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LPIN2 (lipin 2)

Gene

9663

Lipin 2

LPIN2

CRMO1, MJDS

18p11.31

Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hy

Show/Hide all(18)

SNP ID	Visualize variation	Clinical significance	Consequence
rs17555442	G>A	Conflicting-interpretations-of-pathogenicity, benign	Genic downstream transcript variant, coding sequence variant, synonymous variant
rs80338806	AT>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs80338807	G>A	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs80338808	C>G	Pathogenic	Splice donor variant, genic downstream transcript variant
rs104895500	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, non coding transcript variant, missense variant
rs116643915	G>A	Conflicting-interpretations-of-pathogenicity	Intron variant, genic upstream transcript variant, 5 prime UTR variant
rs140249737	A>G	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant, genic downstream transcript variant
rs150022314	A>C,G	Benign-likely-benign, likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, non coding transcript variant, coding sequence variant
rs200648652	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant, genic downstream transcript variant
rs201325845	C>T	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, non coding transcript variant
rs318240736	AG>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant
rs746626720	A>-,AA,AAAAAAAA	Conflicting-interpretations-of-pathogenicity, benign-likely-benign	Intron variant
rs750126005	G>A	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs756933588	C>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs876660982	->ACAC	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs916009547	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs1175109245	G>A,T	Pathogenic	Intron variant, missense variant, stop gained, coding sequence variant
rs1598522408	GCTGTTCCTTGCCACCCACCTGAAGGATTGAGCTTACTTGG>-	Likely-pathogenic	Coding sequence variant, splice donor variant, genic downstream transcript variant, intron variant

