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PCK1 (phosphoenolpyruvate carboxykinase 1)

Gene

5105

Phosphoenolpyruvate carboxykinase 1

PCK1

PCKDC, PEPCK-C, PEPCK1, PEPCKC

20q13.31

This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expressio

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs147120329	C>T	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant, missense variant, coding sequence variant
rs148684857	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs201186470	G>A	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs373906233	G>A	Likely-pathogenic	Coding sequence variant, missense variant

Show/Hide all(379)

miRTarBase ID	miRNA	Experiments	Reference
MIRT054920	hsa-miR-33b-5p	Luciferase reporter assay, qRT-PCR	23716591
MIRT607464	hsa-miR-8485	HITS-CLIP	22927820
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	22927820
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT626357	hsa-miR-8064	HITS-CLIP	22927820
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT607464	hsa-miR-8485	HITS-CLIP	23313552
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23313552
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23313552
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23313552
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT607464	hsa-miR-8485	HITS-CLIP	23313552
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT626357	hsa-miR-8064	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT620256	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT620255	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT620254	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT620253	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT620252	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT620251	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620250	hsa-miR-3163	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT647684	hsa-miR-548aa	HITS-CLIP	23824327
MIRT647683	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT647682	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT626357	hsa-miR-8064	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT620256	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT620255	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT620254	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT620253	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT620252	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT620251	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620250	hsa-miR-3163	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	23824327
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT607464	hsa-miR-8485	HITS-CLIP	24906430
MIRT607463	hsa-miR-4789-3p	HITS-CLIP	24906430
MIRT607462	hsa-miR-5011-5p	HITS-CLIP	24906430
MIRT607461	hsa-miR-190a-3p	HITS-CLIP	24906430
MIRT607460	hsa-miR-1277-5p	HITS-CLIP	24906430
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	27418678
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	27418678
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	27418678
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT576692	hsa-miR-8064	HITS-CLIP	27418678
MIRT576695	hsa-miR-8485	HITS-CLIP	27418678
MIRT576695	hsa-miR-8485	HITS-CLIP	27418678
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	28735896
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	28735896
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	28735896
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	28735896
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	28735896
MIRT576695	hsa-miR-8485	HITS-CLIP	22927820
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	22927820
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT576692	hsa-miR-8064	HITS-CLIP	22927820
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT576695	hsa-miR-8485	HITS-CLIP	23313552
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23313552
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23313552
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23313552
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT576695	hsa-miR-8485	HITS-CLIP	23313552
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576692	hsa-miR-8064	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT620256	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT620255	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT620254	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT620253	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT620252	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT620251	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620250	hsa-miR-3163	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT647684	hsa-miR-548aa	HITS-CLIP	23824327
MIRT647683	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT647682	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT639566	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT639565	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT639564	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576692	hsa-miR-8064	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT620256	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT620255	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT620254	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT620253	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT620252	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT620251	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620250	hsa-miR-3163	HITS-CLIP	23824327
MIRT620249	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT620248	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT620247	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620246	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT620245	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT576695	hsa-miR-8485	HITS-CLIP	23824327
MIRT576694	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT576693	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT576691	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT576690	hsa-miR-1277-5p	HITS-CLIP	23824327

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
ATF2	Activation	12453892
CEBPA	Unknown	12237288
SP1	Activation	14744869
SREBF1	Repression	14744869

Show/Hide all(56)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	11851336
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	IBA	21873635
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	IDA	30193097, 32322062
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	IMP	26971250
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	ISS
GO:0004613	Function	Phosphoenolpyruvate carboxykinase (GTP) activity	TAS
GO:0005525	Function	GTP binding	IDA	11851336
GO:0005737	Component	Cytoplasm	ISS
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	32322062
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	32322062
GO:0005829	Component	Cytosol	TAS
GO:0006006	Process	Glucose metabolic process	IMP	14764811
GO:0006094	Process	Gluconeogenesis	IBA	21873635
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006094	Process	Gluconeogenesis	IMP	26971250
GO:0006094	Process	Gluconeogenesis	ISS
GO:0006094	Process	Gluconeogenesis	TAS
GO:0006107	Process	Oxaloacetate metabolic process	IDA	30193097
GO:0007568	Process	Aging	IEA
GO:0014823	Process	Response to activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	32322062
GO:0019003	Function	GDP binding	IEA
GO:0019543	Process	Propionate catabolic process	IBA	21873635
GO:0030145	Function	Manganese ion binding	IBA	21873635
GO:0030145	Function	Manganese ion binding	IDA	11851336
GO:0031406	Function	Carboxylic acid binding	IDA	11851336
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032868	Process	Response to insulin	IDA	14764811
GO:0032869	Process	Cellular response to insulin stimulus	IBA	21873635
GO:0032869	Process	Cellular response to insulin stimulus	IDA	32322062
GO:0033993	Process	Response to lipid	IBA	21873635
GO:0042593	Process	Glucose homeostasis	ISS
GO:0042594	Process	Response to starvation	IBA	21873635
GO:0043382	Process	Positive regulation of memory T cell differentiation	ISS
GO:0046327	Process	Glycerol biosynthetic process from pyruvate	IBA	21873635
GO:0046327	Process	Glycerol biosynthetic process from pyruvate	ISS
GO:0046890	Process	Regulation of lipid biosynthetic process	IDA	32322062
GO:0051365	Process	Cellular response to potassium ion starvation	IEA
GO:0061402	Process	Positive regulation of transcription from RNA polymerase II promoter in response to acidic pH	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070365	Process	Hepatocyte differentiation	IBA	21873635
GO:0070741	Process	Response to interleukin-6	IEA
GO:0071300	Process	Cellular response to retinoic acid	IEA
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0071332	Process	Cellular response to fructose stimulus	IEA
GO:0071333	Process	Cellular response to glucose stimulus	IBA	21873635
GO:0071333	Process	Cellular response to glucose stimulus	IDA	30193097
GO:0071347	Process	Cellular response to interleukin-1	IEA
GO:0071356	Process	Cellular response to tumor necrosis factor	IEA
GO:0071377	Process	Cellular response to glucagon stimulus	IEA
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0071549	Process	Cellular response to dexamethasone stimulus	IBA	21873635
GO:0106264	Function	Protein serine kinase activity (using GTP as donor)	IDA	32322062
GO:1904640	Process	Response to methionine	IEA

MIM	HGNC	e!Ensembl
614168	8724	ENSG00000124253

Protein

UniProt ID

P35558

Protein name

Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-)

Protein function

Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:24863970, PubMed:26971250, PubMed:28216384, PubMe

PDB

1KHB , 1KHE , 1KHF , 1KHG , 1M51 , 1NHX , 2GMV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17297	PEPCK_N	29 → 256	Phosphoenolpyruvate carboxykinase N-terminal domain	Domain
PF00821	PEPCK_GTP	260 → 619	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain	Domain

Sequence

MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQM
EEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEE
DFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPV
LEAVGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSL
LGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMNPSL
PGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNV
AETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAW
ESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPF
AMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWM
FNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLEDQV
NADLPCEIEREILALKQRISQM

Sequence length

622

Interactions

View interactions

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