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MAP2K4 (mitogen-activated protein kinase kinase 4)

Gene

6416

Mitogen-activated protein kinase kinase 4

MAP2K4

JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1

17p12

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, different

Show/Hide all(616)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019756	hsa-miR-375	Microarray	20215506
MIRT028937	hsa-miR-26b-5p	Microarray	19088304
MIRT023483	hsa-miR-15b-5p	CLASH	23622248
MIRT053655	hsa-miR-145-5p	Microarray	22942087
MIRT053698	hsa-miR-188-5p	Microarray	22942087
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assay, Western blot	24556602
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assay, Western blot	24556602
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assay, Western blot	24556602
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assay, Western blot	24556602
MIRT437965	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705900
MIRT556342	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT556341	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT437965	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT556340	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT556339	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT030360	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT556338	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT556337	hsa-miR-548ab	PAR-CLIP	21572407
MIRT556336	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT556335	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT556334	hsa-miR-548ak	PAR-CLIP	21572407
MIRT556333	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT556332	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT556331	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT556330	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT556329	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT556328	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT556327	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT556326	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT556325	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT556324	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT556323	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT556322	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT556321	hsa-miR-548i	PAR-CLIP	21572407
MIRT556320	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT556319	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT556318	hsa-miR-548w	PAR-CLIP	21572407
MIRT556317	hsa-miR-548y	PAR-CLIP	21572407
MIRT556316	hsa-miR-559	PAR-CLIP	21572407
MIRT556315	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT556314	hsa-miR-3614-5p	PAR-CLIP	21572407
MIRT556313	hsa-miR-5193	PAR-CLIP	21572407
MIRT556312	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT556311	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT556310	hsa-miR-3185	PAR-CLIP	21572407
MIRT556309	hsa-miR-4691-5p	PAR-CLIP	21572407
MIRT556308	hsa-miR-6792-3p	PAR-CLIP	21572407
MIRT556307	hsa-miR-6749-3p	PAR-CLIP	21572407
MIRT556306	hsa-miR-7703	PAR-CLIP	21572407
MIRT556305	hsa-miR-4325	PAR-CLIP	21572407
MIRT556304	hsa-miR-7855-5p	PAR-CLIP	21572407
MIRT556303	hsa-miR-6818-3p	PAR-CLIP	21572407
MIRT473860	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT473859	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT473858	hsa-miR-4534	PAR-CLIP	23592263
MIRT473857	hsa-miR-8082	PAR-CLIP	23592263
MIRT473856	hsa-miR-3134	PAR-CLIP	23592263
MIRT473855	hsa-miR-4261	PAR-CLIP	23592263
MIRT473854	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT473853	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT473852	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT473851	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT030360	hsa-miR-25-3p	Western blot	27353001
