PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5293 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PIK3CD |
SynonymsGene synonyms aliases
|
APDS, IMD14, IMD14A, IMD14B, P110DELTA, PI3K, ROCHIS, p110D |
ChromosomeChromosome number
|
1 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
1p36.22 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), th |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs28730670 |
C>A,G,T |
Pathogenic, benign, uncertain-significance |
Coding sequence variant, synonymous variant, missense variant, non coding transcript variant |
rs397518423 |
G>A |
Pathogenic |
Coding sequence variant, missense variant, non coding transcript variant |
rs587777389 |
G>A |
Pathogenic |
Coding sequence variant, missense variant, non coding transcript variant |
rs587777390 |
T>C |
Pathogenic |
Coding sequence variant, missense variant, non coding transcript variant |
rs1064795762 |
A>G |
Likely-pathogenic |
Missense variant, coding sequence variant, non coding transcript variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
miRTarBase ID |
miRNA |
Experiments |
Reference |
MIRT006777 |
hsa-miR-7-5p |
Luciferase reporter assay |
22234835 |
MIRT006777 |
hsa-miR-7-5p |
Luciferase reporter assay |
22234835 |
MIRT006777 |
hsa-miR-7-5p |
Luciferase reporter assay |
22234835 |
MIRT006777 |
hsa-miR-7-5p |
Luciferase reporter assay |
22234835 |
MIRT006777 |
hsa-miR-7-5p |
Luciferase reporter assay |
22234835 |
MIRT006777 |
hsa-miR-7-5p |
Luciferase reporter assay |
22234835 |
MIRT007097 |
hsa-miR-30a-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
23486085 |
MIRT007097 |
hsa-miR-30a-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
23486085 |
MIRT047463 |
hsa-miR-10b-5p |
CLASH |
23622248 |
MIRT053622 |
hsa-miR-125b-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
23160634 |
MIRT054421 |
hsa-miR-663a |
Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot |
24523440 |
MIRT054421 |
hsa-miR-663a |
Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot |
24523440 |
MIRT053622 |
hsa-miR-125b-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
24517182 |
MIRT053622 |
hsa-miR-125b-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
24517182 |
MIRT006777 |
hsa-miR-7-5p |
qRT-PCR, Western blot |
27391479 |
MIRT735307 |
hsa-miR-30b-3p |
Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR, In situ hybridization, ELISA |
32336754 |
MIRT1234134 |
hsa-miR-1228 |
CLIP-seq |
|
MIRT1234135 |
hsa-miR-1258 |
CLIP-seq |
|
MIRT1234136 |
hsa-miR-1285 |
CLIP-seq |
|
MIRT1234137 |
hsa-miR-1292 |
CLIP-seq |
|
MIRT1234138 |
hsa-miR-1827 |
CLIP-seq |
|
MIRT1234139 |
hsa-miR-190 |
CLIP-seq |
|
MIRT1234140 |
hsa-miR-190b |
CLIP-seq |
|
MIRT1234141 |
hsa-miR-24 |
CLIP-seq |
|
MIRT1234142 |
hsa-miR-298 |
CLIP-seq |
|
MIRT1234143 |
hsa-miR-3125 |
CLIP-seq |
|
