-3p	HITS-CLIP	23313552
MIRT314098	hsa-miR-107	PAR-CLIP	23446348
MIRT314098	hsa-miR-107	PAR-CLIP, HITS-CLIP	21572407
MIRT314098	hsa-miR-107	HITS-CLIP	23824327
MIRT314098	hsa-miR-107	HITS-CLIP	23313552
MIRT314099	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT314099	hsa-miR-190a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT314099	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT314100	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT314100	hsa-miR-4524a-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314100	hsa-miR-4524a-5p	HITS-CLIP	23824327
MIRT314100	hsa-miR-4524a-5p	HITS-CLIP	23313552
MIRT314101	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT314101	hsa-miR-5011-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314101	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT314102	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT314102	hsa-miR-4524b-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT314102	hsa-miR-4524b-5p	HITS-CLIP	23824327
MIRT314102	hsa-miR-4524b-5p	HITS-CLIP	23313552
MIRT438233	hsa-miR-221-3p	Western blot	24147037
MIRT438233	hsa-miR-221-3p	Microarray, Next Generation Sequencing (NGS), qRT-PCR	25236949
MIRT506169	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT506169	hsa-miR-1277-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT506169	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT506170	hsa-miR-6783-3p	PAR-CLIP	23446348
MIRT506170	hsa-miR-6783-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT506171	hsa-miR-1343-3p	PAR-CLIP	23446348
MIRT506171	hsa-miR-1343-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT506172	hsa-miR-6742-3p	PAR-CLIP	23446348
MIRT506172	hsa-miR-6742-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT506173	hsa-miR-6852-5p	PAR-CLIP	23446348
MIRT506173	hsa-miR-6852-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT506174	hsa-miR-939-3p	PAR-CLIP	23446348
MIRT506174	hsa-miR-939-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT506175	hsa-miR-4793-5p	PAR-CLIP	23446348
MIRT506175	hsa-miR-4793-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT510966	hsa-miR-3924	PAR-CLIP	23446348
MIRT510966	hsa-miR-3924	PAR-CLIP, HITS-CLIP	21572407
MIRT510967	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT510967	hsa-miR-4789-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT510967	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT510967	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT510968	hsa-miR-466	PAR-CLIP	23446348
MIRT510968	hsa-miR-466	PAR-CLIP, HITS-CLIP	21572407
MIRT510969	hsa-miR-455-5p	PAR-CLIP	23446348
MIRT510969	hsa-miR-455-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT510970	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT510970	hsa-miR-5580-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT510971	hsa-miR-4643	PAR-CLIP	23446348
MIRT510971	hsa-miR-4643	PAR-CLIP, HITS-CLIP	21572407
MIRT510972	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT510972	hsa-miR-4789-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT510972	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT510972	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT521890	hsa-miR-3941	PAR-CLIP	23446348
MIRT521890	hsa-miR-3941	PAR-CLIP, HITS-CLIP	21572407
MIRT521890	hsa-miR-3941	HITS-CLIP	23824327
MIRT521890	hsa-miR-3941	HITS-CLIP	23313552
MIRT521891	hsa-miR-603	PAR-CLIP	23446348
MIRT521891	hsa-miR-603	PAR-CLIP, HITS-CLIP	21572407
MIRT521891	hsa-miR-603	HITS-CLIP	23824327
MIRT521891	hsa-miR-603	HITS-CLIP	23313552
MIRT521892	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT521892	hsa-miR-362-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT521892	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT521892	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT521893	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT521893	hsa-miR-329-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT521893	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT521893	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT521894	hsa-miR-8485	PAR-CLIP	23446348
MIRT521894	hsa-miR-8485	PAR-CLIP, HITS-CLIP	21572407
MIRT521894	hsa-miR-8485	HITS-CLIP	23824327
MIRT521894	hsa-miR-8485	HITS-CLIP	23313552
MIRT555603	hsa-miR-6721-5p	PAR-CLIP	21572407
MIRT555604	hsa-miR-6860	PAR-CLIP	21572407
MIRT555605	hsa-miR-612	PAR-CLIP	21572407
MIRT555606	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT555607	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT555608	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT732229	hsa-miR-542-3p	Immunohistochemistry, Luciferase reporter assay, Western blot	26286747
MIRT733065	hsa-miR-218-1-3p	qRT-PCR, Western blot, MTT	25760926
MIRT733439	hsa-miR-143-3p	ELISA, Microarray, qRT-PCR	28270439
MIRT733521	hsa-miR-128-3p	Chromatin immunoprecipitation, Immunoblot, Luciferase reporter assay, Microarray, qRT-PCR	27893811
MIRT734707	hsa-miR-487a-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27827315
MIRT735338	hsa-miR-486-5p	Luciferase reporter assay, Next Generation Sequencing (NGS), qRT-PCR, Western blot	25475121
MIRT735959	hsa-miR-1202	PAR-CLIP	26701625
MIRT736682	hsa-miR-126-3p	PAR-CLIP	26701625
MIRT739185	hsa-miR-23a-3p	PAR-CLIP	26701625
MIRT739195	hsa-miR-23b-3p	PAR-CLIP	26701625
MIRT739636	hsa-miR-302a-5p	PAR-CLIP	26701625
MIRT741944	hsa-miR-3658	PAR-CLIP	26701625
MIRT743194	hsa-miR-3972	PAR-CLIP	26701625
MIRT744014	hsa-miR-4317	PAR-CLIP	26701625
MIRT748369	hsa-miR-4755-3p	PAR-CLIP	26701625
MIRT749419	hsa-miR-5006-5p	PAR-CLIP	26701625
MIRT749430	hsa-miR-5007-5p	PAR-CLIP	26701625
MIRT759967	hsa-miR-7856-5p	PAR-CLIP	26701625
MIRT760511	hsa-miR-924	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001678	Process	Cellular glucose homeostasis	ISS
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0001953	Process	Negative regulation of cell-matrix adhesion	IEA
GO:0005068	Function	Transmembrane receptor protein tyrosine kinase adaptor activity	ISS
GO:0005158	Function	Insulin receptor binding	IPI	7537849
