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OS9 (OS9 endoplasmic reticulum lectin)

Gene

10956

OS9 endoplasmic reticulum lectin

OS9

ERLEC2, OS-9

12q13.3-q14.1

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate t

Show/Hide all(199)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1205769	hsa-miR-103a	CLIP-seq
MIRT1205770	hsa-miR-107	CLIP-seq
MIRT1205771	hsa-miR-1179	CLIP-seq
MIRT1205772	hsa-miR-1228	CLIP-seq
MIRT1205773	hsa-miR-1287	CLIP-seq
MIRT1205774	hsa-miR-1294	CLIP-seq
MIRT1205775	hsa-miR-1538	CLIP-seq
MIRT1205776	hsa-miR-218	CLIP-seq
MIRT1205777	hsa-miR-2682	CLIP-seq
MIRT1205778	hsa-miR-3135b	CLIP-seq
MIRT1205779	hsa-miR-3689d	CLIP-seq
MIRT1205780	hsa-miR-377	CLIP-seq
MIRT1205781	hsa-miR-3977	CLIP-seq
MIRT1205782	hsa-miR-4257	CLIP-seq
MIRT1205783	hsa-miR-4268	CLIP-seq
MIRT1205784	hsa-miR-4310	CLIP-seq
MIRT1205785	hsa-miR-4420	CLIP-seq
MIRT1205786	hsa-miR-4433	CLIP-seq
MIRT1205787	hsa-miR-4459	CLIP-seq
MIRT1205788	hsa-miR-4493	CLIP-seq
MIRT1205789	hsa-miR-449c	CLIP-seq
MIRT1205790	hsa-miR-4658	CLIP-seq
MIRT1205791	hsa-miR-4693-3p	CLIP-seq
MIRT1205792	hsa-miR-4710	CLIP-seq
MIRT1205793	hsa-miR-4719	CLIP-seq
MIRT1205794	hsa-miR-4745-3p	CLIP-seq
MIRT1205795	hsa-miR-4747-3p	CLIP-seq
MIRT1205796	hsa-miR-4758-5p	CLIP-seq
MIRT1205797	hsa-miR-4761-5p	CLIP-seq
MIRT1205798	hsa-miR-4765	CLIP-seq
MIRT1205799	hsa-miR-4768-3p	CLIP-seq
MIRT1205800	hsa-miR-4783-3p	CLIP-seq
MIRT1205801	hsa-miR-5096	CLIP-seq
MIRT1205802	hsa-miR-513a-5p	CLIP-seq
MIRT1205803	hsa-miR-513c	CLIP-seq
MIRT1205804	hsa-miR-514b-5p	CLIP-seq
MIRT1205805	hsa-miR-541	CLIP-seq
MIRT1205806	hsa-miR-654-5p	CLIP-seq
MIRT1205807	hsa-miR-940	CLIP-seq
MIRT1205769	hsa-miR-103a	CLIP-seq
MIRT1205770	hsa-miR-107	CLIP-seq
MIRT1205771	hsa-miR-1179	CLIP-seq
MIRT1205772	hsa-miR-1228	CLIP-seq
MIRT1205808	hsa-miR-1266	CLIP-seq
MIRT1205809	hsa-miR-15a	CLIP-seq
MIRT1205810	hsa-miR-15b	CLIP-seq
MIRT1205811	hsa-miR-16	CLIP-seq
MIRT1205812	hsa-miR-1909	CLIP-seq
MIRT1205813	hsa-miR-1915	CLIP-seq
MIRT1205814	hsa-miR-195	CLIP-seq
MIRT1205815	hsa-miR-214	CLIP-seq
MIRT1205816	hsa-miR-219-5p	CLIP-seq
MIRT1205817	hsa-miR-3150a-3p	CLIP-seq
MIRT1205818	hsa-miR-3175	CLIP-seq
MIRT1205819	hsa-miR-3619-5p	CLIP-seq
MIRT1205780	hsa-miR-377	CLIP-seq
MIRT1205781	hsa-miR-3977	CLIP-seq
MIRT1205820	hsa-miR-424	CLIP-seq
MIRT1205784	hsa-miR-4310	CLIP-seq
MIRT1205785	hsa-miR-4420	CLIP-seq
MIRT1205821	hsa-miR-4445	CLIP-seq
MIRT1205822	hsa-miR-4518	CLIP-seq
