GediPNet logo

MET (MET proto-oncogene, receptor tyrosine kinase)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4233
Gene nameGene Name - the full gene name approved by the HGNC.
MET proto-oncogene, receptor tyrosine kinase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MET
SynonymsGene synonyms aliases
AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs34589476 C>T Likely-pathogenic, conflicting-interpretations-of-pathogenicity, likely-benign Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
rs35776110 C>T Conflicting-interpretations-of-pathogenicity, likely-benign, benign-likely-benign Non coding transcript variant, genic upstream transcript variant, missense variant, intron variant, coding sequence variant
rs45520237 C>T Conflicting-interpretations-of-pathogenicity, likely-benign Non coding transcript variant, synonymous variant, coding sequence variant
rs56311081 C>A,T Conflicting-interpretations-of-pathogenicity, likely-benign Non coding transcript variant, stop gained, genic upstream transcript variant, missense variant, intron variant, coding sequence variant
rs56391007 C>T Uncertain-significance, conflicting-interpretations-of-pathogenicity, likely-pathogenic, benign-likely-benign Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001969 hsa-miR-199a-3p Luciferase reporter assay, Western blot 18456660
MIRT004292 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR, Western blot 19490101
MIRT004292 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR, Western blot 19490101
MIRT004292 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR, Western blot 19490101
MIRT004292 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR, Western blot 19490101
Transcription factors
Transcription factor Regulation Reference
FOXP2 Repression 21832174
HIF1A Activation 16099863
MITF Unknown 17371876
PAX3 Unknown 8633043
PAX5 Activation 24628993
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001886 Process Endothelial cell morphogenesis IDA 14500721
GO:0001889 Process Liver development IBA 21873635
GO:0004713 Function Protein tyrosine kinase activity NAS 3325883
GO:0004713 Function Protein tyrosine kinase activity TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P08581
Protein name Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Protein function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and su
PDB 1FYR , 1R0P , 1R1W , 1SHY , 1SSL , 2G15 , 2RFN , 2RFS , 2UZX , 2UZY , 2WD1 , 2WGJ , 2WKM , 3A4P , 3BUX , 3C1X , 3CCN , 3CD8 , 3CE3 , 3CTH , 3CTJ , 3DKC , 3DKF , 3DKG , 3EFJ , 3EFK , 3F66 , 3F82 , 3I5N , 3L8V , 3LQ8 , 3Q6U , 3Q6W , 3QTI , 3R7O , 3RHK , 3U6H , 3U6I , 3VW8 , 3ZBX , 3ZC5 , 3ZCL , 3ZXZ , 3ZZE , 4AOI , 4AP7 , 4DEG , 4DEH , 4DEI , 4EEV , 4GG5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01403 Sema
54 493
Sema domain
Family
PF01437 PSI
519 562
Plexin repeat
Family
PF01833 TIG
563 654
IPT/TIG domain
Domain
PF01833 TIG
657 738
IPT/TIG domain
Domain
PF01833 TIG
742 832
IPT/TIG domain
Domain
PF07714 PK_Tyr_Ser-Thr
1078 1337
Protein tyrosine and serine/threonine kinase
Domain
Sequence
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVE
HTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICL
PAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSY
VDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSY
REDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFD
LIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRI
SAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS
Sequence length 1390
Interactions View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412