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27594411
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27594411
MIRT736251	hsa-miR-200a-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry, Immunocytochemistry (ICC)	32016794
MIRT737290	hsa-miR-512-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR	32850377
MIRT556342	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT556341	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT437965	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT556340	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT556339	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT030360	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT556338	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT556337	hsa-miR-548ab	PAR-CLIP	21572407
MIRT556336	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT556335	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT556334	hsa-miR-548ak	PAR-CLIP	21572407
MIRT556333	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT556332	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT556331	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT556330	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT556329	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT556328	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT556327	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT556326	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT556325	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT556324	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT556323	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT556322	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT556321	hsa-miR-548i	PAR-CLIP	21572407
MIRT556320	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT556319	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT556318	hsa-miR-548w	PAR-CLIP	21572407
MIRT556317	hsa-miR-548y	PAR-CLIP	21572407
MIRT556316	hsa-miR-559	PAR-CLIP	21572407
MIRT556315	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT556314	hsa-miR-3614-5p	PAR-CLIP	21572407
MIRT556313	hsa-miR-5193	PAR-CLIP	21572407
MIRT556312	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT556311	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT556310	hsa-miR-3185	PAR-CLIP	21572407
MIRT556309	hsa-miR-4691-5p	PAR-CLIP	21572407
MIRT556308	hsa-miR-6792-3p	PAR-CLIP	21572407
MIRT556307	hsa-miR-6749-3p	PAR-CLIP	21572407
MIRT556306	hsa-miR-7703	PAR-CLIP	21572407
MIRT556305	hsa-miR-4325	PAR-CLIP	21572407
MIRT556304	hsa-miR-7855-5p	PAR-CLIP	21572407
MIRT556303	hsa-miR-6818-3p	PAR-CLIP	21572407
MIRT473860	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT473859	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT473858	hsa-miR-4534	PAR-CLIP	23592263
MIRT473857	hsa-miR-8082	PAR-CLIP	23592263
MIRT473856	hsa-miR-3134	PAR-CLIP	23592263
MIRT473855	hsa-miR-4261	PAR-CLIP	23592263
MIRT473854	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT473853	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT473852	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT473851	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT1128003	hsa-miR-1231	CLIP-seq
MIRT1128004	hsa-miR-1255a	CLIP-seq
MIRT1128005	hsa-miR-1255b	CLIP-seq
MIRT1128006	hsa-miR-125a-3p	CLIP-seq
MIRT1128007	hsa-miR-1266	CLIP-seq
MIRT1128008	hsa-miR-1273c	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128010	hsa-miR-1284	CLIP-seq
MIRT1128011	hsa-miR-1285	CLIP-seq
MIRT1128012	hsa-miR-129-3p	CLIP-seq
MIRT1128013	hsa-miR-134	CLIP-seq
MIRT1128014	hsa-miR-137	CLIP-seq
MIRT1128015	hsa-miR-140-3p	CLIP-seq
MIRT1128016	hsa-miR-15a	CLIP-seq
MIRT1128017	hsa-miR-15b	CLIP-seq
MIRT1128018	hsa-miR-16	CLIP-seq
MIRT1128019	hsa-miR-195	CLIP-seq
MIRT1128020	hsa-miR-1972	CLIP-seq
MIRT1128021	hsa-miR-2115	CLIP-seq
