MAPK13 (mitogen-activated protein kinase 13)

Gene

• Entrez ID: 5603
• Gene name: Mitogen-activated protein kinase 13
• Gene symbol: MAPK13
• Synonyms: MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta
• Chromosome: 6
• Chromosome location: 6p21.31
• Summary: This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, tra

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT519502	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT519501	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT519499	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT519500	hsa-miR-4761-5p	PAR-CLIP	23446348
MIRT519498	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT519497	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT519496	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT519495	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT519494	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT462717	hsa-miR-4773	PAR-CLIP	23592263
MIRT462716	hsa-miR-4690-3p	PAR-CLIP	23592263
MIRT462715	hsa-miR-5685	PAR-CLIP	23592263
MIRT462714	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT462713	hsa-miR-4534	PAR-CLIP	23592263
MIRT462711	hsa-miR-8082	PAR-CLIP	23592263
MIRT462712	hsa-miR-3134	PAR-CLIP	23592263
MIRT462710	hsa-miR-4434	PAR-CLIP	23592263
MIRT462709	hsa-miR-4516	PAR-CLIP	23592263
MIRT462708	hsa-miR-5703	PAR-CLIP	23592263
MIRT462707	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT462706	hsa-miR-4525	PAR-CLIP	23592263
MIRT462705	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT462704	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT462702	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT462703	hsa-miR-4531	PAR-CLIP	23592263
MIRT462701	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT519502	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT519501	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT519499	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT519500	hsa-miR-4761-5p	PAR-CLIP	23446348
MIRT519498	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT519497	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT519496	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT519495	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT519494	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT462717	hsa-miR-4773	PAR-CLIP	23592263
MIRT462716	hsa-miR-4690-3p	PAR-CLIP	23592263
MIRT462715	hsa-miR-5685	PAR-CLIP	23592263
MIRT462714	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT462713	hsa-miR-4534	PAR-CLIP	23592263
MIRT462711	hsa-miR-8082	PAR-CLIP	23592263
MIRT462712	hsa-miR-3134	PAR-CLIP	23592263
MIRT462710	hsa-miR-4434	PAR-CLIP	23592263
MIRT462709	hsa-miR-4516	PAR-CLIP	23592263
MIRT462708	hsa-miR-5703	PAR-CLIP	23592263
MIRT462707	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT462706	hsa-miR-4525	PAR-CLIP	23592263
MIRT462705	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT462704	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT462702	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT462703	hsa-miR-4531	PAR-CLIP	23592263
MIRT462701	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT1130354	hsa-miR-103a	CLIP-seq
MIRT1130355	hsa-miR-107	CLIP-seq
MIRT1130356	hsa-miR-122	CLIP-seq
MIRT1130357	hsa-miR-1276	CLIP-seq
MIRT1130358	hsa-miR-1288	CLIP-seq
MIRT1130359	hsa-miR-134	CLIP-seq
MIRT1130360	hsa-miR-200b	CLIP-seq
MIRT1130361	hsa-miR-200c	CLIP-seq
MIRT1130362	hsa-miR-2110	CLIP-seq
MIRT1130363	hsa-miR-3118	CLIP-seq
MIRT1130364	hsa-miR-3156-5p	CLIP-seq
MIRT1130365	hsa-miR-3164	CLIP-seq
MIRT1130366	hsa-miR-3189-3p	CLIP-seq
MIRT1130367	hsa-miR-320e	CLIP-seq
MIRT1130368	hsa-miR-34a	CLIP-seq
MIRT1130369	hsa-miR-34c-5p	CLIP-seq
MIRT1130370	hsa-miR-377	CLIP-seq
MIRT1130371	hsa-miR-3942-5p	CLIP-seq
MIRT1130372	hsa-miR-4251	CLIP-seq
MIRT1130373	hsa-miR-4271	CLIP-seq
MIRT1130374	hsa-miR-429	CLIP-seq
MIRT1130375	hsa-miR-4324	CLIP-seq
MIRT1130376	hsa-miR-4446-3p	CLIP-seq
MIRT1130377	hsa-miR-4463	CLIP-seq
