GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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NRAS (NRAS proto-oncogene, GTPase)

Gene

4893

NRAS proto-oncogene, GTPase

NRAS

ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6

1p13.2

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

Show/Hide all(19)

SNP ID	Visualize variation	Clinical significance	Consequence
rs11554290	T>A,C,G	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs121434595	C>A,G,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs121434596	C>A,G,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs121913237	C>A,G,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs121913248	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant
rs121913250	C>A,G,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs121913254	G>A,C,T	Pathogenic, uncertain-significance, drug-response, likely-pathogenic, not-provided	Stop gained, missense variant, coding sequence variant
rs121913255	T>A,G	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs267606920	C>T	Pathogenic	Missense variant, coding sequence variant
rs267606921	G>A	Pathogenic	Missense variant, coding sequence variant
rs397514553	G>A,C	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs730880965	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs730880967	->CCT	Pathogenic	Splice acceptor variant, coding sequence variant
rs869025573	A>T	Pathogenic	Missense variant, coding sequence variant
rs1057519695	TT>CA,CC	Pathogenic	Missense variant, coding sequence variant
rs1057519834	TG>CT	Likely-pathogenic	Missense variant, coding sequence variant
rs1553244454	G>A	Likely-pathogenic	Coding sequence variant, stop gained
rs1557982817	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1570874751	G>T	Likely-pathogenic	Coding sequence variant, missense variant