MIRT1234144 |
hsa-miR-3178 |
CLIP-seq |
|
MIRT1234145 |
hsa-miR-3187-5p |
CLIP-seq |
|
MIRT1234146 |
hsa-miR-3192 |
CLIP-seq |
|
MIRT1234147 |
hsa-miR-34b |
CLIP-seq |
|
MIRT1234148 |
hsa-miR-3613-3p |
CLIP-seq |
|
MIRT1234149 |
hsa-miR-3614-5p |
CLIP-seq |
|
MIRT1234150 |
hsa-miR-3664-3p |
CLIP-seq |
|
MIRT1234151 |
hsa-miR-3667-5p |
CLIP-seq |
|
MIRT1234152 |
hsa-miR-3689a-3p |
CLIP-seq |
|
MIRT1234153 |
hsa-miR-3689c |
CLIP-seq |
|
MIRT1234154 |
hsa-miR-371-5p |
CLIP-seq |
|
MIRT1234155 |
hsa-miR-371b-5p |
CLIP-seq |
|
MIRT1234156 |
hsa-miR-3916 |
CLIP-seq |
|
MIRT1234157 |
hsa-miR-3929 |
CLIP-seq |
|
MIRT1234158 |
hsa-miR-4265 |
CLIP-seq |
|
MIRT1234159 |
hsa-miR-4284 |
CLIP-seq |
|
MIRT1234160 |
hsa-miR-4296 |
CLIP-seq |
|
MIRT1234161 |
hsa-miR-4322 |
CLIP-seq |
|
MIRT1234162 |
hsa-miR-4417 |
CLIP-seq |
|
MIRT1234163 |
hsa-miR-4419b |
CLIP-seq |
|
MIRT1234164 |
hsa-miR-4433 |
CLIP-seq |
|
MIRT1234165 |
hsa-miR-4471 |
CLIP-seq |
|
MIRT1234166 |
hsa-miR-4478 |
CLIP-seq |
|
MIRT1234167 |
hsa-miR-4481 |
CLIP-seq |
|
MIRT1234168 |
hsa-miR-4646-5p |
CLIP-seq |
|
MIRT1234169 |
hsa-miR-4649-3p |
CLIP-seq |
|
MIRT1234170 |
hsa-miR-4661-3p |
CLIP-seq |
|
MIRT1234171 |
hsa-miR-4684-5p |
CLIP-seq |
|
MIRT1234172 |
hsa-miR-4695-5p |
CLIP-seq |
|
MIRT1234173 |
hsa-miR-4728-5p |
CLIP-seq |
|
MIRT1234174 |
hsa-miR-4731-5p |
CLIP-seq |
|
MIRT1234175 |
hsa-miR-4745-5p |
CLIP-seq |
|
MIRT1234176 |
hsa-miR-485-5p |
CLIP-seq |
|
MIRT1234177 |
hsa-miR-490-3p |
CLIP-seq |
|
MIRT1234178 |
hsa-miR-510 |
CLIP-seq |
|
MIRT1234179 |
hsa-miR-512-5p |
CLIP-seq |
|
MIRT1234180 |
hsa-miR-612 |
CLIP-seq |
|
MIRT1234181 |
hsa-miR-644 |
CLIP-seq |
|
MIRT1234182 |
hsa-miR-651 |
CLIP-seq |
|
MIRT1234183 |
hsa-miR-661 |
CLIP-seq |
|
MIRT1234184 |
hsa-miR-663b |
CLIP-seq |
|
MIRT1234185 |
hsa-miR-7 |
CLIP-seq |
|
MIRT1234186 |
hsa-miR-759 |
CLIP-seq |
|
MIRT1234138 |
hsa-miR-1827 |
CLIP-seq |
|
MIRT2068978 |
hsa-miR-1910 |
CLIP-seq |
|
MIRT1234141 |
hsa-miR-24 |
CLIP-seq |
|
MIRT2068979 |
hsa-miR-2467-5p |
CLIP-seq |
|
MIRT1234142 |
hsa-miR-298 |
CLIP-seq |
|
MIRT2068980 |
hsa-miR-3065-3p |
CLIP-seq |
|
MIRT2068981 |
hsa-miR-3122 |
CLIP-seq |
|
MIRT2068982 |
hsa-miR-3165 |
CLIP-seq |
|
MIRT1234144 |
hsa-miR-3178 |
CLIP-seq |
|
MIRT1234146 |
hsa-miR-3192 |
CLIP-seq |
|
MIRT2068983 |
hsa-miR-342-3p |
CLIP-seq |
|
MIRT1234147 |
hsa-miR-34b |
CLIP-seq |
|
MIRT1234149 |
hsa-miR-3614-5p |
CLIP-seq |
|
MIRT2068984 |
hsa-miR-3656 |
CLIP-seq |
|
MIRT1234150 |
hsa-miR-3664-3p |
CLIP-seq |
|
MIRT2068985 |
hsa-miR-3682-5p |
CLIP-seq |
|
MIRT1234152 |
hsa-miR-3689a-3p |
CLIP-seq |
|
MIRT1234153 |
hsa-miR-3689c |
CLIP-seq |
|
MIRT2068986 |
hsa-miR-3913-5p |
CLIP-seq |
|
MIRT1234157 |
hsa-miR-3929 |
CLIP-seq |
|
MIRT2068987 |
hsa-miR-3937 |
CLIP-seq |
|
MIRT1234163 |
hsa-miR-4419b |
CLIP-seq |
|
MIRT1234164 |
hsa-miR-4433 |
CLIP-seq |
|
