Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
51701 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Nemo like kinase |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
NLK |
SynonymsGene synonyms aliases
|
- |
ChromosomeChromosome number
|
17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q11.2 |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
FOXO1 |
Unknown |
23144700 |
STAT3 |
Unknown |
15764709 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000165 |
Process |
MAPK cascade |
IEA |
|
GO:0000287 |
Function |
Magnesium ion binding |
ISS |
|
GO:0004672 |
Function |
Protein kinase activity |
TAS |
10863097 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IBA |
21873635 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
TAS |
|
GO:0004707 |
Function |
MAP kinase activity |
IBA |
21873635 |
GO:0004707 |
Function |
MAP kinase activity |
ISS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
15764709, 16713569, 21454679, 21516116, 21988832, 22773187, 23602568, 25241761, 25416956, 25910212, 31515488, 32296183, 32814053 |
GO:0005524 |
Function |
ATP binding |
ISS |
|
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
ISS |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006355 |
Process |
Regulation of transcription, DNA-templated |
ISS |
|
GO:0006468 |
Process |
Protein phosphorylation |
ISS |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IMP |
15004007 |
GO:0007223 |
Process |
Wnt signaling pathway, calcium modulating pathway |
TAS |
|
GO:0008134 |
Function |
Transcription factor binding |
IPI |
16714285, 25512613 |
GO:0018107 |
Process |
Peptidyl-threonine phosphorylation |
ISS |
|
GO:0030178 |
Process |
Negative regulation of Wnt signaling pathway |
ISS |
|
GO:0031625 |
Function |
Ubiquitin protein ligase binding |
IPI |
16714285 |
GO:0035556 |
Process |
Intracellular signal transduction |
IBA |
21873635 |
GO:0035556 |
Process |
Intracellular signal transduction |
ISS |
|
GO:0042169 |
Function |
SH2 domain binding |
ISS |
|
GO:0042501 |
Process |
Serine phosphorylation of STAT protein |
ISS |
|
GO:0046777 |
Process |
Protein autophosphorylation |
IEA |
|
GO:0050821 |
Process |
Protein stabilization |
IDA |
25512613 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q9UBE8 |
Protein name |
Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) |
Protein function |
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination (PubMed:12482967, PubMed:14960582, PubMed:15004007, PubMed:15764709, PubMed:20061393, PubMed:20874444, PubMed:21454679). P |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
138 → 427 |
Protein kinase domain |
Domain |
|
Sequence |
|
Sequence length |
527 |
Interactions |
View interactions |