NECTIN3 (nectin cell adhesion molecule 3)

Gene

• Entrez ID: 25945
• Gene name: Nectin cell adhesion molecule 3
• Gene symbol: NECTIN3
• Synonyms: CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRL3, PVRR3
• Chromosome: 3
• Chromosome location: 3q13.13
• Summary: This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regu

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs79006549	A>C,G	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT450740	hsa-miR-548n	PAR-CLIP	22100165
MIRT450739	hsa-miR-548a-5p	PAR-CLIP	22100165
MIRT450738	hsa-miR-548ab	PAR-CLIP	22100165
MIRT450737	hsa-miR-548ad-5p	PAR-CLIP	22100165
MIRT450736	hsa-miR-548ae-5p	PAR-CLIP	22100165
MIRT450735	hsa-miR-548ak	PAR-CLIP	22100165
MIRT450734	hsa-miR-548am-5p	PAR-CLIP	22100165
MIRT450733	hsa-miR-548ap-5p	PAR-CLIP	22100165
MIRT450732	hsa-miR-548aq-5p	PAR-CLIP	22100165
MIRT450731	hsa-miR-548ar-5p	PAR-CLIP	22100165
MIRT450730	hsa-miR-548as-5p	PAR-CLIP	22100165
MIRT450729	hsa-miR-548au-5p	PAR-CLIP	22100165
MIRT450728	hsa-miR-548ay-5p	PAR-CLIP	22100165
MIRT450727	hsa-miR-548b-5p	PAR-CLIP	22100165
MIRT450726	hsa-miR-548bb-5p	PAR-CLIP	22100165
MIRT450725	hsa-miR-548c-5p	PAR-CLIP	22100165
MIRT450724	hsa-miR-548d-5p	PAR-CLIP	22100165
MIRT450723	hsa-miR-548h-5p	PAR-CLIP	22100165
MIRT450722	hsa-miR-548i	PAR-CLIP	22100165
MIRT450721	hsa-miR-548j-5p	PAR-CLIP	22100165
MIRT450720	hsa-miR-548o-5p	PAR-CLIP	22100165
MIRT450719	hsa-miR-548w	PAR-CLIP	22100165
MIRT450718	hsa-miR-548y	PAR-CLIP	22100165
MIRT450717	hsa-miR-559	PAR-CLIP	22100165
MIRT450716	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450715	hsa-miR-3163	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002089	Process	Lens morphogenesis in camera-type eye	IEA
GO:0005515	Function	Protein binding	IPI	19011627, 21982860, 23758976, 25416956, 31515488, 32814053
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	ISS
GO:0005912	Component	Adherens junction	IBA	21873635
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IBA	21873635
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	ISS
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA	21873635
GO:0007286	Process	Spermatid development	IEA
GO:0009566	Process	Fertilization	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0034332	Process	Adherens junction organization	TAS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043296	Component	Apical junction complex	IBA	21873635
GO:0044291	Component	Cell-cell contact zone	IEA
GO:0050839	Function	Cell adhesion molecule binding	IPI	12438620
GO:0060042	Process	Retina morphogenesis in camera-type eye	IEA
GO:0061951	Process	Establishment of protein localization to plasma membrane	ISS
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0099061	Component	Integral component of postsynaptic density membrane	IEA
GO:1902414	Process	Protein localization to cell junction	IEA

Other IDs

• MIM: 607147
• HGNC: 17664
• e!Ensembl: ENSG00000177707

Protein

• UniProt ID: Q9NQS3
• Protein name: Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
• Protein function: Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with P
• PDB: 4FOM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	61 → 167	Immunoglobulin V-set domain	Domain
  PF08205	C2-set_2	173 → 257	CD80-like C2-set immunoglobulin domain	Domain

• Sequence:

  MARTLRPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPI
  IVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGR
  VLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDS
  LIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFAR
  GRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPF
  KSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPT
  TTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVS
  VLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNN
  LIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGS
  VISRREWYV

• Sequence length: 549