MYL12B (myosin light chain 12B)

Gene

• Entrez ID: 103910
• Gene name: Myosin light chain 12B
• Gene symbol: MYL12B
• Synonyms: MLC-B, MRLC2
• Chromosome: 18
• Chromosome location: 18p11.31
• Summary: The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT041406	hsa-miR-193b-3p	CLASH	23622248
MIRT080000	hsa-miR-379-3p	PAR-CLIP	20371350
MIRT080001	hsa-miR-411-3p	PAR-CLIP	20371350
MIRT080002	hsa-miR-1253	PAR-CLIP	20371350
MIRT080003	hsa-miR-4311	PAR-CLIP	20371350
MIRT080004	hsa-miR-4251	PAR-CLIP	20371350
MIRT080005	hsa-miR-548ao-5p	PAR-CLIP	20371350
MIRT080006	hsa-miR-548ax	PAR-CLIP	20371350
MIRT080009	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT561167	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT561168	hsa-miR-4329	PAR-CLIP	20371350
MIRT561169	hsa-miR-641	PAR-CLIP	20371350
MIRT561170	hsa-miR-582-3p	PAR-CLIP	20371350
MIRT561171	hsa-miR-3617-5p	PAR-CLIP	20371350

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	19328794, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0006936	Process	Muscle contraction	TAS
GO:0016459	Component	Myosin complex	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0099738	Component	Cell cortex region	IDA	23870127

Other IDs

• MIM: 609211
• HGNC: 29827
• e!Ensembl: ENSG00000118680

Protein

• UniProt ID: O14950
• Protein name: Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
• Protein function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13405	EF-hand_6	33 → 62	EF-hand domain	Domain
  PF08976	EF-hand_11	92 → 168	EF-hand domain	Domain

• Sequence:

  MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
  LGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE
  DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD

• Sequence length: 172