MIRT1205823	hsa-miR-4685-5p	CLIP-seq
MIRT1205824	hsa-miR-4688	CLIP-seq
MIRT1205825	hsa-miR-4782-3p	CLIP-seq
MIRT1205826	hsa-miR-486-3p	CLIP-seq
MIRT1205827	hsa-miR-491-5p	CLIP-seq
MIRT1205828	hsa-miR-497	CLIP-seq
MIRT1205829	hsa-miR-508-3p	CLIP-seq
MIRT1205801	hsa-miR-5096	CLIP-seq
MIRT1205805	hsa-miR-541	CLIP-seq
MIRT1205806	hsa-miR-654-5p	CLIP-seq
MIRT1205830	hsa-miR-761	CLIP-seq
MIRT1205831	hsa-miR-939	CLIP-seq
MIRT1205832	hsa-miR-142-3p	CLIP-seq
MIRT1205833	hsa-miR-3179	CLIP-seq
MIRT1205834	hsa-miR-4255	CLIP-seq
MIRT1205835	hsa-miR-4280	CLIP-seq
MIRT1205836	hsa-miR-4320	CLIP-seq
MIRT1205837	hsa-miR-455-3p	CLIP-seq
MIRT1205838	hsa-miR-4676-5p	CLIP-seq
MIRT1205839	hsa-miR-4782-5p	CLIP-seq
MIRT1205840	hsa-miR-575	CLIP-seq
MIRT1205841	hsa-miR-665	CLIP-seq
MIRT1205816	hsa-miR-219-5p	CLIP-seq
MIRT1205821	hsa-miR-4445	CLIP-seq
MIRT1205825	hsa-miR-4782-3p	CLIP-seq
MIRT1205829	hsa-miR-508-3p	CLIP-seq
MIRT1205771	hsa-miR-1179	CLIP-seq
MIRT2287610	hsa-miR-1238	CLIP-seq
MIRT1205813	hsa-miR-1915	CLIP-seq
MIRT2287611	hsa-miR-296-5p	CLIP-seq
MIRT2287612	hsa-miR-3612	CLIP-seq
MIRT2287613	hsa-miR-3918	CLIP-seq
MIRT2287614	hsa-miR-3925-3p	CLIP-seq
MIRT1205782	hsa-miR-4257	CLIP-seq
MIRT1205783	hsa-miR-4268	CLIP-seq
MIRT1205784	hsa-miR-4310	CLIP-seq
MIRT1205836	hsa-miR-4320	CLIP-seq
MIRT1205788	hsa-miR-4493	CLIP-seq
MIRT1205837	hsa-miR-455-3p	CLIP-seq
MIRT1205838	hsa-miR-4676-5p	CLIP-seq
MIRT1205823	hsa-miR-4685-5p	CLIP-seq
MIRT1205839	hsa-miR-4782-5p	CLIP-seq
MIRT1205802	hsa-miR-513a-5p	CLIP-seq
MIRT2287615	hsa-miR-545	CLIP-seq
MIRT1205840	hsa-miR-575	CLIP-seq
MIRT2287616	hsa-miR-650	CLIP-seq
MIRT1205841	hsa-miR-665	CLIP-seq
MIRT2287617	hsa-miR-766	CLIP-seq
MIRT2585610	hsa-miR-1178	CLIP-seq
MIRT2585611	hsa-miR-148a	CLIP-seq
MIRT2585612	hsa-miR-148b	CLIP-seq
MIRT2585613	hsa-miR-152	CLIP-seq
MIRT1205815	hsa-miR-214	CLIP-seq
MIRT1205777	hsa-miR-2682	CLIP-seq
MIRT2585614	hsa-miR-2861	CLIP-seq
MIRT2585615	hsa-miR-3125	CLIP-seq
MIRT2585616	hsa-miR-3145-5p	CLIP-seq
MIRT2585617	hsa-miR-3150b-3p	CLIP-seq
MIRT2585618	hsa-miR-34c-3p	CLIP-seq
MIRT1205819	hsa-miR-3619-5p	CLIP-seq
MIRT2585619	hsa-miR-3665	CLIP-seq
MIRT2585620	hsa-miR-3916	CLIP-seq
MIRT2287614	hsa-miR-3925-3p	CLIP-seq
MIRT2585621	hsa-miR-4278	CLIP-seq
MIRT2585622	hsa-miR-4290	CLIP-seq
MIRT2585623	hsa-miR-4327	CLIP-seq
MIRT2585624	hsa-miR-4436b-3p	CLIP-seq
MIRT2585625	hsa-miR-4447	CLIP-seq
MIRT2585626	hsa-miR-4472	CLIP-seq
MIRT2585627	hsa-miR-4488	CLIP-seq
