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MAP3K7 (mitogen-activated protein kinase kinase kinase 7)

Gene

6885

Mitogen-activated protein kinase kinase kinase 7

MAP3K7

CSCF, FMD2, MEKK7, TAK1, TGF1a

6q15

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcripti

Show/Hide all(13)

SNP ID	Visualize variation	Clinical significance	Consequence
rs886039230	G>A,C,T	Pathogenic	Coding sequence variant, intron variant, missense variant
rs886039231	C>G	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs886039232	A>T	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs886039233	C>G	Pathogenic	Coding sequence variant, missense variant
rs886039234	TCTTCC>-	Pathogenic	5 prime UTR variant, inframe deletion, coding sequence variant
rs886039235	C>A	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs886039236	AAC>-	Pathogenic	5 prime UTR variant, inframe deletion, coding sequence variant
rs886039237	A>C,T	Pathogenic	Coding sequence variant, missense variant
rs1057517758	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1064795771	C>T	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, missense variant
rs1180249151	C>A,T	Likely-pathogenic	Splice acceptor variant
rs1554184177	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1582233787	AAC>-	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, inframe deletion

Show/Hide all(375)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005509	hsa-miR-10a-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20624982
MIRT025316	hsa-miR-34a-5p	Sequencing	20371350
MIRT005509	hsa-miR-10a-5p	Reporter assay;Other	20624982
MIRT027011	hsa-miR-103a-3p	Sequencing	20371350
MIRT051235	hsa-miR-16-5p	CLASH	23622248
MIRT036539	hsa-miR-1226-5p	CLASH	23622248
MIRT053639	hsa-miR-143-3p	Microarray	22942087
MIRT616961	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616960	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616959	hsa-miR-3671	HITS-CLIP	23824327
MIRT616958	hsa-miR-5696	HITS-CLIP	23824327
MIRT616957	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT616956	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT616955	hsa-miR-607	HITS-CLIP	23824327
MIRT616954	hsa-miR-1305	HITS-CLIP	23824327
MIRT616953	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT566834	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT566833	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT051235	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT566832	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT566831	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT566830	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT566829	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT566828	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT566827	hsa-miR-646	PAR-CLIP	20371350
MIRT566826	hsa-miR-875-5p	PAR-CLIP	20371350
MIRT566825	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT566824	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT566823	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT566822	hsa-miR-599	PAR-CLIP	20371350
MIRT512946	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT512945	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT512944	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT512943	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT512942	hsa-miR-940	PAR-CLIP	20371350