MIRT1130378	hsa-miR-4476	CLIP-seq
MIRT1130379	hsa-miR-449a	CLIP-seq
MIRT1130380	hsa-miR-449b	CLIP-seq
MIRT1130381	hsa-miR-4501	CLIP-seq
MIRT1130382	hsa-miR-4504	CLIP-seq
MIRT1130383	hsa-miR-4533	CLIP-seq
MIRT1130384	hsa-miR-4632	CLIP-seq
MIRT1130385	hsa-miR-4656	CLIP-seq
MIRT1130386	hsa-miR-4667-5p	CLIP-seq
MIRT1130387	hsa-miR-4682	CLIP-seq
MIRT1130388	hsa-miR-4700-5p	CLIP-seq
MIRT1130389	hsa-miR-4703-5p	CLIP-seq
MIRT1130390	hsa-miR-4725-3p	CLIP-seq
MIRT1130391	hsa-miR-4765	CLIP-seq
MIRT1130392	hsa-miR-580	CLIP-seq
MIRT1130393	hsa-miR-619	CLIP-seq
MIRT1130394	hsa-miR-635	CLIP-seq
MIRT1130354	hsa-miR-103a	CLIP-seq
MIRT1130355	hsa-miR-107	CLIP-seq
MIRT1130356	hsa-miR-122	CLIP-seq
MIRT2037149	hsa-miR-3154	CLIP-seq
MIRT1130376	hsa-miR-4446-3p	CLIP-seq
MIRT2037150	hsa-miR-4452	CLIP-seq
MIRT1130377	hsa-miR-4463	CLIP-seq
MIRT1130382	hsa-miR-4504	CLIP-seq
MIRT1130385	hsa-miR-4656	CLIP-seq
MIRT1130387	hsa-miR-4682	CLIP-seq
MIRT2037151	hsa-miR-4742-3p	CLIP-seq
MIRT2037152	hsa-miR-4747-3p	CLIP-seq
MIRT1130391	hsa-miR-4765	CLIP-seq
MIRT2037153	hsa-miR-544	CLIP-seq
MIRT2037154	hsa-miR-630	CLIP-seq
MIRT1130364	hsa-miR-3156-5p	CLIP-seq
MIRT2267194	hsa-miR-3159	CLIP-seq
MIRT1130370	hsa-miR-377	CLIP-seq
MIRT1130376	hsa-miR-4446-3p	CLIP-seq
MIRT1130382	hsa-miR-4504	CLIP-seq
MIRT1130385	hsa-miR-4656	CLIP-seq
MIRT1130387	hsa-miR-4682	CLIP-seq
MIRT2267195	hsa-miR-541	CLIP-seq
MIRT2267196	hsa-miR-654-5p	CLIP-seq
MIRT1130354	hsa-miR-103a	CLIP-seq
MIRT1130355	hsa-miR-107	CLIP-seq
MIRT1130356	hsa-miR-122	CLIP-seq
MIRT1130357	hsa-miR-1276	CLIP-seq
MIRT1130358	hsa-miR-1288	CLIP-seq
MIRT2566995	hsa-miR-2355-5p	CLIP-seq
MIRT1130367	hsa-miR-320e	CLIP-seq
MIRT1130371	hsa-miR-3942-5p	CLIP-seq
MIRT2566996	hsa-miR-4320	CLIP-seq
MIRT2037150	hsa-miR-4452	CLIP-seq
MIRT1130378	hsa-miR-4476	CLIP-seq
MIRT1130383	hsa-miR-4533	CLIP-seq
MIRT1130384	hsa-miR-4632	CLIP-seq
MIRT1130389	hsa-miR-4703-5p	CLIP-seq
MIRT2037152	hsa-miR-4747-3p	CLIP-seq
MIRT1130391	hsa-miR-4765	CLIP-seq
MIRT2037153	hsa-miR-544	CLIP-seq
MIRT2037150	hsa-miR-4452	CLIP-seq
MIRT2037152	hsa-miR-4747-3p	CLIP-seq
MIRT2037153	hsa-miR-544	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	12244047, 15850461
GO:0004707	Function	MAP kinase activity	IBA	21873635
GO:0004707	Function	MAP kinase activity	IDA	9218798, 9731215
GO:0005515	Function	Protein binding	IPI	19135240, 22447027
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006970	Process	Response to osmotic stress	IDA	9731215
GO:0007049	Process	Cell cycle	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	15850461
GO:0032755	Process	Positive regulation of interleukin-6 production	IMP	19279008
GO:0034644	Process	Cellular response to UV	IDA	9218798
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0050729	Process	Positive regulation of inflammatory response	IC	19279008
GO:0051403	Process	Stress-activated MAPK cascade	IDA	9218798
GO:0070301	Process	Cellular response to hydrogen peroxide	IDA	9218798
GO:0071347	Process	Cellular response to interleukin-1	IDA	9218798
GO:0072709	Process	Cellular response to sorbitol	IDA	9218798
GO:0072740	Process	Cellular response to anisomycin	IDA	9218798
GO:1903936	Process	Cellular response to sodium arsenite	IDA	9218798

Other IDs

• MIM: 602899
• HGNC: 6875
• e!Ensembl: ENSG00000156711

Protein

• UniProt ID: O15264
• Protein name: Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
• Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli su
• PDB: 3COI, 4EYJ, 4EYM, 4MYG, 4YNO, 5EKN, 5EKO, 8X23
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	25 → 308	Protein kinase domain	Domain

• Sequence:

  MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF
  QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM
  EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT
  GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG
  VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA
  QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR
  SGMKL

• Sequence length: 365