MIRT1234166 |
hsa-miR-4478 |
CLIP-seq |
|
MIRT1234167 |
hsa-miR-4481 |
CLIP-seq |
|
MIRT1234169 |
hsa-miR-4649-3p |
CLIP-seq |
|
MIRT1234172 |
hsa-miR-4695-5p |
CLIP-seq |
|
MIRT1234173 |
hsa-miR-4728-5p |
CLIP-seq |
|
MIRT1234175 |
hsa-miR-4745-5p |
CLIP-seq |
|
MIRT1234176 |
hsa-miR-485-5p |
CLIP-seq |
|
MIRT2068988 |
hsa-miR-498 |
CLIP-seq |
|
MIRT1234178 |
hsa-miR-510 |
CLIP-seq |
|
MIRT1234179 |
hsa-miR-512-5p |
CLIP-seq |
|
MIRT1234185 |
hsa-miR-7 |
CLIP-seq |
|
MIRT1234136 |
hsa-miR-1285 |
CLIP-seq |
|
MIRT1234138 |
hsa-miR-1827 |
CLIP-seq |
|
MIRT1234141 |
hsa-miR-24 |
CLIP-seq |
|
MIRT2068979 |
hsa-miR-2467-5p |
CLIP-seq |
|
MIRT2295996 |
hsa-miR-25 |
CLIP-seq |
|
MIRT1234142 |
hsa-miR-298 |
CLIP-seq |
|
MIRT2068981 |
hsa-miR-3122 |
CLIP-seq |
|
MIRT1234143 |
hsa-miR-3125 |
CLIP-seq |
|
MIRT2068982 |
hsa-miR-3165 |
CLIP-seq |
|
MIRT1234145 |
hsa-miR-3187-5p |
CLIP-seq |
|
MIRT1234146 |
hsa-miR-3192 |
CLIP-seq |
|
MIRT2295997 |
hsa-miR-32 |
CLIP-seq |
|
MIRT1234147 |
hsa-miR-34b |
CLIP-seq |
|
MIRT1234149 |
hsa-miR-3614-5p |
CLIP-seq |
|
MIRT2295998 |
hsa-miR-363 |
CLIP-seq |
|
MIRT2068984 |
hsa-miR-3656 |
CLIP-seq |
|
MIRT1234150 |
hsa-miR-3664-3p |
CLIP-seq |
|
MIRT2295999 |
hsa-miR-367 |
CLIP-seq |
|
MIRT1234152 |
hsa-miR-3689a-3p |
CLIP-seq |
|
MIRT1234153 |
hsa-miR-3689c |
CLIP-seq |
|
MIRT2068986 |
hsa-miR-3913-5p |
CLIP-seq |
|
MIRT1234156 |
hsa-miR-3916 |
CLIP-seq |
|
MIRT1234157 |
hsa-miR-3929 |
CLIP-seq |
|
MIRT2068987 |
hsa-miR-3937 |
CLIP-seq |
|
MIRT1234163 |
hsa-miR-4419b |
CLIP-seq |
|
MIRT1234164 |
hsa-miR-4433 |
CLIP-seq |
|
MIRT1234166 |
hsa-miR-4478 |
CLIP-seq |
|
MIRT1234169 |
hsa-miR-4649-3p |
CLIP-seq |
|
MIRT1234171 |
hsa-miR-4684-5p |
CLIP-seq |
|
MIRT1234172 |
hsa-miR-4695-5p |
CLIP-seq |
|
MIRT1234173 |
hsa-miR-4728-5p |
CLIP-seq |
|
MIRT2296000 |
hsa-miR-4793-3p |
CLIP-seq |
|
MIRT1234176 |
hsa-miR-485-5p |
CLIP-seq |
|
MIRT1234177 |
hsa-miR-490-3p |
CLIP-seq |
|
MIRT2296001 |
hsa-miR-508-5p |
CLIP-seq |
|
MIRT1234178 |
hsa-miR-510 |
CLIP-seq |
|
MIRT1234179 |
hsa-miR-512-5p |
CLIP-seq |
|
MIRT1234180 |
hsa-miR-612 |
CLIP-seq |
|
MIRT1234183 |
hsa-miR-661 |
CLIP-seq |
|
MIRT1234185 |
hsa-miR-7 |
CLIP-seq |
|
MIRT2296002 |
hsa-miR-766 |
CLIP-seq |
|
MIRT2296003 |
hsa-miR-767-5p |
CLIP-seq |
|
MIRT2296004 |
hsa-miR-92a |
CLIP-seq |
|
MIRT2296005 |
hsa-miR-92b |
CLIP-seq |
|
MIRT2392525 |
hsa-miR-4297 |
CLIP-seq |
|
MIRT2456500 |
hsa-miR-1225-5p |
CLIP-seq |
|
MIRT1234136 |
hsa-miR-1285 |
CLIP-seq |
|
MIRT1234138 |
hsa-miR-1827 |
CLIP-seq |
|
MIRT1234142 |
hsa-miR-298 |
CLIP-seq |
|
MIRT1234143 |
hsa-miR-3125 |
CLIP-seq |
|
MIRT1234145 |
hsa-miR-3187-5p |
CLIP-seq |
|
MIRT1234146 |
hsa-miR-3192 |
CLIP-seq |
|
MIRT1234147 |
hsa-miR-34b |
CLIP-seq |
|
MIRT1234149 |
hsa-miR-3614-5p |
CLIP-seq |
|
MIRT1234152 |
hsa-miR-3689a-3p |
CLIP-seq |
|
MIRT1234153 |