MIRT1205789	hsa-miR-449c	CLIP-seq
MIRT2585628	hsa-miR-4639-5p	CLIP-seq
MIRT1205790	hsa-miR-4658	CLIP-seq
MIRT2585629	hsa-miR-4697-5p	CLIP-seq
MIRT2585630	hsa-miR-4722-3p	CLIP-seq
MIRT2585631	hsa-miR-4736	CLIP-seq
MIRT1205796	hsa-miR-4758-5p	CLIP-seq
MIRT2585632	hsa-miR-4763-5p	CLIP-seq
MIRT2585633	hsa-miR-4784	CLIP-seq
MIRT2585634	hsa-miR-499-3p	CLIP-seq
MIRT2585635	hsa-miR-499a-3p	CLIP-seq
MIRT2585636	hsa-miR-515-3p	CLIP-seq
MIRT2585637	hsa-miR-519e	CLIP-seq
MIRT2585638	hsa-miR-548ad	CLIP-seq
MIRT2585639	hsa-miR-550a	CLIP-seq
MIRT2585640	hsa-miR-595	CLIP-seq
MIRT1205830	hsa-miR-761	CLIP-seq
MIRT2287617	hsa-miR-766	CLIP-seq
MIRT1205807	hsa-miR-940	CLIP-seq
MIRT2585610	hsa-miR-1178	CLIP-seq
MIRT2686870	hsa-miR-1224-3p	CLIP-seq
MIRT2585611	hsa-miR-148a	CLIP-seq
MIRT2585612	hsa-miR-148b	CLIP-seq
MIRT2585613	hsa-miR-152	CLIP-seq
MIRT1205815	hsa-miR-214	CLIP-seq
MIRT1205777	hsa-miR-2682	CLIP-seq
MIRT2585614	hsa-miR-2861	CLIP-seq
MIRT2585615	hsa-miR-3125	CLIP-seq
MIRT2585616	hsa-miR-3145-5p	CLIP-seq
MIRT2585617	hsa-miR-3150b-3p	CLIP-seq
MIRT2585618	hsa-miR-34c-3p	CLIP-seq
MIRT1205819	hsa-miR-3619-5p	CLIP-seq
MIRT2585619	hsa-miR-3665	CLIP-seq
MIRT2686871	hsa-miR-371b-5p	CLIP-seq
MIRT2585620	hsa-miR-3916	CLIP-seq
MIRT2287614	hsa-miR-3925-3p	CLIP-seq
MIRT2585621	hsa-miR-4278	CLIP-seq
MIRT2585622	hsa-miR-4290	CLIP-seq
MIRT2585623	hsa-miR-4327	CLIP-seq
MIRT2585624	hsa-miR-4436b-3p	CLIP-seq
MIRT2585625	hsa-miR-4447	CLIP-seq
MIRT2585626	hsa-miR-4472	CLIP-seq
MIRT2585627	hsa-miR-4488	CLIP-seq
MIRT1205789	hsa-miR-449c	CLIP-seq
MIRT2585628	hsa-miR-4639-5p	CLIP-seq
MIRT1205790	hsa-miR-4658	CLIP-seq
MIRT2686872	hsa-miR-4667-3p	CLIP-seq
MIRT2686873	hsa-miR-4684-5p	CLIP-seq
MIRT2585629	hsa-miR-4697-5p	CLIP-seq
MIRT2585630	hsa-miR-4722-3p	CLIP-seq
MIRT2585631	hsa-miR-4736	CLIP-seq
MIRT1205796	hsa-miR-4758-5p	CLIP-seq
MIRT2585632	hsa-miR-4763-5p	CLIP-seq
MIRT1205798	hsa-miR-4765	CLIP-seq
MIRT2585633	hsa-miR-4784	CLIP-seq
MIRT2585634	hsa-miR-499-3p	CLIP-seq
MIRT2585635	hsa-miR-499a-3p	CLIP-seq
MIRT2686874	hsa-miR-502-5p	CLIP-seq
MIRT2585636	hsa-miR-515-3p	CLIP-seq
MIRT2585637	hsa-miR-519e	CLIP-seq
MIRT2585638	hsa-miR-548ad	CLIP-seq
MIRT2585639	hsa-miR-550a	CLIP-seq
MIRT2585640	hsa-miR-595	CLIP-seq
MIRT1205830	hsa-miR-761	CLIP-seq
MIRT2287617	hsa-miR-766	CLIP-seq
MIRT2686875	hsa-miR-888	CLIP-seq
MIRT1205807	hsa-miR-940	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000836	Component	Hrd1p ubiquitin ligase complex	NAS	18502753, 19084021
