PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

Gene

• Entrez ID: 5294
• Gene name: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
• Gene symbol: PIK3CG
• Synonyms: IMD97, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K
• Chromosome: 7
• Chromosome location: 7q22.3
• Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta)

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006815	hsa-miR-29b-3p	Microarray, qRT-PCR, Western blot	22297492
MIRT006831	hsa-miR-126-3p	Immunocytochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22900072
MIRT019349	hsa-miR-148b-3p	Microarray	17612493
MIRT029342	hsa-miR-26b-5p	Microarray	19088304
MIRT006831	hsa-miR-126-3p	Microarray, qRT-PCR, Western blot, SILAC (Stable Isotope Labeling of Amino acids in Culture)	23142521
MIRT437359	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR	24086481
MIRT437359	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR	24086481
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24522205
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24522205
MIRT438277	hsa-miR-7-5p	Luciferase reporter assay, Western blot	24603851
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24522205
MIRT438408	hsa-miR-10a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24522205
MIRT438277	hsa-miR-7-5p	Luciferase reporter assay, Western blot	24603851
MIRT516718	hsa-miR-8485	HITS-CLIP	21572407
MIRT516717	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT516716	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT516715	hsa-miR-603	HITS-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT516707	hsa-miR-3941	HITS-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT693454	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT693453	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT693452	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT693451	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT693450	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT693449	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT693448	hsa-miR-548g-3p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	HITS-CLIP	23313552
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT693447	hsa-miR-3163	HITS-CLIP	23313552
MIRT542012	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT693446	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT516712	hsa-miR-4679	HITS-CLIP	23313552
MIRT516711	hsa-miR-3689a-5p	HITS-CLIP	23313552
MIRT516710	hsa-miR-3689b-5p	HITS-CLIP	23313552
MIRT516709	hsa-miR-3689e	HITS-CLIP	23313552
MIRT516708	hsa-miR-3689f	HITS-CLIP	23313552
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	PAR-CLIP	21572407
MIRT516717	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT516716	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT516715	hsa-miR-603	PAR-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT542012	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516707	hsa-miR-3941	PAR-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516718	hsa-miR-8485	PAR-CLIP	23446348
MIRT516717	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT516716	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT516715	hsa-miR-603	PAR-CLIP	23446348
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516712	hsa-miR-4679	PAR-CLIP	23446348
MIRT516711	hsa-miR-3689a-5p	PAR-CLIP	23446348
MIRT516710	hsa-miR-3689b-5p	PAR-CLIP	23446348
MIRT516709	hsa-miR-3689e	PAR-CLIP	23446348
MIRT516708	hsa-miR-3689f	PAR-CLIP	23446348
MIRT516707	hsa-miR-3941	PAR-CLIP	23446348
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT439973	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT439973	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT006831	hsa-miR-126-3p	Luciferase reporter assay	27729613
MIRT006831	hsa-miR-126-3p	qRT-PCR, Western blot	26659078
MIRT516718	hsa-miR-8485	HITS-CLIP	21572407
MIRT516717	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT516716	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT516715	hsa-miR-603	HITS-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT516707	hsa-miR-3941	HITS-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT693454	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT693453	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT693452	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT693451	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT693450	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT693449	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT693448	hsa-miR-548g-3p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	HITS-CLIP	23313552
MIRT516714	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT542013	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT693447	hsa-miR-3163	HITS-CLIP	23313552
MIRT542012	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT516713	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT693446	hsa-miR-511-3p	HITS-CLIP	23313552
MIRT516712	hsa-miR-4679	HITS-CLIP	23313552
MIRT516711	hsa-miR-3689a-5p	HITS-CLIP	23313552
MIRT516710	hsa-miR-3689b-5p	HITS-CLIP	23313552
MIRT516709	hsa-miR-3689e	HITS-CLIP	23313552
MIRT516708	hsa-miR-3689f	HITS-CLIP	23313552
MIRT516705	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT516704	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT516718	hsa-miR-8485	PAR-CLIP	21572407
MIRT516717	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT516716	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT516715	hsa-miR-603	PAR-CLIP	21572407
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT542013	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT542012	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT516707	hsa-miR-3941	PAR-CLIP	21572407
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT516718	hsa-miR-8485	PAR-CLIP	23446348
MIRT516717	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT516716	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT516715	hsa-miR-603	PAR-CLIP	23446348
MIRT516714	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT516713	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516712	hsa-miR-4679	PAR-CLIP	23446348
MIRT516711	hsa-miR-3689a-5p	PAR-CLIP	23446348
MIRT516710	hsa-miR-3689b-5p	PAR-CLIP	23446348
MIRT516709	hsa-miR-3689e	PAR-CLIP	23446348
MIRT516708	hsa-miR-3689f	PAR-CLIP	23446348
MIRT516707	hsa-miR-3941	PAR-CLIP	23446348
MIRT516706	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516705	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516704	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1234187	hsa-miR-1276	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT1234190	hsa-miR-3199	CLIP-seq
