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MAPK10 (mitogen-activated protein kinase 10)

Gene

5602

Mitogen-activated protein kinase 10

MAPK10

JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK

4q21.3

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcrip

Show/Hide all(246)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053727	hsa-miR-221-3p	Microarray	22942087
MIRT667467	hsa-miR-3617-5p	HITS-CLIP	23824327
MIRT667466	hsa-miR-641	HITS-CLIP	23824327
MIRT607689	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT667465	hsa-miR-3152-3p	HITS-CLIP	23824327
MIRT667464	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT667463	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT667462	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT607691	hsa-miR-4455	HITS-CLIP	23824327
MIRT607680	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607697	hsa-miR-5002-5p	HITS-CLIP	24906430
MIRT607696	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT607695	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT607694	hsa-miR-4651	HITS-CLIP	24906430
MIRT607693	hsa-miR-608	HITS-CLIP	24906430
MIRT607692	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT607691	hsa-miR-4455	HITS-CLIP	24906430
MIRT607690	hsa-miR-3650	HITS-CLIP	24906430
MIRT607689	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT607688	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT607687	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT607686	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT607685	hsa-miR-3170	HITS-CLIP	24906430
MIRT607684	hsa-miR-6855-5p	HITS-CLIP	24906430
MIRT607683	hsa-miR-450a-2-3p	HITS-CLIP	24906430
MIRT607682	hsa-miR-4260	HITS-CLIP	24906430
MIRT607681	hsa-miR-5572	HITS-CLIP	24906430
MIRT607680	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT667464	hsa-miR-208a-3p	HITS-CLIP	27418678
MIRT667463	hsa-miR-208b-3p	HITS-CLIP	27418678
MIRT667465	hsa-miR-3152-3p	HITS-CLIP	27418678
MIRT667465	hsa-miR-3152-3p	HITS-CLIP	27418678
MIRT667465	hsa-miR-3152-3p	HITS-CLIP	27418678
MIRT607685	hsa-miR-3170	HITS-CLIP	27418678
MIRT607685	hsa-miR-3170	HITS-CLIP	27418678
MIRT607696	hsa-miR-342-5p	HITS-CLIP	27418678
MIRT607696	hsa-miR-342-5p	HITS-CLIP	27418678
MIRT667467	hsa-miR-3617-5p	HITS-CLIP	27418678
MIRT607690	hsa-miR-3650	HITS-CLIP	27418678
MIRT607690	hsa-miR-3650	HITS-CLIP	27418678
MIRT607682	hsa-miR-4260	HITS-CLIP	27418678
MIRT607682	hsa-miR-4260	HITS-CLIP	27418678
MIRT607691	hsa-miR-4455	HITS-CLIP	27418678
MIRT607691	hsa-miR-4455	HITS-CLIP	27418678
MIRT607691	hsa-miR-4455	HITS-CLIP	27418678
MIRT607683	hsa-miR-450a-2-3p	HITS-CLIP	27418678
MIRT607683	hsa-miR-450a-2-3p	HITS-CLIP	27418678
MIRT607694	hsa-miR-4651	HITS-CLIP	27418678
MIRT607694	hsa-miR-4651	HITS-CLIP	27418678
MIRT607695	hsa-miR-4664-5p	HITS-CLIP	27418678
MIRT607695	hsa-miR-4664-5p	HITS-CLIP	27418678
MIRT667462	hsa-miR-499a-5p	HITS-CLIP	27418678
MIRT607697	hsa-miR-5002-5p	HITS-CLIP	27418678
MIRT607697	hsa-miR-5002-5p	HITS-CLIP	27418678
MIRT607681	hsa-miR-5572	HITS-CLIP	27418678
