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PDCD10 (programmed cell death 10)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11235
Gene nameGene Name - the full gene name approved by the HGNC.
Programmed cell death 10
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PDCD10
SynonymsGene synonyms aliases
CCM3, TFAR15
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q26.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is ph
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs886041888 ->T Pathogenic Frameshift variant, coding sequence variant
rs1057517786 G>A Pathogenic Stop gained, 5 prime UTR variant, coding sequence variant
rs1303470125 G>A,C Pathogenic Missense variant, stop gained, coding sequence variant
rs1357917630 G>A Pathogenic Stop gained, coding sequence variant
rs1404676956 G>A Pathogenic Coding sequence variant, stop gained
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020819 hsa-miR-155-5p Proteomics 18668040
MIRT023428 hsa-miR-30b-5p Sequencing 20371350
MIRT023815 hsa-miR-1-3p Proteomics 18668040
MIRT023815 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT028601 hsa-miR-30a-5p Proteomics 18668040
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0001525 Process Angiogenesis IEA
GO:0005515 Function Protein binding IPI 16189514, 17360971, 17657516, 18782753, 20332113, 20489202, 21516116, 21561863, 23266514, 23455922, 23541896, 23665169, 24366813, 25416956, 26496610, 27807006, 28514442, 31515488, 32296183
GO:0005737 Component Cytoplasm IDA 22652780
GO:0005794 Component Golgi apparatus IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9BUL8
Protein name Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15)
Protein function Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed
PDB 3AJM , 3L8I , 3L8J , 3RQE , 3RQF , 3RQG , 3W8H , 3W8I , 4GEH , 4TVQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06840 DUF1241
14 161
Family
Sequence
Sequence length 212
Interactions View interactions

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