MIRT512941	hsa-miR-2682-5p	PAR-CLIP	20371350
MIRT512940	hsa-miR-34b-5p	PAR-CLIP	20371350
MIRT512939	hsa-miR-449c-5p	PAR-CLIP	20371350
MIRT512938	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT512937	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT027011	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT512936	hsa-miR-107	PAR-CLIP	20371350
MIRT512935	hsa-miR-548au-3p	PAR-CLIP	20371350
MIRT512946	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT512945	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT512944	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT512943	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT512942	hsa-miR-940	PAR-CLIP	23446348
MIRT512941	hsa-miR-2682-5p	PAR-CLIP	23446348
MIRT512940	hsa-miR-34b-5p	PAR-CLIP	23446348
MIRT512939	hsa-miR-449c-5p	PAR-CLIP	23446348
MIRT512938	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT512937	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT027011	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT512936	hsa-miR-107	PAR-CLIP	23446348
MIRT512935	hsa-miR-548au-3p	PAR-CLIP	23446348
MIRT449701	hsa-miR-3914	PAR-CLIP	22100165
MIRT445925	hsa-miR-4635	PAR-CLIP	22100165
MIRT445926	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT445925	hsa-miR-4635	PAR-CLIP	22100165
MIRT445926	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT735700	hsa-miR-129-5p	Luciferase reporter assay, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR	32048803
MIRT736428	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT616961	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616960	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616959	hsa-miR-3671	HITS-CLIP	23824327
MIRT616958	hsa-miR-5696	HITS-CLIP	23824327
MIRT616957	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT616956	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT616955	hsa-miR-607	HITS-CLIP	23824327
MIRT616954	hsa-miR-1305	HITS-CLIP	23824327
MIRT616953	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT566834	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT566833	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT051235	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT566832	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT566831	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT566830	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT566829	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT566828	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT566827	hsa-miR-646	PAR-CLIP	20371350
MIRT566826	hsa-miR-875-5p	PAR-CLIP	20371350
MIRT566825	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT566824	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT566823	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT566822	hsa-miR-599	PAR-CLIP	20371350
MIRT512946	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT512945	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT512944	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT512943	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT512942	hsa-miR-940	PAR-CLIP	20371350
MIRT512941	hsa-miR-2682-5p	PAR-CLIP	20371350
MIRT512940	hsa-miR-34b-5p	PAR-CLIP	20371350
MIRT512939	hsa-miR-449c-5p	PAR-CLIP	20371350
MIRT512938	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT512937	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT027011	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT512936	hsa-miR-107	PAR-CLIP	20371350