MIRT607681	hsa-miR-5572	HITS-CLIP	27418678
MIRT607680	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607680	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607680	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607693	hsa-miR-608	HITS-CLIP	27418678
MIRT607693	hsa-miR-608	HITS-CLIP	27418678
MIRT667466	hsa-miR-641	HITS-CLIP	27418678
MIRT607688	hsa-miR-6737-5p	HITS-CLIP	27418678
MIRT607688	hsa-miR-6737-5p	HITS-CLIP	27418678
MIRT607692	hsa-miR-6747-5p	HITS-CLIP	27418678
MIRT607692	hsa-miR-6747-5p	HITS-CLIP	27418678
MIRT607687	hsa-miR-6812-5p	HITS-CLIP	27418678
MIRT607687	hsa-miR-6812-5p	HITS-CLIP	27418678
MIRT607686	hsa-miR-6819-5p	HITS-CLIP	27418678
MIRT607686	hsa-miR-6819-5p	HITS-CLIP	27418678
MIRT607684	hsa-miR-6855-5p	HITS-CLIP	27418678
MIRT607684	hsa-miR-6855-5p	HITS-CLIP	27418678
MIRT607689	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607689	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607689	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT733960	hsa-miR-205-3p	Luciferase reporter assay, Western blotting	32046433
MIRT667467	hsa-miR-3617-5p	HITS-CLIP	23824327
MIRT667466	hsa-miR-641	HITS-CLIP	23824327
MIRT607689	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT667465	hsa-miR-3152-3p	HITS-CLIP	23824327
MIRT667464	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT667463	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT667462	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT607691	hsa-miR-4455	HITS-CLIP	23824327
MIRT607680	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1130045	hsa-miR-124	CLIP-seq
MIRT1130046	hsa-miR-2682	CLIP-seq
MIRT1130047	hsa-miR-3714	CLIP-seq
MIRT1130048	hsa-miR-3910	CLIP-seq
MIRT1130049	hsa-miR-4328	CLIP-seq
MIRT1130050	hsa-miR-4477b	CLIP-seq
MIRT1130051	hsa-miR-449c	CLIP-seq
MIRT1130052	hsa-miR-4795-3p	CLIP-seq
MIRT1130053	hsa-miR-506	CLIP-seq
MIRT1130054	hsa-miR-197	CLIP-seq
MIRT1130055	hsa-miR-3977	CLIP-seq
MIRT1130056	hsa-miR-412	CLIP-seq
MIRT1130057	hsa-miR-4252	CLIP-seq
MIRT1130058	hsa-miR-4722-3p	CLIP-seq
MIRT1130059	hsa-miR-1256	CLIP-seq
MIRT738743	hsa-miR-1273g	CLIP-seq
MIRT738741	hsa-miR-1275	CLIP-seq
MIRT738745	hsa-miR-342-3p	CLIP-seq
MIRT1130060	hsa-miR-3942-3p	CLIP-seq
MIRT738744	hsa-miR-4318	CLIP-seq
MIRT1130049	hsa-miR-4328	CLIP-seq
MIRT738742	hsa-miR-4665-5p	CLIP-seq
MIRT1130061	hsa-miR-4720-5p	CLIP-seq
MIRT1130062	hsa-miR-4799-3p	CLIP-seq
MIRT738743	hsa-miR-1273g	CLIP-seq
MIRT738741	hsa-miR-1275	CLIP-seq
MIRT738745	hsa-miR-342-3p	CLIP-seq
MIRT738744	hsa-miR-4318	CLIP-seq
MIRT738742	hsa-miR-4665-5p	CLIP-seq
MIRT2037034	hsa-miR-562	CLIP-seq
MIRT2267079	hsa-miR-1197	CLIP-seq
MIRT2267080	hsa-miR-1224-5p	CLIP-seq
MIRT2267081	hsa-miR-1233	CLIP-seq
MIRT2267082	hsa-miR-125a-5p	CLIP-seq
MIRT2267083	hsa-miR-125b	CLIP-seq
MIRT2267084	hsa-miR-193a-3p	CLIP-seq
MIRT2267085	hsa-miR-193b	CLIP-seq
MIRT2267086	hsa-miR-2052	CLIP-seq
MIRT2267087	hsa-miR-21	CLIP-seq
MIRT2267088	hsa-miR-2110	CLIP-seq
MIRT2267089	hsa-miR-3128	CLIP-seq
MIRT2267090	hsa-miR-3137	CLIP-seq
MIRT2267091	hsa-miR-3150a-3p	CLIP-seq
