Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
4967 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Oxoglutarate dehydrogenase |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
OGDH |
SynonymsGene synonyms aliases
|
AKGDH, E1k, E1o, HsOGDH, KGD1, OGDC, OGDH-E1, OGDH2, OGDHD |
ChromosomeChromosome number
|
7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7p13 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial |
miRNAmiRNA information provided by mirtarbase database.
|
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q02218 |
Protein name |
2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehyd |
Protein function |
2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to s |
PDB |
3ERY
,
7WGR
,
8I0K
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF16078 |
2-oxogl_dehyd_N |
47 → 87 |
2-oxoglutarate dehydrogenase N-terminus |
Family |
PF00676 |
E1_dh |
256 → 582 |
Dehydrogenase E1 component |
Family |
PF02779 |
Transket_pyr |
649 → 866 |
Transketolase, pyrimidine binding domain |
Domain |
PF16870 |
OxoGdeHyase_C |
869 → 1014 |
2-oxoglutarate dehydrogenase C-terminal |
Family |
|
Sequence |
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Sequence length |
1023 |
Interactions |
View interactions |