PDCD10 (programmed cell death 10)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
11235 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Programmed cell death 10 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PDCD10 |
SynonymsGene synonyms aliases
|
CCM3, TFAR15 |
ChromosomeChromosome number
|
3 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
3q26.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is ph |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs886041888 |
->T |
Pathogenic |
Frameshift variant, coding sequence variant |
rs1057517786 |
G>A |
Pathogenic |
Stop gained, 5 prime UTR variant, coding sequence variant |
rs1303470125 |
G>A,C |
Pathogenic |
Missense variant, stop gained, coding sequence variant |
rs1357917630 |
G>A |
Pathogenic |
Stop gained, coding sequence variant |
rs1404676956 |
G>A |
Pathogenic |
Coding sequence variant, stop gained |
rs1553758385 |
T>A,G |
Uncertain-significance, likely-pathogenic |
Splice acceptor variant |
rs1553759042 |
ACTT>- |
Pathogenic |
Splice donor variant, intron variant, coding sequence variant |
rs1553759059 |
G>C |
Pathogenic, likely-pathogenic |
Stop gained, coding sequence variant |
rs1553759139 |
C>T |
Pathogenic, likely-pathogenic |
Intron variant |
rs1553760888 |
->T |
Pathogenic |
Frameshift variant, coding sequence variant |
rs1553760900 |
G>A |
Pathogenic |
Stop gained, coding sequence variant |
rs1553761217 |
C>T |
Pathogenic |
Splice donor variant |
rs1553761266 |
CTTT>- |
Pathogenic |
Frameshift variant, 5 prime UTR variant, coding sequence variant |
rs1553762839 |
C>A,T |
Likely-pathogenic |
Splice donor variant |
rs1559941951 |
->A |
Likely-pathogenic |
Frameshift variant, coding sequence variant |
rs1559944592 |
A>- |
Likely-pathogenic |
Frameshift variant, coding sequence variant |
rs1559944602 |
C>A |
Likely-pathogenic |
Stop gained, coding sequence variant |
rs1559945126 |
T>A |
Likely-pathogenic |
Splice acceptor variant |
rs1559945136 |
G>C |
Pathogenic |
Intron variant |
rs1559952217 |
A>C |
Likely-pathogenic |
Splice donor variant |
rs1559952220 |
C>T |
Likely-pathogenic |
Splice donor variant |
rs1559952317 |
->T |
Pathogenic |
Frameshift variant, coding sequence variant |
rs1559952461 |
CT>- |
Likely-pathogenic |
Splice acceptor variant, coding sequence variant |
rs1559952467 |
C>G |
Likely-pathogenic |
Splice acceptor variant |
rs1559953791 |
C>- |
Likely-pathogenic |
Splice donor variant, coding sequence variant |
rs1559960758 |
A>- |
Likely-pathogenic |
Frameshift variant, 5 prime UTR variant, coding sequence variant |
rs1577317859 |
C>T |
Pathogenic |
Splice acceptor variant |
rs1577329627 |
T>A |
Pathogenic |
Stop gained, coding sequence variant |
rs1577329665 |
G>A |
Pathogenic |
Stop gained, coding sequence variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000139 |
Component |
Golgi membrane |
IEA |
|
GO:0001525 |
Process |
Angiogenesis |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
16189514, 17360971, 17657516, 18782753, 20332113, 20489202, 21516116, 21561863, 23266514, 23455922, 23541896, 23665169, 24366813, 25416956, 26496610, 27807006, 28514442, 31515488, 32296183 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
22652780 |
GO:0005794 |
Component |
Golgi apparatus |
IBA |
21873635 |
GO:0005794 |
Component |
Golgi apparatus |
IDA |
20332113 |
GO:0005794 |
Component |
Golgi apparatus |
IDA |
22652780 |
GO:0005829 |
Component |
Cytosol |
IDA |
17360971, 20489202 |
GO:0005886 |
Component |
Plasma membrane |
IEA |
|
GO:0008284 |
Process |
Positive regulation of cell population proliferation |
IDA |
17360971, 23541896 |
GO:0010628 |
Process |
Positive regulation of gene expression |
IMP |
23388056 |
GO:0010629 |
Process |
Negative regulation of gene expression |
IMP |
23388056 |
GO:0019901 |
Function |
Protein kinase binding |
IBA |
21873635 |
GO:0019901 |
Function |
Protein kinase binding |
IPI |
20332113, 22652780 |
GO:0030335 |
Process |
Positive regulation of cell migration |
IDA |
23541896 |
GO:0030335 |
Process |
Positive regulation of cell migration |
IMP |
20332113 |
GO:0032874 |
Process |
Positive regulation of stress-activated MAPK cascade |
IDA |
22652780 |
GO:0033138 |
Process |
Positive regulation of peptidyl-serine phosphorylation |
IMP |
20332113 |
GO:0035023 |
Process |
Regulation of Rho protein signal transduction |
IMP |
20332113 |
GO:0036481 |
Process |
Intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
IGI |
22652780 |
GO:0042542 |
Process |
Response to hydrogen peroxide |
IDA |
22291017 |
GO:0042803 |
Function |
Protein homodimerization activity |
IPI |
20489202, 21561863 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IDA |
17360971 |
GO:0043149 |
Process |
Stress fiber assembly |
IMP |
20332113 |
GO:0043406 |
Process |
Positive regulation of MAP kinase activity |
IBA |
21873635 |
GO:0043406 |
Process |
Positive regulation of MAP kinase activity |
IDA |
17360971 |
GO:0044319 |
Process |
Wound healing, spreading of cells |
IMP |
20332113 |
GO:0045747 |
Process |
Positive regulation of Notch signaling pathway |
IMP |
23388056 |
GO:0047485 |
Function |
Protein N-terminus binding |
IPI |
20489202 |
GO:0050821 |
Process |
Protein stabilization |
IMP |
20332113, 22652780 |
GO:0051683 |
Process |
Establishment of Golgi localization |
IMP |
20332113 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867, 20458337, 23533145 |
GO:0071902 |
Process |
Positive regulation of protein serine/threonine kinase activity |
IMP |
20332113 |
GO:0090051 |
Process |
Negative regulation of cell migration involved in sprouting angiogenesis |
IMP |
23388056 |
GO:0090168 |
Process |
Golgi reassembly |
IMP |
20332113 |
GO:0090316 |
Process |
Positive regulation of intracellular protein transport |
IMP |
27807006 |
GO:0090443 |
Component |
FAR/SIN/STRIPAK complex |
IBA |
21873635 |
GO:1903358 |
Process |
Regulation of Golgi organization |
IBA |
21873635 |
GO:1903588 |
Process |
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
IMP |
23388056 |
GO:1990830 |
Process |
Cellular response to leukemia inhibitory factor |
IEA |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
Q9BUL8 |
Protein name |
Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15) |
Protein function |
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed |
PDB |
3AJM
,
3L8I
,
3L8J
,
3RQE
,
3RQF
,
3RQG
,
3W8H
,
3W8I
,
4GEH
,
4TVQ
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF06840 |
DUF1241 |
14 → 161 |
|
Family |
|
Sequence |
|
Sequence length |
212 |
Interactions |
View interactions |
|
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