Show/Hide all(318)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017765	hsa-miR-335-5p	Microarray	18185580
MIRT039153	hsa-miR-769-5p	CLASH	23622248
MIRT1116381	hsa-miR-1915	CLIP-seq
MIRT1116382	hsa-miR-197	CLIP-seq
MIRT1116383	hsa-miR-2052	CLIP-seq
MIRT1116384	hsa-miR-3143	CLIP-seq
MIRT1116385	hsa-miR-3153	CLIP-seq
MIRT1116386	hsa-miR-3173-3p	CLIP-seq
MIRT1116387	hsa-miR-3545-3p	CLIP-seq
MIRT1116388	hsa-miR-3671	CLIP-seq
MIRT1116389	hsa-miR-3913-3p	CLIP-seq
MIRT1116390	hsa-miR-409-5p	CLIP-seq
MIRT1116391	hsa-miR-4261	CLIP-seq
MIRT1116392	hsa-miR-4286	CLIP-seq
MIRT1116393	hsa-miR-4650-5p	CLIP-seq
MIRT1116394	hsa-miR-4713-3p	CLIP-seq
MIRT1116395	hsa-miR-4726-3p	CLIP-seq
MIRT1116396	hsa-miR-4732-3p	CLIP-seq
MIRT1116397	hsa-miR-4738-3p	CLIP-seq
MIRT1116398	hsa-miR-4779	CLIP-seq
MIRT1116399	hsa-miR-4786-3p	CLIP-seq
MIRT1116400	hsa-miR-489	CLIP-seq
MIRT1116401	hsa-miR-5096	CLIP-seq
MIRT1116402	hsa-miR-518a-5p	CLIP-seq
MIRT1116403	hsa-miR-527	CLIP-seq
MIRT1116404	hsa-miR-543	CLIP-seq
MIRT1116405	hsa-miR-583	CLIP-seq
MIRT1116406	hsa-miR-626	CLIP-seq
MIRT1116407	hsa-miR-766	CLIP-seq
MIRT2032834	hsa-miR-1228	CLIP-seq
MIRT2032835	hsa-miR-1236	CLIP-seq
MIRT2032836	hsa-miR-1324	CLIP-seq
MIRT2032837	hsa-miR-133a	CLIP-seq
MIRT2032838	hsa-miR-133b	CLIP-seq
MIRT2032839	hsa-miR-214	CLIP-seq
MIRT2032840	hsa-miR-298	CLIP-seq
MIRT2032841	hsa-miR-3065-3p	CLIP-seq
MIRT2032842	hsa-miR-3200-5p	CLIP-seq
MIRT2032843	hsa-miR-3619-5p	CLIP-seq
MIRT2032844	hsa-miR-3670	CLIP-seq
MIRT2032845	hsa-miR-4291	CLIP-seq
MIRT2032846	hsa-miR-4292	CLIP-seq
MIRT2032847	hsa-miR-4307	CLIP-seq
MIRT2032848	hsa-miR-4308	CLIP-seq
MIRT2032849	hsa-miR-4446-5p	CLIP-seq
MIRT2032850	hsa-miR-4649-3p	CLIP-seq
MIRT2032851	hsa-miR-4711-5p	CLIP-seq
MIRT2032852	hsa-miR-4755-5p	CLIP-seq
MIRT2032853	hsa-miR-548q	CLIP-seq
MIRT2032854	hsa-miR-579	CLIP-seq
MIRT2032855	hsa-miR-602	CLIP-seq
MIRT2032856	hsa-miR-670	CLIP-seq
MIRT2032857	hsa-miR-761	CLIP-seq
MIRT2032858	hsa-miR-767-3p	CLIP-seq
MIRT2032859	hsa-miR-922	CLIP-seq
MIRT2263217	hsa-miR-103a	CLIP-seq
MIRT2263218	hsa-miR-107	CLIP-seq
MIRT2263219	hsa-miR-1183	CLIP-seq
MIRT2263220	hsa-miR-1184	CLIP-seq
MIRT2263221	hsa-miR-1197	CLIP-seq
MIRT2263222	hsa-miR-1205	CLIP-seq
MIRT2263223	hsa-miR-1243	CLIP-seq
MIRT2263224	hsa-miR-1278	CLIP-seq
MIRT2263225	hsa-miR-1305	CLIP-seq
MIRT2032836	hsa-miR-1324	CLIP-seq
MIRT2263226	hsa-miR-141	CLIP-seq
MIRT2263227	hsa-miR-145	CLIP-seq
MIRT2263228	hsa-miR-200a	CLIP-seq
MIRT2032841	hsa-miR-3065-3p	CLIP-seq
MIRT2263229	hsa-miR-3065-5p	CLIP-seq
MIRT2263230	hsa-miR-3120-3p	CLIP-seq
MIRT2263231	hsa-miR-3126-5p	CLIP-seq
MIRT2263232	hsa-miR-3127-3p	CLIP-seq
MIRT2263233	hsa-miR-3129-3p	CLIP-seq
MIRT2263234	hsa-miR-3130-3p	CLIP-seq
