GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

NFKBIB (NFKB inhibitor beta)

Gene

4793

NFKB inhibitor beta

NFKBIB

IKBB, TRIP9

19q13.2

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the

Show/Hide all(226)

miRTarBase ID	miRNA	Experiments	Reference
MIRT731837	hsa-miR-20a-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26286834
MIRT731837	hsa-miR-20a-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26286834
MIRT1183525	hsa-miR-1	CLIP-seq
MIRT1183526	hsa-miR-206	CLIP-seq
MIRT1183527	hsa-miR-3064-3p	CLIP-seq
MIRT1183528	hsa-miR-3121-5p	CLIP-seq
MIRT1183529	hsa-miR-3168	CLIP-seq
MIRT1183530	hsa-miR-3652	CLIP-seq
MIRT1183531	hsa-miR-3663-5p	CLIP-seq
MIRT1183532	hsa-miR-3673	CLIP-seq
MIRT1183533	hsa-miR-4252	CLIP-seq
MIRT1183534	hsa-miR-4302	CLIP-seq
MIRT1183535	hsa-miR-4430	CLIP-seq
MIRT1183536	hsa-miR-4715-3p	CLIP-seq
MIRT1183537	hsa-miR-4763-5p	CLIP-seq
MIRT1183538	hsa-miR-4776-3p	CLIP-seq
MIRT1183539	hsa-miR-515-5p	CLIP-seq
MIRT1183540	hsa-miR-613	CLIP-seq
MIRT1183525	hsa-miR-1	CLIP-seq
MIRT2053178	hsa-miR-106a	CLIP-seq
MIRT2053179	hsa-miR-106b	CLIP-seq
MIRT2053180	hsa-miR-1182	CLIP-seq
MIRT2053181	hsa-miR-1234	CLIP-seq
MIRT2053182	hsa-miR-150	CLIP-seq
MIRT2053183	hsa-miR-17	CLIP-seq
MIRT2053184	hsa-miR-193a-5p	CLIP-seq
MIRT1183526	hsa-miR-206	CLIP-seq
MIRT2053185	hsa-miR-20a	CLIP-seq
MIRT2053186	hsa-miR-20b	CLIP-seq
MIRT2053187	hsa-miR-302a	CLIP-seq
MIRT2053188	hsa-miR-302b	CLIP-seq
MIRT2053189	hsa-miR-302c	CLIP-seq
MIRT2053190	hsa-miR-302d	CLIP-seq
MIRT2053191	hsa-miR-302e	CLIP-seq
MIRT1183527	hsa-miR-3064-3p	CLIP-seq
MIRT1183528	hsa-miR-3121-5p	CLIP-seq
MIRT1183529	hsa-miR-3168	CLIP-seq
MIRT2053192	hsa-miR-3187-3p	CLIP-seq
MIRT1183530	hsa-miR-3652	CLIP-seq
MIRT1183531	hsa-miR-3663-5p	CLIP-seq
MIRT1183532	hsa-miR-3673	CLIP-seq
MIRT2053193	hsa-miR-372	CLIP-seq
MIRT2053194	hsa-miR-373	CLIP-seq
MIRT1183533	hsa-miR-4252	CLIP-seq
MIRT2053195	hsa-miR-431	CLIP-seq
MIRT1183535	hsa-miR-4430	CLIP-seq
MIRT2053196	hsa-miR-4435	CLIP-seq
MIRT2053197	hsa-miR-4438	CLIP-seq
MIRT2053198	hsa-miR-4659a-5p	CLIP-seq
MIRT2053199	hsa-miR-4659b-5p	CLIP-seq
MIRT2053200	hsa-miR-4682	CLIP-seq
MIRT2053201	hsa-miR-4701-5p	CLIP-seq
MIRT1183536	hsa-miR-4715-3p	CLIP-seq
MIRT2053202	hsa-miR-4716-5p	CLIP-seq
MIRT2053203	hsa-miR-4731-5p	CLIP-seq
MIRT2053204	hsa-miR-4755-3p	CLIP-seq
MIRT1183537	hsa-miR-4763-5p	CLIP-seq
MIRT1183538	hsa-miR-4776-3p	CLIP-seq
