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MAP2K7 (mitogen-activated protein kinase kinase 7)
Gene
Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5609
Gene nameGene Name - the full gene name approved by the HGNC.
Mitogen-activated protein kinase kinase 7
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MAP2K7
SynonymsGene synonyms aliases
JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4
ChromosomeChromosome number
19
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.2
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT045769 hsa-miR-125a-5p CLASH 23622248
MIRT054426 hsa-miR-493-3p Immunohistochemistry, Luciferase reporter assay, Western blot 24533778
MIRT440290 hsa-miR-218-5p HITS-CLIP 23212916
MIRT473817 hsa-miR-4732-5p PAR-CLIP 23592263
MIRT473817 hsa-miR-4732-5p PAR-CLIP 26701625
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs
GO ID Ontology Definition Evidence Reference
GO:0000187 Process Activation of MAPK activity IBA 21873635
GO:0000287 Function Magnesium ion binding IDA 9535930
GO:0004674 Function Protein serine/threonine kinase activity IEA
GO:0004708 Function MAP kinase kinase activity IBA 21873635
GO:0004708 Function MAP kinase kinase activity IDA 9535930
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Other IDs
UniProt ID O14733
Protein name Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
Protein function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).
PDB 2DYL , 3WZU , 4UX9 , 5B2K , 5B2L , 5B2M , 5Y8U , 5Y90 , 5Z1D , 5Z1E , 6IB0 , 6IB2 , 6QFL , 6QFR , 6QFT , 6QG4 , 6QG7 , 6QHO , 6QHR , 6YFZ , 6YG0 , 6YG1 , 6YG2 , 6YG3 , 6YG4 , 6YG5 , 6YG6 , 6YG7 , 6YZ4 , 7CBX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
120 → 380
Protein kinase domain
 Domain
Sequence
Sequence length 419
Interactions View interactions

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