MIRT2267092	hsa-miR-3185	CLIP-seq
MIRT2267093	hsa-miR-3194-3p	CLIP-seq
MIRT2267094	hsa-miR-3529	CLIP-seq
MIRT2267095	hsa-miR-3660	CLIP-seq
MIRT2267096	hsa-miR-3686	CLIP-seq
MIRT2267097	hsa-miR-379	CLIP-seq
MIRT2267098	hsa-miR-4319	CLIP-seq
MIRT2267099	hsa-miR-4450	CLIP-seq
MIRT2267100	hsa-miR-4451	CLIP-seq
MIRT2267101	hsa-miR-4526	CLIP-seq
MIRT2267102	hsa-miR-4643	CLIP-seq
MIRT2267103	hsa-miR-4645-3p	CLIP-seq
MIRT2267104	hsa-miR-4650-3p	CLIP-seq
MIRT2267105	hsa-miR-4732-5p	CLIP-seq
MIRT2267106	hsa-miR-4751	CLIP-seq
MIRT2267107	hsa-miR-544b	CLIP-seq
MIRT2267108	hsa-miR-590-5p	CLIP-seq
MIRT2267109	hsa-miR-629	CLIP-seq
MIRT2267110	hsa-miR-642b	CLIP-seq
MIRT2267111	hsa-miR-656	CLIP-seq
MIRT2267112	hsa-miR-892b	CLIP-seq
MIRT738743	hsa-miR-1273g	CLIP-seq
MIRT738741	hsa-miR-1275	CLIP-seq
MIRT738745	hsa-miR-342-3p	CLIP-seq
MIRT738744	hsa-miR-4318	CLIP-seq
MIRT738742	hsa-miR-4665-5p	CLIP-seq
MIRT2453701	hsa-miR-2113	CLIP-seq
MIRT2453702	hsa-miR-3926	CLIP-seq
MIRT2453703	hsa-miR-4493	CLIP-seq
MIRT2453704	hsa-miR-4753-5p	CLIP-seq
MIRT2453705	hsa-miR-550a	CLIP-seq
MIRT2566944	hsa-miR-1193	CLIP-seq
MIRT2566945	hsa-miR-1228	CLIP-seq
MIRT2566946	hsa-miR-1287	CLIP-seq
MIRT2566947	hsa-miR-1301	CLIP-seq
MIRT2566948	hsa-miR-3135b	CLIP-seq
MIRT2566949	hsa-miR-3148	CLIP-seq
MIRT2566950	hsa-miR-3160-5p	CLIP-seq
MIRT2566951	hsa-miR-345	CLIP-seq
MIRT2566952	hsa-miR-3675-3p	CLIP-seq
MIRT2566953	hsa-miR-3675-5p	CLIP-seq
MIRT2566954	hsa-miR-3688-3p	CLIP-seq
MIRT2566955	hsa-miR-3920	CLIP-seq
MIRT2566956	hsa-miR-3927	CLIP-seq
MIRT1130057	hsa-miR-4252	CLIP-seq
MIRT2566957	hsa-miR-4282	CLIP-seq
MIRT2566958	hsa-miR-4436b-3p	CLIP-seq
MIRT2566959	hsa-miR-4473	CLIP-seq
MIRT2566960	hsa-miR-450b-5p	CLIP-seq
MIRT2267102	hsa-miR-4643	CLIP-seq
MIRT2267103	hsa-miR-4645-3p	CLIP-seq
MIRT2566961	hsa-miR-4684-5p	CLIP-seq
MIRT2566962	hsa-miR-4696	CLIP-seq
MIRT2566963	hsa-miR-4711-3p	CLIP-seq
MIRT2566964	hsa-miR-4717-5p	CLIP-seq
MIRT2566965	hsa-miR-4718	CLIP-seq
MIRT2566966	hsa-miR-4735-5p	CLIP-seq
MIRT2566967	hsa-miR-4742-3p	CLIP-seq
MIRT2566968	hsa-miR-5047	CLIP-seq
MIRT2566969	hsa-miR-507	CLIP-seq
MIRT2566970	hsa-miR-5095	CLIP-seq
MIRT2566971	hsa-miR-512-3p	CLIP-seq
MIRT2566972	hsa-miR-520f	CLIP-seq
MIRT2566973	hsa-miR-552	CLIP-seq
MIRT2566974	hsa-miR-557	CLIP-seq
MIRT2037034	hsa-miR-562	CLIP-seq
MIRT2566975	hsa-miR-592	CLIP-seq
MIRT2566976	hsa-miR-599	CLIP-seq
MIRT2267110	hsa-miR-642b	CLIP-seq
MIRT2566977	hsa-miR-935	CLIP-seq
MIRT2566978	hsa-miR-942	CLIP-seq
MIRT2566944	hsa-miR-1193	CLIP-seq
MIRT2566945	hsa-miR-1228	CLIP-seq
MIRT2566946	hsa-miR-1287	CLIP-seq
MIRT2566947	hsa-miR-1301	CLIP-seq
MIRT2566948	hsa-miR-3135b	CLIP-seq
MIRT2566949	hsa-miR-3148	CLIP-seq
MIRT2566951	hsa-miR-345	CLIP-seq
MIRT2566952	hsa-miR-3675-3p	CLIP-seq
MIRT2566953	hsa-miR-3675-5p	CLIP-seq
MIRT2566954	hsa-miR-3688-3p	CLIP-seq
MIRT2684570	hsa-miR-377	CLIP-seq
MIRT2453702	hsa-miR-3926	CLIP-seq
MIRT2566956	hsa-miR-3927	CLIP-seq
MIRT2684571	hsa-miR-3976	CLIP-seq
MIRT1130057	hsa-miR-4252	CLIP-seq
MIRT2566957	hsa-miR-4282	CLIP-seq
