LY96 (lymphocyte antigen 96)

Gene

• Entrez ID: 23643
• Gene name: Lymphocyte antigen 96
• Gene symbol: LY96
• Synonyms: ESOP-1, MD-2, MD2, ly-96
• Chromosome: 8
• Chromosome location: 8q21.11
• Summary: This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

Transcription factors

Transcription factor	Regulation	Reference
CREB5	Repression	21132541
STAT1	Activation	21572044

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001530	Function	Lipopolysaccharide binding	IEA
GO:0001875	Function	Lipopolysaccharide immune receptor activity	IBA	21873635
GO:0001875	Function	Lipopolysaccharide immune receptor activity	IDA	19252480
GO:0002224	Process	Toll-like receptor signaling pathway	TAS
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0002756	Process	MyD88-independent toll-like receptor signaling pathway	TAS
GO:0005515	Function	Protein binding	IPI	15728506, 17803912, 19060881, 19252480, 20547845, 22474354, 22532668, 32296183
GO:0005615	Component	Extracellular space	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0006968	Process	Cellular defense response	TAS	10359581
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10359581
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	TAS
GO:0010008	Component	Endosome membrane	TAS
GO:0015026	Function	Coreceptor activity	TAS	10359581
GO:0031226	Component	Intrinsic component of plasma membrane	IDA	11274165
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IEA
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	IBA	21873635
GO:0032496	Process	Response to lipopolysaccharide	IDA	12594207
GO:0032497	Process	Detection of lipopolysaccharide	IBA	21873635
GO:0032497	Process	Detection of lipopolysaccharide	IDA	19252480
GO:0032760	Process	Positive regulation of tumor necrosis factor production	ISS
GO:0034128	Process	Negative regulation of MyD88-independent toll-like receptor signaling pathway	TAS
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IBA	21873635
GO:0034142	Process	Toll-like receptor 4 signaling pathway	ISS
GO:0034142	Process	Toll-like receptor 4 signaling pathway	TAS
GO:0035662	Function	Toll-like receptor 4 binding	IEA
GO:0035666	Process	TRIF-dependent toll-like receptor signaling pathway	TAS
GO:0045087	Process	Innate immune response	IEA
GO:0046696	Component	Lipopolysaccharide receptor complex	IBA	21873635
GO:0046696	Component	Lipopolysaccharide receptor complex	IDA	11274165, 19252480
GO:0070266	Process	Necroptotic process	TAS
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA	21873635
GO:0097190	Process	Apoptotic signaling pathway	TAS

Other IDs

• MIM: 605243
• HGNC: 17156
• e!Ensembl: ENSG00000154589

Protein

• UniProt ID: Q9Y6Y9
• Protein name: Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2)
• Protein function: Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
• PDB: 1T2Z, 2E56, 2E59, 2Z65, 3FXI, 3ULA, 4G8A
• Sequence:

  MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGL
  LHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFS
  FKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN

• Sequence length: 160