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MAP2K2 (mitogen-activated protein kinase kinase 2)

Gene

5605

Mitogen-activated protein kinase kinase 2

MAP2K2

CFC4, MAPKK2, MEK2, MKK2, PRKMK2

19p13.3

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2

Show/Hide all(28)

SNP ID	Visualize variation	Clinical significance	Consequence
rs117945277	G>A,C	Likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, genic downstream transcript variant, missense variant
rs121434497	A>C,T	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs121434498	A>C,G,T	Uncertain-significance, pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121434499	A>G	Pathogenic-likely-pathogenic, pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs139404261	G>A	Likely-benign, conflicting-interpretations-of-pathogenicity, benign	Synonymous variant, coding sequence variant
rs267607230	G>A,C,T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs387906800	C>T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs539611844	G>A,T	Conflicting-interpretations-of-pathogenicity	Intron variant
rs727504370	T>C	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs727504382	C>T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs727504836	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Intron variant
rs730880511	C>A,T	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs730880517	T>C	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs730880518	C>A	Likely-pathogenic	Coding sequence variant, missense variant
rs730880522	C>T	Likely-pathogenic	Downstream transcript variant, genic downstream transcript variant, missense variant, coding sequence variant, intron variant
rs759061964	T>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, missense variant
rs763424788	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Downstream transcript variant, intron variant, genic downstream transcript variant
rs763469132	TTC>-	Conflicting-interpretations-of-pathogenicity	Downstream transcript variant, coding sequence variant, inframe deletion, genic downstream transcript variant, intron variant
rs886041310	T>A,G	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs1057519806	T>C,G	Pathogenic, likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1057519807	A>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057519808	T>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1057519809	G>A,C	Likely-pathogenic	Coding sequence variant, missense variant
rs1057519810	C>A,T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057519910	A>C,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs1114167351	ATC>-	Pathogenic	Coding sequence variant, inframe deletion
rs1135401787	A>C,G	Likely-pathogenic	Coding sequence variant, missense variant
rs1599307313	ACCTTG>-	Likely-pathogenic	Coding sequence variant, inframe deletion