MIRT2053205	hsa-miR-4781-3p	CLIP-seq
MIRT2053206	hsa-miR-498	CLIP-seq
MIRT2053207	hsa-miR-5095	CLIP-seq
MIRT2053208	hsa-miR-512-3p	CLIP-seq
MIRT1183539	hsa-miR-515-5p	CLIP-seq
MIRT2053209	hsa-miR-519d	CLIP-seq
MIRT2053210	hsa-miR-520a-3p	CLIP-seq
MIRT2053211	hsa-miR-520b	CLIP-seq
MIRT2053212	hsa-miR-520c-3p	CLIP-seq
MIRT2053213	hsa-miR-520d-3p	CLIP-seq
MIRT2053214	hsa-miR-520e	CLIP-seq
MIRT2053215	hsa-miR-520g	CLIP-seq
MIRT2053216	hsa-miR-520h	CLIP-seq
MIRT2053217	hsa-miR-548s	CLIP-seq
MIRT2053218	hsa-miR-588	CLIP-seq
MIRT1183540	hsa-miR-613	CLIP-seq
MIRT2053219	hsa-miR-614	CLIP-seq
MIRT2053220	hsa-miR-93	CLIP-seq
MIRT1183525	hsa-miR-1	CLIP-seq
MIRT2053178	hsa-miR-106a	CLIP-seq
MIRT2053179	hsa-miR-106b	CLIP-seq
MIRT2053180	hsa-miR-1182	CLIP-seq
MIRT2053181	hsa-miR-1234	CLIP-seq
MIRT2282475	hsa-miR-136	CLIP-seq
MIRT2053182	hsa-miR-150	CLIP-seq
MIRT2053183	hsa-miR-17	CLIP-seq
MIRT2282476	hsa-miR-1915	CLIP-seq
MIRT2053184	hsa-miR-193a-5p	CLIP-seq
MIRT1183526	hsa-miR-206	CLIP-seq
MIRT2053185	hsa-miR-20a	CLIP-seq
MIRT2053186	hsa-miR-20b	CLIP-seq
MIRT2053187	hsa-miR-302a	CLIP-seq
MIRT2053188	hsa-miR-302b	CLIP-seq
MIRT2053189	hsa-miR-302c	CLIP-seq
MIRT2053190	hsa-miR-302d	CLIP-seq
MIRT2053191	hsa-miR-302e	CLIP-seq
MIRT2282477	hsa-miR-3160-3p	CLIP-seq
MIRT2053192	hsa-miR-3187-3p	CLIP-seq
MIRT2282478	hsa-miR-34b	CLIP-seq
MIRT1183530	hsa-miR-3652	CLIP-seq
MIRT1183531	hsa-miR-3663-5p	CLIP-seq
MIRT1183532	hsa-miR-3673	CLIP-seq
MIRT2053193	hsa-miR-372	CLIP-seq
MIRT2053194	hsa-miR-373	CLIP-seq
MIRT2282479	hsa-miR-411	CLIP-seq
MIRT2282480	hsa-miR-4279	CLIP-seq
MIRT1183534	hsa-miR-4302	CLIP-seq
MIRT2053195	hsa-miR-431	CLIP-seq
MIRT2282481	hsa-miR-4420	CLIP-seq
MIRT1183535	hsa-miR-4430	CLIP-seq
MIRT2053196	hsa-miR-4435	CLIP-seq
MIRT2053197	hsa-miR-4438	CLIP-seq
MIRT2282482	hsa-miR-4487	CLIP-seq
MIRT2282483	hsa-miR-4488	CLIP-seq
MIRT2053198	hsa-miR-4659a-5p	CLIP-seq
MIRT2053199	hsa-miR-4659b-5p	CLIP-seq
MIRT2282484	hsa-miR-4697-5p	CLIP-seq
MIRT2053201	hsa-miR-4701-5p	CLIP-seq
MIRT2053202	hsa-miR-4716-5p	CLIP-seq
MIRT2282485	hsa-miR-4726-3p	CLIP-seq
MIRT2053203	hsa-miR-4731-5p	CLIP-seq
MIRT2053204	hsa-miR-4755-3p	CLIP-seq
MIRT1183537	hsa-miR-4763-5p	CLIP-seq
MIRT2282486	hsa-miR-4772-3p	CLIP-seq
MIRT1183538	hsa-miR-4776-3p	CLIP-seq
MIRT2282487	hsa-miR-4777-3p	CLIP-seq
MIRT2053205	hsa-miR-4781-3p	CLIP-seq
MIRT2053207	hsa-miR-5095	CLIP-seq
MIRT2053208	hsa-miR-512-3p	CLIP-seq
