MPO (myeloperoxidase)

Gene

• Entrez ID: 4353
• Gene name: Myeloperoxidase
• Gene symbol: MPO
• Synonyms: -
• Chromosome: 17
• Chromosome location: 17q22
• Summary: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs35897051	T>G	Pathogenic	Splice acceptor variant
rs78950939	T>C	Pathogenic	Missense variant, coding sequence variant
rs119468010	G>A	Pathogenic	Coding sequence variant, missense variant
rs119469012	A>C,G	Pathogenic	Coding sequence variant, missense variant
rs119469013	C>A,T	Pathogenic	Coding sequence variant, missense variant
rs119469014	G>A,C	Pathogenic	Coding sequence variant, missense variant
rs536522394	TTGGGTTCCATGGG>-,TTGGGTTCCATGGGTTGGGTTCCATGGG	Pathogenic, pathogenic-likely-pathogenic	Frameshift variant, coding sequence variant
rs762933005	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs778013714	C>A	Likely-pathogenic	Stop gained, coding sequence variant
rs1555607599	A>G	Likely-pathogenic	Splice donor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	22012620
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	20371350
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	26701625
MIRT532435	hsa-miR-4716-5p	PAR-CLIP	27292025
MIRT532436	hsa-miR-1324	PAR-CLIP	22012620
MIRT532436	hsa-miR-1324	PAR-CLIP	20371350
MIRT532436	hsa-miR-1324	PAR-CLIP	26701625
MIRT532436	hsa-miR-1324	PAR-CLIP	27292025
MIRT532437	hsa-miR-8485	PAR-CLIP	22012620
MIRT532437	hsa-miR-8485	PAR-CLIP	20371350
MIRT532437	hsa-miR-8485	PAR-CLIP	26701625
MIRT532437	hsa-miR-8485	PAR-CLIP	27292025

Transcription factors

Transcription factor	Regulation	Reference
RUNX1	Unknown	11023523
SP1	Activation	17521322;8662930
SP1	Unknown	12057865

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001878	Process	Response to yeast	IEA
GO:0002149	Process	Hypochlorous acid biosynthetic process	IEA
GO:0002679	Process	Respiratory burst involved in defense response	IEA
GO:0003682	Function	Chromatin binding	TAS	2829220
GO:0004601	Function	Peroxidase activity	IBA	21873635
GO:0004601	Function	Peroxidase activity	IDA	10772654, 11907569, 24035742
GO:0005515	Function	Protein binding	IPI	24355864, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	10772654, 25645918
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005654	Component	Nucleoplasm	IDA
GO:0005764	Component	Lysosome	TAS	8621627
GO:0006952	Process	Defense response	TAS	8621627
GO:0006979	Process	Response to oxidative stress	TAS	2903767
GO:0007568	Process	Aging	IEA
GO:0008201	Function	Heparin binding	IDA	11907569
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0019430	Process	Removal of superoxide radicals	IEA
GO:0020037	Function	Heme binding	IEA
GO:0030141	Component	Secretory granule	IDA	11907569
GO:0032094	Process	Response to food	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034374	Process	Low-density lipoprotein particle remodeling	IDA	10772654
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0042582	Component	Azurophil granule	IDA	2981589
GO:0042742	Process	Defense response to bacterium	IBA	21873635
GO:0042744	Process	Hydrogen peroxide catabolic process	IDA	10772654, 11907569
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10801811
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045454	Process	Cell redox homeostasis	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0050832	Process	Defense response to fungus	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0097013	Component	Phagocytic vesicle lumen	TAS
GO:1990268	Process	Response to gold nanoparticle	IEA

Other IDs

• MIM: 606989
• HGNC: 7218
• e!Ensembl: ENSG00000005381

Protein

• UniProt ID: P05164
• Protein name: Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]
• Protein function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
• PDB: 1CXP, 1D2V, 1D5L, 1D7W, 1DNU, 1DNW, 1MHL, 1MYP, 3F9P, 3ZS0, 3ZS1, 4C1M, 4DL1, 4EJX, 5FIW, 5MFA, 5UZU, 6AZP, 6BMT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03098	An_peroxidase	173 → 718	Animal haem peroxidase	Domain

• Sequence:

  MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
  LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
  VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
  NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
  QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
  PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
  GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
  REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
  SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
  GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
  AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
  LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
  NSYPRDFVNCSTLPALNLASWREAS

• Sequence length: 745