MIRT1234191	hsa-miR-3653	CLIP-seq
MIRT1234192	hsa-miR-3658	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234197	hsa-miR-4496	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234203	hsa-miR-4778-3p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT1234205	hsa-miR-619	CLIP-seq
MIRT1234206	hsa-miR-885-5p	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068990	hsa-miR-1289	CLIP-seq
MIRT2068991	hsa-miR-1343	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT2068993	hsa-miR-3198	CLIP-seq
MIRT1234190	hsa-miR-3199	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2068994	hsa-miR-4294	CLIP-seq
MIRT2068995	hsa-miR-4309	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT2068997	hsa-miR-4534	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234189	hsa-miR-24	CLIP-seq
MIRT2296006	hsa-miR-2467-3p	CLIP-seq
MIRT2296007	hsa-miR-3125	CLIP-seq
MIRT2296008	hsa-miR-3692	CLIP-seq
MIRT1234193	hsa-miR-378g	CLIP-seq
MIRT2296009	hsa-miR-3916	CLIP-seq
MIRT2296010	hsa-miR-3925-3p	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2296011	hsa-miR-4308	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234195	hsa-miR-4437	CLIP-seq
MIRT1234196	hsa-miR-4438	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT2296012	hsa-miR-4530	CLIP-seq
MIRT1234199	hsa-miR-4674	CLIP-seq
MIRT2296013	hsa-miR-4685-5p	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT1234203	hsa-miR-4778-3p	CLIP-seq
MIRT1234204	hsa-miR-5095	CLIP-seq
MIRT2296014	hsa-miR-515-5p	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT1234205	hsa-miR-619	CLIP-seq
MIRT2296015	hsa-miR-766	CLIP-seq
MIRT2296016	hsa-miR-922	CLIP-seq
MIRT2068989	hsa-miR-1200	CLIP-seq
MIRT2068992	hsa-miR-1911	CLIP-seq
MIRT1234188	hsa-miR-1976	CLIP-seq
MIRT1234194	hsa-miR-4269	CLIP-seq
MIRT2068996	hsa-miR-4324	CLIP-seq
MIRT1234198	hsa-miR-4514	CLIP-seq
MIRT1234200	hsa-miR-4692	CLIP-seq
MIRT1234201	hsa-miR-4722-3p	CLIP-seq
MIRT1234202	hsa-miR-4742-5p	CLIP-seq
MIRT2068998	hsa-miR-544b	CLIP-seq
MIRT2593958	hsa-miR-500a	CLIP-seq
MIRT2593959	hsa-miR-539	CLIP-seq
MIRT2593960	hsa-miR-548aa	CLIP-seq
MIRT2593961	hsa-miR-548ac	CLIP-seq
MIRT2593962	hsa-miR-548d-3p	CLIP-seq
MIRT2593963	hsa-miR-548z	CLIP-seq
MIRT2593959	hsa-miR-539	CLIP-seq
MIRT2593960	hsa-miR-548aa	CLIP-seq
MIRT2593961	hsa-miR-548ac	CLIP-seq
MIRT2593962	hsa-miR-548d-3p	CLIP-seq
MIRT2593963	hsa-miR-548z	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001816	Process	Cytokine production	TAS	19075988
GO:0002250	Process	Adaptive immune response	TAS	17290298
GO:0002407	Process	Dendritic cell chemotaxis	TAS	18278175
GO:0002675	Process	Positive regulation of acute inflammatory response	IEA
GO:0002679	Process	Respiratory burst involved in defense response	TAS	19075988
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IMP	18558630
GO:0004672	Function	Protein kinase activity	TAS	19376709
GO:0005515	Function	Protein binding	IPI	12507995, 21393242, 23824069, 25556234, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	12507995
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0005943	Component	Phosphatidylinositol 3-kinase complex, class IA	IBA	21873635
GO:0005944	Component	Phosphatidylinositol 3-kinase complex, class IB	IBA	21873635
GO:0005944	Component	Phosphatidylinositol 3-kinase complex, class IB	IDA	12507995
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0006897	Process	Endocytosis	IEA
GO:0006954	Process	Inflammatory response	TAS	17290298
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	12507995
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IMP	18558630
GO:0010818	Process	T cell chemotaxis	TAS	18278175
GO:0010897	Process	Negative regulation of triglyceride catabolic process	IEA
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IBA	21873635
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IDA	12507995
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IMP	18558630
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	TAS	17290298
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	12507995
GO:0016301	Function	Kinase activity	IDA	25327288
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	IBA	21873635
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	IDA	11277933, 16123124
GO:0016310	Process	Phosphorylation	IDA	25327288
GO:0016477	Process	Cell migration	IBA	21873635
GO:0030168	Process	Platelet activation	TAS
GO:0030593	Process	Neutrophil chemotaxis	TAS	17290298
GO:0032252	Process	Secretory granule localization	IEA
GO:0033628	Process	Regulation of cell adhesion mediated by integrin	TAS	18278175
GO:0035004	Function	Phosphatidylinositol 3-kinase activity	TAS	17290298
GO:0035005	Function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA	21873635
GO:0035005	Function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA	16123124
GO:0035022	Process	Positive regulation of Rac protein signal transduction	IMP	18558630
GO:0035747	Process	Natural killer cell chemotaxis	TAS	18278175
GO:0036092	Process	Phosphatidylinositol-3-phosphate biosynthetic process	IBA	21873635
GO:0042098	Process	T cell proliferation	TAS	19075988
GO:0042110	Process	T cell activation	TAS	17290298
GO:0042802	Function	Identical protein binding	IPI	20562859, 23824069
GO:0043303	Process	Mast cell degranulation	TAS	17290298
GO:0043406	Process	Positive regulation of MAP kinase activity	IDA	12507995
GO:0045087	Process	Innate immune response	TAS	17290298
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046875	Function	Ephrin receptor binding	IPI	11416136
GO:0046934	Function	Phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA	15135396, 16123124
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0051897	Process	Positive regulation of protein kinase B signaling	IDA	12507995
GO:0052742	Function	Phosphatidylinositol kinase activity	IBA	21873635
GO:0052812	Function	Phosphatidylinositol-3,4-bisphosphate 5-kinase activity	IEA
GO:0055118	Process	Negative regulation of cardiac muscle contraction	TAS	19147653
GO:0070527	Process	Platelet aggregation	TAS	21035500
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0072672	Process	Neutrophil extravasation	TAS	18278175
GO:0097284	Process	Hepatocyte apoptotic process	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1903169	Process	Regulation of calcium ion transmembrane transport	IEA
GO:2000270	Process	Negative regulation of fibroblast apoptotic process	IEA