MIRT512935	hsa-miR-548au-3p	PAR-CLIP	20371350
MIRT512946	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT512945	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT512944	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT512943	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT512942	hsa-miR-940	PAR-CLIP	23446348
MIRT512941	hsa-miR-2682-5p	PAR-CLIP	23446348
MIRT512940	hsa-miR-34b-5p	PAR-CLIP	23446348
MIRT512939	hsa-miR-449c-5p	PAR-CLIP	23446348
MIRT512938	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT512937	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT027011	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT512936	hsa-miR-107	PAR-CLIP	23446348
MIRT512935	hsa-miR-548au-3p	PAR-CLIP	23446348
MIRT449701	hsa-miR-3914	PAR-CLIP	22100165
MIRT445925	hsa-miR-4635	PAR-CLIP	22100165
MIRT445926	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT445925	hsa-miR-4635	PAR-CLIP	22100165
MIRT445926	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT1129023	hsa-miR-103a	CLIP-seq
MIRT1129024	hsa-miR-106a	CLIP-seq
MIRT1129025	hsa-miR-106b	CLIP-seq
MIRT1129026	hsa-miR-1256	CLIP-seq
MIRT1129027	hsa-miR-1297	CLIP-seq
MIRT1129028	hsa-miR-17	CLIP-seq
MIRT1129029	hsa-miR-20a	CLIP-seq
MIRT1129030	hsa-miR-20b	CLIP-seq
MIRT1129031	hsa-miR-224	CLIP-seq
MIRT1129032	hsa-miR-2682	CLIP-seq
MIRT1129033	hsa-miR-26a	CLIP-seq
MIRT1129034	hsa-miR-26b	CLIP-seq
MIRT1129035	hsa-miR-302a	CLIP-seq
MIRT1129036	hsa-miR-302b	CLIP-seq
MIRT1129037	hsa-miR-302c	CLIP-seq
MIRT1129038	hsa-miR-302d	CLIP-seq
MIRT1129039	hsa-miR-302e	CLIP-seq
MIRT1129040	hsa-miR-372	CLIP-seq
MIRT1129041	hsa-miR-373	CLIP-seq
MIRT1129042	hsa-miR-4465	CLIP-seq
MIRT1129043	hsa-miR-449c	CLIP-seq
MIRT1129044	hsa-miR-4642	CLIP-seq
MIRT1129045	hsa-miR-4684-3p	CLIP-seq
MIRT1129046	hsa-miR-4715-5p	CLIP-seq
MIRT1129047	hsa-miR-4716-5p	CLIP-seq
MIRT1129048	hsa-miR-494	CLIP-seq
MIRT1129049	hsa-miR-512-3p	CLIP-seq
MIRT1129050	hsa-miR-518a-5p	CLIP-seq
MIRT1129051	hsa-miR-519d	CLIP-seq
MIRT1129052	hsa-miR-520a-3p	CLIP-seq
MIRT1129053	hsa-miR-520b	CLIP-seq
MIRT1129054	hsa-miR-520c-3p	CLIP-seq
MIRT1129055	hsa-miR-520d-3p	CLIP-seq
MIRT1129056	hsa-miR-520e	CLIP-seq
MIRT1129057	hsa-miR-520g	CLIP-seq
MIRT1129058	hsa-miR-520h	CLIP-seq
MIRT1129059	hsa-miR-527	CLIP-seq
MIRT1129060	hsa-miR-545	CLIP-seq
MIRT1129061	hsa-miR-582-5p	CLIP-seq
MIRT1129062	hsa-miR-767-3p	CLIP-seq
MIRT1129063	hsa-miR-93	CLIP-seq
MIRT1129023	hsa-miR-103a	CLIP-seq
MIRT1129064	hsa-miR-1205	CLIP-seq
MIRT1129065	hsa-miR-1286	CLIP-seq
MIRT1129032	hsa-miR-2682	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT1129067	hsa-miR-4418	CLIP-seq
MIRT1129043	hsa-miR-449c	CLIP-seq
MIRT1129068	hsa-miR-4722-5p	CLIP-seq
MIRT1129069	hsa-miR-509-3-5p	CLIP-seq
MIRT1129070	hsa-miR-509-5p	CLIP-seq
MIRT1129060	hsa-miR-545	CLIP-seq
MIRT1129071	hsa-miR-1258	CLIP-seq
MIRT1129072	hsa-miR-1264	CLIP-seq
MIRT1129073	hsa-miR-15a	CLIP-seq
MIRT1129074	hsa-miR-15b	CLIP-seq
MIRT1129075	hsa-miR-16	CLIP-seq
MIRT1129076	hsa-miR-188-5p	CLIP-seq
MIRT1129077	hsa-miR-195	CLIP-seq
MIRT1129078	hsa-miR-3124-3p	CLIP-seq
MIRT1129079	hsa-miR-3614-3p	CLIP-seq
MIRT1129080	hsa-miR-377	CLIP-seq
MIRT1129081	hsa-miR-424	CLIP-seq
MIRT1129082	hsa-miR-4509	CLIP-seq
MIRT1129083	hsa-miR-4524	CLIP-seq
