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MAP2K7 (mitogen-activated protein kinase kinase 7)

Gene

5609

Mitogen-activated protein kinase kinase 7

MAP2K7

JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4

19p13.2

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase k

Show/Hide all(321)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045769	hsa-miR-125a-5p	CLASH	23622248
MIRT054426	hsa-miR-493-3p	Immunohistochemistry, Luciferase reporter assay, Western blot	24533778
MIRT054426	hsa-miR-493-3p	Immunohistochemistry, Luciferase reporter assay, Western blot	24533778
MIRT502019	hsa-miR-4311	PAR-CLIP	24398324
MIRT473843	hsa-miR-8080	PAR-CLIP	23592263
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT473840	hsa-miR-2278	PAR-CLIP	23592263
MIRT473839	hsa-miR-3125	PAR-CLIP	23592263
MIRT473838	hsa-miR-3916	PAR-CLIP	23592263
MIRT473837	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT473833	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT473832	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT473831	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT473830	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT473829	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT473828	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT473827	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT473826	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT473825	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT473823	hsa-miR-4458	PAR-CLIP	23592263
MIRT473824	hsa-miR-4500	PAR-CLIP	23592263
MIRT473822	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT473820	hsa-miR-6077	PAR-CLIP	23592263
MIRT473818	hsa-miR-4451	PAR-CLIP	23592263
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT440290	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440290	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT473832	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT473832	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT473832	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT473832	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT473831	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT473831	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT473831	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT473831	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT473830	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT473830	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT473830	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT473830	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT473829	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT473829	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT473829	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT473829	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT473828	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT473828	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT473828	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT473828	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT473827	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT473827	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT473827	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT473827	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT473826	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT473826	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT473826	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT473826	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT473825	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT473825	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT473825	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT473825	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT473840	hsa-miR-2278	PAR-CLIP	26701625