MIRT1183539	hsa-miR-515-5p	CLIP-seq
MIRT2053209	hsa-miR-519d	CLIP-seq
MIRT2053210	hsa-miR-520a-3p	CLIP-seq
MIRT2053211	hsa-miR-520b	CLIP-seq
MIRT2053212	hsa-miR-520c-3p	CLIP-seq
MIRT2053213	hsa-miR-520d-3p	CLIP-seq
MIRT2053214	hsa-miR-520e	CLIP-seq
MIRT2053215	hsa-miR-520g	CLIP-seq
MIRT2053216	hsa-miR-520h	CLIP-seq
MIRT2053217	hsa-miR-548s	CLIP-seq
MIRT2282488	hsa-miR-558	CLIP-seq
MIRT2282489	hsa-miR-562	CLIP-seq
MIRT2053218	hsa-miR-588	CLIP-seq
MIRT1183540	hsa-miR-613	CLIP-seq
MIRT2053219	hsa-miR-614	CLIP-seq
MIRT2282490	hsa-miR-637	CLIP-seq
MIRT2053220	hsa-miR-93	CLIP-seq
MIRT2053180	hsa-miR-1182	CLIP-seq
MIRT2053184	hsa-miR-193a-5p	CLIP-seq
MIRT2455110	hsa-miR-3149	CLIP-seq
MIRT2282479	hsa-miR-411	CLIP-seq
MIRT2455111	hsa-miR-4735-5p	CLIP-seq
MIRT2455112	hsa-miR-4775	CLIP-seq
MIRT2455113	hsa-miR-4787-3p	CLIP-seq
MIRT2455114	hsa-miR-590-3p	CLIP-seq
MIRT2053180	hsa-miR-1182	CLIP-seq
MIRT2053184	hsa-miR-193a-5p	CLIP-seq
MIRT2455110	hsa-miR-3149	CLIP-seq
MIRT2282479	hsa-miR-411	CLIP-seq
MIRT2455111	hsa-miR-4735-5p	CLIP-seq
MIRT2455112	hsa-miR-4775	CLIP-seq
MIRT2455114	hsa-miR-590-3p	CLIP-seq
MIRT2053180	hsa-miR-1182	CLIP-seq
MIRT2053181	hsa-miR-1234	CLIP-seq
MIRT2053182	hsa-miR-150	CLIP-seq
MIRT2282476	hsa-miR-1915	CLIP-seq
MIRT2053184	hsa-miR-193a-5p	CLIP-seq
MIRT2455110	hsa-miR-3149	CLIP-seq
MIRT2282479	hsa-miR-411	CLIP-seq
MIRT2282480	hsa-miR-4279	CLIP-seq
MIRT2053195	hsa-miR-431	CLIP-seq
MIRT2282485	hsa-miR-4726-3p	CLIP-seq
MIRT2455111	hsa-miR-4735-5p	CLIP-seq
MIRT1183537	hsa-miR-4763-5p	CLIP-seq
MIRT2455112	hsa-miR-4775	CLIP-seq
MIRT2282487	hsa-miR-4777-3p	CLIP-seq
MIRT2455113	hsa-miR-4787-3p	CLIP-seq
MIRT2053206	hsa-miR-498	CLIP-seq
MIRT2282489	hsa-miR-562	CLIP-seq
MIRT2455114	hsa-miR-590-3p	CLIP-seq
MIRT1183525	hsa-miR-1	CLIP-seq
MIRT2053178	hsa-miR-106a	CLIP-seq
MIRT2053179	hsa-miR-106b	CLIP-seq
MIRT2053180	hsa-miR-1182	CLIP-seq
MIRT2053181	hsa-miR-1234	CLIP-seq
MIRT2053182	hsa-miR-150	CLIP-seq
MIRT2053183	hsa-miR-17	CLIP-seq
MIRT2282476	hsa-miR-1915	CLIP-seq
MIRT2053184	hsa-miR-193a-5p	CLIP-seq
MIRT1183526	hsa-miR-206	CLIP-seq
MIRT2053185	hsa-miR-20a	CLIP-seq
MIRT2053186	hsa-miR-20b	CLIP-seq
MIRT2053187	hsa-miR-302a	CLIP-seq
MIRT2053188	hsa-miR-302b	CLIP-seq
MIRT2053189	hsa-miR-302c	CLIP-seq
MIRT2053190	hsa-miR-302d	CLIP-seq
MIRT2053191	hsa-miR-302e	CLIP-seq
MIRT2455110	hsa-miR-3149	CLIP-seq
MIRT1183530	hsa-miR-3652	CLIP-seq
MIRT1183532	hsa-miR-3673	CLIP-seq