GO:0002020	Function	Protease binding	IEA
GO:0005515	Function	Protein binding	IDA	18264092, 19346256
GO:0005515	Function	Protein binding	IPI	15721254, 18264092, 18502753, 18711132, 20546900, 22119785, 26551274, 26972000, 28827405
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005788	Component	Endoplasmic reticulum lumen	IBA	21873635
GO:0005788	Component	Endoplasmic reticulum lumen	IDA	18264092, 18417469, 19084021
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	19084021
GO:0006605	Process	Protein targeting	IEA
GO:0006621	Process	Protein retention in ER lumen	IDA	18417469
GO:0016567	Process	Protein ubiquitination	IMP	19084021
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IBA	21873635
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IMP	18264092, 18417469, 19346256
GO:0030970	Process	Retrograde protein transport, ER to cytosol	IBA	21873635
GO:0034976	Process	Response to endoplasmic reticulum stress	IDA	19084021
GO:0044322	Component	Endoplasmic reticulum quality control compartment	IEA
GO:0055085	Process	Transmembrane transport	TAS
GO:1904153	Process	Negative regulation of retrograde protein transport, ER to cytosol	IMP	25660456
GO:1904380	Process	Endoplasmic reticulum mannose trimming	TAS

MIM	HGNC	e!Ensembl
609677	16994	ENSG00000135506

Protein

UniProt ID

Q13438

Protein name

Protein OS-9 (Amplified in osteosarcoma 9)

Protein function

Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD) (PubMed:18264092, PubMed:18417469, PubMed:19084021, PubMed:19346256, PubMed:21172656, PubMed:24899641). Spec

PDB

3AIH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07915	PRKCSH	108 → 181	Glucosidase II beta subunit-like protein	Family

Sequence

MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV
VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY
EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA
PQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGAS
PTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIR
SPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDED
EDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGL
KKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHR
VRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWA
EGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTG
DLDEFDF

Sequence length

667

Interactions

View interactions

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