MIRT1129084	hsa-miR-4528	CLIP-seq
MIRT1129085	hsa-miR-4652-3p	CLIP-seq
MIRT1129086	hsa-miR-497	CLIP-seq
MIRT1129087	hsa-miR-503	CLIP-seq
MIRT1129088	hsa-miR-507	CLIP-seq
MIRT1129089	hsa-miR-548m	CLIP-seq
MIRT1129090	hsa-miR-557	CLIP-seq
MIRT1129091	hsa-miR-602	CLIP-seq
MIRT1551122	hsa-miR-590-3p	CLIP-seq
MIRT2036731	hsa-miR-448	CLIP-seq
MIRT1129023	hsa-miR-103a	CLIP-seq
MIRT1129026	hsa-miR-1256	CLIP-seq
MIRT1129071	hsa-miR-1258	CLIP-seq
MIRT2266921	hsa-miR-142-5p	CLIP-seq
MIRT1129032	hsa-miR-2682	CLIP-seq
MIRT2266922	hsa-miR-297	CLIP-seq
MIRT2266923	hsa-miR-3149	CLIP-seq
MIRT2266924	hsa-miR-329	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT1129079	hsa-miR-3614-3p	CLIP-seq
MIRT2266925	hsa-miR-362-3p	CLIP-seq
MIRT1129080	hsa-miR-377	CLIP-seq
MIRT2266926	hsa-miR-3941	CLIP-seq
MIRT2266927	hsa-miR-421	CLIP-seq
MIRT2266928	hsa-miR-4282	CLIP-seq
MIRT2266929	hsa-miR-4474-5p	CLIP-seq
MIRT1129043	hsa-miR-449c	CLIP-seq
MIRT2266930	hsa-miR-4517	CLIP-seq
MIRT1129044	hsa-miR-4642	CLIP-seq
MIRT1129085	hsa-miR-4652-3p	CLIP-seq
MIRT2266931	hsa-miR-4694-3p	CLIP-seq
MIRT2266932	hsa-miR-4705	CLIP-seq
MIRT1129046	hsa-miR-4715-5p	CLIP-seq
MIRT1129047	hsa-miR-4716-5p	CLIP-seq
MIRT2266933	hsa-miR-4789-3p	CLIP-seq
MIRT1129048	hsa-miR-494	CLIP-seq
MIRT2266934	hsa-miR-495	CLIP-seq
MIRT2266935	hsa-miR-526b	CLIP-seq
MIRT1129060	hsa-miR-545	CLIP-seq
MIRT1129061	hsa-miR-582-5p	CLIP-seq
MIRT1551122	hsa-miR-590-3p	CLIP-seq
MIRT1129091	hsa-miR-602	CLIP-seq
MIRT2266936	hsa-miR-603	CLIP-seq
MIRT1129064	hsa-miR-1205	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT1129067	hsa-miR-4418	CLIP-seq
MIRT1129069	hsa-miR-509-3-5p	CLIP-seq
MIRT1129070	hsa-miR-509-5p	CLIP-seq
MIRT2453690	hsa-miR-570	CLIP-seq
MIRT1129024	hsa-miR-106a	CLIP-seq
MIRT1129025	hsa-miR-106b	CLIP-seq
MIRT2566477	hsa-miR-10a	CLIP-seq
MIRT2566478	hsa-miR-10b	CLIP-seq
MIRT1129072	hsa-miR-1264	CLIP-seq
MIRT2566479	hsa-miR-1273f	CLIP-seq
MIRT2566480	hsa-miR-1278	CLIP-seq
MIRT2566481	hsa-miR-129-3p	CLIP-seq
MIRT1129027	hsa-miR-1297	CLIP-seq
MIRT2266921	hsa-miR-142-5p	CLIP-seq
MIRT2566482	hsa-miR-143	CLIP-seq
MIRT2566483	hsa-miR-153	CLIP-seq
MIRT1129028	hsa-miR-17	CLIP-seq
MIRT1129029	hsa-miR-20a	CLIP-seq
MIRT1129030	hsa-miR-20b	CLIP-seq
MIRT1129031	hsa-miR-224	CLIP-seq
MIRT1129033	hsa-miR-26a	CLIP-seq
MIRT1129034	hsa-miR-26b	CLIP-seq
MIRT2566484	hsa-miR-300	CLIP-seq
MIRT1129035	hsa-miR-302a	CLIP-seq
MIRT1129036	hsa-miR-302b	CLIP-seq
MIRT1129037	hsa-miR-302c	CLIP-seq
MIRT1129038	hsa-miR-302d	CLIP-seq
MIRT1129039	hsa-miR-302e	CLIP-seq
MIRT2566485	hsa-miR-3122	CLIP-seq
MIRT1129078	hsa-miR-3124-3p	CLIP-seq
MIRT2566486	hsa-miR-3148	CLIP-seq
MIRT2566487	hsa-miR-3153	CLIP-seq
MIRT2566488	hsa-miR-330-3p	CLIP-seq
MIRT2566489	hsa-miR-339-5p	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT2566490	hsa-miR-369-3p	CLIP-seq
MIRT1129040	hsa-miR-372	CLIP-seq
MIRT1129041	hsa-miR-373	CLIP-seq
MIRT2566491	hsa-miR-374a	CLIP-seq
MIRT2566492	hsa-miR-374b	CLIP-seq
MIRT2566493	hsa-miR-381	CLIP-seq
MIRT2566494	hsa-miR-3913-5p	CLIP-seq
MIRT2566495	hsa-miR-4421	CLIP-seq
MIRT1129042	hsa-miR-4465	CLIP-seq
MIRT2566496	hsa-miR-4477a	CLIP-seq
MIRT2036731	hsa-miR-448	CLIP-seq
MIRT2566497	hsa-miR-4639-3p	CLIP-seq
MIRT1129044	hsa-miR-4642	CLIP-seq
MIRT2566498	hsa-miR-4668-5p	CLIP-seq
MIRT2566499	hsa-miR-4682	CLIP-seq
MIRT1129045	hsa-miR-4684-3p	CLIP-seq
MIRT2566500	hsa-miR-4698	CLIP-seq