MIRT2684572	hsa-miR-4297	CLIP-seq
MIRT2684573	hsa-miR-4432	CLIP-seq
MIRT2566958	hsa-miR-4436b-3p	CLIP-seq
MIRT2566959	hsa-miR-4473	CLIP-seq
MIRT2453703	hsa-miR-4493	CLIP-seq
MIRT2566960	hsa-miR-450b-5p	CLIP-seq
MIRT2267102	hsa-miR-4643	CLIP-seq
MIRT2267103	hsa-miR-4645-3p	CLIP-seq
MIRT2684574	hsa-miR-4662a-3p	CLIP-seq
MIRT2566961	hsa-miR-4684-5p	CLIP-seq
MIRT2566962	hsa-miR-4696	CLIP-seq
MIRT2566963	hsa-miR-4711-3p	CLIP-seq
MIRT2566964	hsa-miR-4717-5p	CLIP-seq
MIRT2566965	hsa-miR-4718	CLIP-seq
MIRT2566966	hsa-miR-4735-5p	CLIP-seq
MIRT2566967	hsa-miR-4742-3p	CLIP-seq
MIRT2453704	hsa-miR-4753-5p	CLIP-seq
MIRT2566968	hsa-miR-5047	CLIP-seq
MIRT2566969	hsa-miR-507	CLIP-seq
MIRT2566970	hsa-miR-5095	CLIP-seq
MIRT2566971	hsa-miR-512-3p	CLIP-seq
MIRT2566972	hsa-miR-520f	CLIP-seq
MIRT2684575	hsa-miR-548u	CLIP-seq
MIRT2566973	hsa-miR-552	CLIP-seq
MIRT2566974	hsa-miR-557	CLIP-seq
MIRT2037034	hsa-miR-562	CLIP-seq
MIRT2566975	hsa-miR-592	CLIP-seq
MIRT2566976	hsa-miR-599	CLIP-seq
MIRT2267110	hsa-miR-642b	CLIP-seq
MIRT2566977	hsa-miR-935	CLIP-seq
MIRT2566978	hsa-miR-942	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004705	Function	JUN kinase activity	IBA	21873635
GO:0004705	Function	JUN kinase activity	ISS	8654373
GO:0004707	Function	MAP kinase activity	IBA	21873635
GO:0004708	Function	MAP kinase kinase activity	TAS	7826642
GO:0005515	Function	Protein binding	IPI	19294699, 19527717, 19782076, 19879840, 21988832, 22327296
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	ISS
GO:0005739	Component	Mitochondrion	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	ISS
GO:0006468	Process	Protein phosphorylation	IMP	22441692
GO:0006468	Process	Protein phosphorylation	ISS
GO:0007165	Process	Signal transduction	TAS	8654373
GO:0007254	Process	JNK cascade	IBA	21873635
GO:0007254	Process	JNK cascade	ISS	8654373
GO:0007254	Process	JNK cascade	TAS
GO:0007258	Process	JUN phosphorylation	IEA
GO:0009416	Process	Response to light stimulus	ISS
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042752	Process	Regulation of circadian rhythm	ISS
GO:0048511	Process	Rhythmic process	IEA
GO:0051090	Process	Regulation of DNA-binding transcription factor activity	TAS

MIM	HGNC	e!Ensembl
602897	6872	ENSG00000109339

Protein

UniProt ID

P53779

Protein name

Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)

Protein function

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-

PDB

1JNK , 1PMN , 1PMU , 1PMV , 2B1P , 2EXC , 2O0U , 2O2U , 2OK1 , 2P33 , 2R9S , 2WAJ , 2ZDT , 2ZDU , 3CGF , 3CGO , 3DA6 , 3FI2 , 3FI3 , 3FV8 , 3G90 , 3G9L , 3G9N , 3KVX , 3OXI , 3OY1 , 3PTG , 3RTP , 3TTI , 3TTJ , 3V6R , 3V6S , 4H36 , 4H39 , 4H3B , 4KKE , 4KKG , 4KKH , 4U79 , 4W4V , 4W4W , 4W4X , 4W4Y , 4WHZ , 4X21 , 4Y46 , 4Y5H , 4Z9L , 6EKD , 6EMH , 6EQ9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	64 → 359	Protein kinase domain	Domain

Sequence

MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR

Sequence length

464

Interactions

View interactions

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