Show/Hide all(102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001854	hsa-let-7a-5p	Western blot	19110058
MIRT001854	hsa-let-7a-5p	Luciferase reporter assay, Microarray	15766527
MIRT003836	hsa-let-7b-5p	Luciferase reporter assay	17699775
MIRT003836	hsa-let-7b-5p	Immunohistochemistry, qRT-PCR	19966857
MIRT003836	hsa-let-7b-5p	Proteomics	18668040
MIRT003903	hsa-miR-20a-5p	Western blot	19110058
MIRT004531	hsa-let-7c-5p	Microarray, Northern blot, qRT-PCR, Western blot	15766527
MIRT007107	hsa-miR-145-5p	Luciferase reporter assay, Western blot	23201159
MIRT007107	hsa-miR-145-5p	Immunoblot, Immunohistochemistry, Luciferase reporter assay, Northern blot, qRT-PCR	22592534
MIRT007107	hsa-miR-145-5p	Luciferase reporter assay, qRT-PCR, Western blot	28332309
MIRT007317	hsa-miR-148b-3p	Western blot	23238785
MIRT007317	hsa-miR-148b-3p	Luciferase reporter assay	23233531
MIRT023141	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT027862	hsa-miR-98-5p	Microarray	19088304
MIRT027862	hsa-miR-98-5p	Immunofluorescence, In situ hybridization, Microarray, qRT-PCR, Western blot	26244871
MIRT037130	hsa-miR-877-3p	CLASH	23622248
MIRT054716	hsa-miR-214-3p	Luciferase reporter assay, Western blot, qRT-PCR	24811402
MIRT058802	hsa-miR-519c-5p	PAR-CLIP	24398324
MIRT058803	hsa-miR-519b-5p	PAR-CLIP	24398324
MIRT058804	hsa-miR-523-5p	PAR-CLIP	24398324
MIRT058805	hsa-miR-518f-5p	PAR-CLIP	24398324
MIRT058806	hsa-miR-526a	PAR-CLIP	24398324
MIRT058807	hsa-miR-520c-5p	PAR-CLIP	24398324
MIRT058809	hsa-miR-518e-5p	PAR-CLIP	24398324
MIRT058810	hsa-miR-518d-5p	PAR-CLIP	24398324
MIRT058811	hsa-miR-522-5p	PAR-CLIP	24398324
MIRT058812	hsa-miR-519a-5p	PAR-CLIP	24398324
MIRT058817	hsa-miR-4686	PAR-CLIP	22100165
MIRT058831	hsa-miR-2681-5p	PAR-CLIP	23446348
MIRT058831	hsa-miR-2681-5p	PAR-CLIP	20371350
MIRT179789	hsa-miR-2113	PAR-CLIP	23592263
MIRT246065	hsa-miR-3123	PAR-CLIP	24398324
MIRT246067	hsa-miR-3925-5p	PAR-CLIP	24398324
MIRT332202	hsa-miR-4468	PAR-CLIP	24398324
MIRT404771	hsa-miR-543	PAR-CLIP	24398324
MIRT443333	hsa-miR-4480	PAR-CLIP	22100165
MIRT443334	hsa-miR-2276-3p	PAR-CLIP	22100165
MIRT443335	hsa-miR-4772-3p	PAR-CLIP	22100165
MIRT443336	hsa-miR-7109-3p	PAR-CLIP	22100165
MIRT443337	hsa-miR-3662	PAR-CLIP	22100165
MIRT471919	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT471919	hsa-miR-513a-5p	PAR-CLIP	24398324
MIRT471920	hsa-miR-1193	PAR-CLIP	23592263
MIRT471920	hsa-miR-1193	PAR-CLIP	24398324
MIRT471921	hsa-miR-3613-3p	PAR-CLIP	23592263
MIRT471922	hsa-miR-2392	PAR-CLIP	23592263
MIRT471922	hsa-miR-2392	PAR-CLIP	24398324
MIRT471923	hsa-miR-7161-5p	PAR-CLIP	23592263
MIRT471923	hsa-miR-7161-5p	PAR-CLIP	24398324
MIRT471924	hsa-miR-548u	PAR-CLIP	23592263
MIRT471924	hsa-miR-548u	PAR-CLIP	24398324
MIRT471925	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT471925	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT471926	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT471926	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT471927	hsa-miR-6833-5p	PAR-CLIP	23592263
MIRT471928	hsa-miR-218-5p	PAR-CLIP	23592263
MIRT471929	hsa-miR-8068	PAR-CLIP	23592263
MIRT471930	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT471931	hsa-miR-3650	PAR-CLIP	23592263
MIRT471932	hsa-miR-6077	PAR-CLIP	23592263
MIRT471933	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT471934	hsa-miR-7-5p	PAR-CLIP	23592263
MIRT471935	hsa-miR-7114-5p	PAR-CLIP	23592263
MIRT471936	hsa-miR-4257	PAR-CLIP	23592263
MIRT471937	hsa-miR-548b-3p	PAR-CLIP	23592263
MIRT501794	hsa-miR-1303	PAR-CLIP	24398324
MIRT501795	hsa-miR-3143	PAR-CLIP	24398324
MIRT501796	hsa-miR-4537	PAR-CLIP	24398324
MIRT501797	hsa-miR-520g-5p	PAR-CLIP	24398324
MIRT501798	hsa-miR-2278	PAR-CLIP	24398324
MIRT511057	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT511057	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT511058	hsa-miR-922	PAR-CLIP	23446348
MIRT511058	hsa-miR-922	PAR-CLIP	20371350
MIRT511059	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT511059	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT511059	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT511060	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT511060	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT511061	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT511061	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT511061	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT511062	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT511062	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT511063	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT511063	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT511064	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT511064	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT511064	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT555957	hsa-miR-5585-3p	PAR-CLIP	21572407
MIRT555958	hsa-miR-3160-5p	PAR-CLIP	21572407
MIRT555959	hsa-miR-642b-3p	PAR-CLIP	21572407
MIRT555960	hsa-miR-642a-3p	PAR-CLIP	21572407
MIRT555961	hsa-miR-4774-5p	PAR-CLIP	21572407
MIRT555962	hsa-miR-4490	PAR-CLIP	21572407
MIRT555963	hsa-miR-4719	PAR-CLIP	21572407
MIRT555965	hsa-miR-425-5p	PAR-CLIP	21572407
MIRT561844	hsa-miR-944	PAR-CLIP	20371350
MIRT732062	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26458859
MIRT734574	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27517749
MIRT734616	hsa-miR-98-3p	Luciferase reporter assay	27042128

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
AR	Repression	16281084

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000165	Process	MAPK cascade	TAS
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IMP	23619365
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0003924	Function	GTPase activity	IDA	30712867
GO:0005515	Function	Protein binding	IPI	18641128, 20080631, 21478863, 28514442, 30712867, 31980649, 32296183, 32814053
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA	21968647
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0007265	Process	Ras protein signal transduction	IBA	21873635
GO:0007265	Process	Ras protein signal transduction	IDA	30712867
GO:0007265	Process	Ras protein signal transduction	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0019003	Function	GDP binding	IBA	21873635
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0044877	Function	Protein-containing complex binding	IDA	23209302
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070821	Component	Tertiary granule membrane	TAS

MIM	HGNC	e!Ensembl
164790	7989	ENSG00000213281

Protein

UniProt ID

P01111

Protein name

GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)

Protein function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

PDB

2N9C , 3CON , 5UHV , 6E6H , 6MPP , 6ULI , 6ULK , 6ULN , 6ULR , 6UON , 6WGH , 6ZIO , 6ZIR , 6ZIZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	5 → 165	Ras family	Domain

Sequence

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM

Sequence length

189

Interactions

View interactions

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