MIRT1128022	hsa-miR-2276	CLIP-seq
MIRT1128023	hsa-miR-2278	CLIP-seq
MIRT1128024	hsa-miR-25	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT1128027	hsa-miR-3065-5p	CLIP-seq
MIRT1128028	hsa-miR-3118	CLIP-seq
MIRT1128029	hsa-miR-3164	CLIP-seq
MIRT1128030	hsa-miR-3171	CLIP-seq
MIRT1128031	hsa-miR-3183	CLIP-seq
MIRT1128032	hsa-miR-3187-5p	CLIP-seq
MIRT1128033	hsa-miR-32	CLIP-seq
MIRT1128034	hsa-miR-3202	CLIP-seq
MIRT1128035	hsa-miR-34b	CLIP-seq
MIRT1128036	hsa-miR-3591-3p	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128038	hsa-miR-3611	CLIP-seq
MIRT1128039	hsa-miR-3622a-3p	CLIP-seq
MIRT1128040	hsa-miR-3622b-3p	CLIP-seq
MIRT1128041	hsa-miR-363	CLIP-seq
MIRT1128042	hsa-miR-3664-3p	CLIP-seq
MIRT1128043	hsa-miR-3665	CLIP-seq
MIRT1128044	hsa-miR-367	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT1128046	hsa-miR-369-3p	CLIP-seq
MIRT1128047	hsa-miR-374a	CLIP-seq
MIRT1128048	hsa-miR-374b	CLIP-seq
MIRT1128049	hsa-miR-378g	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT1128051	hsa-miR-3977	CLIP-seq
MIRT1128052	hsa-miR-424	CLIP-seq
MIRT1128053	hsa-miR-4256	CLIP-seq
MIRT1128054	hsa-miR-4271	CLIP-seq
MIRT1128055	hsa-miR-431	CLIP-seq
MIRT1128056	hsa-miR-4452	CLIP-seq
MIRT1128057	hsa-miR-4486	CLIP-seq
MIRT1128058	hsa-miR-4501	CLIP-seq
MIRT1128059	hsa-miR-4502	CLIP-seq
MIRT1128060	hsa-miR-4518	CLIP-seq
MIRT1128061	hsa-miR-4524	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128063	hsa-miR-4649-5p	CLIP-seq
MIRT1128064	hsa-miR-4650-5p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT1128066	hsa-miR-4690-3p	CLIP-seq
MIRT1128067	hsa-miR-4690-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT1128068	hsa-miR-4717-3p	CLIP-seq
MIRT1128069	hsa-miR-4723-3p	CLIP-seq
MIRT1128070	hsa-miR-4725-3p	CLIP-seq
MIRT1128071	hsa-miR-4747-5p	CLIP-seq
MIRT1128072	hsa-miR-4764-5p	CLIP-seq
MIRT1128073	hsa-miR-4772-3p	CLIP-seq
MIRT1128074	hsa-miR-4777-5p	CLIP-seq
MIRT1128075	hsa-miR-4789-5p	CLIP-seq
MIRT1128076	hsa-miR-497	CLIP-seq
MIRT1128077	hsa-miR-503	CLIP-seq
MIRT1128078	hsa-miR-505	CLIP-seq
MIRT1128079	hsa-miR-5095	CLIP-seq
MIRT1128080	hsa-miR-513a-5p	CLIP-seq
MIRT1128081	hsa-miR-516a-3p	CLIP-seq
MIRT1128082	hsa-miR-518d-5p	CLIP-seq
MIRT1128083	hsa-miR-519b-5p	CLIP-seq
MIRT1128084	hsa-miR-519c-5p	CLIP-seq
MIRT1128085	hsa-miR-520c-5p	CLIP-seq
MIRT1128086	hsa-miR-526a	CLIP-seq
MIRT1128087	hsa-miR-544	CLIP-seq
MIRT1128088	hsa-miR-612	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT1128089	hsa-miR-646	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT1128091	hsa-miR-758	CLIP-seq
MIRT1128092	hsa-miR-92a	CLIP-seq
MIRT1128093	hsa-miR-92b	CLIP-seq
MIRT1556631	hsa-miR-1302	CLIP-seq
MIRT1556632	hsa-miR-22	CLIP-seq
MIRT1556633	hsa-miR-221	CLIP-seq
MIRT1556634	hsa-miR-222	CLIP-seq
MIRT1556635	hsa-miR-3122	CLIP-seq
MIRT1556636	hsa-miR-3649	CLIP-seq
MIRT1556637	hsa-miR-382	CLIP-seq
MIRT1556638	hsa-miR-3913-5p	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT1556639	hsa-miR-4298	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT1556640	hsa-miR-548v	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT2036388	hsa-miR-1229	CLIP-seq
MIRT1128007	hsa-miR-1266	CLIP-seq
MIRT1128008	hsa-miR-1273c	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128012	hsa-miR-129-3p	CLIP-seq
MIRT1128015	hsa-miR-140-3p	CLIP-seq
MIRT2036389	hsa-miR-145	CLIP-seq
MIRT2036390	hsa-miR-150	CLIP-seq
MIRT1128020	hsa-miR-1972	CLIP-seq
MIRT1128021	hsa-miR-2115	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT2036391	hsa-miR-299-3p	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT1128031	hsa-miR-3183	CLIP-seq
MIRT1128034	hsa-miR-3202	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128039	hsa-miR-3622a-3p	CLIP-seq
MIRT1128040	hsa-miR-3622b-3p	CLIP-seq
MIRT2036394	hsa-miR-3647-3p	CLIP-seq