Show/Hide all(103)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025900	hsa-miR-7-5p	Microarray	19073608
MIRT032459	hsa-let-7b-5p	Proteomics	18668040
MIRT639737	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT639736	hsa-miR-3607-5p	HITS-CLIP	23824327
MIRT639735	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT639734	hsa-miR-3119	HITS-CLIP	23824327
MIRT639733	hsa-miR-3672	HITS-CLIP	23824327
MIRT639732	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT639731	hsa-miR-7856-5p	HITS-CLIP	23824327
MIRT531861	hsa-miR-370-3p	PAR-CLIP	22012620
MIRT531860	hsa-miR-6893-3p	PAR-CLIP	22012620
MIRT531859	hsa-miR-196b-3p	PAR-CLIP	22012620
MIRT531858	hsa-miR-3692-5p	PAR-CLIP	22012620
MIRT531857	hsa-miR-7155-5p	PAR-CLIP	22012620
MIRT531856	hsa-miR-4731-5p	PAR-CLIP	22012620
MIRT531854	hsa-miR-5589-5p	PAR-CLIP	22012620
MIRT531855	hsa-miR-492	PAR-CLIP	22012620
MIRT531852	hsa-miR-3649	PAR-CLIP	22012620
MIRT531853	hsa-miR-193b-5p	PAR-CLIP	22012620
MIRT531851	hsa-miR-3170	PAR-CLIP	22012620
MIRT531850	hsa-miR-6855-5p	PAR-CLIP	22012620
MIRT639737	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT639736	hsa-miR-3607-5p	HITS-CLIP	23824327
MIRT639735	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT639734	hsa-miR-3119	HITS-CLIP	23824327
MIRT639733	hsa-miR-3672	HITS-CLIP	23824327
MIRT639732	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT639731	hsa-miR-7856-5p	HITS-CLIP	23824327
MIRT531861	hsa-miR-370-3p	PAR-CLIP	22012620
MIRT531860	hsa-miR-6893-3p	PAR-CLIP	22012620
MIRT531859	hsa-miR-196b-3p	PAR-CLIP	22012620
MIRT531858	hsa-miR-3692-5p	PAR-CLIP	22012620
MIRT531857	hsa-miR-7155-5p	PAR-CLIP	22012620
MIRT531856	hsa-miR-4731-5p	PAR-CLIP	22012620
MIRT531854	hsa-miR-5589-5p	PAR-CLIP	22012620
MIRT531855	hsa-miR-492	PAR-CLIP	22012620
MIRT531852	hsa-miR-3649	PAR-CLIP	22012620
MIRT531853	hsa-miR-193b-5p	PAR-CLIP	22012620
MIRT531851	hsa-miR-3170	PAR-CLIP	22012620
MIRT531850	hsa-miR-6855-5p	PAR-CLIP	22012620
MIRT1127938	hsa-miR-1181	CLIP-seq
MIRT1127939	hsa-miR-1226	CLIP-seq
MIRT1127940	hsa-miR-2052	CLIP-seq
MIRT1127941	hsa-miR-339-5p	CLIP-seq
MIRT1127942	hsa-miR-3622b-5p	CLIP-seq
MIRT1127943	hsa-miR-3921	CLIP-seq
MIRT1127944	hsa-miR-4251	CLIP-seq
MIRT1127945	hsa-miR-4287	CLIP-seq
MIRT1127946	hsa-miR-4329	CLIP-seq
MIRT1127947	hsa-miR-4469	CLIP-seq
MIRT1127948	hsa-miR-4520a-3p	CLIP-seq
MIRT1127949	hsa-miR-4653-5p	CLIP-seq
MIRT1127950	hsa-miR-4685-3p	CLIP-seq
MIRT1127951	hsa-miR-4733-3p	CLIP-seq
MIRT1127952	hsa-miR-4736	CLIP-seq
MIRT1127953	hsa-miR-4768-5p	CLIP-seq
MIRT1127954	hsa-miR-4786-5p	CLIP-seq
MIRT1127955	hsa-miR-503	CLIP-seq
MIRT1127956	hsa-miR-541	CLIP-seq
MIRT1127957	hsa-miR-654-5p	CLIP-seq
MIRT1127958	hsa-miR-769-5p	CLIP-seq
MIRT2036341	hsa-miR-3194-5p	CLIP-seq
MIRT2036342	hsa-miR-3197	CLIP-seq
MIRT1127938	hsa-miR-1181	CLIP-seq
MIRT2566262	hsa-miR-1247	CLIP-seq
MIRT2566263	hsa-miR-1250	CLIP-seq
MIRT2566264	hsa-miR-1827	CLIP-seq
MIRT2566265	hsa-miR-1909	CLIP-seq
MIRT2566266	hsa-miR-2355-5p	CLIP-seq
MIRT2566267	hsa-miR-3074-5p	CLIP-seq
MIRT2566268	hsa-miR-3150b-3p	CLIP-seq
MIRT2566269	hsa-miR-3907	CLIP-seq
MIRT2566270	hsa-miR-4258	CLIP-seq
MIRT2566271	hsa-miR-4316	CLIP-seq
MIRT2566272	hsa-miR-4707-5p	CLIP-seq
MIRT2566273	hsa-miR-4710	CLIP-seq
MIRT2566274	hsa-miR-4722-5p	CLIP-seq
MIRT2566275	hsa-miR-4768-3p	CLIP-seq
MIRT2566276	hsa-miR-4784	CLIP-seq
MIRT1127954	hsa-miR-4786-5p	CLIP-seq
MIRT1127955	hsa-miR-503	CLIP-seq
MIRT1127958	hsa-miR-769-5p	CLIP-seq
MIRT2566277	hsa-miR-940	CLIP-seq
MIRT1127938	hsa-miR-1181	CLIP-seq
MIRT2566262	hsa-miR-1247	CLIP-seq
MIRT2566263	hsa-miR-1250	CLIP-seq
MIRT2566264	hsa-miR-1827	CLIP-seq
MIRT2566265	hsa-miR-1909	CLIP-seq
MIRT2566266	hsa-miR-2355-5p	CLIP-seq
MIRT2566267	hsa-miR-3074-5p	CLIP-seq
MIRT2566268	hsa-miR-3150b-3p	CLIP-seq
MIRT2566269	hsa-miR-3907	CLIP-seq
MIRT2566270	hsa-miR-4258	CLIP-seq
MIRT2566271	hsa-miR-4316	CLIP-seq
MIRT2566272	hsa-miR-4707-5p	CLIP-seq
MIRT2566273	hsa-miR-4710	CLIP-seq
MIRT2566274	hsa-miR-4722-5p	CLIP-seq
MIRT2566275	hsa-miR-4768-3p	CLIP-seq
MIRT2566276	hsa-miR-4784	CLIP-seq
MIRT1127954	hsa-miR-4786-5p	CLIP-seq
MIRT1127955	hsa-miR-503	CLIP-seq
MIRT1127958	hsa-miR-769-5p	CLIP-seq
MIRT2566277	hsa-miR-940	CLIP-seq

