MYL12A (myosin light chain 12A)

Gene

• Entrez ID: 10627
• Gene name: Myosin light chain 12A
• Gene symbol: MYL12A
• Synonyms: HEL-S-24, MLC-2B, MLCB, MRCL3, MRLC3, MYL2B
• Chromosome: 18
• Chromosome location: 18p11.31
• Summary: This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT462577	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT462578	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT462579	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT462580	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT462581	hsa-miR-1275	PAR-CLIP	23592263
MIRT462582	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT462583	hsa-miR-4525	PAR-CLIP	23592263
MIRT462584	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT462585	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT462586	hsa-miR-5698	PAR-CLIP	23592263
MIRT462587	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT462588	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT462589	hsa-miR-3175	PAR-CLIP	23592263
MIRT462590	hsa-miR-762	PAR-CLIP	23592263
MIRT462591	hsa-miR-5001-5p	PAR-CLIP	23592263
MIRT462592	hsa-miR-4492	PAR-CLIP	23592263
MIRT462593	hsa-miR-4498	PAR-CLIP	23592263
MIRT462594	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT462595	hsa-miR-5703	PAR-CLIP	23592263
MIRT462596	hsa-miR-4516	PAR-CLIP	23592263
MIRT462597	hsa-miR-4434	PAR-CLIP	23592263
MIRT462598	hsa-miR-133a-5p	PAR-CLIP	23592263
MIRT462599	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT462600	hsa-miR-154-5p	PAR-CLIP	23592263
MIRT462601	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT462602	hsa-miR-6502-3p	PAR-CLIP	23592263
MIRT462603	hsa-miR-3154	PAR-CLIP	23592263
MIRT462604	hsa-miR-140-3p	PAR-CLIP	23592263

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	21457715
GO:0005829	Component	Cytosol	TAS
GO:0006936	Process	Muscle contraction	TAS
GO:0016459	Component	Myosin complex	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070527	Process	Platelet aggregation	HMP	23382103

Other IDs

• MIM: HGNC

Protein

• UniProt ID: P19105
• Protein name: Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)
• Protein function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
• UniProt ID: O14950
• Protein name: Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
• Protein function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13405	EF-hand_6	33 → 62	EF-hand domain	Domain
  PF08976	EF-hand_11	92 → 168	EF-hand domain	Domain

• Sequence:

  MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS
  LGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE
  DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD

• Sequence length: 172