MIRT1128042	hsa-miR-3664-3p	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT1128051	hsa-miR-3977	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2036397	hsa-miR-4267	CLIP-seq
MIRT1128054	hsa-miR-4271	CLIP-seq
MIRT1128055	hsa-miR-431	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2036399	hsa-miR-4491	CLIP-seq
MIRT1128060	hsa-miR-4518	CLIP-seq
MIRT2036400	hsa-miR-452	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128064	hsa-miR-4650-5p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT2036402	hsa-miR-4657	CLIP-seq
MIRT2036403	hsa-miR-4676-3p	CLIP-seq
MIRT2036404	hsa-miR-4681	CLIP-seq
MIRT1128066	hsa-miR-4690-3p	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT2036406	hsa-miR-4713-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT1128069	hsa-miR-4723-3p	CLIP-seq
MIRT1128070	hsa-miR-4725-3p	CLIP-seq
MIRT1128071	hsa-miR-4747-5p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT1128081	hsa-miR-516a-3p	CLIP-seq
MIRT2036409	hsa-miR-532-3p	CLIP-seq
MIRT2036410	hsa-miR-548h	CLIP-seq
MIRT2036411	hsa-miR-548j	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT2036413	hsa-miR-887	CLIP-seq
MIRT2036414	hsa-miR-892a	CLIP-seq
MIRT2036415	hsa-miR-942	CLIP-seq
MIRT2036416	hsa-miR-943	CLIP-seq
MIRT2266617	hsa-miR-1205	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT1128003	hsa-miR-1231	CLIP-seq
MIRT2266618	hsa-miR-124	CLIP-seq
MIRT2266619	hsa-miR-127-3p	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128010	hsa-miR-1284	CLIP-seq
MIRT1128011	hsa-miR-1285	CLIP-seq
MIRT2266620	hsa-miR-136	CLIP-seq
MIRT2266621	hsa-miR-141	CLIP-seq
MIRT2036389	hsa-miR-145	CLIP-seq
MIRT2266622	hsa-miR-200a	CLIP-seq
MIRT2266623	hsa-miR-204	CLIP-seq
MIRT2266624	hsa-miR-211	CLIP-seq
MIRT1128024	hsa-miR-25	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT2266625	hsa-miR-29a	CLIP-seq
MIRT2266626	hsa-miR-29b	CLIP-seq
MIRT2266627	hsa-miR-29c	CLIP-seq
MIRT2266628	hsa-miR-3065-3p	CLIP-seq
MIRT1128027	hsa-miR-3065-5p	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT2266629	hsa-miR-3161	CLIP-seq
MIRT1128032	hsa-miR-3187-5p	CLIP-seq
MIRT1128033	hsa-miR-32	CLIP-seq
MIRT1128035	hsa-miR-34b	CLIP-seq
MIRT1128036	hsa-miR-3591-3p	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128038	hsa-miR-3611	CLIP-seq
MIRT2266630	hsa-miR-3619-3p	CLIP-seq
MIRT1128041	hsa-miR-363	CLIP-seq
MIRT2266631	hsa-miR-3660	CLIP-seq
MIRT2266632	hsa-miR-3661	CLIP-seq
MIRT2266633	hsa-miR-3663-5p	CLIP-seq
MIRT1128044	hsa-miR-367	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT2266634	hsa-miR-3690	CLIP-seq
MIRT2266635	hsa-miR-3692	CLIP-seq
MIRT1128049	hsa-miR-378g	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT2266636	hsa-miR-409-3p	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2266637	hsa-miR-4254	CLIP-seq
MIRT1128053	hsa-miR-4256	CLIP-seq
MIRT2266638	hsa-miR-4287	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2266639	hsa-miR-433	CLIP-seq
MIRT2266640	hsa-miR-4469	CLIP-seq
MIRT1128057	hsa-miR-4486	CLIP-seq
MIRT2266641	hsa-miR-4520a-3p	CLIP-seq
MIRT2266642	hsa-miR-4526	CLIP-seq
MIRT2266643	hsa-miR-4638-3p	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128063	hsa-miR-4649-5p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT2266644	hsa-miR-4685-3p	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT2266645	hsa-miR-4712-5p	CLIP-seq
MIRT2036406	hsa-miR-4713-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT1128068	hsa-miR-4717-3p	CLIP-seq
MIRT2266646	hsa-miR-4738-3p	CLIP-seq
MIRT2266647	hsa-miR-4742-5p	CLIP-seq
MIRT2266648	hsa-miR-4771	CLIP-seq
MIRT2266649	hsa-miR-4775	CLIP-seq
MIRT2266650	hsa-miR-4776-5p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT1128075	hsa-miR-4789-5p	CLIP-seq
MIRT2266651	hsa-miR-487b	CLIP-seq
MIRT1128078	hsa-miR-505	CLIP-seq
MIRT2266652	hsa-miR-506	CLIP-seq
MIRT2266653	hsa-miR-5096	CLIP-seq
MIRT1128080	hsa-miR-513a-5p	CLIP-seq
MIRT2036410	hsa-miR-548h	CLIP-seq