MIRT2266932	hsa-miR-4705	CLIP-seq
MIRT2566501	hsa-miR-4708-5p	CLIP-seq
MIRT2566502	hsa-miR-4720-5p	CLIP-seq
MIRT2566503	hsa-miR-4770	CLIP-seq
MIRT2566504	hsa-miR-4799-3p	CLIP-seq
MIRT2566505	hsa-miR-4799-5p	CLIP-seq
MIRT2566506	hsa-miR-511	CLIP-seq
MIRT1129049	hsa-miR-512-3p	CLIP-seq
MIRT2566507	hsa-miR-513a-3p	CLIP-seq
MIRT1129050	hsa-miR-518a-5p	CLIP-seq
MIRT1129051	hsa-miR-519d	CLIP-seq
MIRT1129052	hsa-miR-520a-3p	CLIP-seq
MIRT1129053	hsa-miR-520b	CLIP-seq
MIRT1129054	hsa-miR-520c-3p	CLIP-seq
MIRT1129055	hsa-miR-520d-3p	CLIP-seq
MIRT1129056	hsa-miR-520e	CLIP-seq
MIRT1129057	hsa-miR-520g	CLIP-seq
MIRT1129058	hsa-miR-520h	CLIP-seq
MIRT1129059	hsa-miR-527	CLIP-seq
MIRT2566508	hsa-miR-640	CLIP-seq
MIRT1129062	hsa-miR-767-3p	CLIP-seq
MIRT2566509	hsa-miR-889	CLIP-seq
MIRT1129063	hsa-miR-93	CLIP-seq
MIRT2566510	hsa-miR-938	CLIP-seq
MIRT2566511	hsa-miR-944	CLIP-seq
MIRT1129024	hsa-miR-106a	CLIP-seq
MIRT1129025	hsa-miR-106b	CLIP-seq
MIRT2566477	hsa-miR-10a	CLIP-seq
MIRT2566478	hsa-miR-10b	CLIP-seq
MIRT1129072	hsa-miR-1264	CLIP-seq
MIRT2566479	hsa-miR-1273f	CLIP-seq
MIRT2566480	hsa-miR-1278	CLIP-seq
MIRT2566481	hsa-miR-129-3p	CLIP-seq
MIRT1129027	hsa-miR-1297	CLIP-seq
MIRT2566482	hsa-miR-143	CLIP-seq
MIRT2566483	hsa-miR-153	CLIP-seq
MIRT1129028	hsa-miR-17	CLIP-seq
MIRT1129029	hsa-miR-20a	CLIP-seq
MIRT1129030	hsa-miR-20b	CLIP-seq
MIRT1129031	hsa-miR-224	CLIP-seq
MIRT1129033	hsa-miR-26a	CLIP-seq
MIRT1129034	hsa-miR-26b	CLIP-seq
MIRT1129035	hsa-miR-302a	CLIP-seq
MIRT1129036	hsa-miR-302b	CLIP-seq
MIRT1129037	hsa-miR-302c	CLIP-seq
MIRT1129038	hsa-miR-302d	CLIP-seq
MIRT1129039	hsa-miR-302e	CLIP-seq
MIRT2566485	hsa-miR-3122	CLIP-seq
MIRT1129078	hsa-miR-3124-3p	CLIP-seq
MIRT2566486	hsa-miR-3148	CLIP-seq
MIRT2566487	hsa-miR-3153	CLIP-seq
MIRT2566488	hsa-miR-330-3p	CLIP-seq
MIRT2566489	hsa-miR-339-5p	CLIP-seq
MIRT1129066	hsa-miR-34b	CLIP-seq
MIRT2566490	hsa-miR-369-3p	CLIP-seq
MIRT1129040	hsa-miR-372	CLIP-seq
MIRT1129041	hsa-miR-373	CLIP-seq
MIRT2566491	hsa-miR-374a	CLIP-seq
MIRT2566492	hsa-miR-374b	CLIP-seq
MIRT2566494	hsa-miR-3913-5p	CLIP-seq
MIRT2566495	hsa-miR-4421	CLIP-seq
MIRT1129042	hsa-miR-4465	CLIP-seq
MIRT2566496	hsa-miR-4477a	CLIP-seq
MIRT2036731	hsa-miR-448	CLIP-seq
MIRT2566497	hsa-miR-4639-3p	CLIP-seq
MIRT1129044	hsa-miR-4642	CLIP-seq
MIRT2566498	hsa-miR-4668-5p	CLIP-seq
MIRT2566499	hsa-miR-4682	CLIP-seq
MIRT1129045	hsa-miR-4684-3p	CLIP-seq
MIRT2566500	hsa-miR-4698	CLIP-seq
MIRT2266932	hsa-miR-4705	CLIP-seq
MIRT2566501	hsa-miR-4708-5p	CLIP-seq
MIRT2566502	hsa-miR-4720-5p	CLIP-seq
MIRT2566503	hsa-miR-4770	CLIP-seq
MIRT2566504	hsa-miR-4799-3p	CLIP-seq
MIRT2566505	hsa-miR-4799-5p	CLIP-seq
MIRT2566506	hsa-miR-511	CLIP-seq
MIRT1129049	hsa-miR-512-3p	CLIP-seq
MIRT2566507	hsa-miR-513a-3p	CLIP-seq
MIRT1129050	hsa-miR-518a-5p	CLIP-seq
MIRT1129051	hsa-miR-519d	CLIP-seq
MIRT1129052	hsa-miR-520a-3p	CLIP-seq
MIRT1129053	hsa-miR-520b	CLIP-seq
MIRT1129054	hsa-miR-520c-3p	CLIP-seq
MIRT1129055	hsa-miR-520d-3p	CLIP-seq
MIRT1129056	hsa-miR-520e	CLIP-seq
MIRT1129057	hsa-miR-520g	CLIP-seq
MIRT1129058	hsa-miR-520h	CLIP-seq
MIRT1129059	hsa-miR-527	CLIP-seq
MIRT1129091	hsa-miR-602	CLIP-seq
MIRT2566508	hsa-miR-640	CLIP-seq
MIRT1129062	hsa-miR-767-3p	CLIP-seq
MIRT2566509	hsa-miR-889	CLIP-seq
MIRT1129063	hsa-miR-93	CLIP-seq
MIRT2566510	hsa-miR-938	CLIP-seq
MIRT2566511	hsa-miR-944	CLIP-seq

