Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5601 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Mitogen-activated protein kinase 9 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
MAPK9 |
SynonymsGene synonyms aliases
|
JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK |
ChromosomeChromosome number
|
5 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q35.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IBA |
21873635 |
GO:0004705 |
Function |
JUN kinase activity |
IBA |
21873635 |
GO:0004705 |
Function |
JUN kinase activity |
IDA |
8654373 |
GO:0004707 |
Function |
MAP kinase activity |
IBA |
21873635 |
GO:0004712 |
Function |
Protein serine/threonine/tyrosine kinase activity |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
10376527, 15158451, 16189514, 16288922, 19060904, 20871632, 21516116, 21988832, 25241761, 25416956, 28089251, 29892012, 31515488, 32296183 |
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005739 |
Component |
Mitochondrion |
IEA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006468 |
Process |
Protein phosphorylation |
IMP |
22441692 |
GO:0007254 |
Process |
JNK cascade |
IBA |
21873635 |
GO:0007254 |
Process |
JNK cascade |
IDA |
8654373 |
GO:0007254 |
Process |
JNK cascade |
TAS |
|
GO:0007258 |
Process |
JUN phosphorylation |
IEA |
|
GO:0008134 |
Function |
Transcription factor binding |
IDA |
10376527 |
GO:0010628 |
Process |
Positive regulation of gene expression |
IMP |
18262097 |
GO:0010744 |
Process |
Positive regulation of macrophage derived foam cell differentiation |
IMP |
18262097 |
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
IDA |
21856198 |
GO:0031398 |
Process |
Positive regulation of protein ubiquitination |
IEA |
|
GO:0034614 |
Process |
Cellular response to reactive oxygen species |
IMP |
26514923 |
GO:0035556 |
Process |
Intracellular signal transduction |
IBA |
21873635 |
GO:0038095 |
Process |
Fc-epsilon receptor signaling pathway |
TAS |
|
GO:0042752 |
Process |
Regulation of circadian rhythm |
ISS |
|
GO:0048511 |
Process |
Rhythmic process |
IEA |
|
GO:0051090 |
Process |
Regulation of DNA-binding transcription factor activity |
TAS |
|
GO:0061833 |
Process |
Protein localization to tricellular tight junction |
IEA |
|
GO:0071276 |
Process |
Cellular response to cadmium ion |
IMP |
26514923 |
GO:0071803 |
Process |
Positive regulation of podosome assembly |
IEA |
|
GO:1901485 |
Process |
Positive regulation of transcription factor catabolic process |
IEA |
|
GO:2001235 |
Process |
Positive regulation of apoptotic signaling pathway |
IEA |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P45984 |
Protein name |
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) |
Protein function |
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death (PubMed:10376527, PubMed:15805466, PubMed:17525747, PubMed:19675674, PubMed:20595622, |
PDB |
3E7O
,
3NPC
,
7CML
,
7N8T
,
8ELC
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
26 → 321 |
Protein kinase domain |
Domain |
|
Sequence |
|
Sequence length |
424 |
Interactions |
View interactions |