MIRT2036411	hsa-miR-548j	CLIP-seq
MIRT2266654	hsa-miR-590-3p	CLIP-seq
MIRT1128088	hsa-miR-612	CLIP-seq
MIRT2266655	hsa-miR-617	CLIP-seq
MIRT2266656	hsa-miR-619	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT2266657	hsa-miR-631	CLIP-seq
MIRT2266658	hsa-miR-634	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT1128091	hsa-miR-758	CLIP-seq
MIRT2266659	hsa-miR-767-5p	CLIP-seq
MIRT2266660	hsa-miR-770-5p	CLIP-seq
MIRT2036413	hsa-miR-887	CLIP-seq
MIRT2036414	hsa-miR-892a	CLIP-seq
MIRT1128092	hsa-miR-92a	CLIP-seq
MIRT1128093	hsa-miR-92b	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT2390550	hsa-miR-3174	CLIP-seq
MIRT2390551	hsa-miR-339-5p	CLIP-seq
MIRT2390552	hsa-miR-3606	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT2390553	hsa-miR-3682-5p	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2266638	hsa-miR-4287	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2390554	hsa-miR-4424	CLIP-seq
MIRT2266640	hsa-miR-4469	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT2266644	hsa-miR-4685-3p	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT2036406	hsa-miR-4713-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT2390555	hsa-miR-921	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128010	hsa-miR-1284	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT1128038	hsa-miR-3611	CLIP-seq
MIRT2438485	hsa-miR-4704-5p	CLIP-seq
MIRT1128075	hsa-miR-4789-5p	CLIP-seq
MIRT2266653	hsa-miR-5096	CLIP-seq
MIRT1128080	hsa-miR-513a-5p	CLIP-seq
MIRT1128091	hsa-miR-758	CLIP-seq
MIRT2453656	hsa-miR-1321	CLIP-seq
MIRT2453657	hsa-miR-148a	CLIP-seq
MIRT2453658	hsa-miR-148b	CLIP-seq
MIRT2453659	hsa-miR-152	CLIP-seq
MIRT2453660	hsa-miR-3136-3p	CLIP-seq
MIRT2453661	hsa-miR-4270	CLIP-seq
MIRT2453662	hsa-miR-4276	CLIP-seq
MIRT2453663	hsa-miR-4441	CLIP-seq
MIRT2453664	hsa-miR-4739	CLIP-seq
MIRT2453665	hsa-miR-4755-3p	CLIP-seq
MIRT2453666	hsa-miR-4756-5p	CLIP-seq
MIRT2453656	hsa-miR-1321	CLIP-seq
MIRT2453657	hsa-miR-148a	CLIP-seq
MIRT2453658	hsa-miR-148b	CLIP-seq
MIRT2453659	hsa-miR-152	CLIP-seq
MIRT2453660	hsa-miR-3136-3p	CLIP-seq
MIRT2453661	hsa-miR-4270	CLIP-seq
MIRT2453662	hsa-miR-4276	CLIP-seq
MIRT2453663	hsa-miR-4441	CLIP-seq
MIRT2453664	hsa-miR-4739	CLIP-seq
MIRT2453665	hsa-miR-4755-3p	CLIP-seq
MIRT2453666	hsa-miR-4756-5p	CLIP-seq
MIRT2566278	hsa-miR-1200	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT1128003	hsa-miR-1231	CLIP-seq
MIRT2266618	hsa-miR-124	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128010	hsa-miR-1284	CLIP-seq
MIRT2566279	hsa-miR-135a	CLIP-seq
MIRT2566280	hsa-miR-135b	CLIP-seq
MIRT1128014	hsa-miR-137	CLIP-seq
MIRT2266621	hsa-miR-141	CLIP-seq
MIRT2036389	hsa-miR-145	CLIP-seq
MIRT2266622	hsa-miR-200a	CLIP-seq
MIRT1556632	hsa-miR-22	CLIP-seq
MIRT2566281	hsa-miR-2277-3p	CLIP-seq
MIRT1128023	hsa-miR-2278	CLIP-seq
MIRT1128024	hsa-miR-25	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT2566282	hsa-miR-3117-3p	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2566283	hsa-miR-3133	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT2566284	hsa-miR-3166	CLIP-seq
MIRT2566285	hsa-miR-3169	CLIP-seq
MIRT1128033	hsa-miR-32	CLIP-seq
MIRT1128036	hsa-miR-3591-3p	CLIP-seq
MIRT2566286	hsa-miR-3605-5p	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128038	hsa-miR-3611	CLIP-seq
MIRT1128039	hsa-miR-3622a-3p	CLIP-seq
MIRT1128040	hsa-miR-3622b-3p	CLIP-seq
MIRT1128041	hsa-miR-363	CLIP-seq
MIRT1128044	hsa-miR-367	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT2566287	hsa-miR-3714	CLIP-seq
MIRT2566288	hsa-miR-376c	CLIP-seq
MIRT2566289	hsa-miR-3908	CLIP-seq
MIRT2566290	hsa-miR-3910	CLIP-seq
MIRT2566291	hsa-miR-3919	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2566292	hsa-miR-3942-3p	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2566293	hsa-miR-4324	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2566294	hsa-miR-4421	CLIP-seq
