LAMA4 (laminin subunit alpha 4)

Gene

• Entrez ID: 3910
• Gene name: Laminin subunit alpha 4
• Gene symbol: LAMA4
• Synonyms: CMD1JJ, LAMA3, LAMA4*-1
• Chromosome: 6
• Chromosome location: 6q21
• Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, n

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs3752579	A>T	Conflicting-interpretations-of-pathogenicity, benign	Genic downstream transcript variant, coding sequence variant, non coding transcript variant, missense variant
rs145897390	G>A,C	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, coding sequence variant, non coding transcript variant, missense variant
rs150084275	G>A,C	Likely-benign, conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, coding sequence variant, non coding transcript variant, missense variant
rs200112094	A>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant, genic downstream transcript variant
rs201209516	G>A	Conflicting-interpretations-of-pathogenicity	Intron variant, genic downstream transcript variant
rs371906362	C>A,G,T	Conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, intron variant
rs782010849	C>T	Conflicting-interpretations-of-pathogenicity	Non coding transcript variant, genic downstream transcript variant, missense variant, coding sequence variant
rs863223690	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022144	hsa-miR-124-3p	Microarray	18668037
MIRT038757	hsa-miR-93-3p	CLASH	23622248
MIRT462261	hsa-miR-4274	PAR-CLIP	23592263
MIRT462260	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT462259	hsa-miR-7705	PAR-CLIP	23592263
MIRT462258	hsa-miR-922	PAR-CLIP	23592263
MIRT462257	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT462256	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT462255	hsa-miR-761	PAR-CLIP	23592263
MIRT462254	hsa-miR-103b	PAR-CLIP	23592263
MIRT462253	hsa-miR-3665	PAR-CLIP	23592263
MIRT462252	hsa-miR-657	PAR-CLIP	23592263
MIRT462251	hsa-miR-4291	PAR-CLIP	23592263
MIRT462261	hsa-miR-4274	PAR-CLIP	23592263
MIRT462260	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT462259	hsa-miR-7705	PAR-CLIP	23592263
MIRT462258	hsa-miR-922	PAR-CLIP	23592263
MIRT462257	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT462256	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT462255	hsa-miR-761	PAR-CLIP	23592263
MIRT462254	hsa-miR-103b	PAR-CLIP	23592263
MIRT462253	hsa-miR-3665	PAR-CLIP	23592263
MIRT462252	hsa-miR-657	PAR-CLIP	23592263
MIRT462251	hsa-miR-4291	PAR-CLIP	23592263
MIRT1103250	hsa-miR-3183	CLIP-seq
MIRT1103251	hsa-miR-4723-3p	CLIP-seq
MIRT1103252	hsa-miR-590-3p	CLIP-seq
MIRT1103253	hsa-miR-1273f	CLIP-seq
MIRT1103254	hsa-miR-1297	CLIP-seq
MIRT1103255	hsa-miR-2467-3p	CLIP-seq
MIRT1103256	hsa-miR-26a	CLIP-seq
MIRT1103257	hsa-miR-26b	CLIP-seq
MIRT1103258	hsa-miR-3678-3p	CLIP-seq
MIRT1103259	hsa-miR-4272	CLIP-seq
MIRT1103260	hsa-miR-4465	CLIP-seq
MIRT1103261	hsa-miR-450b-3p	CLIP-seq
MIRT1103262	hsa-miR-4528	CLIP-seq
MIRT1103263	hsa-miR-4695-3p	CLIP-seq
MIRT1103264	hsa-miR-4713-3p	CLIP-seq
MIRT1103265	hsa-miR-4756-3p	CLIP-seq
MIRT1103266	hsa-miR-634	CLIP-seq
MIRT1103267	hsa-miR-638	CLIP-seq
MIRT1103268	hsa-miR-769-3p	CLIP-seq
MIRT1103262	hsa-miR-4528	CLIP-seq
MIRT2028226	hsa-miR-122	CLIP-seq
MIRT2028227	hsa-miR-3135b	CLIP-seq
MIRT2028228	hsa-miR-3652	CLIP-seq
MIRT2028229	hsa-miR-4423-5p	CLIP-seq