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000186	Process	Activation of MAPKK activity	IDA	8663074, 9079627
GO:0000187	Process	Activation of MAPK activity	IDA	9079627
GO:0000187	Process	Activation of MAPK activity	TAS
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002726	Process	Positive regulation of T cell cytokine production	IMP	15125833
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0004672	Function	Protein kinase activity	IDA	10094049
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	10702308, 11460167, 20538596
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004709	Function	MAP kinase kinase kinase activity	EXP	11460167
GO:0004709	Function	MAP kinase kinase kinase activity	IBA	21873635
GO:0004709	Function	MAP kinase kinase kinase activity	IDA	11460167
GO:0005515	Function	Protein binding	IPI	10094049, 11460167, 12496252, 15075345, 15764709, 16840345, 16845370, 17079228, 17110930, 17158449, 17449468, 17709393, 18286207, 18591963, 18758450, 19820695, 21512573, 21903422, 22081109, 22158122, 22904686, 25241761, 26334375, 27426733
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005671	Component	Ada2/Gcn5/Ada3 transcription activator complex	IDA	18838386
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	TAS	9466656
GO:0007223	Process	Wnt signaling pathway, calcium modulating pathway	TAS
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	TAS
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	IMP	10094049, 15125833
GO:0007252	Process	I-kappaB phosphorylation	IDA	11460167
GO:0007254	Process	JNK cascade	IBA	21873635
GO:0007254	Process	JNK cascade	IDA	9079627
GO:0007254	Process	JNK cascade	TAS
GO:0008385	Component	IkappaB kinase complex	IPI	10094049
GO:0010008	Component	Endosome membrane	TAS
GO:0016032	Process	Viral process	IEA
GO:0016239	Process	Positive regulation of macroautophagy	ISS
GO:0016579	Process	Protein deubiquitination	TAS
GO:0030971	Function	Receptor tyrosine kinase binding	IPI	18762249
GO:0032743	Process	Positive regulation of interleukin-2 production	IMP	15125833
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042802	Function	Identical protein binding	IPI	27426733
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	14982987
GO:0043276	Process	Anoikis	ISS
GO:0043507	Process	Positive regulation of JUN kinase activity	IDA	11460167
GO:0043507	Process	Positive regulation of JUN kinase activity	IMP	10094049
GO:0043966	Process	Histone H3 acetylation	IDA	18838386
GO:0050852	Process	T cell receptor signaling pathway	NAS	15125833
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	TAS
GO:0051403	Process	Stress-activated MAPK cascade	IDA	9079627
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0097110	Function	Scaffold protein binding	IDA	23776175

MIM	HGNC	e!Ensembl
602614	6859	ENSG00000135341

Protein

UniProt ID

O43318

Protein name

Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)

Protein function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Pl

PDB

2EVA , 2YIY , 4GS6 , 4L3P , 4L52 , 4L53 , 4O91 , 5E7R , 5GJD , 5GJF , 5GJG , 5J7S , 5J8I , 5J9L , 5JGA , 5JGB , 5JGD , 5JH6 , 5JK3 , 5V5N , 7NTH , 7NTI , 8GW3 , 9FPD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07714	PK_Tyr_Ser-Thr	36 → 284	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
KRQGTS

Sequence length

606

Interactions

View interactions

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