MIRT2263235	hsa-miR-3157-5p	CLIP-seq
MIRT2263236	hsa-miR-3158-5p	CLIP-seq
MIRT2263237	hsa-miR-3166	CLIP-seq
MIRT2263238	hsa-miR-3167	CLIP-seq
MIRT2263239	hsa-miR-3180-5p	CLIP-seq
MIRT2263240	hsa-miR-338-3p	CLIP-seq
MIRT2263241	hsa-miR-342-3p	CLIP-seq
MIRT2263242	hsa-miR-3682-3p	CLIP-seq
MIRT1116389	hsa-miR-3913-3p	CLIP-seq
MIRT2263243	hsa-miR-3942-5p	CLIP-seq
MIRT2263244	hsa-miR-4270	CLIP-seq
MIRT2263245	hsa-miR-4276	CLIP-seq
MIRT2263246	hsa-miR-4280	CLIP-seq
MIRT2032845	hsa-miR-4291	CLIP-seq
MIRT2263247	hsa-miR-4302	CLIP-seq
MIRT2263248	hsa-miR-4441	CLIP-seq
MIRT2263249	hsa-miR-4502	CLIP-seq
MIRT2263250	hsa-miR-4503	CLIP-seq
MIRT2263251	hsa-miR-4514	CLIP-seq
MIRT2263252	hsa-miR-451b	CLIP-seq
MIRT2263253	hsa-miR-4646-5p	CLIP-seq
MIRT2263254	hsa-miR-4662a-5p	CLIP-seq
MIRT2263255	hsa-miR-4688	CLIP-seq
MIRT2263256	hsa-miR-4690-5p	CLIP-seq
MIRT2263257	hsa-miR-4691-3p	CLIP-seq
MIRT2263258	hsa-miR-4692	CLIP-seq
MIRT2263259	hsa-miR-4703-5p	CLIP-seq
MIRT2263260	hsa-miR-4704-3p	CLIP-seq
MIRT2263261	hsa-miR-4719	CLIP-seq
MIRT1116396	hsa-miR-4732-3p	CLIP-seq
MIRT2263262	hsa-miR-4747-5p	CLIP-seq
MIRT1116399	hsa-miR-4786-3p	CLIP-seq
MIRT1116400	hsa-miR-489	CLIP-seq
MIRT2263263	hsa-miR-513b	CLIP-seq
MIRT2263264	hsa-miR-545	CLIP-seq
MIRT2263265	hsa-miR-570	CLIP-seq
MIRT2032855	hsa-miR-602	CLIP-seq
MIRT2263266	hsa-miR-603	CLIP-seq
MIRT2263267	hsa-miR-646	CLIP-seq
MIRT2263268	hsa-miR-767-5p	CLIP-seq
MIRT2263269	hsa-miR-876-5p	CLIP-seq
MIRT2032839	hsa-miR-214	CLIP-seq
MIRT2032840	hsa-miR-298	CLIP-seq
MIRT2263230	hsa-miR-3120-3p	CLIP-seq
MIRT2263236	hsa-miR-3158-5p	CLIP-seq
MIRT2263237	hsa-miR-3166	CLIP-seq
MIRT2032842	hsa-miR-3200-5p	CLIP-seq
MIRT2032843	hsa-miR-3619-5p	CLIP-seq
MIRT2032845	hsa-miR-4291	CLIP-seq
MIRT2032850	hsa-miR-4649-3p	CLIP-seq
MIRT2390310	hsa-miR-4771	CLIP-seq
MIRT2263264	hsa-miR-545	CLIP-seq
MIRT2390311	hsa-miR-558	CLIP-seq
MIRT2032857	hsa-miR-761	CLIP-seq
MIRT2032859	hsa-miR-922	CLIP-seq
MIRT1116388	hsa-miR-3671	CLIP-seq
MIRT1116406	hsa-miR-626	CLIP-seq
MIRT2263217	hsa-miR-103a	CLIP-seq
MIRT2263218	hsa-miR-107	CLIP-seq
MIRT2263220	hsa-miR-1184	CLIP-seq
MIRT2263222	hsa-miR-1205	CLIP-seq
MIRT2263223	hsa-miR-1243	CLIP-seq
MIRT2562613	hsa-miR-1245b-3p	CLIP-seq
MIRT2562614	hsa-miR-1253	CLIP-seq
MIRT2562615	hsa-miR-125a-5p	CLIP-seq
MIRT2562616	hsa-miR-125b	CLIP-seq
MIRT2562617	hsa-miR-1276	CLIP-seq
MIRT2562618	hsa-miR-1301	CLIP-seq
MIRT2032836	hsa-miR-1324	CLIP-seq
MIRT2032837	hsa-miR-133a	CLIP-seq
MIRT2032838	hsa-miR-133b	CLIP-seq
MIRT2263226	hsa-miR-141	CLIP-seq
MIRT2562619	hsa-miR-151-3p	CLIP-seq
MIRT1116382	hsa-miR-197	CLIP-seq
MIRT2263228	hsa-miR-200a	CLIP-seq
MIRT2562620	hsa-miR-204	CLIP-seq
MIRT2562621	hsa-miR-211	CLIP-seq
MIRT2562622	hsa-miR-2117	CLIP-seq
