NIT2 (nitrilase family member 2)

Gene

• Entrez ID: 56954
• Gene name: Nitrilase family member 2
• Gene symbol: NIT2
• Synonyms: HEL-S-8a
• Chromosome: 3
• Chromosome location: 3q12.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044603	hsa-miR-320a	CLASH	23622248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	TAS
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006107	Process	Oxaloacetate metabolic process	IBA	21873635
GO:0006107	Process	Oxaloacetate metabolic process	IDA	22674578
GO:0006528	Process	Asparagine metabolic process	IBA	21873635
GO:0006528	Process	Asparagine metabolic process	IDA	22674578
GO:0006541	Process	Glutamine metabolic process	IBA	21873635
GO:0006541	Process	Glutamine metabolic process	IDA	22674578
GO:0035580	Component	Specific granule lumen	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0050152	Function	Omega-amidase activity	IBA	21873635
GO:0050152	Function	Omega-amidase activity	IDA	22674578
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1904724	Component	Tertiary granule lumen	TAS

Other IDs

• MIM: 616769
• HGNC: 29878
• e!Ensembl: ENSG00000114021

Protein

• UniProt ID: Q9NQR4
• Protein name: Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2)
• Protein function: Has omega-amidase activity (PubMed:22674578, PubMed:19595734). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00795	CN_hydrolase	5 → 256	Carbon-nitrogen hydrolase	Family

• Sequence:

  MTSFRLALIQLQISSIKSDNVTRACSFIREAATQGAKIVSLPECFNSPYGAKYFPEYAEK
  IPGESTQKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDV
  PGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFN
  LTTGPAHWELLQRSRAVDNQVYVATASPARDDKASYVAWGHSTVVNPWGEVLAKAGTEEA
  IVYSDIDLKKLAEIRQQIPVFRQKRSDLYAVEMKKP

• Sequence length: 276