Other IDs

• MIM: 601232
• HGNC: 8978
• e!Ensembl: ENSG00000105851

Protein

• UniProt ID: P48736
• Protein name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase
• Protein function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the memb
• PDB: 1E8Y, 1E8Z, 1HE8, 2A4Z, 2A5U, 2CHW, 2CHX, 2CHZ, 2V4L, 3APC, 3APD, 3APF, 3CSF, 3CST, 3DBS, 3DPD, 3ENE, 3IBE, 3L08, 3L13, 3L16, 3L17, 3L54, 3LJ3, 3MJW, 3ML8, 3ML9, 3NZS, 3NZU, 3OAW, 3P2B, 3PRE, 3PRZ, 3PS6, 3QAQ, 3QAR, 3QJZ, 3QK0, 3R7Q, 3R7R, 3S2A, 3SD5, 3T8M, 3TJP, 3TL5, 3ZVV, 3ZW3, 4ANU, 4ANV, 4ANW, 4ANX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00794	PI3K_rbd	203 → 312	PI3-kinase family, ras-binding domain	Domain
  PF00792	PI3K_C2	377 → 519	Phosphoinositide 3-kinase C2	Domain
  PF00613	PI3Ka	543 → 733	Phosphoinositide 3-kinase family, accessory domain (PIK domain)	Family
  PF00454	PI3_PI4_kinase	827 → 1044	Phosphatidylinositol 3- and 4-kinase	Family

• Sequence:

  MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLH
  VAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLD
  CLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGL
  VTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT
  PGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG
  EEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
  FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKI
  KDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEY
  VLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEG
  DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
  QEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
  LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
  LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP
  ESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ
  DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG
  AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNL
  FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLAL
  RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGW
  TVQFNWFLHLVLGIKQGEKHSA

• Sequence length: 1102