MIRT2566295	hsa-miR-4428	CLIP-seq
MIRT2566296	hsa-miR-4433	CLIP-seq
MIRT2566297	hsa-miR-4490	CLIP-seq
MIRT2566298	hsa-miR-4515	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT2438485	hsa-miR-4704-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT2566299	hsa-miR-4707-5p	CLIP-seq
MIRT2266645	hsa-miR-4712-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT1128068	hsa-miR-4717-3p	CLIP-seq
MIRT1128071	hsa-miR-4747-5p	CLIP-seq
MIRT2566300	hsa-miR-4759	CLIP-seq
MIRT2566301	hsa-miR-4773	CLIP-seq
MIRT2566302	hsa-miR-4778-5p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT1128075	hsa-miR-4789-5p	CLIP-seq
MIRT2566303	hsa-miR-4802-5p	CLIP-seq
MIRT2266652	hsa-miR-506	CLIP-seq
MIRT2266653	hsa-miR-5096	CLIP-seq
MIRT1128080	hsa-miR-513a-5p	CLIP-seq
MIRT2566304	hsa-miR-526b	CLIP-seq
MIRT2566305	hsa-miR-544b	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT2566306	hsa-miR-627	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT1128091	hsa-miR-758	CLIP-seq
MIRT2566307	hsa-miR-765	CLIP-seq
MIRT2266660	hsa-miR-770-5p	CLIP-seq
MIRT2036414	hsa-miR-892a	CLIP-seq
MIRT2566308	hsa-miR-922	CLIP-seq
MIRT2566309	hsa-miR-924	CLIP-seq
MIRT1128092	hsa-miR-92a	CLIP-seq
MIRT1128093	hsa-miR-92b	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT1128003	hsa-miR-1231	CLIP-seq
MIRT1128007	hsa-miR-1266	CLIP-seq
MIRT2684463	hsa-miR-1273e	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128011	hsa-miR-1285	CLIP-seq
MIRT2566279	hsa-miR-135a	CLIP-seq
MIRT2566280	hsa-miR-135b	CLIP-seq
MIRT1128014	hsa-miR-137	CLIP-seq
MIRT2266621	hsa-miR-141	CLIP-seq
MIRT2036389	hsa-miR-145	CLIP-seq
MIRT2684464	hsa-miR-1825	CLIP-seq
MIRT1128020	hsa-miR-1972	CLIP-seq
MIRT2684465	hsa-miR-199a-5p	CLIP-seq
MIRT2684466	hsa-miR-199b-5p	CLIP-seq
MIRT2266622	hsa-miR-200a	CLIP-seq
MIRT2684467	hsa-miR-218	CLIP-seq
MIRT1556632	hsa-miR-22	CLIP-seq
MIRT2566281	hsa-miR-2277-3p	CLIP-seq
MIRT1128024	hsa-miR-25	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT1128032	hsa-miR-3187-5p	CLIP-seq
MIRT1128033	hsa-miR-32	CLIP-seq
MIRT1128036	hsa-miR-3591-3p	CLIP-seq
MIRT2566286	hsa-miR-3605-5p	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128039	hsa-miR-3622a-3p	CLIP-seq
MIRT1128040	hsa-miR-3622b-3p	CLIP-seq
MIRT1128041	hsa-miR-363	CLIP-seq
MIRT1128042	hsa-miR-3664-3p	CLIP-seq
MIRT1128044	hsa-miR-367	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT2566287	hsa-miR-3714	CLIP-seq
MIRT1128049	hsa-miR-378g	CLIP-seq
MIRT2566289	hsa-miR-3908	CLIP-seq
MIRT2566291	hsa-miR-3919	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2684468	hsa-miR-4302	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2684469	hsa-miR-4422	CLIP-seq
MIRT2566296	hsa-miR-4433	CLIP-seq
MIRT1128057	hsa-miR-4486	CLIP-seq
MIRT1128060	hsa-miR-4518	CLIP-seq
MIRT2036400	hsa-miR-452	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128063	hsa-miR-4649-5p	CLIP-seq
MIRT1128064	hsa-miR-4650-5p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT2036403	hsa-miR-4676-3p	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT2566299	hsa-miR-4707-5p	CLIP-seq
MIRT2266645	hsa-miR-4712-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT1128068	hsa-miR-4717-3p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT2566303	hsa-miR-4802-5p	CLIP-seq
MIRT2566304	hsa-miR-526b	CLIP-seq
MIRT1128088	hsa-miR-612	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT2566306	hsa-miR-627	CLIP-seq
MIRT2684470	hsa-miR-636	CLIP-seq
MIRT2684471	hsa-miR-648	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT2566307	hsa-miR-765	CLIP-seq
MIRT2266660	hsa-miR-770-5p	CLIP-seq
MIRT2036414	hsa-miR-892a	CLIP-seq
MIRT2566308	hsa-miR-922	CLIP-seq
MIRT1128092	hsa-miR-92a	CLIP-seq
MIRT1128093	hsa-miR-92b	CLIP-seq
MIRT2036416	hsa-miR-943	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
HSF2	Repression	11557063

