MAPK12 (mitogen-activated protein kinase 12)

Gene

• Entrez ID: 6300
• Gene name: Mitogen-activated protein kinase 12
• Gene symbol: MAPK12
• Synonyms: ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3
• Chromosome: 22
• Chromosome location: 22q13.33
• Summary: Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1551126	hsa-miR-1203	CLIP-seq
MIRT1551127	hsa-miR-4715-3p	CLIP-seq
MIRT1551128	hsa-miR-4756-3p	CLIP-seq
MIRT1551126	hsa-miR-1203	CLIP-seq
MIRT2037039	hsa-miR-3667-3p	CLIP-seq
MIRT1551127	hsa-miR-4715-3p	CLIP-seq
MIRT1551128	hsa-miR-4756-3p	CLIP-seq
MIRT2267114	hsa-miR-1226	CLIP-seq
MIRT2037039	hsa-miR-3667-3p	CLIP-seq
MIRT2267115	hsa-miR-4267	CLIP-seq
MIRT2267116	hsa-miR-4758-3p	CLIP-seq
MIRT2453711	hsa-miR-1207-5p	CLIP-seq
MIRT2453712	hsa-miR-125a-3p	CLIP-seq
MIRT2453713	hsa-miR-1266	CLIP-seq
MIRT2453714	hsa-miR-24	CLIP-seq
MIRT2453715	hsa-miR-3190	CLIP-seq
MIRT2453716	hsa-miR-3202	CLIP-seq
MIRT2453717	hsa-miR-3664-3p	CLIP-seq
MIRT2453718	hsa-miR-3922-5p	CLIP-seq
MIRT2453719	hsa-miR-3934	CLIP-seq
MIRT2453720	hsa-miR-4257	CLIP-seq
MIRT2453721	hsa-miR-4437	CLIP-seq
MIRT2453722	hsa-miR-4514	CLIP-seq
MIRT2453723	hsa-miR-4518	CLIP-seq
MIRT2453724	hsa-miR-4533	CLIP-seq
MIRT2453725	hsa-miR-4690-5p	CLIP-seq
MIRT2453726	hsa-miR-4692	CLIP-seq
MIRT2453727	hsa-miR-4763-3p	CLIP-seq
MIRT2453728	hsa-miR-493	CLIP-seq
MIRT2453729	hsa-miR-764	CLIP-seq
MIRT2453730	hsa-miR-940	CLIP-seq
MIRT2453711	hsa-miR-1207-5p	CLIP-seq
MIRT2453714	hsa-miR-24	CLIP-seq
MIRT2453718	hsa-miR-3922-5p	CLIP-seq
MIRT2453720	hsa-miR-4257	CLIP-seq
MIRT2453721	hsa-miR-4437	CLIP-seq
MIRT2453722	hsa-miR-4514	CLIP-seq
MIRT2453725	hsa-miR-4690-5p	CLIP-seq
MIRT2453726	hsa-miR-4692	CLIP-seq
MIRT2453727	hsa-miR-4763-3p	CLIP-seq
MIRT2453730	hsa-miR-940	CLIP-seq
MIRT2453711	hsa-miR-1207-5p	CLIP-seq
MIRT2453714	hsa-miR-24	CLIP-seq
MIRT2453718	hsa-miR-3922-5p	CLIP-seq
MIRT2453720	hsa-miR-4257	CLIP-seq
MIRT2453721	hsa-miR-4437	CLIP-seq
MIRT2453722	hsa-miR-4514	CLIP-seq
MIRT2453725	hsa-miR-4690-5p	CLIP-seq
MIRT2453726	hsa-miR-4692	CLIP-seq
MIRT2453727	hsa-miR-4763-3p	CLIP-seq
MIRT2453730	hsa-miR-940	CLIP-seq
MIRT2453711	hsa-miR-1207-5p	CLIP-seq
MIRT2453714	hsa-miR-24	CLIP-seq
MIRT2037039	hsa-miR-3667-3p	CLIP-seq
MIRT2453718	hsa-miR-3922-5p	CLIP-seq
MIRT2453720	hsa-miR-4257	CLIP-seq
MIRT2453721	hsa-miR-4437	CLIP-seq
MIRT2453722	hsa-miR-4514	CLIP-seq
MIRT2453725	hsa-miR-4690-5p	CLIP-seq
MIRT2453726	hsa-miR-4692	CLIP-seq
MIRT2453727	hsa-miR-4763-3p	CLIP-seq
MIRT2453730	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000287	Function	Magnesium ion binding	IDA	10508788
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	8633070, 15850461
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	18221368
GO:0004707	Function	MAP kinase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	12761180, 15158451, 19294699, 24550280, 25158884, 25241761, 25416956, 30126976, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006975	Process	DNA damage induced protein phosphorylation	TAS	10848581
GO:0007050	Process	Cell cycle arrest	TAS	10848581
GO:0007165	Process	Signal transduction	TAS	8633070
GO:0007517	Process	Muscle organ development	TAS	8633070
GO:0010952	Process	Positive regulation of peptidase activity	NAS	18221368
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	15850461
GO:0018105	Process	Peptidyl-serine phosphorylation	TAS	18221368
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0045445	Process	Myoblast differentiation	IDA	8633070
GO:0051149	Process	Positive regulation of muscle cell differentiation	TAS

Other IDs

• MIM: 602399
• HGNC: 6874
• e!Ensembl: ENSG00000188130

Protein

• UniProt ID: P53778
• Protein name: Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
• Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli su
• PDB: 1CM8, 4QUM, 6UNA, 7CGA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	27 → 311	Protein kinase domain	Domain

• Sequence:

  MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
  PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
  KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
  EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
  VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
  TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
  VSKETPL

• Sequence length: 367