MIRT473840	hsa-miR-2278	PAR-CLIP	26701625
MIRT473840	hsa-miR-2278	PAR-CLIP	26701625
MIRT473840	hsa-miR-2278	PAR-CLIP	26701625
MIRT473839	hsa-miR-3125	PAR-CLIP	26701625
MIRT473839	hsa-miR-3125	PAR-CLIP	26701625
MIRT473838	hsa-miR-3916	PAR-CLIP	26701625
MIRT473838	hsa-miR-3916	PAR-CLIP	26701625
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT473833	hsa-miR-3928-3p	PAR-CLIP	26701625
MIRT473833	hsa-miR-3928-3p	PAR-CLIP	26701625
MIRT473818	hsa-miR-4451	PAR-CLIP	26701625
MIRT473818	hsa-miR-4451	PAR-CLIP	26701625
MIRT473818	hsa-miR-4451	PAR-CLIP	26701625
MIRT473818	hsa-miR-4451	PAR-CLIP	26701625
MIRT473823	hsa-miR-4458	PAR-CLIP	26701625
MIRT473823	hsa-miR-4458	PAR-CLIP	26701625
MIRT473823	hsa-miR-4458	PAR-CLIP	26701625
MIRT473823	hsa-miR-4458	PAR-CLIP	26701625
MIRT473824	hsa-miR-4500	PAR-CLIP	26701625
MIRT473824	hsa-miR-4500	PAR-CLIP	26701625
MIRT473824	hsa-miR-4500	PAR-CLIP	26701625
MIRT473824	hsa-miR-4500	PAR-CLIP	26701625
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	26701625
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	26701625
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	26701625
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	26701625
MIRT473820	hsa-miR-6077	PAR-CLIP	26701625
MIRT473820	hsa-miR-6077	PAR-CLIP	26701625
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT473837	hsa-miR-6859-5p	PAR-CLIP	26701625
MIRT473837	hsa-miR-6859-5p	PAR-CLIP	26701625
MIRT473843	hsa-miR-8080	PAR-CLIP	26701625
MIRT473843	hsa-miR-8080	PAR-CLIP	26701625
MIRT473822	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT473822	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT473822	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT473822	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT502019	hsa-miR-4311	PAR-CLIP	27292025
MIRT734747	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR	33921710
MIRT736015	hsa-miR-331-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32776229
MIRT502019	hsa-miR-4311	PAR-CLIP	24398324
MIRT473843	hsa-miR-8080	PAR-CLIP	23592263
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT473840	hsa-miR-2278	PAR-CLIP	23592263
MIRT473839	hsa-miR-3125	PAR-CLIP	23592263
MIRT473838	hsa-miR-3916	PAR-CLIP	23592263
MIRT473837	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT473833	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT473832	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT473831	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT473830	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT473829	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT473828	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT473827	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT473826	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT473825	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT473823	hsa-miR-4458	PAR-CLIP	23592263
MIRT473824	hsa-miR-4500	PAR-CLIP	23592263
MIRT473822	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT473820	hsa-miR-6077	PAR-CLIP	23592263
MIRT473818	hsa-miR-4451	PAR-CLIP	23592263
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT1128094	hsa-let-7a	CLIP-seq
MIRT1128095	hsa-let-7b	CLIP-seq
MIRT1128096	hsa-let-7c	CLIP-seq
MIRT1128097	hsa-let-7d	CLIP-seq
MIRT1128098	hsa-let-7e	CLIP-seq
MIRT1128099	hsa-let-7f	CLIP-seq
MIRT1128100	hsa-let-7g	CLIP-seq
MIRT1128101	hsa-let-7i	CLIP-seq
MIRT1128102	hsa-miR-1287	CLIP-seq
MIRT1128103	hsa-miR-1538	CLIP-seq
MIRT1128104	hsa-miR-1908	CLIP-seq
MIRT1128105	hsa-miR-1909	CLIP-seq
MIRT1128106	hsa-miR-2861	CLIP-seq
MIRT1128107	hsa-miR-3150a-3p	CLIP-seq