Show/Hide all(41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000187	Process	Activation of MAPK activity	IBA	21873635
GO:0000187	Process	Activation of MAPK activity	TAS	19565474
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004708	Function	MAP kinase kinase activity	IBA	21873635
GO:0004708	Function	MAP kinase kinase activity	IDA	8388392
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	TAS	19565474
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005078	Function	MAP-kinase scaffold activity	IMP	29433126
GO:0005515	Function	Protein binding	IPI	11909642, 17979178, 21615688, 21988832, 24746704, 25416956, 25600339, 25852190, 27086506, 28514442, 29433126, 31980649, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	NAS	8388392
GO:0005634	Component	Nucleus	TAS	19565474
GO:0005739	Component	Mitochondrion	TAS	19565474
GO:0005769	Component	Early endosome	TAS	19565474
GO:0005770	Component	Late endosome	TAS	19565474
GO:0005778	Component	Peroxisomal membrane	HDA	21525035
GO:0005783	Component	Endoplasmic reticulum	IDA	21615688
GO:0005794	Component	Golgi apparatus	IDA	21615688
GO:0005794	Component	Golgi apparatus	TAS	19565474
GO:0005829	Component	Cytosol	TAS	19565474
GO:0005874	Component	Microtubule	IDA	21615688
GO:0005911	Component	Cell-cell junction	IDA	21615688
GO:0005925	Component	Focal adhesion	TAS	19565474
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	21615688
GO:0010629	Process	Negative regulation of gene expression	IGI	23626836
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0030165	Function	PDZ domain binding	IDA	21615688
GO:0032872	Process	Regulation of stress-activated MAPK cascade	TAS	19565474
GO:0036289	Process	Peptidyl-serine autophosphorylation	IDA	8388392
GO:0043539	Function	Protein serine/threonine kinase activator activity	IDA	8388392
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	24375836
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	21615688
GO:0070371	Process	ERK1 and ERK2 cascade	IMP	24375836
GO:0070371	Process	ERK1 and ERK2 cascade	TAS
GO:0071902	Process	Positive regulation of protein serine/threonine kinase activity	IDA	8388392
GO:0090170	Process	Regulation of Golgi inheritance	TAS	19565474
GO:0097110	Function	Scaffold protein binding	IPI	10409742, 21615688
GO:1903800	Process	Positive regulation of production of miRNAs involved in gene silencing by miRNA	IMP	24375836
GO:2000641	Process	Regulation of early endosome to late endosome transport	TAS	19565474

MIM	HGNC	e!Ensembl
601263	6842	ENSG00000126934

Protein

UniProt ID

P36507

Protein name

Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)

Protein function

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by bind

PDB

1S9I , 4H3Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	72 → 369	Protein kinase domain	Domain

Sequence

MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV

Sequence length

400

Interactions

View interactions

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