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MAPK1 (mitogen-activated protein kinase 1)
Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5594
Gene nameGene Name - the full gene name approved by the HGNC.
Mitogen-activated protein kinase 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MAPK1
SynonymsGene synonyms aliases
ERK, ERK-2, ERK2, ERT1, MAPK2, NS13, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
ChromosomeChromosome number
22
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.22
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as p
SNPsSNP information provided by dbSNP.
Gene SNPs Transcription factors Other IDs
SNP ID Visualize variation Clinical significance Consequence
rs797044892 C>G Pathogenic Missense variant, coding sequence variant
rs1057519911 C>T Likely-pathogenic Coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT003983 hsa-miR-199a-3p Western blot 18456660
MIRT003983 hsa-miR-199a-3p Luciferase reporter assay 18456660
MIRT006418 hsa-miR-28-5p Luciferase reporter assay 20445018
MIRT006447 hsa-miR-335-5p Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22382496
MIRT006447 hsa-miR-335-5p Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22382496
Transcription factors
Gene SNPs Transcription factors Other IDs
Transcription factor Regulation Reference
MYC Unknown 21933022
SPI1 Repression 22075620
TWIST1 Activation 23222305
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0000186 Process Activation of MAPKK activity TAS
GO:0000187 Process Activation of MAPK activity TAS
GO:0001784 Function Phosphotyrosine residue binding IEA
GO:0003690 Function Double-stranded DNA binding IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P28482
Protein name Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Protein function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling casc
PDB 1PME , 1TVO , 1WZY , 2OJG , 2OJI , 2OJJ , 2Y9Q , 3D42 , 3D44 , 3I5Z , 3I60 , 3SA0 , 3TEI , 3W55 , 4FMQ , 4FUX , 4FUY , 4FV0 , 4FV1 , 4FV2 , 4FV3 , 4FV4 , 4FV5 , 4FV6 , 4FV7 , 4FV8 , 4FV9 , 4G6N , 4G6O , 4H3P , 4H3Q , 4IZ5 , 4IZ7 , 4IZA , 4N0S , 4NIF , 4O6E , 4QP1 , 4QP2 , 4QP3 , 4QP4 , 4QP6 , 4QP7 , 4QP8 , 4QP9 , 4QPA , 4QTA , 4QTE , 4XJ0 , 4ZXT , 4ZZM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
25 → 313
Protein kinase domain
 Domain
Sequence
Sequence length 360
Interactions View interactions

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