MPO (myeloperoxidase)

Gene

• Entrez ID: 4353
• Gene name: Myeloperoxidase
• Gene symbol: MPO
• Synonyms: -
• Chromosome: 17
• Chromosome location: 17q22
• Summary: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heav

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs35897051	T>G	Pathogenic	Splice acceptor variant
rs78950939	T>C	Pathogenic	Missense variant, coding sequence variant
rs119468010	G>A	Pathogenic	Coding sequence variant, missense variant
rs119469012	A>C,G	Pathogenic	Coding sequence variant, missense variant
rs119469013	C>A,T	Pathogenic	Coding sequence variant, missense variant
rs119469014	G>A,C	Pathogenic	Coding sequence variant, missense variant
rs536522394	TTGGGTTCCATGGG>-,TTGGGTTCCATGGGTTGGGTTCCATGGG	Pathogenic, pathogenic-likely-pathogenic	Frameshift variant, coding sequence variant
rs762933005	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs778013714	C>A	Likely-pathogenic	Stop gained, coding sequence variant
rs1555607599	A>G	Likely-pathogenic	Splice donor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT532437	hsa-miR-8485	PAR-CLIP	20371350
MIRT532436	hsa-miR-1324	PAR-CLIP	20371350
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	20371350
MIRT532437	hsa-miR-8485	PAR-CLIP	22012620
MIRT532436	hsa-miR-1324	PAR-CLIP	22012620
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	22012620
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	27292025
MIRT532436	hsa-miR-1324	PAR-CLIP	27292025
MIRT532436	hsa-miR-1324	PAR-CLIP	27292025
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	27292025
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	27292025
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	27292025
MIRT532437	hsa-miR-8485	PAR-CLIP	27292025
MIRT532437	hsa-miR-8485	PAR-CLIP	27292025
MIRT532437	hsa-miR-8485	PAR-CLIP	27292025
MIRT532437	hsa-miR-8485	PAR-CLIP	20371350
MIRT532436	hsa-miR-1324	PAR-CLIP	20371350
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	20371350
MIRT532437	hsa-miR-8485	PAR-CLIP	22012620
MIRT532436	hsa-miR-1324	PAR-CLIP	22012620
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	22012620
MIRT1156259	hsa-miR-3646	CLIP-seq
MIRT1156260	hsa-miR-3907	CLIP-seq
MIRT1156261	hsa-miR-3915	CLIP-seq
MIRT1156262	hsa-miR-3928	CLIP-seq
MIRT1156263	hsa-miR-451b	CLIP-seq
MIRT1156264	hsa-miR-4694-3p	CLIP-seq
MIRT1156265	hsa-miR-4710	CLIP-seq
MIRT1156266	hsa-miR-522	CLIP-seq
MIRT1156260	hsa-miR-3907	CLIP-seq
MIRT2273957	hsa-miR-3194-3p	CLIP-seq
MIRT1156260	hsa-miR-3907	CLIP-seq
MIRT2273958	hsa-miR-4267	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
RUNX1	Unknown	11023523
SP1	Activation	17521322;8662930
SP1	Unknown	12057865

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001878	Process	Response to yeast	IEA
GO:0002149	Process	Hypochlorous acid biosynthetic process	IEA
GO:0002679	Process	Respiratory burst involved in defense response	IEA
GO:0003682	Function	Chromatin binding	TAS	2829220
GO:0004601	Function	Peroxidase activity	IBA	21873635
GO:0004601	Function	Peroxidase activity	IDA	10772654, 11907569, 24035742
GO:0005515	Function	Protein binding	IPI	24355864, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	10772654, 25645918
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005654	Component	Nucleoplasm	IDA
GO:0005764	Component	Lysosome	TAS	8621627
GO:0006952	Process	Defense response	TAS	8621627
GO:0006979	Process	Response to oxidative stress	TAS	2903767
GO:0007568	Process	Aging	IEA
GO:0008201	Function	Heparin binding	IDA	11907569
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0019430	Process	Removal of superoxide radicals	IEA
GO:0020037	Function	Heme binding	IEA
GO:0030141	Component	Secretory granule	IDA	11907569
GO:0032094	Process	Response to food	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034374	Process	Low-density lipoprotein particle remodeling	IDA	10772654
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0042582	Component	Azurophil granule	IDA	2981589
GO:0042742	Process	Defense response to bacterium	IBA	21873635
GO:0042744	Process	Hydrogen peroxide catabolic process	IDA	10772654, 11907569
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10801811
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045454	Process	Cell redox homeostasis	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0050832	Process	Defense response to fungus	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0097013	Component	Phagocytic vesicle lumen	TAS
GO:1990268	Process	Response to gold nanoparticle	IEA

Other IDs

• MIM: 606989
• HGNC: 7218
• e!Ensembl: ENSG00000005381

Protein

• UniProt ID: P05164
• Protein name: Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]
• Protein function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid
• PDB: 1CXP, 1D2V, 1D5L, 1D7W, 1DNU, 1DNW, 1MHL, 1MYP, 3F9P, 3ZS0, 3ZS1, 4C1M, 4DL1, 4EJX, 5FIW, 5MFA, 5UZU, 6AZP, 6BMT, 7OIH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03098	An_peroxidase	173 → 718	Animal haem peroxidase	Domain

• Sequence:

  MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
  LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
  VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
  NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
  QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
  PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
  GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
  REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
  SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
  GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
  AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
  LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
  NSYPRDFVNCSTLPALNLASWREAS

• Sequence length: 745