LPIN3 (lipin 3)

Gene

• Entrez ID: 64900
• Gene name: Lipin 3
• Gene symbol: LPIN3
• Synonyms: LIPN3L, SMP2, dJ620E11.2
• Chromosome: 20
• Chromosome location: 20q12
• Summary: The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018816	hsa-miR-335-5p	Microarray	18185580
MIRT761144	hsa-miR-10a-5p	PAR-CLIP	27292025
MIRT761168	hsa-miR-10b-5p	PAR-CLIP	27292025
MIRT761550	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT761955	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT762209	hsa-miR-1285-3p	PAR-CLIP	27292025
MIRT763505	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT764234	hsa-miR-25-5p	PAR-CLIP	27292025
MIRT765312	hsa-miR-3187-5p	PAR-CLIP	27292025
MIRT765674	hsa-miR-339-5p	PAR-CLIP	27292025
MIRT766562	hsa-miR-3667-5p	PAR-CLIP	27292025
MIRT767423	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT768012	hsa-miR-4252	PAR-CLIP	27292025
MIRT768835	hsa-miR-4421	PAR-CLIP	27292025
MIRT769295	hsa-miR-4459	PAR-CLIP	27292025
MIRT770169	hsa-miR-4537	PAR-CLIP	27292025
MIRT770358	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT771636	hsa-miR-4725-5p	PAR-CLIP	27292025
MIRT772401	hsa-miR-4793-3p	PAR-CLIP	27292025
MIRT773164	hsa-miR-508-5p	PAR-CLIP	27292025
MIRT773562	hsa-miR-5189-5p	PAR-CLIP	27292025
MIRT775077	hsa-miR-5694	PAR-CLIP	27292025
MIRT775182	hsa-miR-5699-3p	PAR-CLIP	27292025
MIRT775347	hsa-miR-589-3p	PAR-CLIP	27292025
MIRT775554	hsa-miR-6086	PAR-CLIP	27292025
MIRT775675	hsa-miR-6087	PAR-CLIP	27292025
MIRT775853	hsa-miR-612	PAR-CLIP	27292025
MIRT776298	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT776915	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT777155	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT777350	hsa-miR-658	PAR-CLIP	27292025
MIRT777437	hsa-miR-661	PAR-CLIP	27292025
MIRT777761	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT780301	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT780561	hsa-miR-6860	PAR-CLIP	27292025
MIRT781871	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT782021	hsa-miR-7703	PAR-CLIP	27292025
MIRT782815	hsa-miR-939-3p	PAR-CLIP	27292025

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA	21873635
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	TAS
GO:0006656	Process	Phosphatidylcholine biosynthetic process	TAS
GO:0008195	Function	Phosphatidate phosphatase activity	IBA	21873635
GO:0009062	Process	Fatty acid catabolic process	IBA	21873635
GO:0016311	Process	Dephosphorylation	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IBA	21873635
GO:0032869	Process	Cellular response to insulin stimulus	IBA	21873635
GO:0044255	Process	Cellular lipid metabolic process	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635

Other IDs

• MIM: 605520
• HGNC: 14451
• e!Ensembl: ENSG00000132793

Protein

• UniProt ID: Q9BQK8
• Protein name: Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like)
• Protein function: Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04571	Lipin_N	1 → 107	lipin, N-terminal conserved region	Family
  PF16876	Lipin_mid	438 → 531	Lipin/Ned1/Smp2 multi-domain protein middle domain	Family
  PF08235	LNS2	592 → 817	LNS2 (Lipin/Ned1/Smp2)	Domain

• Sequence:

  MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFRCSPFHVRFGKLGVLRS
  REKVVDIELNGEPVDLHMKLGDSGEAFFVQELESDDEHVPPGLCTSPIPWGGLSGFPSDS
  QLGTASEPEGLVMAGTASTGRRKRRRRRKPKQKEDAVATDSSPEELEAGAESELSLPEKL
  RPEPPGVQLEEKSSLQPKDIYPYSDGEWPPQASLSAGELTSPKSDSELEVRTPEPSPLRA
  ESHMQWAWGRLPKVARAERPESSVVLEGRAGATSPPRGGPSTPSTSVAGGVDPLGLPIQQ
  TEAGADLQPDTEDPTLVGPPLHTPETEESKTQSSGDMGLPPASKSWSWATLEVPVPTGQP
  ERVSRGKGSPKRSQHLGPSDIYLDDLPSLDSENAALYFPQSDSGLGARRWSEPSSQKSLR
  DPNPEHEPEPTLDTVDTIALSLCGGLADSRDISLEKFNQHSVSYQDLTKNPGLLDDPNLV
  VKINGKHYNWAVAAPMILSLQAFQKNLPKSTMDKLEREKMPRKGGRWWFSWRRRDFLAEE
  RSAQKEKTAAKEQQGEKTEVLSSDDDAPDSPVILEIPSLPPSTPPSTPTYKKSLRLSSDQ
  IRRLNLQEGANDVVFSVTTQYQGTCRCKATIYLWKWDDKVVISDIDGTITKSDALGHILP
  QLGKDWTHQGITSLYHKIQLNGYKFLYCSARAIGMADLTKGYLQWVSEGGCSLPKGPILL
  SPSSLFSALHREVIEKKPEVFKVACLSDIQQLFLPHGQPFYAAFGNRPNDVFAYRQVGLP
  ESRIFTVNPRGELIQELIKNHKSTYERLGEVVELLFPPVARGPSTDLANPEYSNFCYWRE
  PLPAVDLDTLD

• Sequence length: 851