hsa-miR-3689c |
CLIP-seq |
|
MIRT1234156 |
hsa-miR-3916 |
CLIP-seq |
|
MIRT1234171 |
hsa-miR-4684-5p |
CLIP-seq |
|
MIRT1234173 |
hsa-miR-4728-5p |
CLIP-seq |
|
MIRT2296000 |
hsa-miR-4793-3p |
CLIP-seq |
|
MIRT1234177 |
hsa-miR-490-3p |
CLIP-seq |
|
MIRT2296001 |
hsa-miR-508-5p |
CLIP-seq |
|
MIRT1234180 |
hsa-miR-612 |
CLIP-seq |
|
MIRT1234183 |
hsa-miR-661 |
CLIP-seq |
|
MIRT1234185 |
hsa-miR-7 |
CLIP-seq |
|
MIRT2296002 |
hsa-miR-766 |
CLIP-seq |
|
MIRT2456500 |
hsa-miR-1225-5p |
CLIP-seq |
|
MIRT1234136 |
hsa-miR-1285 |
CLIP-seq |
|
MIRT1234138 |
hsa-miR-1827 |
CLIP-seq |
|
MIRT1234141 |
hsa-miR-24 |
CLIP-seq |
|
MIRT2068979 |
hsa-miR-2467-5p |
CLIP-seq |
|
MIRT1234142 |
hsa-miR-298 |
CLIP-seq |
|
MIRT2068981 |
hsa-miR-3122 |
CLIP-seq |
|
MIRT1234143 |
hsa-miR-3125 |
CLIP-seq |
|
MIRT2068982 |
hsa-miR-3165 |
CLIP-seq |
|
MIRT1234145 |
hsa-miR-3187-5p |
CLIP-seq |
|
MIRT1234146 |
hsa-miR-3192 |
CLIP-seq |
|
MIRT1234147 |
hsa-miR-34b |
CLIP-seq |
|
MIRT1234149 |
hsa-miR-3614-5p |
CLIP-seq |
|
MIRT2068984 |
hsa-miR-3656 |
CLIP-seq |
|
MIRT1234152 |
hsa-miR-3689a-3p |
CLIP-seq |
|
MIRT1234153 |
hsa-miR-3689c |
CLIP-seq |
|
MIRT2068986 |
hsa-miR-3913-5p |
CLIP-seq |
|
MIRT1234156 |
hsa-miR-3916 |
CLIP-seq |
|
MIRT2068987 |
hsa-miR-3937 |
CLIP-seq |
|
MIRT1234171 |
hsa-miR-4684-5p |
CLIP-seq |
|
MIRT1234173 |
hsa-miR-4728-5p |
CLIP-seq |
|
MIRT2296000 |
hsa-miR-4793-3p |
CLIP-seq |
|
MIRT1234177 |
hsa-miR-490-3p |
CLIP-seq |
|
MIRT2296001 |
hsa-miR-508-5p |
CLIP-seq |
|
MIRT1234180 |
hsa-miR-612 |
CLIP-seq |
|
MIRT1234183 |
hsa-miR-661 |
CLIP-seq |
|
MIRT1234185 |
hsa-miR-7 |
CLIP-seq |
|
MIRT2296002 |
hsa-miR-766 |
CLIP-seq |
|
MIRT2456500 |
hsa-miR-1225-5p |
CLIP-seq |
|
MIRT1234136 |
hsa-miR-1285 |
CLIP-seq |
|
MIRT1234138 |
hsa-miR-1827 |
CLIP-seq |
|
MIRT1234141 |
hsa-miR-24 |
CLIP-seq |
|
MIRT2068979 |
hsa-miR-2467-5p |
CLIP-seq |
|
MIRT1234142 |
hsa-miR-298 |
CLIP-seq |
|
MIRT2068981 |
hsa-miR-3122 |
CLIP-seq |
|
MIRT1234143 |
hsa-miR-3125 |
CLIP-seq |
|
MIRT2068982 |
hsa-miR-3165 |
CLIP-seq |
|
MIRT1234145 |
hsa-miR-3187-5p |
CLIP-seq |
|
MIRT1234146 |
hsa-miR-3192 |
CLIP-seq |
|
MIRT1234147 |
hsa-miR-34b |
CLIP-seq |
|
MIRT1234149 |
hsa-miR-3614-5p |
CLIP-seq |
|
MIRT2068984 |
hsa-miR-3656 |
CLIP-seq |
|
MIRT1234151 |
hsa-miR-3667-5p |
CLIP-seq |
|
MIRT1234152 |
hsa-miR-3689a-3p |
CLIP-seq |
|
MIRT1234153 |
hsa-miR-3689c |
CLIP-seq |
|
MIRT2068986 |
hsa-miR-3913-5p |
CLIP-seq |
|
MIRT1234156 |
hsa-miR-3916 |
CLIP-seq |
|
MIRT2068987 |
hsa-miR-3937 |
CLIP-seq |
|
MIRT1234164 |
hsa-miR-4433 |
CLIP-seq |
|
MIRT1234171 |
hsa-miR-4684-5p |
CLIP-seq |
|
MIRT1234173 |
hsa-miR-4728-5p |
CLIP-seq |
|
MIRT2296000 |
hsa-miR-4793-3p |
CLIP-seq |
|
MIRT1234177 |
hsa-miR-490-3p |
CLIP-seq |
|
MIRT2296001 |
hsa-miR-508-5p |
CLIP-seq |
|
MIRT1234180 |
hsa-miR-612 |
CLIP-seq |
|
MIRT1234183 |