GO:0005159	Function	Insulin-like growth factor receptor binding	IPI	7541045
GO:0005168	Function	Neurotrophin TRKA receptor binding	IPI	15488758
GO:0005515	Function	Protein binding	IPI	1314164, 1330535, 1380456, 1382595, 7536927, 7537096, 7568038, 7584133, 7589433, 7642582, 7657594, 7680095, 7680644, 7692233, 7782332, 7797556, 7807015, 8146197, 8183372, 8276809, 8382612, 8564419, 8603569, 8670861, 9153411, 9160881, 9398332, 9417079, 9593725, 9658397, 9813138, 9890970
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IDA	20348923
GO:0005801	Component	Cis-Golgi network	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IEA
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	ISS
GO:0005943	Component	Phosphatidylinositol 3-kinase complex, class IA	ISS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006606	Process	Protein import into nucleus	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007411	Process	Axon guidance	TAS
GO:0008134	Function	Transcription factor binding	IPI	20348923
GO:0008286	Process	Insulin receptor signaling pathway	IBA	21873635
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IEA
GO:0008630	Process	Intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:0010592	Process	Positive regulation of lamellipodium assembly	ISS
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IDA	7782332
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IMP	21321938
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019903	Function	Protein phosphatase binding	IPI	14699157
GO:0030168	Process	Platelet activation	TAS
GO:0030183	Process	B cell differentiation	IEA
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0031295	Process	T cell costimulation	TAS
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032869	Process	Cellular response to insulin stimulus	ISS
GO:0033120	Process	Positive regulation of RNA splicing	IMP	20348923
GO:0034446	Process	Substrate adhesion-dependent cell spreading	ISS
GO:0034644	Process	Cellular response to UV	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IDA	20348923
GO:0034976	Process	Response to endoplasmic reticulum stress	ISS
GO:0035014	Function	Phosphatidylinositol 3-kinase regulator activity	ISS
GO:0036312	Function	Phosphatidylinositol 3-kinase regulatory subunit binding	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0038128	Process	ERBB2 signaling pathway	TAS
GO:0042307	Process	Positive regulation of protein import into nucleus	IDA	20348923
GO:0043066	Process	Negative regulation of apoptotic process	IMP	20348923
GO:0043125	Function	ErbB-3 class receptor binding	IDA	10572067
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	ISS
GO:0043551	Process	Regulation of phosphatidylinositol 3-kinase activity	IBA	21873635
GO:0043551	Process	Regulation of phosphatidylinositol 3-kinase activity	ISS
GO:0043559	Function	Insulin binding	IDA	8440175
GO:0043560	Function	Insulin receptor substrate binding	IEA
GO:0045671	Process	Negative regulation of osteoclast differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	20348923
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046326	Process	Positive regulation of glucose import	ISS	8052599
GO:0046626	Process	Regulation of insulin receptor signaling pathway	IEA
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046854	Process	Phosphatidylinositol phosphorylation	ISS
GO:0046935	Function	1-phosphatidylinositol-3-kinase regulator activity	IBA	21873635
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0048009	Process	Insulin-like growth factor receptor signaling pathway	IDA	7782332
GO:0048009	Process	Insulin-like growth factor receptor signaling pathway	IPI	7541045
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	TAS
GO:0048015	Process	Phosphatidylinositol-mediated signaling	TAS
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0050821	Process	Protein stabilization	IDA	20348923
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0050900	Process	Leukocyte migration	TAS
GO:0051491	Process	Positive regulation of filopodium assembly	ISS
GO:0051497	Process	Negative regulation of stress fiber assembly	ISS
GO:0051897	Process	Positive regulation of protein kinase B signaling	TAS
GO:0060396	Process	Growth hormone receptor signaling pathway	IDA	7782332
GO:0120183	Process	Positive regulation of focal adhesion disassembly	ISS
GO:1900103	Process	Positive regulation of endoplasmic reticulum unfolded protein response	IMP	20348923
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	ISS	8052599
GO:1990578	Component	Perinuclear endoplasmic reticulum membrane	IEA

Other IDs

• MIM: 171833
• HGNC: 8979
• e!Ensembl: ENSG00000145675

Protein

• UniProt ID: P27986
• Protein name: Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
• Protein function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
• PDB: 1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4WAF, 4YKN, 4ZOP, 5AUL, 5FI4, 5GJI, 5ITD, 5M6U, 5SW8, 5SWG, 5SWO, 5SWP, 5SWR, 5SWT, 5SX8, 5SX9, 5SXA, 5SXB, 5SXC, 5SXD, 5SXE, 5SXF, 5SXI, 5SXJ, 5SXK, 5UBT, 5UK8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	129 → 282	RhoGAP domain	Domain
  PF00017	SH2	333 → 408	SH2 domain	Domain
  PF16454	PI3K_P85_iSH2	431 → 599	Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain	Domain
  PF00017	SH2	624 → 698	SH2 domain	Domain

• Sequence:

  MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
  ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
  QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
  VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
  QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
  RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
  STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
  DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
  RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
  SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
  ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
  VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
  QQRR

• Sequence length: 724