MIRT2028230	hsa-miR-4430	CLIP-seq
MIRT2442319	hsa-miR-3166	CLIP-seq
MIRT1103258	hsa-miR-3678-3p	CLIP-seq
MIRT2442320	hsa-miR-4771	CLIP-seq
MIRT2028226	hsa-miR-122	CLIP-seq
MIRT2452853	hsa-miR-1267	CLIP-seq
MIRT2028227	hsa-miR-3135b	CLIP-seq
MIRT2028228	hsa-miR-3652	CLIP-seq
MIRT2452854	hsa-miR-3664-5p	CLIP-seq
MIRT2028229	hsa-miR-4423-5p	CLIP-seq
MIRT2028230	hsa-miR-4430	CLIP-seq
MIRT2452855	hsa-miR-4639-3p	CLIP-seq
MIRT1103263	hsa-miR-4695-3p	CLIP-seq
MIRT2559722	hsa-miR-1184	CLIP-seq
MIRT2028226	hsa-miR-122	CLIP-seq
MIRT2559723	hsa-miR-1226	CLIP-seq
MIRT2452853	hsa-miR-1267	CLIP-seq
MIRT2559724	hsa-miR-197	CLIP-seq
MIRT2559725	hsa-miR-205	CLIP-seq
MIRT2559726	hsa-miR-214	CLIP-seq
MIRT2559727	hsa-miR-2964a-3p	CLIP-seq
MIRT2559728	hsa-miR-300	CLIP-seq
MIRT2028227	hsa-miR-3135b	CLIP-seq
MIRT2442319	hsa-miR-3166	CLIP-seq
MIRT2028228	hsa-miR-3652	CLIP-seq
MIRT2452854	hsa-miR-3664-5p	CLIP-seq
MIRT1103258	hsa-miR-3678-3p	CLIP-seq
MIRT2559729	hsa-miR-381	CLIP-seq
MIRT2559730	hsa-miR-4252	CLIP-seq
MIRT2559731	hsa-miR-4418	CLIP-seq
MIRT2028229	hsa-miR-4423-5p	CLIP-seq
MIRT2028230	hsa-miR-4430	CLIP-seq
MIRT2452855	hsa-miR-4639-3p	CLIP-seq
MIRT1103263	hsa-miR-4695-3p	CLIP-seq
MIRT2559732	hsa-miR-4733-3p	CLIP-seq
MIRT2442320	hsa-miR-4771	CLIP-seq
MIRT2559733	hsa-miR-483-3p	CLIP-seq
MIRT2559734	hsa-miR-509-3-5p	CLIP-seq
MIRT2559735	hsa-miR-509-5p	CLIP-seq
MIRT2559736	hsa-miR-5096	CLIP-seq
MIRT2559722	hsa-miR-1184	CLIP-seq
MIRT2028226	hsa-miR-122	CLIP-seq
MIRT2559723	hsa-miR-1226	CLIP-seq
MIRT2452853	hsa-miR-1267	CLIP-seq
MIRT2559724	hsa-miR-197	CLIP-seq
MIRT2559725	hsa-miR-205	CLIP-seq
MIRT2559726	hsa-miR-214	CLIP-seq
MIRT2559727	hsa-miR-2964a-3p	CLIP-seq
MIRT2559728	hsa-miR-300	CLIP-seq
MIRT2028227	hsa-miR-3135b	CLIP-seq
MIRT2442319	hsa-miR-3166	CLIP-seq
MIRT2683722	hsa-miR-3545-3p	CLIP-seq
MIRT2028228	hsa-miR-3652	CLIP-seq
MIRT2452854	hsa-miR-3664-5p	CLIP-seq
MIRT1103258	hsa-miR-3678-3p	CLIP-seq
MIRT2559729	hsa-miR-381	CLIP-seq
MIRT2559730	hsa-miR-4252	CLIP-seq
MIRT2559731	hsa-miR-4418	CLIP-seq
MIRT2028229	hsa-miR-4423-5p	CLIP-seq
MIRT2028230	hsa-miR-4430	CLIP-seq
MIRT2452855	hsa-miR-4639-3p	CLIP-seq
MIRT1103263	hsa-miR-4695-3p	CLIP-seq
MIRT2559732	hsa-miR-4733-3p	CLIP-seq
MIRT2442320	hsa-miR-4771	CLIP-seq
MIRT2559733	hsa-miR-483-3p	CLIP-seq
MIRT2559734	hsa-miR-509-3-5p	CLIP-seq
MIRT2559735	hsa-miR-509-5p	CLIP-seq
MIRT2559736	hsa-miR-5096	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005201	Function	Extracellular matrix structural constituent	ISS
GO:0005201	Function	Extracellular matrix structural constituent	RCA	25037231, 27068509, 27559042, 28675934
GO:0005515	Function	Protein binding	IPI	16169070, 25241761
GO:0005576	Component	Extracellular region	TAS
GO:0005604	Component	Basement membrane	IDA	14557481
GO:0007155	Process	Cell adhesion	IEA
GO:0030155	Process	Regulation of cell adhesion	IEA
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030334	Process	Regulation of cell migration	IEA
GO:0045995	Process	Regulation of embryonic development	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 27068509, 27559042, 28675934
GO:0062023	Component	Collagen-containing extracellular matrix	ISS	22261194
GO:0070062	Component	Extracellular exosome	HDA	19199708, 21362503
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	28973559