hsa-miR-661 |
CLIP-seq |
|
MIRT1234185 |
hsa-miR-7 |
CLIP-seq |
|
MIRT2296002 |
hsa-miR-766 |
CLIP-seq |
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
RUNX1 |
Unknown |
19638627 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001779 |
Process |
Natural killer cell differentiation |
TAS |
20940048 |
GO:0001816 |
Process |
Cytokine production |
TAS |
20940048 |
GO:0001938 |
Process |
Positive regulation of endothelial cell proliferation |
IGI |
31915155 |
GO:0002250 |
Process |
Adaptive immune response |
TAS |
17290298 |
GO:0002551 |
Process |
Mast cell chemotaxis |
TAS |
20940048 |
GO:0002679 |
Process |
Respiratory burst involved in defense response |
TAS |
20940048 |
GO:0005515 |
Function |
Protein binding |
IPI |
21827948, 22020336, 24165795, 28514442, 31031754, 32296183 |
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
IBA |
21873635 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0005942 |
Component |
Phosphatidylinositol 3-kinase complex |
IBA |
21873635 |
GO:0005942 |
Component |
Phosphatidylinositol 3-kinase complex |
NAS |
9113989, 9235916 |
GO:0006468 |
Process |
Protein phosphorylation |
NAS |
9113989 |
GO:0006661 |
Process |
Phosphatidylinositol biosynthetic process |
TAS |
|
GO:0006954 |
Process |
Inflammatory response |
TAS |
17290298, 20940048 |
GO:0007165 |
Process |
Signal transduction |
NAS |
9113989 |
GO:0007411 |
Process |
Axon guidance |
TAS |
|
GO:0010595 |
Process |
Positive regulation of endothelial cell migration |
IGI |
31915155 |
GO:0010628 |
Process |
Positive regulation of gene expression |
IMP |
22079609 |
GO:0010818 |
Process |
T cell chemotaxis |
TAS |
20940048 |
GO:0014065 |
Process |
Phosphatidylinositol 3-kinase signaling |
IBA |
21873635 |
GO:0014065 |
Process |
Phosphatidylinositol 3-kinase signaling |
IGI |
31915155 |
GO:0014065 |
Process |
Phosphatidylinositol 3-kinase signaling |
IMP |
25339672 |
GO:0014065 |
Process |
Phosphatidylinositol 3-kinase signaling |
TAS |
17290298 |
GO:0014068 |
Process |
Positive regulation of phosphatidylinositol 3-kinase signaling |
TAS |
|
GO:0016020 |
Component |
Membrane |
IBA |
21873635 |
GO:0016301 |
Function |
Kinase activity |
IDA |
25327288 |
GO:0016303 |
Function |
1-phosphatidylinositol-3-kinase activity |
IBA |
21873635 |
GO:0016303 |
Function |
1-phosphatidylinositol-3-kinase activity |
NAS |
9235916 |
GO:0016310 |
Process |
Phosphorylation |
IDA |
25327288 |
GO:0016477 |
Process |
Cell migration |
IBA |
21873635 |
GO:0019221 |
Process |
Cytokine-mediated signaling pathway |
TAS |
|
GO:0030101 |
Process |
Natural killer cell activation |
TAS |
20940048 |
GO:0030217 |
Process |
T cell differentiation |
TAS |
20940048 |
GO:0030335 |
Process |
Positive regulation of cell migration |
IMP |
22079609 |
GO:0030593 |
Process |
Neutrophil chemotaxis |
TAS |
20940048 |
GO:0033031 |