MIRT2562623	hsa-miR-23a	CLIP-seq
MIRT2562624	hsa-miR-23b	CLIP-seq
MIRT2562625	hsa-miR-23c	CLIP-seq
MIRT2032841	hsa-miR-3065-3p	CLIP-seq
MIRT2263229	hsa-miR-3065-5p	CLIP-seq
MIRT2562626	hsa-miR-31	CLIP-seq
MIRT2263230	hsa-miR-3120-3p	CLIP-seq
MIRT2562627	hsa-miR-3123	CLIP-seq
MIRT2263231	hsa-miR-3126-5p	CLIP-seq
MIRT2263232	hsa-miR-3127-3p	CLIP-seq
MIRT2562628	hsa-miR-3151	CLIP-seq
MIRT1116385	hsa-miR-3153	CLIP-seq
MIRT2263236	hsa-miR-3158-5p	CLIP-seq
MIRT2562629	hsa-miR-3160-5p	CLIP-seq
MIRT2562630	hsa-miR-3194-3p	CLIP-seq
MIRT2562631	hsa-miR-3197	CLIP-seq
MIRT2562632	hsa-miR-330-3p	CLIP-seq
MIRT1116387	hsa-miR-3545-3p	CLIP-seq
MIRT2562633	hsa-miR-3605-5p	CLIP-seq
MIRT2562634	hsa-miR-3613-3p	CLIP-seq
MIRT2562635	hsa-miR-3653	CLIP-seq
MIRT2562636	hsa-miR-3657	CLIP-seq
MIRT1116388	hsa-miR-3671	CLIP-seq
MIRT2562637	hsa-miR-3679-3p	CLIP-seq
MIRT1116389	hsa-miR-3913-3p	CLIP-seq
MIRT2562638	hsa-miR-3919	CLIP-seq
MIRT2562639	hsa-miR-3929	CLIP-seq
MIRT2263243	hsa-miR-3942-5p	CLIP-seq
MIRT2562640	hsa-miR-3944-5p	CLIP-seq
MIRT2562641	hsa-miR-3977	CLIP-seq
MIRT1116390	hsa-miR-409-5p	CLIP-seq
MIRT1116391	hsa-miR-4261	CLIP-seq
MIRT2263245	hsa-miR-4276	CLIP-seq
MIRT2562642	hsa-miR-4277	CLIP-seq
MIRT2263246	hsa-miR-4280	CLIP-seq
MIRT2562643	hsa-miR-4287	CLIP-seq
MIRT2032845	hsa-miR-4291	CLIP-seq
MIRT2263247	hsa-miR-4302	CLIP-seq
MIRT2562644	hsa-miR-4310	CLIP-seq
MIRT2562645	hsa-miR-4311	CLIP-seq
MIRT2562646	hsa-miR-4319	CLIP-seq
MIRT2562647	hsa-miR-4419b	CLIP-seq
MIRT2562648	hsa-miR-4420	CLIP-seq
MIRT2562649	hsa-miR-4421	CLIP-seq
MIRT2562650	hsa-miR-4427	CLIP-seq
MIRT2562651	hsa-miR-4447	CLIP-seq
MIRT2562652	hsa-miR-4450	CLIP-seq
MIRT2562653	hsa-miR-4463	CLIP-seq
MIRT2562654	hsa-miR-4469	CLIP-seq
MIRT2562655	hsa-miR-4472	CLIP-seq
MIRT2562656	hsa-miR-4477a	CLIP-seq
MIRT2562657	hsa-miR-4478	CLIP-seq
MIRT2562658	hsa-miR-4493	CLIP-seq
MIRT2562659	hsa-miR-4499	CLIP-seq
MIRT2263251	hsa-miR-4514	CLIP-seq
MIRT2263252	hsa-miR-451b	CLIP-seq
MIRT2562660	hsa-miR-4537	CLIP-seq
MIRT2562661	hsa-miR-4539	CLIP-seq
MIRT2562662	hsa-miR-4641	CLIP-seq
MIRT2562663	hsa-miR-4645-3p	CLIP-seq
MIRT2562664	hsa-miR-4645-5p	CLIP-seq
MIRT2562665	hsa-miR-4660	CLIP-seq
MIRT2562666	hsa-miR-4662a-3p	CLIP-seq
MIRT2562667	hsa-miR-4669	CLIP-seq
MIRT2562668	hsa-miR-4673	CLIP-seq
MIRT2562669	hsa-miR-4680-3p	CLIP-seq
MIRT2562670	hsa-miR-4685-3p	CLIP-seq
MIRT2263256	hsa-miR-4690-5p	CLIP-seq
MIRT2263258	hsa-miR-4692	CLIP-seq
MIRT2562671	hsa-miR-4699-5p	CLIP-seq
MIRT2263259	hsa-miR-4703-5p	CLIP-seq
MIRT2562672	hsa-miR-4712-3p	CLIP-seq
MIRT2562673	hsa-miR-4722-3p	CLIP-seq
MIRT2562674	hsa-miR-4724-5p	CLIP-seq
MIRT1116396	hsa-miR-4732-3p	CLIP-seq
MIRT2562675	hsa-miR-4733-3p	CLIP-seq
MIRT1116397	hsa-miR-4738-3p	CLIP-seq