Other IDs

• MIM: 600133
• HGNC: 6484
• e!Ensembl: ENSG00000112769

Protein

• UniProt ID: Q16363
• Protein name: Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha)
• Protein function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00053	Laminin_EGF	82 → 129	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	132 → 184	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	187 → 241	Laminin EGF domain	Domain
  PF06008	Laminin_I	298 → 555	Laminin Domain I	Coiled-coil
  PF06009	Laminin_II	734 → 861	Laminin Domain II	Coiled-coil
  PF02210	Laminin_G_2	874 → 1014	Laminin G domain	Domain
  PF02210	Laminin_G_2	1079 → 1210	Laminin G domain	Domain
  PF02210	Laminin_G_2	1263 → 1379	Laminin G domain	Domain
  PF02210	Laminin_G_2	1499 → 1626	Laminin G domain	Domain
  PF02210	Laminin_G_2	1676 → 1801	Laminin G domain	Domain

• Sequence:

  MALSSAWRSVLPLWLLWSAACSRAASGDDNAFPFDIEGSSAVGRQDPPETSEPRVALGRL
  PPAAEKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGD
  SIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLI
  GSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAV
  CNCGGGPCDSVTGECLEEGFEPPTGMDCPTISCDKCVWDLTDALRLAALSIEEGKSGVLS
  VSSGAAAHRHVNEINATIYLLKTKLSERENQYALRKIQINNAENTMKSLLSDVEELVEKE
  NQASRKGQLVQKESMDTINHASQLVEQAHDMRDKIQEINNKMLYYGEEHELSPKEISEKL
  VLAQKMLEEIRSRQPFFTQRELVDEEADEAYELLSQAESWQRLHNETRTLFPVVLEQLDD
  YNAKLSDLQEALDQALNYVRDAEDMNRATAARQRDHEKQQERVREQMEVVNMSLSTSADS
  LTTPRLTLSELDDIIKNASGIYAEIDGAKSELQVKLSNLSNLSHDLVQEAIDHAQDLQQE
  ANELSRKLHSSDMNGLVQKALDASNVYENIVNYVSEANETAEFALNTTDRIYDAVSGIDT
  QIIYHKDESENLLNQARELQAKAESSSDEAVADTSRRVGGALARKSALKTRLSDAVKQLQ
  AAERGDAQQRLGQSRLITEEANRTTMEVQQATAPMANNLTNWSQNLQHFDSSAYNTAVNS
  ARDAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSVASKIQVSMMFDG
  QSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIK
  NDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKF
  IKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLELATLNNDVISLYN
  FKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVR
  TPADNGLILLMVNGSMFFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEIS
  IIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRG
  CMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGG
  FNFRTLQPNGLLFYYASGSDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVS
  PTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFTGCISNAYFTRVD
  RDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWD
  PVALKLPERNTPRNSHCHLSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLR
  TRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLWHDVIFIR
  ERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSN
  LQLNGASITSASQTFSVTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRS
  SSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDS
  NVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDG
  HPVSFSKAALVSGAVSINSCPAA

• Sequence length: 1823