MIRT2053193	hsa-miR-372	CLIP-seq
MIRT2053194	hsa-miR-373	CLIP-seq
MIRT2282479	hsa-miR-411	CLIP-seq
MIRT2282480	hsa-miR-4279	CLIP-seq
MIRT2053195	hsa-miR-431	CLIP-seq
MIRT1183535	hsa-miR-4430	CLIP-seq
MIRT2053197	hsa-miR-4438	CLIP-seq
MIRT2282485	hsa-miR-4726-3p	CLIP-seq
MIRT2053203	hsa-miR-4731-5p	CLIP-seq
MIRT2455111	hsa-miR-4735-5p	CLIP-seq
MIRT1183537	hsa-miR-4763-5p	CLIP-seq
MIRT2455112	hsa-miR-4775	CLIP-seq
MIRT2282487	hsa-miR-4777-3p	CLIP-seq
MIRT2455113	hsa-miR-4787-3p	CLIP-seq
MIRT2053206	hsa-miR-498	CLIP-seq
MIRT2053207	hsa-miR-5095	CLIP-seq
MIRT2053208	hsa-miR-512-3p	CLIP-seq
MIRT2053209	hsa-miR-519d	CLIP-seq
MIRT2053210	hsa-miR-520a-3p	CLIP-seq
MIRT2053211	hsa-miR-520b	CLIP-seq
MIRT2053212	hsa-miR-520c-3p	CLIP-seq
MIRT2053213	hsa-miR-520d-3p	CLIP-seq
MIRT2053214	hsa-miR-520e	CLIP-seq
MIRT2053215	hsa-miR-520g	CLIP-seq
MIRT2053216	hsa-miR-520h	CLIP-seq
MIRT2282489	hsa-miR-562	CLIP-seq
MIRT2455114	hsa-miR-590-3p	CLIP-seq
MIRT1183540	hsa-miR-613	CLIP-seq
MIRT2053220	hsa-miR-93	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SRY	Unknown	12475944

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	TAS	7776974
GO:0005515	Function	Protein binding	IPI	10498867, 14685242, 14743216, 15601829, 21988832, 24973451, 25241761, 25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006351	Process	Transcription, DNA-templated	TAS	7776974
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007253	Process	Cytoplasmic sequestering of NF-kappaB	IBA	21873635
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA	21873635

MIM	HGNC	e!Ensembl
604495	7798	ENSG00000104825

Protein

UniProt ID

Q15653

Protein name

NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)

Protein function

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA

PDB

9CK0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13637	Ank_4	58 → 113		Repeat
PF00023	Ank	126 → 151	Ankyrin repeat	Repeat
PF13637	Ank_4	207 → 261		Repeat

Sequence

MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDT
ALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL
CVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALY
PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC
GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE
PEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV

Sequence length

356

Interactions

View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412