MIRT2562676	hsa-miR-4753-3p	CLIP-seq
MIRT2562677	hsa-miR-4762-5p	CLIP-seq
MIRT2562678	hsa-miR-4763-5p	CLIP-seq
MIRT2562679	hsa-miR-4769-3p	CLIP-seq
MIRT1116399	hsa-miR-4786-3p	CLIP-seq
MIRT2562680	hsa-miR-4803	CLIP-seq
MIRT1116400	hsa-miR-489	CLIP-seq
MIRT2562681	hsa-miR-491-5p	CLIP-seq
MIRT2562682	hsa-miR-5047	CLIP-seq
MIRT2562683	hsa-miR-505	CLIP-seq
MIRT1116401	hsa-miR-5096	CLIP-seq
MIRT2562684	hsa-miR-512-5p	CLIP-seq
MIRT1116402	hsa-miR-518a-5p	CLIP-seq
MIRT1116403	hsa-miR-527	CLIP-seq
MIRT2263264	hsa-miR-545	CLIP-seq
MIRT2562685	hsa-miR-548aa	CLIP-seq
MIRT2562686	hsa-miR-548ae	CLIP-seq
MIRT2562687	hsa-miR-548aj	CLIP-seq
MIRT2562688	hsa-miR-548am	CLIP-seq
MIRT2562689	hsa-miR-548x	CLIP-seq
MIRT2562690	hsa-miR-550b	CLIP-seq
MIRT2562691	hsa-miR-561	CLIP-seq
MIRT1116405	hsa-miR-583	CLIP-seq
MIRT2562692	hsa-miR-590-3p	CLIP-seq
MIRT2562693	hsa-miR-599	CLIP-seq
MIRT2032855	hsa-miR-602	CLIP-seq
MIRT2562694	hsa-miR-607	CLIP-seq
MIRT1116406	hsa-miR-626	CLIP-seq
MIRT2032856	hsa-miR-670	CLIP-seq
MIRT2562695	hsa-miR-892a	CLIP-seq
MIRT2562696	hsa-miR-944	CLIP-seq
MIRT2562614	hsa-miR-1253	CLIP-seq
MIRT2562615	hsa-miR-125a-5p	CLIP-seq
MIRT2562616	hsa-miR-125b	CLIP-seq
MIRT2562617	hsa-miR-1276	CLIP-seq
MIRT2032836	hsa-miR-1324	CLIP-seq
MIRT2562619	hsa-miR-151-3p	CLIP-seq
MIRT2032841	hsa-miR-3065-3p	CLIP-seq
MIRT2263230	hsa-miR-3120-3p	CLIP-seq
MIRT2562627	hsa-miR-3123	CLIP-seq
MIRT1116385	hsa-miR-3153	CLIP-seq
MIRT2562632	hsa-miR-330-3p	CLIP-seq
MIRT1116387	hsa-miR-3545-3p	CLIP-seq
MIRT2562635	hsa-miR-3653	CLIP-seq
MIRT2562636	hsa-miR-3657	CLIP-seq
MIRT1116388	hsa-miR-3671	CLIP-seq
MIRT2562637	hsa-miR-3679-3p	CLIP-seq
MIRT1116389	hsa-miR-3913-3p	CLIP-seq
MIRT2562639	hsa-miR-3929	CLIP-seq
MIRT2562641	hsa-miR-3977	CLIP-seq
MIRT1116390	hsa-miR-409-5p	CLIP-seq
MIRT2562643	hsa-miR-4287	CLIP-seq
MIRT2032845	hsa-miR-4291	CLIP-seq
MIRT2562645	hsa-miR-4311	CLIP-seq
MIRT2562646	hsa-miR-4319	CLIP-seq
MIRT2562647	hsa-miR-4419b	CLIP-seq
MIRT2562648	hsa-miR-4420	CLIP-seq
MIRT2562653	hsa-miR-4463	CLIP-seq
MIRT2562654	hsa-miR-4469	CLIP-seq
MIRT2562656	hsa-miR-4477a	CLIP-seq
MIRT2562657	hsa-miR-4478	CLIP-seq
MIRT2562658	hsa-miR-4493	CLIP-seq
MIRT2562659	hsa-miR-4499	CLIP-seq
MIRT2562660	hsa-miR-4537	CLIP-seq
MIRT2562661	hsa-miR-4539	CLIP-seq
MIRT2562662	hsa-miR-4641	CLIP-seq
MIRT2562666	hsa-miR-4662a-3p	CLIP-seq
MIRT2562667	hsa-miR-4669	CLIP-seq
MIRT2562670	hsa-miR-4685-3p	CLIP-seq
MIRT2562671	hsa-miR-4699-5p	CLIP-seq
MIRT2562673	hsa-miR-4722-3p	CLIP-seq
MIRT2562674	hsa-miR-4724-5p	CLIP-seq
MIRT1116396	hsa-miR-4732-3p	CLIP-seq
MIRT2562678	hsa-miR-4763-5p	CLIP-seq
MIRT2562679	hsa-miR-4769-3p	CLIP-seq
MIRT1116399	hsa-miR-4786-3p	CLIP-seq
MIRT2562680	hsa-miR-4803	CLIP-seq