MIRT1128108	hsa-miR-3175	CLIP-seq
MIRT1128109	hsa-miR-3180	CLIP-seq
MIRT1128110	hsa-miR-3180-3p	CLIP-seq
MIRT1128111	hsa-miR-3187-3p	CLIP-seq
MIRT1128112	hsa-miR-3196	CLIP-seq
MIRT1128113	hsa-miR-3689a-3p	CLIP-seq
MIRT1128114	hsa-miR-3689c	CLIP-seq
MIRT1128115	hsa-miR-3927	CLIP-seq
MIRT1128116	hsa-miR-4529-5p	CLIP-seq
MIRT1128117	hsa-miR-4532	CLIP-seq
MIRT1128118	hsa-miR-4640-5p	CLIP-seq
MIRT1128119	hsa-miR-4651	CLIP-seq
MIRT1128120	hsa-miR-4726-5p	CLIP-seq
MIRT1128121	hsa-miR-4745-3p	CLIP-seq
MIRT1128122	hsa-miR-4747-3p	CLIP-seq
MIRT1128123	hsa-miR-491-5p	CLIP-seq
MIRT1128124	hsa-miR-603	CLIP-seq
MIRT1128125	hsa-miR-608	CLIP-seq
MIRT1128126	hsa-miR-663	CLIP-seq
MIRT1128127	hsa-miR-663b	CLIP-seq
MIRT1128128	hsa-miR-939	CLIP-seq
MIRT1128129	hsa-miR-98	CLIP-seq
MIRT1551118	hsa-miR-1197	CLIP-seq
MIRT2036417	hsa-miR-1913	CLIP-seq
MIRT2036418	hsa-miR-3130-3p	CLIP-seq
MIRT1128111	hsa-miR-3187-3p	CLIP-seq
MIRT2036419	hsa-miR-3189-5p	CLIP-seq
MIRT2036420	hsa-miR-3191	CLIP-seq
MIRT2036421	hsa-miR-3194-3p	CLIP-seq
MIRT2036422	hsa-miR-324-3p	CLIP-seq
MIRT2036423	hsa-miR-328	CLIP-seq
MIRT2036424	hsa-miR-3622a-3p	CLIP-seq
MIRT2036425	hsa-miR-3622b-3p	CLIP-seq
MIRT2036426	hsa-miR-370	CLIP-seq
MIRT2036427	hsa-miR-4287	CLIP-seq
MIRT2036428	hsa-miR-4292	CLIP-seq
MIRT2036429	hsa-miR-4313	CLIP-seq
MIRT2036430	hsa-miR-4447	CLIP-seq
MIRT2036431	hsa-miR-4472	CLIP-seq
MIRT1128116	hsa-miR-4529-5p	CLIP-seq
MIRT1128119	hsa-miR-4651	CLIP-seq
MIRT2036432	hsa-miR-4685-3p	CLIP-seq
MIRT2036433	hsa-miR-4758-3p	CLIP-seq
MIRT2036434	hsa-miR-4780	CLIP-seq
MIRT2036435	hsa-miR-4793-3p	CLIP-seq
MIRT2036436	hsa-miR-541	CLIP-seq
MIRT1128124	hsa-miR-603	CLIP-seq
MIRT1128125	hsa-miR-608	CLIP-seq
MIRT2036437	hsa-miR-623	CLIP-seq
MIRT2036438	hsa-miR-654-5p	CLIP-seq
MIRT1128127	hsa-miR-663b	CLIP-seq
MIRT2036439	hsa-miR-670	CLIP-seq
MIRT2036440	hsa-miR-767-5p	CLIP-seq
MIRT1128094	hsa-let-7a	CLIP-seq
MIRT1128095	hsa-let-7b	CLIP-seq
MIRT1128096	hsa-let-7c	CLIP-seq
MIRT1128097	hsa-let-7d	CLIP-seq
MIRT1128098	hsa-let-7e	CLIP-seq
MIRT1128099	hsa-let-7f	CLIP-seq
MIRT1128100	hsa-let-7g	CLIP-seq
MIRT1128101	hsa-let-7i	CLIP-seq
MIRT2266663	hsa-miR-1234	CLIP-seq
MIRT2266664	hsa-miR-125b	CLIP-seq
MIRT2266665	hsa-miR-128	CLIP-seq
MIRT1128102	hsa-miR-1287	CLIP-seq
MIRT2266666	hsa-miR-141	CLIP-seq
MIRT2266667	hsa-miR-1468	CLIP-seq
MIRT1128105	hsa-miR-1909	CLIP-seq
MIRT2266668	hsa-miR-1976	CLIP-seq
MIRT2266669	hsa-miR-200a	CLIP-seq
MIRT2266670	hsa-miR-27a	CLIP-seq
MIRT2266671	hsa-miR-27b	CLIP-seq
MIRT2036418	hsa-miR-3130-3p	CLIP-seq
MIRT2266672	hsa-miR-3150b-3p	CLIP-seq
MIRT2266673	hsa-miR-3179	CLIP-seq
MIRT2036419	hsa-miR-3189-5p	CLIP-seq
MIRT2036420	hsa-miR-3191	CLIP-seq
MIRT2036421	hsa-miR-3194-3p	CLIP-seq
MIRT2266674	hsa-miR-329	CLIP-seq
MIRT2036424	hsa-miR-3622a-3p	CLIP-seq
MIRT2036425	hsa-miR-3622b-3p	CLIP-seq
MIRT2266675	hsa-miR-362-3p	CLIP-seq
MIRT1128113	hsa-miR-3689a-3p	CLIP-seq
MIRT1128114	hsa-miR-3689c	CLIP-seq
MIRT2036426	hsa-miR-370	CLIP-seq
MIRT1128115	hsa-miR-3927	CLIP-seq
MIRT2266676	hsa-miR-421	CLIP-seq
MIRT2266677	hsa-miR-4319	CLIP-seq
MIRT2266678	hsa-miR-4431	CLIP-seq
MIRT2266679	hsa-miR-4438	CLIP-seq
MIRT2036430	hsa-miR-4447	CLIP-seq
MIRT2036431	hsa-miR-4472	CLIP-seq
MIRT2266680	hsa-miR-4493	CLIP-seq
MIRT2266681	hsa-miR-4522	CLIP-seq
MIRT1128116	hsa-miR-4529-5p	CLIP-seq
MIRT2266682	hsa-miR-4640-3p	CLIP-seq
MIRT1128118	hsa-miR-4640-5p	CLIP-seq
MIRT1128119	hsa-miR-4651	CLIP-seq
MIRT2266683	hsa-miR-4667-3p	CLIP-seq
MIRT2266684	hsa-miR-4709-5p	CLIP-seq
MIRT2266685	hsa-miR-4714-5p	CLIP-seq
MIRT1128120	hsa-miR-4726-5p	CLIP-seq
MIRT2266686	hsa-miR-4732-3p	CLIP-seq
MIRT2266687	hsa-miR-4753-5p	CLIP-seq
MIRT2266688	hsa-miR-4755-3p	CLIP-seq
MIRT2036433	hsa-miR-4758-3p	CLIP-seq
MIRT2266689	hsa-miR-4762-3p	CLIP-seq