Process |
Positive regulation of neutrophil apoptotic process |
IMP |
25339672 |
GO:0035004 |
Function |
Phosphatidylinositol 3-kinase activity |
TAS |
17290298 |
GO:0035005 |
Function |
1-phosphatidylinositol-4-phosphate 3-kinase activity |
IBA |
21873635 |
GO:0035747 |
Process |
Natural killer cell chemotaxis |
TAS |
20940048 |
GO:0035754 |
Process |
B cell chemotaxis |
TAS |
20940048 |
GO:0036092 |
Process |
Phosphatidylinositol-3-phosphate biosynthetic process |
IBA |
21873635 |
GO:0038089 |
Process |
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway |
IGI |
31915155 |
GO:0042110 |
Process |
T cell activation |
TAS |
20940048 |
GO:0042113 |
Process |
B cell activation |
TAS |
20940048 |
GO:0043303 |
Process |
Mast cell degranulation |
TAS |
20940048 |
GO:0045087 |
Process |
Innate immune response |
TAS |
17290298, 20940048 |
GO:0045766 |
Process |
Positive regulation of angiogenesis |
ISS |
|
GO:0046854 |
Process |
Phosphatidylinositol phosphorylation |
IBA |
21873635 |
GO:0046934 |
Function |
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
IEA |
|
GO:0048015 |
Process |
Phosphatidylinositol-mediated signaling |
IBA |
21873635 |
GO:0050852 |
Process |
T cell receptor signaling pathway |
TAS |
20940048 |
GO:0050853 |
Process |
B cell receptor signaling pathway |
TAS |
20940048 |
GO:0051897 |
Process |
Positive regulation of protein kinase B signaling |
IGI |
31915155 |
GO:0051897 |
Process |
Positive regulation of protein kinase B signaling |
TAS |
|
GO:0052742 |
Function |
Phosphatidylinositol kinase activity |
IBA |
21873635 |
GO:0052812 |
Function |
Phosphatidylinositol-3,4-bisphosphate 5-kinase activity |
IEA |
|
GO:0060374 |
Process |
Mast cell differentiation |
TAS |
20940048 |
GO:0072672 |
Process |
Neutrophil extravasation |
TAS |
20940048 |
GO:1905278 |
Process |
Positive regulation of epithelial tube formation |
IGI |
31915155 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
O00329 |
Protein name |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa cataly |
Protein function |
Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5 |
PDB |
5DXU
,
5M6U
,
5T8F
,
5UBT
,
5VLR
,
6G6W
,
6OCO
,
6OCU
,
6PYR
,
6PYU
,
7JIS
,
7LM2
,
7LQ1
,
8BCY
,
8S3R
,
9GCF
,
9GDI
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02192 |
PI3K_p85B |
32 → 107 |
PI3-kinase family, p85-binding domain |
Family |
PF00794 |
PI3K_rbd |
175 → 281 |
PI3-kinase family, ras-binding domain |
Domain |
PF00792 |
PI3K_C2 |
337 → 464 |
Phosphoinositide 3-kinase C2 |
Domain |
PF00613 |
PI3Ka |
499 → 684 |
Phosphoinositide 3-kinase family, accessory domain (PIK domain) |
Family |
PF00454 |
PI3_PI4_kinase |
773 → 991 |
Phosphatidylinositol 3- and 4-kinase |
Family |
|
Sequence |
|
Sequence length |
1044 |
Interactions |
View interactions |
|
|
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