MIRT1116400	hsa-miR-489	CLIP-seq
MIRT1116402	hsa-miR-518a-5p	CLIP-seq
MIRT1116403	hsa-miR-527	CLIP-seq
MIRT2263264	hsa-miR-545	CLIP-seq
MIRT2562691	hsa-miR-561	CLIP-seq
MIRT1116405	hsa-miR-583	CLIP-seq
MIRT2562693	hsa-miR-599	CLIP-seq
MIRT2032855	hsa-miR-602	CLIP-seq
MIRT1116406	hsa-miR-626	CLIP-seq
MIRT2032856	hsa-miR-670	CLIP-seq
MIRT2562696	hsa-miR-944	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA	21873635
GO:0003713	Function	Transcription coactivator activity	ISS
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0006629	Process	Lipid metabolic process	ISS
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	TAS
GO:0006656	Process	Phosphatidylcholine biosynthetic process	TAS
GO:0008195	Function	Phosphatidate phosphatase activity	IBA	21873635
GO:0008195	Function	Phosphatidate phosphatase activity	ISS
GO:0009062	Process	Fatty acid catabolic process	IBA	21873635
GO:0016311	Process	Dephosphorylation	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IBA	21873635
GO:0019432	Process	Triglyceride biosynthetic process	TAS
GO:0032869	Process	Cellular response to insulin stimulus	IBA	21873635
GO:0044255	Process	Cellular lipid metabolic process	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS

MIM	HGNC	e!Ensembl
605519	14450	ENSG00000101577

Protein

UniProt ID

Q92539

Protein name

Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2)

Protein function

Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04571	Lipin_N	1 → 107	lipin, N-terminal conserved region	Family
PF16876	Lipin_mid	469 → 561	Lipin/Ned1/Smp2 multi-domain protein middle domain	Family
PF08235	LNS2	637 → 862	LNS2 (Lipin/Ned1/Smp2)	Domain

Sequence

MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRS
KEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDT
PLVKSGGDETPSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDT
CDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTAC
PKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRV
IPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLD
ADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYF
PKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSEN
GEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPK
ATVESWVKDKMPKKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPA
ENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSSDQIAKLKLHDGPNDVVF
SITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQILPQLGKDWTHQGIAKLY
HSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIE
KKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQ
ERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPEFSSFCYWRDPIPEVDLDDLS

Sequence length

896

Interactions

View interactions

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