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IBA	21873635
GO:0004672	Function	Protein kinase activity	TAS	7716521
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004708	Function	MAP kinase kinase activity	IBA	21873635
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	9808624
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	TAS	7716521
GO:0007254	Process	JNK cascade	TAS
GO:0007257	Process	Activation of JUN kinase activity	IBA	21873635
GO:0008545	Function	JUN kinase kinase activity	IBA	21873635
GO:0009611	Process	Response to wounding	IEA
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0030424	Component	Axon	IEA
GO:0031435	Function	Mitogen-activated protein kinase kinase kinase binding	IEA
GO:0032839	Component	Dendrite cytoplasm	IEA
GO:0034393	Process	Positive regulation of smooth muscle cell apoptotic process	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0043204	Component	Perikaryon	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0045740	Process	Positive regulation of DNA replication	IEA
GO:0051770	Process	Positive regulation of nitric-oxide synthase biosynthetic process	IEA
GO:0061049	Process	Cell growth involved in cardiac muscle cell development	IEA
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:0072709	Process	Cellular response to sorbitol	IEA
GO:2000672	Process	Negative regulation of motor neuron apoptotic process	IEA

MIM	HGNC	e!Ensembl
601335	6844	ENSG00000065559

Protein

UniProt ID

P45985

Protein name

Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1)

Protein function

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,

PDB

3ALN , 3ALO , 3VUT , 8YP5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	102 → 367	Protein kinase domain	Domain

Sequence

MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD

Sequence length

399

Interactions

View interactions

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