MIRT2266690	hsa-miR-4784	CLIP-seq
MIRT2036435	hsa-miR-4793-3p	CLIP-seq
MIRT2266691	hsa-miR-4793-5p	CLIP-seq
MIRT2266692	hsa-miR-485-5p	CLIP-seq
MIRT2266693	hsa-miR-493	CLIP-seq
MIRT2266694	hsa-miR-505	CLIP-seq
MIRT2266695	hsa-miR-513a-5p	CLIP-seq
MIRT2036436	hsa-miR-541	CLIP-seq
MIRT2266696	hsa-miR-548n	CLIP-seq
MIRT2266697	hsa-miR-548t	CLIP-seq
MIRT2266698	hsa-miR-561	CLIP-seq
MIRT1128124	hsa-miR-603	CLIP-seq
MIRT2266699	hsa-miR-604	CLIP-seq
MIRT1128125	hsa-miR-608	CLIP-seq
MIRT2266700	hsa-miR-626	CLIP-seq
MIRT2036438	hsa-miR-654-5p	CLIP-seq
MIRT2036439	hsa-miR-670	CLIP-seq
MIRT2036440	hsa-miR-767-5p	CLIP-seq
MIRT1128129	hsa-miR-98	CLIP-seq
MIRT2390556	hsa-miR-1291	CLIP-seq
MIRT2390557	hsa-miR-1914	CLIP-seq
MIRT2036423	hsa-miR-328	CLIP-seq
MIRT2390558	hsa-miR-3649	CLIP-seq
MIRT2036428	hsa-miR-4292	CLIP-seq
MIRT2566310	hsa-miR-1470	CLIP-seq
MIRT2036418	hsa-miR-3130-3p	CLIP-seq
MIRT2036421	hsa-miR-3194-3p	CLIP-seq
MIRT2036424	hsa-miR-3622a-3p	CLIP-seq
MIRT2036425	hsa-miR-3622b-3p	CLIP-seq
MIRT2266683	hsa-miR-4667-3p	CLIP-seq
MIRT2036435	hsa-miR-4793-3p	CLIP-seq
MIRT2036440	hsa-miR-767-5p	CLIP-seq
MIRT2566310	hsa-miR-1470	CLIP-seq
MIRT2036418	hsa-miR-3130-3p	CLIP-seq
MIRT2036421	hsa-miR-3194-3p	CLIP-seq
MIRT2036424	hsa-miR-3622a-3p	CLIP-seq
MIRT2036425	hsa-miR-3622b-3p	CLIP-seq
MIRT2266683	hsa-miR-4667-3p	CLIP-seq
MIRT2036435	hsa-miR-4793-3p	CLIP-seq
MIRT2036440	hsa-miR-767-5p	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IBA	21873635
GO:0000287	Function	Magnesium ion binding	IDA	9535930
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004708	Function	MAP kinase kinase activity	IBA	21873635
GO:0004708	Function	MAP kinase kinase activity	IDA	9535930
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	15299019, 16840345, 17110930, 17709393, 18286207, 20067578, 25241761, 25284480, 25314077
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006970	Process	Response to osmotic stress	IDA	9535930
GO:0007165	Process	Signal transduction	TAS	9535930
GO:0007254	Process	JNK cascade	TAS
GO:0007257	Process	Activation of JUN kinase activity	IBA	21873635
GO:0007257	Process	Activation of JUN kinase activity	ISS
GO:0008545	Function	JUN kinase kinase activity	IBA	21873635
GO:0009408	Process	Response to heat	IDA	9535930
GO:0009411	Process	Response to UV	IDA	9535930
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0019899	Function	Enzyme binding	IPI	14615289
GO:0019901	Function	Protein kinase binding	IPI	14697235
GO:0019903	Function	Protein phosphatase binding	ISS
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IMP	21531765
GO:0034612	Process	Response to tumor necrosis factor	IDA	9535930
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	28111074
GO:0051403	Process	Stress-activated MAPK cascade	IDA	9535930
GO:0051973	Process	Positive regulation of telomerase activity	IMP	21531765
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	28111074
GO:1904355	Process	Positive regulation of telomere capping	IMP	21531765

MIM	HGNC	e!Ensembl
603014	6847	ENSG00000076984

Protein

UniProt ID

O14733

Protein name

Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal

Protein function

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4,

PDB

2DYL , 3WZU , 4UX9 , 5B2K , 5B2L , 5B2M , 5Y8U , 5Y90 , 5Z1D , 5Z1E , 6IB0 , 6IB2 , 6QFL , 6QFR , 6QFT , 6QG4 , 6QG7 , 6QHO , 6QHR , 6YFZ , 6YG0 , 6YG1 , 6YG2 , 6YG3 , 6YG4 , 6YG5 , 6YG6 , 6YG7 , 6YZ4 , 7CBX , 7OVI , 7OVJ , 7OVK , 7OVL , 7OVM , 7OVN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	120 → 380	Protein kinase domain	Domain

Sequence

MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR

Sequence length

419

Interactions

View interactions

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